LRP-1-mediated intracellular antibody delivery to the Central Nervous System

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Tian, Xiaohe ^a   Nyberg, Sophie ^a   Sharp, Paul S ^b,c   Madsen, Jeppe ^b   Daneshpour, Nooshin ^b,c   Armes, Steven P ^b   Berwick, Jason ^b   Azzouz, Mimoun ^b,c   Shaw, Pamela ^b,c   Abbott, N Joan ^d   Battaglia, Giuseppe ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; LOW DENSITY LIPOPROTEIN RECEPTOR; LRP1 PROTEIN, MOUSE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; POLYMER; PROTEIN BINDING; RAB PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; INTRACELLULAR SPACE; MALE; METABOLISM; MOUSE; PROTEIN TRANSPORT; TRANSCYTOSIS; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIBODIES; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; INTRACELLULAR SPACE; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; MALE; MICE; POLYMERS; PROTEIN BINDING; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RECEPTORS, LDL; TRANSCYTOSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 84937710410     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11990     Document Type: Article

References (50)

1. Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R. & Begley, D. J. Structure and function of the blood-brain barrier. Neurobiology of Disease 37, 13-25 (2010).
2. Abbott, N. J., Ronnback, L. & Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews Neuroscience 7, 41-53 (2006).
3. Daneman, R., Zhou, L., Kebede, A. A. & Barres, B. A. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468, 562-566 (2010).
4. Pardridge, W. M. Brain drug targeting : the future of brain drug development. (Cambridge University Press, Cambridge; 2001).
5. Pardridge, W. M. Crossing the blood-brain barrier: are we getting it right? Drug Discovery Today 6, 1-2 (2001).
6. Pardridge, W. M. & Lawrence, R. N. William Pardridge discusses the lack of BBB research. Drug Discovery Today 7, 223-226 (2002).
7. Tuma, P. L. & Hubbard, A. L. Transcytosis: crossing cellular barriers. Physiological Reviews 83, 871-932 (2003).
8. Salinas, S., Schiavo, G. & Kremer, E. J. A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins. Nature Reviews Microbiology 8, 645-655 (2010).
9. Coloma, M. J. et al. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharmaceutical Research 17, 266-274 (2000).
10. Gabathuler, R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiology of Disease 37, 48-57 (2010).
11. Jones, A. R. & Shusta, E. V. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharmaceutical Research 24, 1759-1771 (2007).
12. Zhang, Y. & Pardridge, W. M. Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor. J Pharmacol Exp Ther 313, 1075-1081 (2005).
13. Béduneau, A. et al. Brain targeting using novel lipid nanovectors. Journal of Controlled Release 126, 44-49 (2008).
14. Tao, Y. H., Han, J. F. & Dou, H. Y. Brain-targeting gene delivery using a rabies virus glycoprotein peptide modulated hollow liposome: bio-behavioral study. Journal of Materials Chemistry 22, 11808-11815 (2012).
15. Ke, W. et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 30, 6976-6985 (2009).
16. Shao, K. et al. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. Journal of Controlled Release 147, 118-126 (2010).
17. Du, J. Z., Tang, Y. Q., Lewis, A. L. & Armes, S. P. pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer. J Am Chem Soc 127, 17982-17983 (2005).
18. Lomas, H. et al. Biomimetic pH sensitive polymersomes for efficient DNA encapsulation and delivery. Advanced Materials 19, 4238-4243 (2007).
19. Lomas, H. et al. Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery. Faraday discussions 139, 143-159 (2008).
20. Massignani, M. et al. Controlling cellular uptake by surface chemistry, size, and surface topology at the nanoscale. Small 5, 2424-2432 (2009).
21. Franke, H., Galla, H.-J. & Beuckmann, C. T. Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro. Brain Research Protocols 5, 248-256 (2000).
22. Nakagawa, S. et al. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochemistry international 54, 253-263 (2009).
