The toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 27849-27858

  Reese, Michael L ^a,d   Shah, ^b,c   Boothroyd, John C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; GTPASES; PSEUDOKINASE;

GUANOSINE TRIPHOSPHATASE; IMMUNITY RELATED GUANOSINE TRIPHOSPHATASE; NUCLEOTIDE BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN ROP17; PROTEIN ROP18; PROTEIN ROP5; PROTEIN SERINE THREONINE KINASE; THREONINE; UNCLASSIFIED DRUG; IIGP1 PROTEIN, MOUSE; PROTOZOAL PROTEIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME POLYMORPHISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; TOXOPLASMA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HOST PARASITE INTERACTION; HUMAN; METABOLISM; MOUSE; PARASITOLOGY; TOXOPLASMOSIS;

ALLOSTERIC REGULATION; ANIMALS; GTP PHOSPHOHYDROLASES; HOST-PARASITE INTERACTIONS; HUMANS; MICE; MODELS, MOLECULAR; PHOSPHOTRANSFERASES; PROTOZOAN PROTEINS; TOXOPLASMA; TOXOPLASMOSIS;

EID: 84907495392     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.567057     Document Type: Article

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