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Volumn 104, Issue , 2016, Pages 124-131

Mfsd2a-based pharmacological strategies for drug delivery across the blood-brain barrier

Author keywords

Blood brain barrier; Central nervous system; Drug delivery; Lysophosphatidylcholine; Mfsd2a; Transcytosis

Indexed keywords

AMINO ACID TRANSPORTER; CARRIER PROTEIN; DOCOSAHEXAENOIC ACID; DOPAMINE; EFAVIRENZ; GLUCOSE TRANSPORTER 1; INDOMETACIN; KETOPROFEN; LYSOPHOSPHATIDYLCHOLINE; MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING PROTEIN 2A; MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING PROTEIN 2A INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VALPROIC ACID; DRUG; MFSD2A PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 84953217908     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.024     Document Type: Article
Times cited : (34)

References (112)
  • 1
    • 84905277233 scopus 로고    scopus 로고
    • Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury
    • E. Esposito, M. Cordaro, and S. Cuzzocrea Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury Pharmacol. Res. 86 2014 26 31
    • (2014) Pharmacol. Res. , vol.86 , pp. 26-31
    • Esposito, E.1    Cordaro, M.2    Cuzzocrea, S.3
  • 2
    • 84904187685 scopus 로고    scopus 로고
    • Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcbl and Abcg2 and restrict their access to the brain
    • G. Moreno-Sanz, B. Barrera, A. Armirotti, S.M. Bertozzi, R. Scarpelli, T. Bandiera, and et al. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcbl and Abcg2 and restrict their access to the brain Pharmacol. Res. 87 2014 87 93
    • (2014) Pharmacol. Res. , vol.87 , pp. 87-93
    • Moreno-Sanz, G.1    Barrera, B.2    Armirotti, A.3    Bertozzi, S.M.4    Scarpelli, R.5    Bandiera, T.6
  • 3
    • 84939967150 scopus 로고    scopus 로고
    • Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders - An overview and advancements
    • K.K. Pulicherla, and M.K. Verma Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders - an overview and advancements AAPS PharmSciTech 16 2015 223 233
    • (2015) AAPS PharmSciTech , vol.16 , pp. 223-233
    • Pulicherla, K.K.1    Verma, M.K.2
  • 4
    • 84934899219 scopus 로고    scopus 로고
    • Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats
    • L. Kong, Y. Wang, X.-J. Wang, X.-T. Wang, Y. Zhao, L.-M. Wang, and et al. Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats Pharmacol. Res. 99 2015 125 136
    • (2015) Pharmacol. Res. , vol.99 , pp. 125-136
    • Kong, L.1    Wang, Y.2    Wang, X.-J.3    Wang, X.-T.4    Zhao, Y.5    Wang, L.-M.6
  • 5
    • 84935033673 scopus 로고    scopus 로고
    • Lipid bilayer crossing-the gate of symmetry: Water-soluble phenylproline-based blood-brain barrier shuttles
    • P. Arranz-Gibert, B. Guixer, M. Malakoutikhah, M. Muttenthaler, F. Guzman, M. Teixido, and et al. Lipid bilayer crossing-the gate of symmetry: water-soluble phenylproline-based blood-brain barrier shuttles J. Am. Chem. Soc. 137 2015 7357 7364
    • (2015) J. Am. Chem. Soc. , vol.137 , pp. 7357-7364
    • Arranz-Gibert, P.1    Guixer, B.2    Malakoutikhah, M.3    Muttenthaler, M.4    Guzman, F.5    Teixido, M.6
  • 6
    • 84925488980 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (BCRP) as active efflux transporter on blood-brain barrier (BBB) permeability
    • P. Garg, R. Dhakne, and V. Belekar Role of breast cancer resistance protein (BCRP) as active efflux transporter on blood-brain barrier (BBB) permeability Mol. Divers. 19 2015 163 172
    • (2015) Mol. Divers. , vol.19 , pp. 163-172
    • Garg, P.1    Dhakne, R.2    Belekar, V.3
  • 7
    • 84887403996 scopus 로고    scopus 로고
    • 'Sealing off the CNS': Cellular and molecular regulation of blood-brain barriergenesis
    • J.A. Siegenthaler, F. Sohet, and R. Daneman 'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis Curr. Opin. Neurobiol. 23 2013 1057 1064
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 1057-1064
    • Siegenthaler, J.A.1    Sohet, F.2    Daneman, R.3
  • 8
    • 84920568095 scopus 로고    scopus 로고
    • "you shall not pass"-tight junctions of the blood brain barrier
    • H.C. Bauer, I.A. Krizbai, H. Bauer, and A. Traweger "You shall not pass"-tight junctions of the blood brain barrier Front. Neurosci. 8 2014 392
    • (2014) Front. Neurosci. , vol.8 , pp. 392
    • Bauer, H.C.1    Krizbai, I.A.2    Bauer, H.3    Traweger, A.4
  • 9
    • 79751525900 scopus 로고    scopus 로고
    • The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?
