Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease

Journal of the Neurological Sciences

Volumn 348, Issue 1-2, 2015, Pages 253-255

  Wang, Jing Zhang ^a   Zhang, Yong ^a  

^a HEBEI UNIVERSITY OF ENGINEERING   (China)

Author keywords

Alzheimer disease; Cis configuration; Immunotherapy; Pin1; Tau protein

Indexed keywords

PEPTIDYLPROLYL ISOMERASE PIN1; PROLINE; PROTEIN ANTIBODY; TAU PROTEIN; THREONINE; VACCINE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CATALYSIS; CIS ISOMER; CIS TRANS ISOMERISM; ENZYME INACTIVATION; HUMAN; IMMUNOTHERAPY; IN VIVO STUDY; MICROTUBULE; MILD COGNITIVE IMPAIRMENT; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TRANS ISOMER; CONFORMATION; METABOLISM; PROCEDURES;

ALZHEIMER DISEASE; HUMANS; IMMUNOTHERAPY; MOLECULAR CONFORMATION; PEPTIDYLPROLYL ISOMERASE; TAU PROTEINS;

EID: 84920945032     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.11.011     Document Type: Article

References (10)

1. J.L. Li, D.N. Liu, L. Sun, Y.T. Lu, and Z.L. Zhang Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective J Neurol Sci 317 2012 1 5
2. H.P. Vranova, E. Henykova, M. Kaiserova, K. Mensikova, M. Vastik, and J. Mares Tau protein, beta-amyloid(1-42) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia J Neurol Sci 343 2014 120 124
3. L. Martin, X. Latypova, and F. Terro Post-translational modifications of tau protein: implications for Alzheimer's disease Neurochem Int 58 2011 458 471
4. K. Nakamura, A. Greenwood, L. Binder, E.H. Bigio, S. Denial, and L. Nicholson Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease Cell 149 2012 232 244
5. P. Nowotny, S. Bertelsen, A.L. Hinrichs, J.S.K. Kauwe, K. Mayo, and S. Jacquart Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease Neurosci Lett 419 2007 15 17
6. J.W. Wu, M. Herman, L. Liu, S. Simoes, C.M. Acker, and H. Figueroa Small misfolded Tau species Are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons J Biol Chem 288 2013 1856 1870
7. I. Landrieu, C. Smet-Nocca, L. Amniai, J.V. Louis, J.M. Wieruszeski, and J. Goris Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau PLoS One 6 2011 e21521
8. K. Nakamura, X.Z. Zhou, and K.P. Lu Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies Prion 7 2013 117 120
9. J.-C. Lambert, F. Bensemain, J. Chapuis, D. Cottel, and P. Amouyel Association study of the PIN1 gene with Alzheimer's disease Neurosci Lett 402 2006 259 261
10. J.Z. Wang, S.R. Li, Y.L. Li, Y.Z. Zhang, T. Zhang, and C.X. Zhao Could Pin1 help us conquer essential hypertension at an earlier stage? A promising early-diagnostic biomarker and its therapeutic implications for the disease Med Hypotheses 81 2013 931 935