-
1
-
-
20444411532
-
Second nature: Biological functions of the Raf-1 "kinase"
-
M. Baccarini Second nature: biological functions of the Raf-1 "kinase" FEBS Lett. 579 2005 3271 3277
-
(2005)
FEBS Lett.
, vol.579
, pp. 3271-3277
-
-
Baccarini, M.1
-
2
-
-
79955545442
-
Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase
-
A. Baljuls, R. Mahr, I. Schwarzenau, T. Müller, L. Polzien, M. Hekman, and U.R. Rapp Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase J. Biol. Chem. 286 2011 16491 16503
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16491-16503
-
-
Baljuls, A.1
Mahr, R.2
Schwarzenau, I.3
Müller, T.4
Polzien, L.5
Hekman, M.6
Rapp, U.R.7
-
3
-
-
34548847447
-
Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: The role of N-region in the evolutionary divergence of RAF kinase function in vertebrates
-
A. Baljuls, T. Mueller, H.C. Drexler, M. Hekman, and U.R. Rapp Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates J. Biol. Chem. 282 2007 26575 26590
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26575-26590
-
-
Baljuls, A.1
Mueller, T.2
Drexler, H.C.3
Hekman, M.4
Rapp, U.R.5
-
4
-
-
2942564430
-
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
-
N. Blom, T. Sicheritz-Pontén, R. Gupta, S. Gammeltoft, and S. Brunak Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence Proteomics 4 2004 1633 1649
-
(2004)
Proteomics
, vol.4
, pp. 1633-1649
-
-
Blom, N.1
Sicheritz-Pontén, T.2
Gupta, R.3
Gammeltoft, S.4
Brunak, S.5
-
5
-
-
79955472800
-
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
-
D.F. Brennan, A.C. Dar, N.T. Hertz, W.C. Chao, A.L. Burlingame, K.M. Shokat, and D. Barford A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK Nature 472 2011 366 369
-
(2011)
Nature
, vol.472
, pp. 366-369
-
-
Brennan, D.F.1
Dar, A.C.2
Hertz, N.T.3
Chao, W.C.4
Burlingame, A.L.5
Shokat, K.M.6
Barford, D.7
-
6
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
M.S. Brose, P. Volpe, M. Feldman, M. Kumar, I. Rishi, R. Gerrero, E. Einhorn, M. Herlyn, J. Minna, and A. Nicholson BRAF and RAS mutations in human lung cancer and melanoma Cancer Res. 62 2002 6997 7000
-
(2002)
Cancer Res.
, vol.62
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
Kumar, M.4
Rishi, I.5
Gerrero, R.6
Einhorn, E.7
Herlyn, M.8
Minna, J.9
Nicholson, A.10
-
7
-
-
0032959886
-
Identification of constitutive and ras-inducible phosphorylation sites of KSR: Implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
-
A.M. Cacace, N.R. Michaud, M. Therrien, K. Mathes, T. Copeland, G.M. Rubin, and D.K. Morrison Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression Mol. Cell. Biol. 19 1999 229 240
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 229-240
-
-
Cacace, A.M.1
Michaud, N.R.2
Therrien, M.3
Mathes, K.4
Copeland, T.5
Rubin, G.M.6
Morrison, D.K.7
-
8
-
-
0035099881
-
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
-
A. Chiloeches, C.S. Mason, and R. Marais S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3 Mol. Cell. Biol. 21 2001 2423 2434
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2423-2434
-
-
Chiloeches, A.1
Mason, C.S.2
Marais, R.3
-
9
-
-
0035898539
-
Positive and negative regulation of Raf kinase activity and function by phosphorylation
-
H. Chong, J. Lee, and K.L. Guan Positive and negative regulation of Raf kinase activity and function by phosphorylation EMBO J. 20 2001 3716 3727
-
(2001)
EMBO J.