    • R. Paolinelli, M. Corada, F. Orsenigo, and E. Dejana The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery? Pharmacol. Res. 63 2011 165 171
    • (2011) Pharmacol. Res. , vol.63 , pp. 165-171
    • Paolinelli, R.1    Corada, M.2    Orsenigo, F.3    Dejana, E.4
  • 10
    • 84886662700 scopus 로고    scopus 로고
    • Nanoparticle accumulation and transcytosis in brain endothelial cell layers
    • D. Ye, M.N. Raghnaill, M. Bramini, E. Mahon, C. Aberg, A. Salvati, and et al. Nanoparticle accumulation and transcytosis in brain endothelial cell layers Nanoscale 5 2013 11153 11165
    • (2013) Nanoscale , vol.5 , pp. 11153-11165
    • Ye, D.1    Raghnaill, M.N.2    Bramini, M.3    Mahon, E.4    Aberg, C.5    Salvati, A.6
  • 11
    • 84872513047 scopus 로고    scopus 로고
    • Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications
    • E. Cristante, S. McArthur, C. Mauro, E. Maggioli, I.A. Romero, M. Wylezinska-Arridge, and et al. Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications Proc. Natl. Acad. Sci. U. S. A. 110 2013 832 841
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 832-841
    • Cristante, E.1    McArthur, S.2    Mauro, C.3    Maggioli, E.4    Romero, I.A.5    Wylezinska-Arridge, M.6
  • 13
    • 84928958251 scopus 로고    scopus 로고
    • The blood-brain barrier transport mechanism controlling analgesic effects of opioid drugs in CNS
    • T. Okura, K. Higuchi, and Y. Deguchi The blood-brain barrier transport mechanism controlling analgesic effects of opioid drugs in CNS Yakugaku Zasshi 135 2015 697 702
    • (2015) Yakugaku Zasshi , vol.135 , pp. 697-702
    • Okura, T.1    Higuchi, K.2    Deguchi, Y.3
  • 14
    • 84928608814 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta(GSK-3 beta) signaling: Implications for Parkinson's disease
    • M. Golpich, E. Amini, F. Hemmati, N.M. Ibrahim, B. Rahmani, Z. Mohamed, and et al. Glycogen synthase kinase-3 beta(GSK-3 beta) signaling: implications for Parkinson's disease Pharmacol. Res. 97 2015 16 26
    • (2015) Pharmacol. Res. , vol.97 , pp. 16-26
    • Golpich, M.1    Amini, E.2    Hemmati, F.3    Ibrahim, N.M.4    Rahmani, B.5    Mohamed, Z.6
  • 15
    • 84901620182 scopus 로고    scopus 로고
    • Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier
    • K. Michalec, C. Mysiorek, M. Kuntz, V. Berezowski, A.A. Szczepankiewicz, G.M. Wilczynski, and et al. Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier Arch. Biochem. Biophys. 554 2014 28 35
    • (2014) Arch. Biochem. Biophys. , vol.554 , pp. 28-35
    • Michalec, K.1    Mysiorek, C.2    Kuntz, M.3    Berezowski, V.4    Szczepankiewicz, A.A.5    Wilczynski, G.M.6
  • 16
    • 66249128230 scopus 로고    scopus 로고
    • Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats
    • M. Gynther, J. Ropponen, K. Laine, J. Leppanen, P. Haapakoski, L. Peura, and et al. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats J. Med. Chem. 52 2009 3348 3353
    • (2009) J. Med. Chem. , vol.52 , pp. 3348-3353
    • Gynther, M.1    Ropponen, J.2    Laine, K.3    Leppanen, J.4    Haapakoski, P.5    Peura, L.6
  • 17
    • 80053517788 scopus 로고    scopus 로고
    • Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: New prodrug design ideas for central nervous system delivery
    • L. Peura, K. Malmioja, K. Laine, J. Leppanen, M. Gynther, A. Isotalo, and et al. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery Mol. Pharm. 8 2011 1857 1866
    • (2011) Mol. Pharm. , vol.8 , pp. 1857-1866
    • Peura, L.1    Malmioja, K.2    Laine, K.3    Leppanen, J.4    Gynther, M.5    Isotalo, A.6
  • 18
    • 84897417806 scopus 로고    scopus 로고
    • Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration
    • C. Chaves, R. Shawahna, A. Jacob, J.M. Scherrmann, and X. Decleves Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration Curr. Pharm. Design 20 2014 1450 1462
    • (2014) Curr. Pharm. Design , vol.20 , pp. 1450-1462
    • Chaves, C.1    Shawahna, R.2    Jacob, A.3    Scherrmann, J.M.4    Decleves, X.5
  • 19
    • 1642454475 scopus 로고    scopus 로고
    • ABC transporters and the blood-brain barrier
    • D.J. Begley ABC transporters and the blood-brain barrier Curr. Pharm. Design 10 2004 1295 1312
    • (2004) Curr. Pharm. Design , vol.10 , pp. 1295-1312
    • Begley, D.J.1
  • 20
    • 84921718391 scopus 로고    scopus 로고
    • Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances
    • L. Liu, and X.D. Liu Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances Front. Pharmacol. 5 2014 273
    • (2014) Front. Pharmacol. , vol.5 , pp. 273
    • Liu, L.1    Liu, X.D.2
  • 21
    • 84883376947 scopus 로고    scopus 로고
    • Dual kinin B1 and B2 receptor activation provides enhanced blood-brain barrier permeability and anticancer drug delivery into brain tumors
    • J. Cote, M. Savard, W. Neugebauer, D. Fortin, M. Lepage, and F. Gobeil Dual kinin B1 and B2 receptor activation provides enhanced blood-brain barrier permeability and anticancer drug delivery into brain tumors Cancer Biol. Ther. 14 2013 806 811
    • (2013) Cancer Biol. Ther. , vol.14 , pp. 806-811
    • Cote, J.1    Savard, M.2    Neugebauer, W.3    Fortin, D.4    Lepage, M.5    Gobeil, F.6
  • 22
    • 84883217556 scopus 로고    scopus 로고
    • Solid lipid nanoparticles carrying chemotherapeutic drug across the blood-brain barrier through insulin receptor-mediated pathway
