-
1
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
Hynes, N. E. & Lane, H. A. ERBB receptors and cancer: the complexity of targeted inhibitors. Nature Rev. Cancer 5, 341-354 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
2
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang, X. et al. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125, 1137-1149 (2006).
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
-
3
-
-
0035700605
-
Mig-6 is a negative regulator of the epidermal growth factor receptor signal
-
Hackel, P. O., Gishizky, M. & Ullrich, A. Mig-6 is a negative regulator of the epidermal growth factor receptor signal. Biol. Chem. 382, 1649-1662 (2001).
-
(2001)
Biol. Chem
, vol.382
, pp. 1649-1662
-
-
Hackel, P.O.1
Gishizky, M.2
Ullrich, A.3
-
4
-
-
13244283225
-
Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function
-
Xu, D., Makkinje, A. & Kyriakis, J. M. Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J. Biol. Chem. 280, 2924-2933 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 2924-2933
-
-
Xu, D.1
Makkinje, A.2
Kyriakis, J.M.3
-
5
-
-
0033796072
-
Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain
-
Fiorentino, L. et al. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol. Cell. Biol. 20, 7735-7750 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 7735-7750
-
-
Fiorentino, L.1
-
6
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood, E. R. et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 64, 6652-6659 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
-
7
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
-
Jeffrey, P. D. et al. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376, 313-320 (1995).
-
(1995)
Nature
, vol.376
, pp. 313-320
-
-
Jeffrey, P.D.1
-
8
-
-
27544450547
-
Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype
-
755-761
-
Ballaro, C. et al. Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype. EMBO Rep. 6, 755-761 (2005).
-
(2005)
EMBO Rep
, vol.6
-
-
Ballaro, C.1
-
9
-
-
33646588346
-
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
-
Ferby, I. et al. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nature Med. 12, 568-573 (2006).
-
(2006)
Nature Med
, vol.12
, pp. 568-573
-
-
Ferby, I.1
-
10
-
-
33846215432
-
Evidence that MIG-6 is a tumor-suppressor gene
-
Zhang, Y. W. et al. Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26, 269-276 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 269-276
-
-
Zhang, Y.W.1
-
11
-
-
33947148666
-
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
-
Shen, F. et al. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol. Biol. Cell 18, 732-742 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 732-742
-
-
Shen, F.1
-
12
-
-
0038037236
-
Feedback inhibition by RALT controls signal output by the ErbB network
-
Anastasi, S. et al. Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene 22, 4221-4234 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 4221-4234
-
-
Anastasi, S.1
-
13
-
-
37149025094
-
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
-
online publication doi:10.1038/sj.onc.1210590 18 June
-
Anastasi, S. et al. The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Oncogene advanced online publication doi:10.1038/sj.onc.1210590 (18 June 2007).
-
(2007)
Oncogene advanced
-
-
Anastasi, S.1
-
14
-
-
0141599428
-
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
-
Stamos, J., Sliwkowski, M. X. & Eigenbrot, C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277, 46265-46272 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 46265-46272
-
-
Stamos, J.1
Sliwkowski, M.X.2
Eigenbrot, C.3
-
15
-
-
26944466110
-
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
-
Depetris, R. S. et al. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol. Cell 20, 325-333 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 325-333
-
-
Depetris, R.S.1
-
16
-
-
18944386711
-
The active conformation of the PAK1 kinase domain
-
Lei, M., Robinson, M. A. & Harrison, S. C. The active conformation of the PAK1 kinase domain. Structure 13, 769-778 (2005).
-
(2005)
Structure
, vol.13
, pp. 769-778
-
-
Lei, M.1
Robinson, M.A.2
Harrison, S.C.3
-
17
-
-
0038732770
-
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
-
Reynolds, A. R. et al. EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nature Cell Biol. 5, 447-453 (2003).
-
(2003)
Nature Cell Biol
, vol.5
, pp. 447-453
-
-
Reynolds, A.R.1
-
18
-
-
5444265657
-
EGF signalling amplification induced by dynamic clustering of EGFR
-
Ichinose, J., Murata, M., Yanagida, T. & Sako, Y. EGF signalling amplification induced by dynamic clustering of EGFR. Biochem. Biophys. Res. Commun. 324, 1143-1149 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.324
, pp. 1143-1149
-
-
Ichinose, J.1
Murata, M.2
Yanagida, T.3
Sako, Y.4
-
19
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
20
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella, R., Bell, D. W., Haber, D. A. & Settleman, J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167 (2004).
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
21
-
-
0034653375
-
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin α
-
Conti, E. & Kuriyan, J. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin α. Structure 8, 329-338 (2000).
-
(2000)
Structure
, vol.8
, pp. 329-338
-
-
Conti, E.1
Kuriyan, J.2
-
22
-
-
0024361631
-
Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor
-
Wedegaertner, P. B. & Gill, G. N. Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. J. Biol. Chem. 264, 11346-11353 (1989).
-
(1989)
J. Biol. Chem
, vol.264
, pp. 11346-11353
-
-
Wedegaertner, P.B.1
Gill, G.N.2
|