, vol.20
, pp. 3716-3727
-
-
Chong, H.1
Lee, J.2
Guan, K.L.3
-
10
-
-
20444399897
-
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation
-
S.W. Cowan-Jacob, G. Fendrich, P.W. Manley, W. Jahnke, D. Fabbro, J. Liebetanz, and T. Meyer The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation Structure 13 2005 861 871
-
(2005)
Structure
, vol.13
, pp. 861-871
-
-
Cowan-Jacob, S.W.1
Fendrich, G.2
Manley, P.W.3
Jahnke, W.4
Fabbro, D.5
Liebetanz, J.6
Meyer, T.7
-
11
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies, G.R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M.J. Garnett, and W. Bottomley Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
12
-
-
0030756069
-
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
-
B. Diaz, D. Barnard, A. Filson, S. MacDonald, A. King, and M. Marshall Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling Mol. Cell. Biol. 17 1997 4509 4516
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4509-4516
-
-
Diaz, B.1
Barnard, D.2
Filson, A.3
Macdonald, S.4
King, A.5
Marshall, M.6
-
13
-
-
0027364980
-
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
-
J.R. Fabian, I.O. Daar, and D.K. Morrison Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase Mol. Cell. Biol. 13 1993 7170 7179
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7170-7179
-
-
Fabian, J.R.1
Daar, I.O.2
Morrison, D.K.3
-
14
-
-
0029807304
-
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
-
M.A. Farrar, J. Alberol-Ila, and R.M. Perlmutter Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization Nature 383 1996 178 181
-
(1996)
Nature
, vol.383
, pp. 178-181
-
-
Farrar, M.A.1
Alberol-Ila, J.2
Perlmutter, R.M.3
-
15
-
-
84874225181
-
Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
-
A.K. Freeman, D.A. Ritt, and D.K. Morrison Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling Mol. Cell 49 2013 751 758
-
(2013)
Mol. Cell
, vol.49
, pp. 751-758
-
-
Freeman, A.K.1
Ritt, D.A.2
Morrison, D.K.3
-
16
-
-
33746265070
-
ERK and beyond: Insights from B-Raf and Raf-1 conditional knockouts
-
G. Galabova-Kovacs, A. Kolbus, D. Matzen, K. Meissl, D. Piazzolla, C. Rubiolo, K. Steinitz, and M. Baccarini ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts Cell Cycle 5 2006 1514 1518
-
(2006)
Cell Cycle
, vol.5
, pp. 1514-1518
-
-
Galabova-Kovacs, G.1
Kolbus, A.2
Matzen, D.3
Meissl, K.4
Piazzolla, D.5
Rubiolo, C.6
Steinitz, K.7
Baccarini, M.8
-
17
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
M.J. Garnett, S. Rana, H. Paterson, D. Barford, and R. Marais Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization Mol. Cell 20 2005 963 969
-
(2005)
Mol. Cell
, vol.20
, pp. 963-969
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
Barford, D.4
Marais, R.5
-
18
-
-
48849095518
-
Potent and selective pyrazole-based inhibitors of B-Raf kinase
-
J.D. Hansen, J. Grina, B. Newhouse, M. Welch, G. Topalov, N. Littman, M. Callejo, S. Gloor, M. Martinson, and E. Laird Potent and selective pyrazole-based inhibitors of B-Raf kinase Bioorg. Med. Chem. Lett. 18 2008 4692 4695
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4692-4695
-
-
Hansen, J.D.1
Grina, J.2
Newhouse, B.3
Welch, M.4
Topalov, G.5
Littman, N.6
Callejo, M.7
Gloor, S.8
Martinson, M.9
Laird, E.10
-
19
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
G. Hatzivassiliou, K. Song, I. Yen, B.J. Brandhuber, D.J. Anderson, R. Alvarado, M.J. Ludlam, D. Stokoe, S.L. Gloor, and G. Vigers RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth Nature 464 2010 431 435
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
Ludlam, M.J.7
Stokoe, D.8
Gloor, S.L.9
Vigers, G.10
-
20
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, N. Dhomen, J. Hussain, J.S. Reis-Filho, C.J. Springer, C. Pritchard, and R. Marais Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
Hussain, J.7
Reis-Filho, J.S.8
Springer, C.J.9
Pritchard, C.10
Marais, R.11
-
21
-
-
39149124469
-
Lsc activity is controlled by oligomerization and regulates integrin adhesion
-
J. Hu, P. Strauch, A. Rubtsov, E.E. Donovan, R. Pelanda, and R.M. Torres Lsc activity is controlled by oligomerization and regulates integrin adhesion Mol. Immunol. 45 2008 1825 1836
-
(2008)
Mol. Immunol.
, vol.45
, pp. 1825-1836
-
-
Hu, J.1
Strauch, P.2
Rubtsov, A.3
Donovan, E.E.4
Pelanda, R.5
Torres, R.M.6
-
22
-
-
79955044151
-
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
-
J. Hu, H. Yu, A.P. Kornev, J. Zhao, E.L. Filbert, S.S. Taylor, and A.S. Shaw Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF Proc. Natl. Acad. Sci. USA 108 2011 6067 6072
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 6067-6072
-
-
Hu, J.1
Yu, H.2
Kornev, A.P.3
Zhao, J.4
Filbert, E.L.5
Taylor, S.S.6
Shaw, A.S.7
-
23
-
-
17744378364
-
MEK kinase activity is not necessary for Raf-1 function
-
M. Hüser, J. Luckett, A. Chiloeches, K. Mercer, M. Iwobi, S. Giblett, X.M. Sun, J. Brown, R. Marais, and C. Pritchard MEK kinase activity is not necessary for Raf-1 function EMBO J. 20 2001 1940 1951
-
(2001)
EMBO J.
