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Volumn 29, Issue 10, 2009, Pages 2816-2827

Dual role of Cdc42 in spindle orientation control of adherent cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; P21 ACTIVATED KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN CDC42; RAC1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; P21 ACTIVATED KINASE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; SMALL INTERFERING RNA;

EID: 66349098739     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01713-08     Document Type: Article
Times cited : (64)

References (50)
  • 1
    • 0025294640 scopus 로고
    • CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
    • Adams, A. E., D. I. Johnson, R. M. Longnecker, B. F. Sloat, and J. R. Pringle. 1990. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111:131-142.
    • (1990) J. Cell Biol , vol.111 , pp. 131-142
    • Adams, A.E.1    Johnson, D.I.2    Longnecker, R.M.3    Sloat, B.F.4    Pringle, J.R.5
  • 2
    • 0346462998 scopus 로고    scopus 로고
    • p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
    • Balasenthil, S., A. A. Sahin, C. J. Barnes, R. A. Wang, R. G. Pestell, R. K. Vadlamudi, and R. Kumar. 2004. p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J. Biol. Chem. 279:1422-1428.
    • (2004) J. Biol. Chem , vol.279 , pp. 1422-1428
    • Balasenthil, S.1    Sahin, A.A.2    Barnes, C.J.3    Wang, R.A.4    Pestell, R.G.5    Vadlamudi, R.K.6    Kumar, R.7
  • 3
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch, G. M. 2003. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72:743-781.
    • (2003) Annu. Rev. Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 4
    • 0030750203 scopus 로고    scopus 로고
    • Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex
    • Carminati, J. L., and T. Stearns. 1997. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J. Cell Biol. 138:629-641.
    • (1997) J. Cell Biol , vol.138 , pp. 629-641
    • Carminati, J.L.1    Stearns, T.2
  • 6
    • 8344221351 scopus 로고    scopus 로고
    • Asymmetric cell division in C. elegans: Cortical polarity and spindle positioning
    • Cowan, C. R., and A. A. Hyman. 2004. Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu. Rev. Cell Dev. Biol. 20:427-453.
    • (2004) Annu. Rev. Cell Dev. Biol , vol.20 , pp. 427-453
    • Cowan, C.R.1    Hyman, A.A.2
  • 8
    • 0033194037 scopus 로고    scopus 로고
    • Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics
    • Edwards, D. C., L. C. Sanders, G. M. Bokoch, and G. N. Gill. 1999. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics. Nat. Cell Biol. 1:253-259.
    • (1999) Nat. Cell Biol , vol.1 , pp. 253-259
    • Edwards, D.C.1    Sanders, L.C.2    Bokoch, G.M.3    Gill, G.N.4
  • 9
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420:629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 10
    • 33646566846 scopus 로고    scopus 로고
    • GIT2 represses Crk-and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
    • Frank, S. R., M. R. Adelstein, and S. H. Hansen. 2006. GIT2 represses Crk-and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J. 25:1848-1859.
    • (2006) EMBO J , vol.25 , pp. 1848-1859
    • Frank, S.R.1    Adelstein, M.R.2    Hansen, S.H.3
  • 11
  • 12
    • 0342265157 scopus 로고    scopus 로고
    • Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo
    • Gonczy, P., S. Pichler, M. Kirkham, and A. A. Hyman. 1999. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. J. Cell Biol. 147:135-150.
    • (1999) J. Cell Biol , vol.147 , pp. 135-150
    • Gonczy, P.1    Pichler, S.2    Kirkham, M.3    Hyman, A.A.4
  • 13
    • 0035799292 scopus 로고    scopus 로고
    • CDC-42 controls early cell polarity and spindle orientation in C. elegans
    • Gotta, M., M. C. Abraham, and J. Ahringer. 2001. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr. Biol. 11:482-488.
    • (2001) Curr. Biol , vol.11 , pp. 482-488
    • Gotta, M.1    Abraham, M.C.2    Ahringer, J.3
  • 14
    • 33745835407 scopus 로고    scopus 로고
    • The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity
    • Haller, C., S. Rauch, N. Michel, S. Hannemann, M. J. Lehmann, O. T. Keppler, and O. T. Fackler. 2006. The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity. J. Biol. Chem. 281:19618-19630.
    • (2006) J. Biol. Chem , vol.281 , pp. 19618-19630
    • Haller, C.1    Rauch, S.2    Michel, N.3    Hannemann, S.4    Lehmann, M.J.5    Keppler, O.T.6    Fackler, O.T.7
  • 15
    • 33646705915 scopus 로고    scopus 로고
    • The multifunctional GIT family of proteins
    • Hoefen, R. J., and B. C. Berk. 2006. The multifunctional GIT family of proteins. J. Cell Sci. 119:1469-1475.