    • Y.C. Kuo, and C.Y. Shih-Huang Solid lipid nanoparticles carrying chemotherapeutic drug across the blood-brain barrier through insulin receptor-mediated pathway J. Drug Target 21 2013 730 738
    • (2013) J. Drug Target , vol.21 , pp. 730-738
    • Kuo, Y.C.1    Shih-Huang, C.Y.2
  • 23
    • 84901267568 scopus 로고    scopus 로고
    • Double function at the blood-brain barrier
    • C. Betsholtz Double function at the blood-brain barrier Nature 509 2014 432 433
    • (2014) Nature , vol.509 , pp. 432-433
    • Betsholtz, C.1
  • 24
    • 84928213789 scopus 로고    scopus 로고
    • The molecular, cellular, and morphological components of blood-brain barrier development during embryogenesis
    • N. Hagan, and A. Ben-Zvi The molecular, cellular, and morphological components of blood-brain barrier development during embryogenesis Semin. Cell Dev. Biol. 38 2015 7 15
    • (2015) Semin. Cell Dev. Biol. , vol.38 , pp. 7-15
    • Hagan, N.1    Ben-Zvi, A.2
  • 25
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    • K. Ulbrich, T. Hekmatara, E. Herbert, and J. Kreuter Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur. J. Pharm. Biopharm. 71 2009 251 256
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 27
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • W.M. Pardridge The blood-brain barrier: bottleneck in brain drug development NeuroRx 2 2005 3 14
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 28
    • 0037665280 scopus 로고    scopus 로고
    • Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity
    • H. Potschka, M. Fedrowitz, and W. Loscher Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity J. Pharmacol. Exp. Ther. 306 2003 124 131
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 124-131
    • Potschka, H.1    Fedrowitz, M.2    Loscher, W.3
  • 29
    • 0344980089 scopus 로고    scopus 로고
    • Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT
    • A. Regina, I.A. Romero, J. Greenwood, P. Adamson, J.M. Bourre, P.O. Couraud, and et al. Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT J. Neurochem. 73 1999 1954 1963
    • (1999) J. Neurochem. , vol.73 , pp. 1954-1963
    • Regina, A.1    Romero, I.A.2    Greenwood, J.3    Adamson, P.4    Bourre, J.M.5    Couraud, P.O.6
  • 30
    • 33747871144 scopus 로고    scopus 로고
    • ABC drug transporter at the blood-brain barrier - Effects on drug metabolism and drug response
    • M. Ebinger, and M. Uhr ABC drug transporter at the blood-brain barrier - effects on drug metabolism and drug response Eur. Arch. Psychiatry Clin. Neurosci. 256 2006 294 298
    • (2006) Eur. Arch. Psychiatry Clin. Neurosci. , vol.256 , pp. 294-298
    • Ebinger, M.1    Uhr, M.2
  • 32
    • 84864246037 scopus 로고    scopus 로고
    • The role of amino acid transporters in GSH synthesis in the blood-brain barrier and central nervous system
    • C. Valdovinos-Flores, and M.E. Gonsebatt The role of amino acid transporters in GSH synthesis in the blood-brain barrier and central nervous system Neurochem. Int. 61 2012 405 414
    • (2012) Neurochem. Int. , vol.61 , pp. 405-414
    • Valdovinos-Flores, C.1    Gonsebatt, M.E.2
  • 33
    • 24144491107 scopus 로고    scopus 로고
    • Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK1
    • P. Soares-da-Silva, P. Serrao, S. Fraga, and M.J. Pinho Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK1 Acta Physiol. Scand. 185 2005 71 78
    • (2005) Acta Physiol. Scand. , vol.185 , pp. 71-78
    • Soares-Da-Silva, P.1    Serrao, P.2    Fraga, S.3    Pinho, M.J.4
  • 34
    • 33751114416 scopus 로고    scopus 로고
    • Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system
    • D.M. Killian, S. Hermeling, and P.J. Chikhale Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system Drug Deliv. Syst. Drug Deliv. 14 2007 25 31
    • (2007) Drug Deliv. Syst. Drug Deliv. , vol.14 , pp. 25-31
    • Killian, D.M.1    Hermeling, S.2    Chikhale, P.J.3
  • 36
    • 84937710410 scopus 로고    scopus 로고
    • LRP-1-mediated intracellular antibody delivery to the central nervous system
    • X.H. Tian, S. Nyberg, P.S. Sharp, J. Madsen, N. Daneshpour, S.P. Armes, and et al. LRP-1-mediated intracellular antibody delivery to the central nervous system Sci. Rep. 5 2015 11990
    • (2015) Sci. Rep. , vol.5 , pp. 11990
    • Tian, X.H.1    Nyberg, S.2    Sharp, P.S.3    Madsen, J.4    Daneshpour, N.5    Armes, S.P.6
  • 37
    • 84896725023 scopus 로고    scopus 로고
    • The wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells
    • C. Artus, F. Glacial, K. Ganeshamoorthy, N. Ziegler, M. Godet, T. Guilbert, and et al. The wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells J. Cereb. Blood Flow Metab. 34 2014 433 440
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 433-440
    • Artus, C.1    Glacial, F.2    Ganeshamoorthy, K.3    Ziegler, N.4    Godet, M.5    Guilbert, T.6
  • 38
    • 78650787293 scopus 로고    scopus 로고
    • Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1
    • S. Dohgu, F. Takata, J. Matsumoto, M. Oda, E. Harada, T. Watanabe, and et al. Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1 Microvasc. Res. 81 2011 103 107
    • (2011) Microvasc. Res. , vol.81 , pp. 103-107
    • Dohgu, S.1    Takata, F.2    Matsumoto, J.3    Oda, M.4    Harada, E.5    Watanabe, T.6
  • 39
    • 78650513388 scopus 로고    scopus 로고
    • The impact of agrin on the formation of orthogonal arrays of particles in cultured astrocytes from wild-type and agrin-null mice