, vol.20
, pp. 1940-1951
-
-
Hüser, M.1
Luckett, J.2
Chiloeches, A.3
Mercer, K.4
Iwobi, M.5
Giblett, S.6
Sun, X.M.7
Brown, J.8
Marais, R.9
Pritchard, C.10
-
24
-
-
34248139038
-
The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases
-
R.E. Joseph, L. Min, and A.H. Andreotti The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases Biochemistry 46 2007 5455 5462
-
(2007)
Biochemistry
, vol.46
, pp. 5455-5462
-
-
Joseph, R.E.1
Min, L.2
Andreotti, A.H.3
-
25
-
-
70449123573
-
C-Raf inhibits MAPK activation and transformation by B-Raf(V600E)
-
F.A. Karreth, G.M. DeNicola, S.P. Winter, and D.A. Tuveson C-Raf inhibits MAPK activation and transformation by B-Raf(V600E) Mol. Cell 36 2009 477 486
-
(2009)
Mol. Cell
, vol.36
, pp. 477-486
-
-
Karreth, F.A.1
Denicola, G.M.2
Winter, S.P.3
Tuveson, D.A.4
-
26
-
-
0032511882
-
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
-
A.J. King, H. Sun, B. Diaz, D. Barnard, W. Miao, S. Bagrodia, and M.S. Marshall The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 Nature 396 1998 180 183
-
(1998)
Nature
, vol.396
, pp. 180-183
-
-
King, A.J.1
Sun, H.2
Diaz, B.3
Barnard, D.4
Miao, W.5
Bagrodia, S.6
Marshall, M.S.7
-
27
-
-
33845730781
-
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
-
A.J. King, D.R. Patrick, R.S. Batorsky, M.L. Ho, H.T. Do, S.Y. Zhang, R. Kumar, D.W. Rusnak, A.K. Takle, and D.M. Wilson Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 Cancer Res. 66 2006 11100 11105
-
(2006)
Cancer Res.
, vol.66
, pp. 11100-11105
-
-
King, A.J.1
Patrick, D.R.2
Batorsky, R.S.3
Ho, M.L.4
Do, H.T.5
Zhang, S.Y.6
Kumar, R.7
Rusnak, D.W.8
Takle, A.K.9
Wilson, D.M.10
-
28
-
-
0027326410
-
Protein kinase C alpha activates RAF-1 by direct phosphorylation
-
W. Kolch, G. Heidecker, G. Kochs, R. Hummel, H. Vahidi, H. Mischak, G. Finkenzeller, D. Marmé, and U.R. Rapp Protein kinase C alpha activates RAF-1 by direct phosphorylation Nature 364 1993 249 252
-
(1993)
Nature
, vol.364
, pp. 249-252
-
-
Kolch, W.1
Heidecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
Finkenzeller, G.7
Marmé, D.8
Rapp, U.R.9
-
29
-
-
33845197964
-
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
-
A.P. Kornev, N.M. Haste, S.S. Taylor, and L.F. Eyck Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism Proc. Nat. Acad. Sci. USA 103 2006 17783 17788
-
(2006)
Proc. Nat. Acad. Sci. USA
, vol.103
, pp. 17783-17788
-
-
Kornev, A.P.1
Haste, N.M.2
Taylor, S.S.3
Eyck, L.F.4
-
31
-
-
0033610850
-
Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue
-
M. LaFevre-Bernt, F. Sicheri, A. Pico, M. Porter, J. Kuriyan, and W.T. Miller Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue J. Biol. Chem. 273 1998 32129 32134
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32129-32134
-
-
Lafevre-Bernt, M.1
Sicheri, F.2
Pico, A.3
Porter, M.4
Kuriyan, J.5
Miller, W.T.6
-
32
-
-
84874361241
-
MEK-1 activates C-Raf through a Ras-independent mechanism
-
D.T. Leicht, V. Balan, J. Zhu, A. Kaplun, A. Bronisz, A. Rana, and G. Tzivion MEK-1 activates C-Raf through a Ras-independent mechanism Biochim. Biophys. Acta 1833 2013 976 986
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 976-986
-
-
Leicht, D.T.1
Balan, V.2
Zhu, J.3
Kaplun, A.4
Bronisz, A.5
Rana, A.6
Tzivion, G.7
-
33
-
-
13444306414
-
Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk
-
X. Lin, M.K. Ayrapetov, S. Lee, K. Parang, and G. Sun Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk Biochemistry 44 2005 1561 1567
-
(2005)
Biochemistry
, vol.44
, pp. 1561-1567
-
-
Lin, X.1
Ayrapetov, M.K.2
Lee, S.3
Parang, K.4
Sun, G.5
-
34
-
-
62349091524
-
Protein kinase activation loop autophosphorylation in cis: Overcoming a Catch-22 situation
-
P.A. Lochhead Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation Sci. Signal. 2 2009 4
-
(2009)
Sci. Signal.
