메뉴 건너뛰기




Volumn 71, Issue 12, 2011, Pages 4303-4313

MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; PROSTATE SPECIFIC ANTIGEN; PROTEIN MST1; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 79958792627     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-4532     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 0029558439 scopus 로고
    • Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
    • DOI 10.1016/0378-1119(95)00653-2
    • Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 1995;167:303-6. (Pubitemid 26035917)
    • (1995) Gene , vol.167 , Issue.1-2 , pp. 303-306
    • Chernoff, J.1
  • 2
    • 43049155951 scopus 로고    scopus 로고
    • Biosignaling of mammalian Ste20-related kinases
    • Ling P, Lu TJ, Yuan CJ, Lai MD. Biosignaling of mammalian Ste20-related kinases. Cell Signal 2008;20:1237-47.
    • (2008) Cell Signal , vol.20 , pp. 1237-1247
    • Ling, P.1    Lu, T.J.2    Yuan, C.J.3    Lai, M.D.4
  • 4
    • 33745700212 scopus 로고    scopus 로고
    • Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
    • Teraishi F, Guo W, Zhang L, Dong F, Davis JJ, Sasazuki T, et al. Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res 2006;66:6072-9.
    • (2006) Cancer Res , vol.66 , pp. 6072-6079
    • Teraishi, F.1    Guo, W.2    Zhang, L.3    Dong, F.4    Davis, J.J.5    Sasazuki, T.6
  • 5
    • 71949114463 scopus 로고    scopus 로고
    • Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse
    • Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, et al. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 2009;29:6309-20.
    • (2009) Mol Cell Biol , vol.29 , pp. 6309-6320
    • Oh, S.1    Lee, D.2    Kim, T.3    Kim, T.S.4    Oh, H.J.5    Hwang, C.Y.6
  • 6
    • 0042232429 scopus 로고    scopus 로고
    • hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • DOI 10.1016/S0092-8674(03)00549-X
    • Wu S, Huang J, Dong J, Pan D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 2003;114:445-56. (Pubitemid 37100993)
    • (2003) Cell , vol.114 , Issue.4 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 7
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    • Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 2010;107:1437-42.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1437-1442
    • Lu, L.1    Li, Y.2    Kim, S.M.3    Bossuyt, W.4    Liu, P.5    Qiu, Q.6
  • 8
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 2008;18:311-21.
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 9
    • 76549127712 scopus 로고    scopus 로고
    • Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    • Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 2010;107:1431-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1431-1436
    • Song, H.1    Mak, K.K.2    Topol, L.3    Yun, K.4    Hu, J.5    Garrett, L.6
  • 10
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 2009;16:425-38.
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3    Park, J.S.4    Payer, B.5    Yin, Y.6
  • 11
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • DOI 10.1016/S0092-8674(03)00557-9
    • Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003;114:457-67. (Pubitemid 37100994)
    • (2003) Cell , vol.114 , Issue.4 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 12
    • 0142123293 scopus 로고    scopus 로고
    • The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    • DOI 10.1101/gad.1134003
    • Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 2003;17:2514-9. (Pubitemid 37271421)
    • (2003) Genes and Development , vol.17 , Issue.20 , pp. 2514-2519
    • Jia, J.1    Zhang, W.2    Wang, B.3    Trinko, R.4    Jiang, J.5
  • 13
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 2003;5:914-20.