    • P. Fallier-Becker, J. Sperveslage, H. Wolburg, and S. Noell The impact of agrin on the formation of orthogonal arrays of particles in cultured astrocytes from wild-type and agrin-null mice Brain Res. 1367 2011 2 12
    • (2011) Brain Res. , vol.1367 , pp. 2-12
    • Fallier-Becker, P.1    Sperveslage, J.2    Wolburg, H.3    Noell, S.4
  • 40
    • 84873745317 scopus 로고    scopus 로고
    • Gut microbiota, immune development and function
    • S. Bengmark Gut microbiota, immune development and function Pharmacol. Res. 69 2013 87 113
    • (2013) Pharmacol. Res. , vol.69 , pp. 87-113
    • Bengmark, S.1
  • 42
    • 84903312324 scopus 로고    scopus 로고
    • Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress
    • E. Gouix, A. Buisson, A. Nieoullon, L. Kerkerian-Le Goff, J.S. Tauskela, N. Blondeau, and et al. Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress Pharmacol. Res. 87 2014 8 17
    • (2014) Pharmacol. Res. , vol.87 , pp. 8-17
    • Gouix, E.1    Buisson, A.2    Nieoullon, A.3    Kerkerian-Le Goff, L.4    Tauskela, J.S.5    Blondeau, N.6
  • 43
    • 84933036615 scopus 로고    scopus 로고
    • Lipid transport and human brain development
    • C. Betsholtz Lipid transport and human brain development Nat. Genet. 47 2015 699 701
    • (2015) Nat. Genet. , vol.47 , pp. 699-701
    • Betsholtz, C.1
  • 44
    • 84924764503 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in the nutrition of the central nervous system
    • P. Campos-Bedolla, F.R. Walter, S. Veszelka, and M.A. Deli Role of the blood-brain barrier in the nutrition of the central nervous system Arch. Med. Res. 45 2014 610 638
    • (2014) Arch. Med. Res. , vol.45 , pp. 610-638
    • Campos-Bedolla, P.1    Walter, F.R.2    Veszelka, S.3    Deli, M.A.4
  • 45
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • A. Ben-Zvi, B. Lacoste, E. Kur, B.J. Andreone, Y. Mayshar, H. Yan, and et al. Mfsd2a is critical for the formation and function of the blood-brain barrier Nature 509 2014 507 511
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1    Lacoste, B.2    Kur, E.3    Andreone, B.J.4    Mayshar, Y.5    Yan, H.6
  • 46
    • 84901260638 scopus 로고    scopus 로고
    • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
    • L.N. Nguyen, D. Ma, G. Shui, P. Wong, A. Cazenave-Gassiot, X. Zhang, and et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Nature 509 2014 503 506
    • (2014) Nature , vol.509 , pp. 503-506
    • Nguyen, L.N.1    Ma, D.2    Shui, G.3    Wong, P.4    Cazenave-Gassiot, A.5    Zhang, X.6
  • 50
    • 84938527006 scopus 로고    scopus 로고
    • Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection
    • M. Yemisci, S. Caban, Y. Gursoy-Ozdemir, S. Lule, R. Novoa-Carballal, R. Riguera, and et al. Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection J. Cereb. Blood Flow Metab. 35 2015 469 475
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 469-475
    • Yemisci, M.1    Caban, S.2    Gursoy-Ozdemir, Y.3    Lule, S.4    Novoa-Carballal, R.5    Riguera, R.6
  • 51
    • 84921312620 scopus 로고    scopus 로고
    • ANG4043, a novel brain-penetrant peptide-mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice
    • A. Regina, M. Demeule, S. Tripathy, S. Lord-Dufour, J.C. Currie, M. Iddir, and et al. ANG4043, a novel brain-penetrant peptide-mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice Mol. Cancer Ther. 14 2015 129 140
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 129-140
    • Regina, A.1    Demeule, M.2    Tripathy, S.3    Lord-Dufour, S.4    Currie, J.C.5    Iddir, M.6
  • 52
    • 84922688468 scopus 로고    scopus 로고
    • Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery
    • C.-H. Fan, C.-Y. Ting, Y.-C. Chang, K.-C. Wei, H.-L. Liu, and C.-K. Yeh Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery Acta Biomater. 15 2015 89 101
    • (2015) Acta Biomater. , vol.15 , pp. 89-101
    • Fan, C.-H.1    Ting, C.-Y.2    Chang, Y.-C.3    Wei, K.-C.4    Liu, H.-L.5    Yeh, C.-K.6
  • 53
    • 84930938169 scopus 로고    scopus 로고
    • Targeting microbubbles-carrying TGF beta 1 inhibitor combined with ultrasound sonication induce BBB/BTB disruption to enhance nanomedicine treatment for brain tumors
    • Y.C. Chen, C.F. Chiang, S.K. Wu, L.F. Chen, W.Y. Hsieh, and W.L. Lin Targeting microbubbles-carrying TGF beta 1 inhibitor combined with ultrasound sonication induce BBB/BTB disruption to enhance nanomedicine treatment for brain tumors J. Control. Release 211 2015 53 62
    • (2015) J. Control. Release , vol.211 , pp. 53-62
    • Chen, Y.C.1    Chiang, C.F.2    Wu, S.K.3    Chen, L.F.4    Hsieh, W.Y.5    Lin, W.L.6
  • 54
    • 84903536534 scopus 로고    scopus 로고
    • Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: Potential for targeting experimental brain tumors
    • R.J. Diaz, P.Z. McVeigh, M.A. O'Reilly, K. Burrell, M. Bebenek, C. Smith, and et al. Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors Nanomed. Nanotechnol. 10 2014 1075 1087
    • (2014) Nanomed. Nanotechnol. , vol.10 , pp. 1075-1087
    • Diaz, R.J.1    McVeigh, P.Z.2    O'Reilly, M.A.3    Burrell, K.4    Bebenek, M.5    Smith, C.6
  • 55
    • 84867359055 scopus 로고    scopus 로고
    • Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model
    • E.-J. Park, Y.-Z. Zhang, N. Vykhodtseva, and N. McDannold Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model J. Control. Release 163 2012 277 284
    • (2012) J. Control. Release , vol.163 , pp. 277-284
