Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 628-635

  Hari, Sanjay B ^a   Merritt, Ethan A ^a   Maly, Dustin J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE TRIPHOSPHATE COMPETITIVE INHIBITOR; DUAL SPECIFICITY PHOSPHATASE 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME INHIBITOR INTERACTION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; HEK293 CELL LINE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901295552     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.02.016     Document Type: Article

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