    • (2003) Nat Cell Biol , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 16
    • 35748980862 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains
    • DOI 10.1074/jbc.M703310200
    • Cinar B, Mukhopadhyay NK, Meng G, Freeman MR. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem 2007;282:29584-93. (Pubitemid 350043392)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.40 , pp. 29584-29593
    • Cinar, B.1    Mukhopadhyay, N.K.2    Meng, G.3    Freeman, M.R.4
  • 18
    • 2342645462 scopus 로고    scopus 로고
    • Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: Implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells
    • DOI 10.1042/BJ20031661
    • Cinar B, Yeung F, Konaka H, Mayo MW, Freeman MR, Zhau HE, et al. Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J 2004;379:421-31. (Pubitemid 38570115)
    • (2004) Biochemical Journal , vol.379 , Issue.2 , pp. 421-431
    • Cinar, B.1    Yeung, F.2    Konaka, H.3    Mayo, M.W.4    Freeman, M.R.5    Zhau, H.E.6    Chung, L.W.K.7
  • 20
    • 0035477330 scopus 로고    scopus 로고
    • Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line
    • Cinar B, Koeneman KS, Edlund M, Prins GS, Zhau HE, Chung LW. Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line. Cancer Res 2001;61:7310-7. (Pubitemid 32946530)
    • (2001) Cancer Research , vol.61 , Issue.19 , pp. 7310-7317
    • Cinar, B.1    Koeneman, K.S.2    Edlund, M.3    Prins, G.S.4    Zhau, H.E.5    Chung, L.W.K.6
  • 21
    • 0031017102 scopus 로고    scopus 로고
    • An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter
    • DOI 10.1210/me.11.2.148
    • Cleutjens KB, Van Der Korput HA, van Eekelen CC, van Rooij HC, Faber PW, Trapman J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol 1997;11:148-61. (Pubitemid 27057428)
    • (1997) Molecular Endocrinology , vol.11 , Issue.2 , pp. 148-161
    • Cleutjens, K.B.J.M.1    Van Der, K.H.A.G.M.2    Van Eekelen, C.C.E.M.3    Van Rooij, H.C.J.4    Faber, P.W.5    Trapman, J.6
  • 22
    • 0242290354 scopus 로고    scopus 로고
    • Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85alpha, Androgen Receptor, and Src
    • DOI 10.1074/jbc.M306295200
    • Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, et al. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem 2003;278:42992-3000. (Pubitemid 37345912)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.44 , pp. 42992-43000
    • Sun, M.1    Yang, L.2    Feldman, R.I.3    Sun, X.-M.4    Bhalla, K.N.5    Jove, R.6    Nicosia, S.V.7    Cheng, J.Q.8
  • 23
    • 34548397326 scopus 로고    scopus 로고
    • Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer
    • DOI 10.2174/156800907781662248
    • Wang Y, Kreisberg JI, Ghosh PM. Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer. Curr Cancer Drug Targets 2007;7:591-604. (Pubitemid 47358145)
    • (2007) Current Cancer Drug Targets , vol.7 , Issue.6 , pp. 591-604
    • Wang, Y.1    Kreisberg, J.I.2    Ghosh, P.M.3
  • 24
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3'-kinase pathway is a dominant growth factor- activated cell survival pathway in LNCaP human prostate carcinoma cells
    • Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 30-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 1999;59:2891-7. (Pubitemid 29283128)
    • (1999) Cancer Research , vol.59 , Issue.12 , pp. 2891-2897
    • Lin, J.1    Adam, R.M.2    Santiestevan, E.3    Freeman, M.R.4
  • 26
    • 63249104202 scopus 로고    scopus 로고
    • Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination
    • Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell 2009;15:270-82.
    • (2009) Cancer Cell , vol.15 , pp. 270-282
    • Xu, K.1    Shimelis, H.2    Linn, D.E.3    Jiang, R.4    Yang, X.5    Sun, F.6
  • 28
    • 0036826887 scopus 로고    scopus 로고
    • PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription
    • DOI 10.1074/jbc.M206741200
    • Nishida T, Yasuda H. PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J Biol Chem 2002;277:41311-7. (Pubitemid 35257430)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.44 , pp. 41311-41317
    • Nishida, T.1    Yasuda, H.2
  • 29
    • 19044380048 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites
    • Gioeli D, Ficarro SB, Kwiek JJ, Aaronson D, Hancock M, Catling AD, et al. Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 2002;277:29304-14.