    • Park, E.-J.1    Zhang, Y.-Z.2    Vykhodtseva, N.3    McDannold, N.4
  • 56
    • 58949088849 scopus 로고    scopus 로고
    • Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    • M. Angers, M. Uldry, D. Kong, J.M. Gimble, and A.M. Jetten Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis Biochem. J. 416 2008 347 355
    • (2008) Biochem. J. , vol.416 , pp. 347-355
    • Angers, M.1    Uldry, M.2    Kong, D.3    Gimble, J.M.4    Jetten, A.M.5
  • 57
    • 79961054838 scopus 로고    scopus 로고
    • A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin
    • J.H. Reiling, C.B. Clish, J.E. Carette, M. Varadarajan, T.R. Brummelkamp, and D.M. Sabatini A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin Proc. Natl. Acad. Sci. U. S. A. 108 2011 11756 11765
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 11756-11765
    • Reiling, J.H.1    Clish, C.B.2    Carette, J.E.3    Varadarajan, M.4    Brummelkamp, T.R.5    Sabatini, D.M.6
  • 58
    • 84920282388 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors
    • X. Zhao, M. Xin, W. Huang, Y. Ren, Q. Jin, F. Tang, and et al. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors Bioorg. Med. Chem. 23 2015 348 364
    • (2015) Bioorg. Med. Chem. , vol.23 , pp. 348-364
    • Zhao, X.1    Xin, M.2    Huang, W.3    Ren, Y.4    Jin, Q.5    Tang, F.6
  • 59
    • 84930083960 scopus 로고    scopus 로고
    • Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR
    • D. Basu, A. Richters, and D. Rauh Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR Bioorg. Med. Chem. 23 2015 2767 2780
    • (2015) Bioorg. Med. Chem. , vol.23 , pp. 2767-2780
    • Basu, D.1    Richters, A.2    Rauh, D.3
  • 60
    • 84969437944 scopus 로고    scopus 로고
    • From catalytic mechanism to rational design of reversible covalent inhibitors of serine and cysteine hydrolases
    • M. Shokhen, M. Hirsch, N. Khazanov, R. Ozeri, N. Perlman, T. Traube, and et al. From catalytic mechanism to rational design of reversible covalent inhibitors of serine and cysteine hydrolases Isr. J. Chem. 54 2014 1137 1151
    • (2014) Isr. J. Chem. , vol.54 , pp. 1137-1151
    • Shokhen, M.1    Hirsch, M.2    Khazanov, N.3    Ozeri, R.4    Perlman, N.5    Traube, T.6
  • 61
    • 84887114695 scopus 로고    scopus 로고
    • Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins
    • X. Tan, C. Bertonati, L. Qin, L. Furio, C. El Amri, A. Hovnanian, and et al. Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins Eur. J. Med. Chem. 70 2013 661 668
    • (2013) Eur. J. Med. Chem. , vol.70 , pp. 661-668
    • Tan, X.1    Bertonati, C.2    Qin, L.3    Furio, L.4    El Amri, C.5    Hovnanian, A.6
  • 62
    • 84890448100 scopus 로고    scopus 로고
    • High-throughput virtual screening identifies novel N′-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors
    • V. Sorna, E.R. Theisen, B. Stephens, S.L. Warner, D.J. Bearss, H. Vankayalapati, and et al. High-throughput virtual screening identifies novel N′-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors J. Med. Chem. 56 2013 9496 9508
    • (2013) J. Med. Chem. , vol.56 , pp. 9496-9508
    • Sorna, V.1    Theisen, E.R.2    Stephens, B.3    Warner, S.L.4    Bearss, D.J.5    Vankayalapati, H.6
  • 63
    • 84887069070 scopus 로고    scopus 로고
    • Virtual screening of novel reversible inhibitors for marine alkaline protease MP
    • X. Ji, Y. Zheng, W. Wang, J. Sheng, J. Hao, and M. Sun Virtual screening of novel reversible inhibitors for marine alkaline protease MP J. Mol. Graph. Model. 46 2013 125 131
    • (2013) J. Mol. Graph. Model. , vol.46 , pp. 125-131
    • Ji, X.1    Zheng, Y.2    Wang, W.3    Sheng, J.4    Hao, J.5    Sun, M.6
  • 64
    • 84880876875 scopus 로고    scopus 로고
    • Prospective use of molecular field points in ligand-based virtual screening: Efficient identification of new reversible Cdc25 inhibitors
    • J.C. Collins, A. Armstrong, K.L. Chapman, H.C. Cordingley, A.A. Jaxa-Chamiec, K.E. Judd, and et al. Prospective use of molecular field points in ligand-based virtual screening: efficient identification of new reversible Cdc25 inhibitors MedChemComm 4 2013 1148 1155
    • (2013) MedChemComm , vol.4 , pp. 1148-1155
    • Collins, J.C.1    Armstrong, A.2    Chapman, K.L.3    Cordingley, H.C.4    Jaxa-Chamiec, A.A.5    Judd, K.E.6
  • 65
    • 84933064751 scopus 로고    scopus 로고
    • A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
    • V. Alakbarzade, A. Hameed, D.Q.Y. Quek, B.A. Chioza, E.L. Baple, A. Cazenave-Gassiot, and et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome Nat. Genet. 47 2015 814 817
    • (2015) Nat. Genet. , vol.47 , pp. 814-817
    • Alakbarzade, V.1    Hameed, A.2    Quek, D.Q.Y.3    Chioza, B.A.4    Baple, E.L.5    Cazenave-Gassiot, A.6
  • 66
    • 84933040235 scopus 로고    scopus 로고
    • Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome
    • A. Guemez-Gamboa, L.N. Nguyen, H. Yang, M.S. Zaki, M. Kara, T. Ben-Omran, and et al. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome Nat. Genet. 47 2015 809 813
    • (2015) Nat. Genet. , vol.47 , pp. 809-813
    • Guemez-Gamboa, A.1    Nguyen, L.N.2    Yang, H.3    Zaki, M.S.4    Kara, M.5    Ben-Omran, T.6
  • 67
    • 84937121327 scopus 로고    scopus 로고
    • Blood-brain barrier endogenous transporters as therapeutic targets: A new model for small molecule CNS drug discovery
    • W.M. Pardridge Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery Expert Opin. Ther. Targets 19 2015 1059 1072