    • (2006) J. Cell Sci , vol.119 , pp. 1469-1475
    • Hoefen, R.J.1    Berk, B.C.2
  • 16
    • 0035153295 scopus 로고    scopus 로고
    • Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores
    • Hoffman, D. B., C. G. Pearson, T. J. Yen, B. J. Howell, and E. D. Salmon. 2001. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol. Biol. Cell 12:1995-2009.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1995-2009
    • Hoffman, D.B.1    Pearson, C.G.2    Yen, T.J.3    Howell, B.J.4    Salmon, E.D.5
  • 17
    • 58149191544 scopus 로고    scopus 로고
    • Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
    • Jaffe, A. B., N. Kaji, J. Durgan, and A. Hall. 2008. Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J. Cell Biol. 183:625-633.
    • (2008) J. Cell Biol , vol.183 , pp. 625-633
    • Jaffe, A.B.1    Kaji, N.2    Durgan, J.3    Hall, A.4
  • 18
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe, A. B., and A. Hall. 2005. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21:247-269.
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 19
    • 41949109595 scopus 로고    scopus 로고
    • LIM-kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning
    • Kaji, N., A. Muramoto, and K. Mizuno. 2008. LIM-kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning. J. Biol. Chem. 283:4983-4992.
    • (2008) J. Biol. Chem , vol.283 , pp. 4983-4992
    • Kaji, N.1    Muramoto, A.2    Mizuno, K.3
  • 20
    • 0037154004 scopus 로고    scopus 로고
    • Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage
    • Le Borgne, R., Y. Bellaiche, and F. Schweisguth. 2002. Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage. Curr. Biol. 12:95-104.
    • (2002) Curr. Biol , vol.12 , pp. 95-104
    • Le Borgne, R.1    Bellaiche, Y.2    Schweisguth, F.3
  • 21
    • 0034604338 scopus 로고    scopus 로고
    • Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
    • Lei, M., W. Lu, W. Meng, M. C. Parrini, M. J. Eck, B. J. Mayer, and S. C. Harrison. 2000. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102:387-397.
    • (2000) Cell , vol.102 , pp. 387-397
    • Lei, M.1    Lu, W.2    Meng, W.3    Parrini, M.C.4    Eck, M.J.5    Mayer, B.J.6    Harrison, S.C.7
  • 22
    • 0035945614 scopus 로고    scopus 로고
    • Adherens junctions inhibit asymmetric division in the Drosophila epithelium
    • Lu, B., F. Roegiers, L. Y. Jan, and Y. N. Jan. 2001. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409:522-525.
    • (2001) Nature , vol.409 , pp. 522-525
    • Lu, B.1    Roegiers, F.2    Jan, L.Y.3    Jan, Y.N.4
  • 24
    • 1542374119 scopus 로고    scopus 로고
    • Parsing the polarity code
    • Macara, I. G. 2004. Parsing the polarity code. Nat. Rev. Mol. Cell Biol. 5:220-231.
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 220-231
    • Macara, I.G.1
  • 25
    • 0037455574 scopus 로고    scopus 로고
    • RhoA is required for cortical retraction and rigidity during mitotic cell rounding
    • Maddox, A. S., and K. Burridge. 2003. RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J. Cell Biol. 160:255-265.
    • (2003) J. Cell Biol , vol.160 , pp. 255-265
    • Maddox, A.S.1    Burridge, K.2
  • 26
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama, T., and J. E. Dixon. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:13375-13378.
    • (1998) J. Biol. Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 27
    • 0026695774 scopus 로고
    • Actin based motility on retraction fibers in mitotic PtK2 cells
    • Mitchison, T. J. 1992. Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil. Cytoskelet. 22:135-151.
    • (1992) Cell Motil. Cytoskelet , vol.22 , pp. 135-151
    • Mitchison, T.J.1
  • 28
    • 33744997166 scopus 로고    scopus 로고
    • Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function
    • Na, J., and M. Zernicka-Goetz. 2006. Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function. Curr. Biol. 16:1249-1254.
    • (2006) Curr. Biol , vol.16 , pp. 1249-1254
    • Na, J.1    Zernicka-Goetz, M.2
  • 29
    • 28444482087 scopus 로고    scopus 로고
    • Regulation of protein activities by phosphoinositide phosphates
    • Niggli, V. 2005. Regulation of protein activities by phosphoinositide phosphates. Annu. Rev. Cell Dev. Biol. 21:57-79.
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 57-79
    • Niggli, V.1
  • 30
    • 0034026122 scopus 로고    scopus 로고
    • Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion
    • O'Connell, C. B., and Y. L. Wang. 2000. Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol. Biol. Cell 11:1765-1774.
    • (2000) Mol. Biol. Cell , vol.11 , pp. 1765-1774
    • O'Connell, C.B.1    Wang, Y.L.2
  • 31
    • 2942557125 scopus 로고    scopus 로고
    • Dynamic microtubules lead the way for spindle positioning
    • Pearson, C. G., and K. Bloom. 2004. Dynamic microtubules lead the way for spindle positioning. Nat. Rev. Mol. Cell Biol. 5:481-492.
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 481-492
    • Pearson, C.G.1    Bloom, K.2
  • 32
    • 0003640903 scopus 로고    scopus 로고
    • Cambridge University Press, Cambridge, United Kingdom
    • Rappaport, R. 1996. Cytokinesis in animal cells. Cambridge University Press, Cambridge, United Kingdom.
