IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways

Nature Communications

Volumn 2, Issue 1, 2011, Pages

  Ashida, Noboru ^a,e   SenBanerjee, Sucharita ^a,b   Kodama, Shohta ^b,f   Foo, Shi Yin ^a,g   Coggins, Matthew ^a   Spencer, Joel A ^c   Zamiri, Parisa ^c,h   Shen, Dongxiao ^a   Li, Ling ^a   Sciuto, Tracey ^a   Dvorak, Ann ^a   Gerszten, Robert E ^a   Lin, Charles P ^c   Karin, Michael ^d   Rosenzweig, Anthony ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^f FUKUOKA UNIVERSITY   (Japan)

^g NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^h Arsenal Medical   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; I KAPPA B KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL FUNCTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; GENE DELETION; MALE; MOUSE; NONHUMAN; PLACENTA; PROTEIN DEPLETION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; CELL MOTION; CYTOLOGY; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT;

MUS;

ANIMALS; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; FEMALE; I-KAPPA B KINASE; MALE; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 79956277581     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1317     Document Type: Article

References (29)

1. Karin, M. Nuclear factor-kappaB in cancer development and progression. Nature 441, 431-436 (2006). (Pubitemid 44050137)
2. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. & Karin, M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91, 243-252 (1997). (Pubitemid 27456391)
3. Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation. Science 278, 860-866 (1997). (Pubitemid 27467923)
4. Rothwarf, D. M., Zandi, E., Natoli, G. & Karin, M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395, 297-300 (1998). (Pubitemid 28447557)
5. Hu, Y. et al. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 410, 710-714 (2001). (Pubitemid 32290360)
6. Senftleben, U. et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293, 1495-1499 (2001). (Pubitemid 32801552)
7. Li, Z. W. et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 189, 1839-1845 (1999).
8. Brand, K. et al. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 97, 1715-1722 (1996). (Pubitemid 26105480)
9. Liu, S. F., Ye, X. & Malik, A. B. Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Mol. Pharmacol. 55, 658-667 (1999). (Pubitemid 29165430)
10. Kisseleva, T. et al. NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer. J. Clin. Invest. 116, 2955-2963 (2006). (Pubitemid 44684480)
11. Chen, F., Lu, Y., Castranova, V., Li, Z. & Karin, M. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J. Biol. Chem. 281, 37142-37149 (2006). (Pubitemid 46042184)
12. Chen, L. W. et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat. Med. 9, 575-581 (2003).
13. Meiler, S. E. et al. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J. Mol. Cell Cardiol. 34, 349-359 (2002). (Pubitemid 37162426)
14. Chen, J. et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat. Med. 11, 1188-1196 (2005). (Pubitemid 43093666)
15. Ackah, E. et al. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115, 2119-2127 (2005). (Pubitemid 41134153)
16. Yang, Z. Z. et al. Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 278, 32124-32131 (2003).
17. Ozes, O. N. et al. NF-kappaB activation by tumour necrosis factor requires the Akt serine- threonine kinase. Nature 401, 82-85 (1999).
18. Romashkova, J. A. & Makarov, S. S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401, 86-90 (1999).
19. Andjelkovic, M. et al. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272, 31515-31524 (1997). (Pubitemid 28013293)
20. Mourkioti, F. et al. Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J. Clin. Invest. 116, 2945-2954 (2006). (Pubitemid 44684479)
21. Shiraishi, I. et al. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ. Res. 94, 884-891 (2004). (Pubitemid 38490065)
22. Su, T. T. et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 3, 780-786 (2002).
23. Zhou, B. P. et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J. Biol. Chem. 275, 8027-8031 (2000). (Pubitemid 30159714)
24. Takeda, K. et al. Limb and skin abnormalities in mice lacking IKKalpha. Science 284, 313-316 (1999). (Pubitemid 129523448)
25. Arkan, M. C. et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005). (Pubitemid 40321355)
26. Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 11, 183-190 (2005). (Pubitemid 40321354)
27. Phung, T. L. et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 10, 159-170 (2006). (Pubitemid 44175906)
28. Matsui, T. et al. Adenoviral gene transfer of activated PI 3-kinse and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100, 2373-2379 (1999).
29. Heller, E. A. et al. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation 112, 578-586 (2005). (Pubitemid 41060799)