    • (2015) Expert Opin. Ther. Targets , vol.19 , pp. 1059-1072
    • Pardridge, W.M.1
  • 68
    • 84883865879 scopus 로고    scopus 로고
    • Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine
    • L. Peura, K. Malmioja, K. Huttunen, J. Leppanen, M. Hamalainen, M.M. Forsberg, and et al. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine Pharm. Res. 30 2013 2523 2537
    • (2013) Pharm. Res. , vol.30 , pp. 2523-2537
    • Peura, L.1    Malmioja, K.2    Huttunen, K.3    Leppanen, J.4    Hamalainen, M.5    Forsberg, M.M.6
  • 69
    • 84929323579 scopus 로고    scopus 로고
    • Targeting of AIDS related encephalopathy using phenylalanine anchored lipidic nanocarrier
    • A. Vyas, A. Jain, P. Hurkat, A. Jain, and S.K. Jain Targeting of AIDS related encephalopathy using phenylalanine anchored lipidic nanocarrier Colloid Surf. B 131 2015 155 161
    • (2015) Colloid Surf. B , vol.131 , pp. 155-161
    • Vyas, A.1    Jain, A.2    Hurkat, P.3    Jain, A.4    Jain, S.K.5
  • 70
    • 84922261208 scopus 로고    scopus 로고
    • Synthesis and evaluation of selenoflavones that have potential neuroprotective effects
    • Y.S. Choi, Y.J. Kim, J.Y. Lee, J. Lee, and J.H. Jeong Synthesis and evaluation of selenoflavones that have potential neuroprotective effects Heterocycles 89 2014 2794 2805
    • (2014) Heterocycles , vol.89 , pp. 2794-2805
    • Choi, Y.S.1    Kim, Y.J.2    Lee, J.Y.3    Lee, J.4    Jeong, J.H.5
  • 71
    • 84928648975 scopus 로고    scopus 로고
    • Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates
    • I. Loryan, V. Sinha, C. Mackie, A. Van Peer, W.H. Drinkenburg, A. Vermeulen, and et al. Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates Mol. Pharm. 12 2015 520 532
    • (2015) Mol. Pharm. , vol.12 , pp. 520-532
    • Loryan, I.1    Sinha, V.2    Mackie, C.3    Van Peer, A.4    Drinkenburg, W.H.5    Vermeulen, A.6
  • 72
    • 84884739997 scopus 로고    scopus 로고
    • NESS06SM reduces body weight with an improved profile relative to SR141716
    • A. Mastinu, M. Pira, G.A. Pinna, C. Pisu, M.A. Casu, R. Reali, and et al. NESS06SM reduces body weight with an improved profile relative to SR141716 Pharmacol. Res. 74 2013 94 108
    • (2013) Pharmacol. Res. , vol.74 , pp. 94-108
    • Mastinu, A.1    Pira, M.2    Pinna, G.A.3    Pisu, C.4    Casu, M.A.5    Reali, R.6
  • 76
    • 84899454204 scopus 로고    scopus 로고
    • Current and potential therapeutic strategies for mucopolysaccharidoses
    • H. Noh, and J.I. Lee Current and potential therapeutic strategies for mucopolysaccharidoses J. Clin. Pharm. Ther. 39 2014 215 224
    • (2014) J. Clin. Pharm. Ther. , vol.39 , pp. 215-224
    • Noh, H.1    Lee, J.I.2
  • 78
    • 84868660382 scopus 로고    scopus 로고
    • The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells
    • M.L. Pinzon-Daza, R. Garzon, P.O. Couraud, I.A. Romero, B. Weksler, D. Ghigo, and et al. The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells Br. J. Pharmacol. 167 2012 1431 1447
    • (2012) Br. J. Pharmacol. , vol.167 , pp. 1431-1447
    • Pinzon-Daza, M.L.1    Garzon, R.2    Couraud, P.O.3    Romero, I.A.4    Weksler, B.5    Ghigo, D.6
  • 79
    • 84921443725 scopus 로고    scopus 로고
    • Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody
    • W.M. Pardridge Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody Expert Opin. Drug Deliv. 12 2015 207 222
    • (2015) Expert Opin. Drug Deliv. , vol.12 , pp. 207-222
    • Pardridge, W.M.1
  • 80
    • 84929138470 scopus 로고    scopus 로고
    • Targeted delivery of protein and gene medicines through the blood-brain barrier
    • W.M. Pardridge Targeted delivery of protein and gene medicines through the blood-brain barrier Clin. Pharmacol. Ther. 97 2015 347 361
    • (2015) Clin. Pharmacol. Ther. , vol.97 , pp. 347-361
    • Pardridge, W.M.1
  • 81
    • 84912112177 scopus 로고    scopus 로고
    • Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease
    • T.E. Park, B. Singh, H. Li, J.Y. Lee, S.K. Kang, Y.J. Choi, and et al. Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease Biomaterials 38 2015 61 71
    • (2015) Biomaterials , vol.38 , pp. 61-71
    • Park, T.E.1    Singh, B.2    Li, H.3    Lee, J.Y.4    Kang, S.K.5    Choi, Y.J.6
  • 82
    • 34247330919 scopus 로고    scopus 로고
    • Modulation of inflammation in brain: A matter of fat
    • A.A. Farooqui, L.A. Horrocks, and T. Farooqui Modulation of inflammation in brain: a matter of fat J. Neurochem. 101 2007 577 599
    • (2007) J. Neurochem. , vol.101 , pp. 577-599
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 83
    • 84942294358 scopus 로고    scopus 로고
    • Essential role of docosahexaenoic acid towards development of a smarter brain
    • K. Gharami, M. Das, and S. Das Essential role of docosahexaenoic acid towards development of a smarter brain Neurochem. Int. 89 2015 51 62
    • (2015) Neurochem. Int. , vol.89 , pp. 51-62
    • Gharami, K.1    Das, M.2    Das, S.3
  • 84
    • 84923257298 scopus 로고    scopus 로고
    • Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease
    • J.J. Liu, P. Green, J.J. Mann, S.I. Rapoport, and M.E. Sublette Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease Brain Res. 1597 2015 220 246
    • (2015) Brain Res. , vol.1597 , pp. 220-246
    • Liu, J.J.1    Green, P.2    Mann, J.J.3    Rapoport, S.I.4    Sublette, M.E.5
  • 85
    • 84906841550 scopus 로고    scopus 로고