    • (1996) Cytokinesis in animal cells
    • Rappaport, R.1
  • 33
    • 33748994545 scopus 로고    scopus 로고
    • Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
    • Ridley, A. J. 2006. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol. 16:522-529.
    • (2006) Trends Cell Biol , vol.16 , pp. 522-529
    • Ridley, A.J.1
  • 34
    • 0036787934 scopus 로고    scopus 로고
    • Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis
    • Roberts, E. C., P. S. Shapiro, T. S. Nahreini, G. Pages, J. Pouyssegur, and N. G. Ahn. 2002. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol. Cell. Biol. 22:7226-7241.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7226-7241
    • Roberts, E.C.1    Shapiro, P.S.2    Nahreini, T.S.3    Pages, G.4    Pouyssegur, J.5    Ahn, N.G.6
  • 36
    • 33644959986 scopus 로고    scopus 로고
    • AlphaPIX and betaPIX and their role in focal adhesion formation
    • Rosenberger, G., and K. Kutsche. 2006. AlphaPIX and betaPIX and their role in focal adhesion formation. Eur. J. Cell Biol. 85:265-274.
    • (2006) Eur. J. Cell Biol , vol.85 , pp. 265-274
    • Rosenberger, G.1    Kutsche, K.2
  • 37
    • 0031105660 scopus 로고    scopus 로고
    • Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    • Sells, M. A., U. G. Knaus, S. Bagrodia, D. M. Ambrose, G. M. Bokoch, and J. Chernoff. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7:202-210.
    • (1997) Curr. Biol , vol.7 , pp. 202-210
    • Sells, M.A.1    Knaus, U.G.2    Bagrodia, S.3    Ambrose, D.M.4    Bokoch, G.M.5    Chernoff, J.6
  • 38
    • 0031127255 scopus 로고    scopus 로고
    • Emerging from the Pak: The p21-activated protein kinase family
    • Sells, M. A., and J. Chernoff. 1997. Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol. 6:162-167.
    • (1997) Trends Cell Biol , vol.6 , pp. 162-167
    • Sells, M.A.1    Chernoff, J.2
  • 39
    • 0347155585 scopus 로고    scopus 로고
    • Phosphorylation of p85 βPix, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth
    • Shin, E., K. Shin, C. Lee, K. Woo, S. Quan, N. Soung, Y. G. Kim, C. I. Cha, S. Kim, D. Park, G. M. Bokoch, and E. Kim. 2002. Phosphorylation of p85 βPix, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. J. Biol. Chem. 277:44417-44430.
    • (2002) J. Biol. Chem , vol.277 , pp. 44417-44430
    • Shin, E.1    Shin, K.2    Lee, C.3    Woo, K.4    Quan, S.5    Soung, N.6    Kim, Y.G.7    Cha, C.I.8    Kim, S.9    Park, D.10    Bokoch, G.M.11    Kim, E.12
  • 40
    • 0037018847 scopus 로고    scopus 로고
    • A role for PI 3-kinase and PKB activity in the G2/M phase of cell cycle
    • Shtivelman, E., J. Sussman, and D. Stokoe. 2002. A role for PI 3-kinase and PKB activity in the G2/M phase of cell cycle. Curr. Biol. 12:919-924.
    • (2002) Curr. Biol , vol.12 , pp. 919-924
    • Shtivelman, E.1    Sussman, J.2    Stokoe, D.3
  • 42
    • 33947596005 scopus 로고    scopus 로고
    • Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner
    • Toyoshima, F., and E. Nishida. 2007. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J. 26:1487-1498.
    • (2007) EMBO J , vol.26 , pp. 1487-1498
    • Toyoshima, F.1    Nishida, E.2
  • 45
    • 0032582669 scopus 로고    scopus 로고
    • Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
    • Walter, B. N., Z. Huang, R. Jakobi, P. T. Tuazon, E. S. Alnemri, G. Litwack, and J. A. Traugh. 1998. Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J. Biol. Chem. 273:28733-28739.
    • (1998) J. Biol. Chem , vol.273 , pp. 28733-28739
    • Walter, B.N.1    Huang, Z.2    Jakobi, R.3    Tuazon, P.T.4    Alnemri, E.S.5    Litwack, G.6    Traugh, J.A.7
  • 48
    • 0141483737 scopus 로고    scopus 로고
    • Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    • Yamashita, Y. M., D. L. Jones, and M. T. Fuller. 2003. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301:1547-1550.
    • (2003) Science , vol.301 , pp. 1547-1550
    • Yamashita, Y.M.1    Jones, D.L.2    Fuller, M.T.3
  • 50
    • 26944442735 scopus 로고    scopus 로고
    • The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A
    • Zhao, Z. S., J. P. Lim, Y. W. Ng, L. Lim, and E. Manser. 2005. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol. Cell 20:237-249.
    • (2005) Mol. Cell , vol.20 , pp. 237-249
    • Zhao, Z.S.1    Lim, J.P.2    Ng, Y.W.3    Lim, L.4    Manser, E.5


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