, vol.2
, pp. 4
-
-
Lochhead, P.A.1
-
35
-
-
0029006126
-
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
-
R. Marais, Y. Light, H.F. Paterson, and C.J. Marshall Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation EMBO J. 14 1995 3136 3145
-
(1995)
EMBO J.
, vol.14
, pp. 3136-3145
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Marshall, C.J.4
-
36
-
-
0031041171
-
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
-
R. Marais, Y. Light, H.F. Paterson, C.S. Mason, and C.J. Marshall Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases J. Biol. Chem. 272 1997 4378 4383
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4378-4383
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Mason, C.S.4
Marshall, C.J.5
-
37
-
-
0033561041
-
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
-
C.S. Mason, C.J. Springer, R.G. Cooper, G. Superti-Furga, C.J. Marshall, and R. Marais Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation EMBO J. 18 1999 2137 2148
-
(1999)
EMBO J.
, vol.18
, pp. 2137-2148
-
-
Mason, C.S.1
Springer, C.J.2
Cooper, R.G.3
Superti-Furga, G.4
Marshall, C.J.5
Marais, R.6
-
38
-
-
79953784580
-
RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling
-
M.M. McKay, D.A. Ritt, and D.K. Morrison RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling Curr. Biol. 21 2011 563 568
-
(2011)
Curr. Biol.
, vol.21
, pp. 563-568
-
-
McKay, M.M.1
Ritt, D.A.2
Morrison, D.K.3
-
39
-
-
17744384002
-
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
-
M. Mikula, M. Schreiber, Z. Husak, L. Kucerova, J. Rüth, R. Wieser, K. Zatloukal, H. Beug, E.F. Wagner, and M. Baccarini Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene EMBO J. 20 2001 1952 1962
-
(2001)
EMBO J.
, vol.20
, pp. 1952-1962
-
-
Mikula, M.1
Schreiber, M.2
Husak, Z.3
Kucerova, L.4
Rüth, J.5
Wieser, R.6
Zatloukal, K.7
Beug, H.8
Wagner, E.F.9
Baccarini, M.10
-
41
-
-
0036239642
-
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
-
A. Nguyen, W.R. Burack, J.L. Stock, R. Kortum, O.V. Chaika, M. Afkarian, W.J. Muller, K.M. Murphy, D.K. Morrison, and R.E. Lewis Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo Mol. Cell. Biol. 22 2002 3035 3045
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3035-3045
-
-
Nguyen, A.1
Burack, W.R.2
Stock, J.L.3
Kortum, R.4
Chaika, O.V.5
Afkarian, M.6
Muller, W.J.7
Murphy, K.M.8
Morrison, D.K.9
Lewis, R.E.10
-
42
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
43
-
-
84862273387
-
Identification of a novel family of BRAF(V600E) inhibitors
-
J. Qin, P. Xie, C. Ventocilla, G. Zhou, A. Vultur, Q. Chen, Q. Liu, M. Herlyn, J. Winkler, and R. Marmorstein Identification of a novel family of BRAF(V600E) inhibitors J. Med. Chem. 55 2012 5220 5230
-
(2012)