    • Production of structured phosphatidylcholine with high content of DHA/EPA by immobilized phospholipase A(1)-catalyzed transesterification
    • X. Li, J.F. Chen, B. Yang, D.M. Li, Y.H. Wang, and W.F. Wang Production of structured phosphatidylcholine with high content of DHA/EPA by immobilized phospholipase A(1)-catalyzed transesterification Int. J. Mol. Sci. 15 2014 15244 15258
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 15244-15258
    • Li, X.1    Chen, J.F.2    Yang, B.3    Li, D.M.4    Wang, Y.H.5    Wang, W.F.6
  • 86
    • 38849194675 scopus 로고    scopus 로고
    • Phospholipase A(1) activity of crude enzyme extracted from the ovaries of skipjack tuna
    • S. Hiratsuka, T. Kitagawa, K. Yamagishi, and S. Wada Phospholipase A(1) activity of crude enzyme extracted from the ovaries of skipjack tuna Fish. Sci. 74 2008 146 152
    • (2008) Fish. Sci. , vol.74 , pp. 146-152
    • Hiratsuka, S.1    Kitagawa, T.2    Yamagishi, K.3    Wada, S.4
  • 87
    • 84931559723 scopus 로고    scopus 로고
    • Fusion of hIgG1-Fc to In-111-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake
    • M. Rotman, M.M. Welling, M.L. van den Boogaard, L.G. Moursel, L.M. van der Graaf, M.A. van Buchem, and et al. Fusion of hIgG1-Fc to In-111-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake Nucl. Med. Biol. 42 2015 695 702
    • (2015) Nucl. Med. Biol. , vol.42 , pp. 695-702
    • Rotman, M.1    Welling, M.M.2    Van Den Boogaard, M.L.3    Moursel, L.G.4    Van Der Graaf, L.M.5    Van Buchem, M.A.6
  • 88
    • 84922895702 scopus 로고    scopus 로고
    • Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer' disease
    • M. Rotman, M.M. Welling, A. Bunschoten, M.E. de Backer, J. Rip, R.J.A. Nabuurs, and et al. Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer' disease J. Control. Release 203 2015 40 50
    • (2015) J. Control. Release , vol.203 , pp. 40-50
    • Rotman, M.1    Welling, M.M.2    Bunschoten, A.3    De Backer, M.E.4    Rip, J.5    Nabuurs, R.J.A.6
  • 89
    • 84931273562 scopus 로고    scopus 로고
    • PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier
    • C. Fornaguera, A. Dols-Perez, G. Caldero, M.J. Garcia-Celma, J. Camarasa, and C. Solans PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier J. Control. Release 211 2015 134 143
    • (2015) J. Control. Release , vol.211 , pp. 134-143
    • Fornaguera, C.1    Dols-Perez, A.2    Caldero, G.3    Garcia-Celma, M.J.4    Camarasa, J.5    Solans, C.6
  • 90
    • 84901984624 scopus 로고    scopus 로고
    • Potential candidate camelid antibodies for the treatment of protein-misfolding diseases
    • M.A. David, D.R. Jones, and M. Tayebi Potential candidate camelid antibodies for the treatment of protein-misfolding diseases J. Neuroimmunol. 272 2014 76 85
    • (2014) J. Neuroimmunol. , vol.272 , pp. 76-85
    • David, M.A.1    Jones, D.R.2    Tayebi, M.3
  • 91
    • 79952538290 scopus 로고    scopus 로고
    • Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse
    • Q.H. Zhou, E.K.W. Hui, J.Z. Lu, R.J. Boado, and W.M. Pardridge Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse Brain Res. 1382 2011 315 320
    • (2011) Brain Res. , vol.1382 , pp. 315-320
    • Zhou, Q.H.1    Hui, E.K.W.2    Lu, J.Z.3    Boado, R.J.4    Pardridge, W.M.5
  • 92
    • 84862653625 scopus 로고    scopus 로고
    • A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys
    • S. Ohshima-Hosoyama, H.A. Simmons, N. Goecks, V. Joers, C.R. Swanson, V. Bondarenko, and et al. A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys PLoS One 7 2012 e39036
    • (2012) PLoS One , vol.7
    • Ohshima-Hosoyama, S.1    Simmons, H.A.2    Goecks, N.3    Joers, V.4    Swanson, C.R.5    Bondarenko, V.6
  • 93
    • 84892366118 scopus 로고    scopus 로고
    • Pin1, endothelial nitric oxide synthase, and amyloid-beta form a feedback signaling loop involved in the pathogenesis of Alzheimer's disease, hypertension, and cerebral amyloid angiopathy
    • J.-Z. Wang, W.-D. Zhu, Z.-X. Xu, W.-T. Du, H.-Y. Zhang, X.-W. Sun, and et al. Pin1, endothelial nitric oxide synthase, and amyloid-beta form a feedback signaling loop involved in the pathogenesis of Alzheimer's disease, hypertension, and cerebral amyloid angiopathy Med. Hypotheses 82 2014 145 150
    • (2014) Med. Hypotheses , vol.82 , pp. 145-150
    • Wang, J.-Z.1    Zhu, W.-D.2    Xu, Z.-X.3    Du, W.-T.4    Zhang, H.-Y.5    Sun, X.-W.6
  • 94
    • 84904556283 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease: Past, present and future
    • B. Spencer, and E. Masliah Immunotherapy for Alzheimer's disease: past, present and future Front. Aging Neurosci. 6 2014 114
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 114
    • Spencer, B.1    Masliah, E.2
  • 95
    • 84920945032 scopus 로고    scopus 로고
    • Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease
    • J.-Z. Wang, and Y. Zhang Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease J. Neurol. Sci. 348 2015 253 255
    • (2015) J. Neurol. Sci. , vol.348 , pp. 253-255
    • Wang, J.-Z.1    Zhang, Y.2
  • 96
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • J. Niewoehner, B. Bohrmann, L. Collin, E. Urich, H. Sade, P. Maier, and et al. Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle Neuron 81 2014 49 60
    • (2014) Neuron , vol.81 , pp. 49-60
    • Niewoehner, J.1    Bohrmann, B.2    Collin, L.3    Urich, E.4    Sade, H.5    Maier, P.6
  • 97
    • 84937849044 scopus 로고    scopus 로고
    • Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