    • (2002) J Biol Chem , vol.277 , pp. 29304-29314
    • Gioeli, D.1    Ficarro, S.B.2    Kwiek, J.J.3    Aaronson, D.4    Hancock, M.5    Catling, A.D.6
  • 31
    • 40849113286 scopus 로고    scopus 로고
    • Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients
    • DOI 10.1038/sj.bjc.6604152, PII 6604152
    • McCall P, Gemmell LK, Mukherjee R, Bartlett JM, Edwards J. Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients. Br J Cancer 2008;98:1094-101. (Pubitemid 351399795)
    • (2008) British Journal of Cancer , vol.98 , Issue.6 , pp. 1094-1101
    • McCall, P.1    Gemmell, L.K.2    Mukherjee, R.3    Bartlett, J.M.S.4    Edwards, J.5
  • 32
    • 0034933130 scopus 로고    scopus 로고
    • MST1-JNK promotes apoptosis via caspase-dependent and independent pathways
    • DOI 10.1046/j.1365-2443.2001.00439.x
    • Ura S, Masuyama N, Graves JD, Gotoh Y. MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Genes Cells 2001;6:519-30. (Pubitemid 32655384)
    • (2001) Genes to Cells , vol.6 , Issue.6 , pp. 519-530
    • Ura, S.1    Masuyama, N.2    Graves, J.D.3    Gotoh, Y.4
  • 33
    • 37349118115 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex
    • DOI 10.1210/er.2007-0019
    • Heemers HV, Tindall DJ. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev 2007;28:778-808. (Pubitemid 350294296)
    • (2007) Endocrine Reviews , vol.28 , Issue.7 , pp. 778-808
    • Heemers, H.V.1    Tindall, D.J.2
  • 34
    • 14844288915 scopus 로고    scopus 로고
    • The androgen receptor recruits nuclear receptor corepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists
    • DOI 10.1074/jbc.M408972200
    • Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, et al. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem 2005;280:6511-9. (Pubitemid 40341200)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 6511-6519
    • Hodgson, M.C.1    Astapova, I.2    Cheng, S.3    Lee, L.J.4    Verhoeven, M.C.5    Choi, E.6    Balk, S.P.7    Hollenberg, A.N.8
  • 36
    • 0035724413 scopus 로고    scopus 로고
    • The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
    • DOI 10.1128/MCB.21.18.6091-6101.2001
    • Guenther MG, Barak O, Lazar MA. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 2001;21:6091-101. (Pubitemid 34263509)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.18 , pp. 6091-6101
    • Guenther, M.G.1    Barak, O.2    Lazar, M.A.3
  • 37
    • 39849097306 scopus 로고    scopus 로고
    • The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals
    • DOI 10.1016/j.ccr.2008.02.011, PII S1535610808000470
    • Zeng Q, Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 2008;13:188-92. (Pubitemid 351318373)
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 188-192
    • Zeng, Q.1    Hong, W.2
  • 39
    • 42449101282 scopus 로고    scopus 로고
    • A crucial role of WW45 in developing epithelial tissues in the mouse
    • Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J 2008;27:1231-42.
    • (2008) EMBO J , vol.27 , pp. 1231-1242
    • Lee, J.H.1    Kim, T.S.2    Yang, T.H.3    Koo, B.K.4    Oh, S.P.5    Lee, K.P.6
  • 40
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis
    • DOI 10.1200/JCO.2005.03.4777
    • Scher HI, Sawyers CL. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 2005;23:8253-61. (Pubitemid 46211563)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.32 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 41
    • 46749099444 scopus 로고    scopus 로고
    • Castration-recurrent prostate cancer is not androgenin-dependent
    • Mohler JL. Castration-recurrent prostate cancer is not androgenin-dependent. Adv Exp Med Biol 2008;617:223-34.
    • (2008) Adv Exp Med Biol , vol.617 , pp. 223-234
    • Mohler, J.L.1
  • 42
    • 0242525635 scopus 로고    scopus 로고
    • Gene Amplifications Associated with the Development of Hormone-Resistant Prostate Cancer
    • Edwards J, Krishna NS, Witton CJ, Bartlett JM. Gene amplifications associated with the development of hormone-resistant prostate cancer. Clin Cancer Res 2003;9:5271-81. (Pubitemid 37413579)
    • (2003) Clinical Cancer Research , vol.9 , Issue.14 , pp. 5271-5281
    • Edwards, J.1    Krishna, N.S.2    Witton, C.J.3    Bartlett, J.M.S.4
  • 44
    • 66749100105 scopus 로고    scopus 로고
    • Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    • King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 2009;41:524-6.
    • (2009) Nat Genet , vol.41 , pp. 524-526
    • King, J.C.1    Xu, J.2    Wongvipat, J.3    Hieronymus, H.4    Carver, B.S.5    Leung, D.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.