J. Med. Chem.
, vol.55
, pp. 5220-5230
-
-
Qin, J.1
Xie, P.2
Ventocilla, C.3
Zhou, G.4
Vultur, A.5
Chen, Q.6
Liu, Q.7
Herlyn, M.8
Winkler, J.9
Marmorstein, R.10
-
44
-
-
70349438995
-
A dimerization-dependent mechanism drives RAF catalytic activation
-
T. Rajakulendran, M. Sahmi, M. Lefrançois, F. Sicheri, and M. Therrien A dimerization-dependent mechanism drives RAF catalytic activation Nature 461 2009 542 545
-
(2009)
Nature
, vol.461
, pp. 542-545
-
-
Rajakulendran, T.1
Sahmi, M.2
Lefrançois, M.3
Sicheri, F.4
Therrien, M.5
-
45
-
-
84879695087
-
ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers
-
A.P. Rebocho, and R. Marais ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers Oncogene 32 2013 3207 3212
-
(2013)
Oncogene
, vol.32
, pp. 3207-3212
-
-
Rebocho, A.P.1
Marais, R.2
-
46
-
-
79551594605
-
Protein kinases: Evolution of dynamic regulatory proteins
-
S.S. Taylor, and A.P. Kornev Protein kinases: evolution of dynamic regulatory proteins Trends Biochem. Sci. 36 2011 65 77
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 65-77
-
-
Taylor, S.S.1
Kornev, A.P.2
-
47
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, and N.K. Haass Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc. Natl. Acad. Sci. USA 105 2008 3041 3046
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Cho, H.5
Mamo, S.6
Bremer, R.7
Gillette, S.8
Kong, J.9
Haass, N.K.10
-
48
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Cancer Genome Project
-
P.T. Wan, M.J. Garnett, S.M. Roe, S. Lee, D. Niculescu-Duvaz, V.M. Good, C.M. Jones, C.J. Marshall, C.J. Springer, D. Barford, R. Marais Cancer Genome Project Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 2004 855 867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
-
51
-
-
78649322633
-
Partner exchange: Protein-protein interactions in the Raf pathway
-
R. Wimmer, and M. Baccarini Partner exchange: protein-protein interactions in the Raf pathway Trends Biochem. Sci. 35 2010 660 668
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 660-668
-
-
Wimmer, R.1
Baccarini, M.2
-
52
-
-
0033001789
-
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
-
W. Xu, A. Doshi, M. Lei, M.J. Eck, and S.C. Harrison Crystal structures of c-Src reveal features of its autoinhibitory mechanism Mol. Cell 3 1999 629 638
-
(1999)
Mol. Cell
, vol.3
, pp. 629-638
-
-
Xu, W.1
Doshi, A.2
Lei, M.3
Eck, M.J.4
Harrison, S.C.5
-
53
-
-
0034675919
-
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
-
B.H. Zhang, and K.L. Guan Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601 EMBO J. 19 2000 5429 5439
-
(2000)
EMBO J.
, vol.19
, pp. 5429-5439
-
-
Zhang, B.H.1
Guan, K.L.2
-
54
-
-
0035087327
-
Regulation of the Raf kinase by phosphorylation
-
B.H. Zhang, and K.L. Guan Regulation of the Raf kinase by phosphorylation Exp. Lung Res. 27 2001 269 295
-
(2001)
Exp. Lung Res.
, vol.27
, pp. 269-295
-
-
Zhang, B.H.1
Guan, K.L.2
-
55
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
X. Zhang, J. Gureasko, K. Shen, P.A. Cole, and J. Kuriyan An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor Cell 125 2006 1137 1149
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
-
56
-
-
84874225181
-
Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
-
A.K. Freeman, D.A. Ritt, and D.K. Morrison Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling Mol. Cell 49 2013 751 758
-
(2013)
Mol. Cell
, vol.49
, pp. 751-758
-
-
Freeman, A.K.1
Ritt, D.A.2
Morrison, D.K.3
-
57
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
G. Hatzivassiliou, K. Song, I. Yen, B.J. Brandhuber, D.J. Anderson, R. Alvarado, M.J. Ludlam, D. Stokoe, S.L. Gloor, and G. Vigers RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth Nature 464 2010 431 435
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
Ludlam, M.J.7
Stokoe, D.8
Gloor, S.L.9
Vigers, G.10
-
58
-
-
79955044151
-
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
-
J. Hu, H. Yu, A.P. Kornev, J. Zhao, E.L. Filbert, S.S. Taylor, and A.S. Shaw Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF Proc. Natl. Acad. Sci. USA 108 2011 6067 6072
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 6067-6072
-
-
Hu, J.1
Yu, H.2
Kornev, A.P.3
Zhao, J.4
Filbert, E.L.5
Taylor, S.S.6
Shaw, A.S.7
-
59
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
60
-
-
0034675919
-
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
-
B.H. Zhang, and K.L. Guan Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601 EMBO J. 19 2000 5429 5439
-
(2000)
EMBO J.
, vol.19
, pp. 5429-5439
-
-
Zhang, B.H.1
Guan, K.L.2
-
61
-
-
0035087327
-
Regulation of the Raf kinase by phosphorylation
-
B.H. Zhang, and K.L. Guan Regulation of the Raf kinase by phosphorylation Exp. Lung Res. 27 2001 269 295
-
(2001)
Exp. Lung Res.
, vol.27
, pp. 269-295
-
-
Zhang, B.H.1
Guan, K.L.2
|