    • A. Kondo, K. Shahpasand, R. Mannix, J.H. Qiu, J. Moncaster, C.H. Chen, and et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy Nature 523 2015 431 436
    • (2015) Nature , vol.523 , pp. 431-436
    • Kondo, A.1    Shahpasand, K.2    Mannix, R.3    Qiu, J.H.4    Moncaster, J.5    Chen, C.H.6
  • 98
    • 84890496218 scopus 로고    scopus 로고
    • Selective permeabilization of the blood-brain barrier at sites of metastasis
    • J.J. Connell, G. Chatain, B. Cornelissen, K.A. Vallis, A. Hamilton, L. Seymour, and et al. Selective permeabilization of the blood-brain barrier at sites of metastasis JNCI 105 2013 1634 1643
    • (2013) JNCI , vol.105 , pp. 1634-1643
    • Connell, J.J.1    Chatain, G.2    Cornelissen, B.3    Vallis, K.A.4    Hamilton, A.5    Seymour, L.6
  • 99
    • 84875705324 scopus 로고    scopus 로고
    • Brain tumor immunotherapy: Seeing the brain in the body
    • L.A. Lampson Brain tumor immunotherapy: seeing the brain in the body Drug Discov. Today 18 2013 399 406
    • (2013) Drug Discov. Today , vol.18 , pp. 399-406
    • Lampson, L.A.1
  • 100
    • 84879399902 scopus 로고    scopus 로고
    • Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: Crossing the blood-brain barrier divide
    • A.M. Chacko, C.S. Li, D.A. Pryma, S. Brem, G. Coukos, and V. Muzykantov Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide Expert Opin. Drug Deliv. 10 2013 907 926
    • (2013) Expert Opin. Drug Deliv. , vol.10 , pp. 907-926
    • Chacko, A.M.1    Li, C.S.2    Pryma, D.A.3    Brem, S.4    Coukos, G.5    Muzykantov, V.6
  • 101
    • 84899973768 scopus 로고    scopus 로고
    • Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption
    • M. Blanchette, L. Tremblay, M. Lepage, and D. Fortin Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption J. Cereb. Blood Flow Metab. 34 2014 820 826
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 820-826
    • Blanchette, M.1    Tremblay, L.2    Lepage, M.3    Fortin, D.4
  • 102
    • 84925504064 scopus 로고    scopus 로고
    • Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy
    • A. Al-Shehri, M.E. Favretto, P.V. Ioannou, I.A. Romero, P.O. Couraud, B.B. Weksler, and et al. Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy Pharm. Res. 32 2015 1072 1083
    • (2015) Pharm. Res. , vol.32 , pp. 1072-1083
    • Al-Shehri, A.1    Favretto, M.E.2    Ioannou, P.V.3    Romero, I.A.4    Couraud, P.O.5    Weksler, B.B.6
  • 104
    • 84906923687 scopus 로고    scopus 로고
    • Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice
    • C.T. Huang, Z.G. Li, Y. Huang, G.Q. Zhang, M. Zhou, Q.Q. Chai, and et al. Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice Antivir. Res. 110 2014 132 141
    • (2014) Antivir. Res. , vol.110 , pp. 132-141
    • Huang, C.T.1    Li, Z.G.2    Huang, Y.3    Zhang, G.Q.4    Zhou, M.5    Chai, Q.Q.6
  • 105
    • 84890054629 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in rabies virus infection and protection
    • L.H. Wang, Y.X. Cao, Q. Tang, and G.D. Liang Role of the blood-brain barrier in rabies virus infection and protection Protein Cell 4 2013 901 903
    • (2013) Protein Cell , vol.4 , pp. 901-903
    • Wang, L.H.1    Cao, Y.X.2    Tang, Q.3    Liang, G.D.4
  • 107
    • 24344471714 scopus 로고    scopus 로고
    • Survival after treatment of rabies - Reply
    • R.E. Willoughby, and C.E. Rupprecht Survival after treatment of rabies - reply N. Engl. J. Med. 353 2005 1069
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1069
    • Willoughby, R.E.1    Rupprecht, C.E.2
  • 109
    • 84897537829 scopus 로고    scopus 로고
    • Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines/cytokines induced by rabies virus infection
    • Q.Q. Chai, W.Q. He, M. Zhou, H.J. Lu, and Z.F. Fu Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines/cytokines induced by rabies virus infection J. Virol. 88 2014 4698 4710
    • (2014) J. Virol. , vol.88 , pp. 4698-4710
    • Chai, Q.Q.1    He, W.Q.2    Zhou, M.3    Lu, H.J.4    Fu, Z.F.5
  • 110
    • 84919459586 scopus 로고    scopus 로고
    • Expression of neuronal CXCL10 induced by rabies virus infection initiates infiltration of inflammatory cells, production of chemokines and cytokines, and enhancement of blood-brain barrier permeability
    • Q.Q. Chai, R.P. She, Y. Huang, and Z.F. Fu Expression of neuronal CXCL10 induced by rabies virus infection initiates infiltration of inflammatory cells, production of chemokines and cytokines, and enhancement of blood-brain barrier permeability J. Virol. 89 2015 870 876
    • (2015) J. Virol. , vol.89 , pp. 870-876
    • Chai, Q.Q.1    She, R.P.2    Huang, Y.3    Fu, Z.F.4
  • 111
    • 84865689941 scopus 로고    scopus 로고
    • Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats
    • P.H. Liao, H.H. Yang, P.T. Chou, M.H. Wang, P.C. Chu, H.L. Liu, and et al. Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats J. Biomed. Sci. 19 2012 61
    • (2012) J. Biomed. Sci. , vol.19 , pp. 61
    • Liao, P.H.1    Yang, H.H.2    Chou, P.T.3    Wang, M.H.4    Chu, P.C.5    Liu, H.L.6
  • 112
    • 84870503828 scopus 로고    scopus 로고
    • Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism
    • J.H. Berger, M.J. Charron, and D.L. Silver Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism PLoS One 7 2012 e50629
    • (2012) PLoS One , vol.7
    • Berger, J.H.1    Charron, M.J.2    Silver, D.L.3


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