23. Discher, D. E. & Eisenberg, A. Polymer vesicles. Science 297, 967-973 (2002).
24. Colley, H. E. et al. Polymersome-mediated delivery of combination anti-cancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation. Molecular Pharmaceutics 11 (4), 1176-1188 (2014)
25. Pegoraro, C. et al. Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes. Cancer letters 334, 328-337 (2013).
26. Wayakanon, K. et al. Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells. The FASEB Journal 27, 4455-4465 (2013).
27. Wang, L. et al. Encapsulation of biomacromolecules within polymersomes by electroporation. Angewandte Chemie International Edition 51, 11122-11125 (2012).
28. Canton, I. et al. Fully synthetic polymer vesicles for intracellular delivery of antibodies in live cells. The FASEB Journal 27, 98-108 (2013).
29. Madsen, J. et al. Nile Blue-Based Nanosized pH Sensors for Simultaneous Far-Red and Near-Infrared Live Bioimaging. J Am Chem Soc 135, 14863-14870 (2013).
30. Massignani, M. et al. Enhanced fluorescence imaging of live cells by effective cytosolic delivery of probes. PLoS One 5, e10459 (2010).
31. Mantovani, G. et al. Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: A suitable alternative to PEGylation chemistry. J Am Chem Soc 127, 2966-2973 (2005).
32. Demeule, M. et al. Identification and design of peptides as a new drug delivery system for the brain. J Pharmacol Exp Ther 324, 1064-1072 (2008).
33. Kumar, P. et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 448, 39-43 (2007).
34. Pardridge, W. M. Blood-brain barrier delivery. Drug discovery today 12, 54-61 (2007).
35. LoPresti, C., Lomas, H., Massignani, M., Smart, T. & Battaglia, G. Polymersomes: nature inspired nanometer sized compartments. Journal of Materials Chemistry 19, 3576-3590 (2009).
36. Lomas, H. et al. Efficient Encapsulation of Plasmid DNA in pH-Sensitive PMPC-PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer-DNA Binding Affinity. Macromolecular Bioscience 10, 513-530 (2010).
37. Nakagawa, S. et al. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochemistry International 54, 253-263 (2009).
38. Armulik, A. et al. Pericytes regulate the blood-brain barrier. Nature 468, 557-U231 (2010).
39. Minamikawa, T., Miyake, T., Takamatsu, T. & Fujita, S. A New Method of Lectin Histochemistry for the Study of Brain Angiogenesis - Lectin Angiography. Histochemistry 87, 317-320 (1987).
40. Moos, T. & Morgan, E. H. Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat. Journal of neurochemistry 79, 119-129 (2001).
41. Strazielle, N. & Ghersi-Egea, J. F. Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Molecular pharmaceutics 10, 1473-1491 (2013).
42. Doronina, S. O. et al. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nature Biotechnology 21, 778-784 (2003).
43. Teicher, B. A. & Chari, R. V. J. Antibody Conjugate Therapeutics: Challenges and Potential. Clin Cancer Res 17, 6389-6397 (2011).
44. Wu, A. M. & Senter, P. D. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol 23, 1137-1146 (2005).
45. Couch, J. A. et al. Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier. Sci Transl Med 5, 183ra57 (2013).
46. Merchant, M. et al. Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. P Natl Acad Sci USA 110, E2987-E2996 (2013).
47. Weaver, J. V. M. et al. Stimulus-responsive water-soluble polymers based on 2-hydroxyethyl methacrylate. Macromolecules 37, 2395-2403 (2004).
48. Madsen, J. et al. Biocompatible wound dressings based on chemically degradable triblock copolymer hydrogels. Biomacromolecules 9, 2265-2275 (2008).
49. Tsarevsky, N. V. & Matyjaszewski, K. Reversible redox cleavage/coupling of polystyrene with disulfide or thiol groups prepared by atom transfer radical polymerization. Macromolecules 35, 9009-9014 (2002).
50. Pounder, R. J., Stanford, M. J., Brooks, P., Richards, S. P. & Dove, A. P. Metal free thiol-maleimide 'Click' reaction as a mild functionalisation strategy for degradable polymers. Chem Commun, 5158-5160 (2008).