High-throughput virtual screening identifies novel N ′-(1- phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9496-9508

  Sorna, Venkataswamy ^a   Theisen, Emily R ^a,b   Stephens, Bret ^a   Warner, Steven L ^a   Bearss, David J ^a   Vankayalapati, Hariprasad ^a,c   Sharma, Sunil ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [1 (5 CHLORO 2 HYDROXYPHENYL)ETHYLIDENE]HYDRAZINECARBONYL] N,N DIMETHYLBENZENESULFONAMIDE; 3 BROMO 4 CHLORO N' [1 (5 CHLOROPYRIDIN 4 YL)ETHYLIDENE]BENZOHYDRAZIDE; 5 BROMO 6 CHLORO N' [1 (5 CHLORO 2 HYDROXYPHENYL)ETHYLIDENE]BENZOHYDRAZIDE; 5 CHLORO N' [1 (5 CHLORO 2 HYDROXYPHENYL)ETHYLIDENE]NICOTINOHYDRAZIDE; AMINE OXIDASE (FLAVIN CONTAINING); ANTINEOPLASTIC AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; ENZYME; ENZYME INHIBITOR; GLUCOSE OXIDASE; HYDRAZIDE DERIVATIVE; LACTATE DEHYDROGENASE; LYSINE SPECIFIC DEMETHYLASE 1; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; N' [1 (2 CHLOROPYRIDIN 4 YL)ETHYLIDENE] 3 (MORPHOLINOSULFONYL)BENZOHYDRAZIDE; N' [1 (2,5 DICHLOROPHENYL)ETHYLIDENE] 3 (MORPHOLINOSULFONYL)BENZOHYDRAZIDE; N' [1 (2,6 DIHYDROXYPHENYL)ETHYLIDENE]BENZOHYDRAZIDE; N' [1 (3 FLUOROPHENYL)ETHYLIDENE] 3 (MORPHOLINOSULFONYL)BENZOHYDRAZIDE; N' [1 (5 CHLORO 2 HYDROXYPHENYL)ETHYLIDENE] 3 (MORPHOLINOSULFONYL)BENZOHYDRAZIDE; N' [1 (5 CHLORO 2 HYDROXYPHENYL)ETHYLIDENE]BENZOHYDRAZIDE; N' [1 (5 CHLORO 2 HYDROXYPHENYL)PROPYLIDENE] 3 (MORPHOLINOSULFONYL)BENZOHYDRAZIDE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; MELTING POINT; MOLECULAR DOCKING; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; VIRTUAL REALITY;

EID: 84890448100     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400870h     Document Type: Article

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