메뉴 건너뛰기




Volumn 6, Issue JUN, 2014, Pages

Immunotherapy for alzheimer's disease: Past, present and future

Author keywords

Alzheimer's disease; A ; Blood brain barrier; Immunization; Immunotherapy

Indexed keywords

BAPINEUZUMAB; CRENEZUMAB; GANTENERUMAB; PONEZUMAB; SOLANEZUMAB;

EID: 84904556283     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00114     Document Type: Review
Times cited : (73)

References (69)
  • 1
    • 84863693043 scopus 로고    scopus 로고
    • An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta
    • doi: 10.1523/jneurosci.4742-11.2012
    • Adolfsson, O., Pihlgren, M., Toni, N., Varisco, Y., Buccarello, A. L., Antoniello, K., et al. (2012). An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta. J. Neurosci. 32, 9677-9689. doi: 10.1523/jneurosci.4742-11.2012
    • (2012) J. Neurosci. , vol.32 , pp. 9677-9689
    • Adolfsson, O.1    Pihlgren, M.2    Toni, N.3    Varisco, Y.4    Buccarello, A.L.5    Antoniello, K.6
  • 2
    • 0242330374 scopus 로고    scopus 로고
    • ADAMs family members as amyloid precursor protein alpha-secretases
    • doi: 10.1002/jnr.10737
    • Allinson, T. M., Parkin, E. T., Turner, A. J., and Hooper, N. M. (2003). ADAMs family members as amyloid precursor protein alpha-secretases. J. Neurosci. Res. 74, 342-352. doi: 10.1002/jnr.10737
    • (2003) J. Neurosci. Res. , vol.74 , pp. 342-352
    • Allinson, T.M.1    Parkin, E.T.2    Turner, A.J.3    Hooper, N.M.4
  • 3
    • 84904561788 scopus 로고    scopus 로고
    • Alzheimer's association
    • Alzheimer's and Dementia
    • Alzheimer's association. (2013). Alzheimer's Disease Facts and Figures. Alzheimer's and Dementia 9.
    • (2013) Alzheimer's Disease Facts and Figures , pp. 9
  • 4
    • 0026545684 scopus 로고
    • An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence
    • doi: 10.1111/j.1471-4159.1992.tb10128.x
    • Anderson, J. P., Chen, Y., Kim, K. S., and Robakis, N. K. (1992). An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. J. Neurochem. 59, 2328-2331. doi: 10.1111/j.1471-4159.1992.tb10128.x
    • (1992) J. Neurochem. , vol.59 , pp. 2328-2331
    • Anderson, J.P.1    Chen, Y.2    Kim, K.S.3    Robakis, N.K.4
  • 5
    • 0036953160 scopus 로고    scopus 로고
    • Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
    • doi: 10.1016/s0196-9781(02)00261-9
    • Banks, W. A., Terrell, B., Farr, S. A., Robinson, S. M., Nonaka, N., and Morley, J. E. (2002). Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides 23, 2223-2226. doi: 10.1016/s0196-9781(02)00261-9
    • (2002) Peptides , vol.23 , pp. 2223-2226
    • Banks, W.A.1    Terrell, B.2    Farr, S.A.3    Robinson, S.M.4    Nonaka, N.5    Morley, J.E.6
  • 6
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • doi: 10.1073/pnas.0436286100
    • Bard, F., Barbour, R., Cannon, C., Carretto, R., Fox, M., Games, D., et al. (2003). Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc. Natl. Acad. Sci. U S A 100, 2023-2028. doi: 10.1073/pnas.0436286100
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , pp. 2023-2028
    • Bard, F.1    Barbour, R.2    Cannon, C.3    Carretto, R.4    Fox, M.5    Games, D.6
  • 7
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • doi: 10.1056/NEJMoa1202753
    • Bateman, R. J., Xiong, C., Benzinger, T. L., Fagan, A. M., Goate, A., Fox, N. C., et al. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795-804. doi: 10.1056/NEJMoa1202753
    • (2012) N. Engl. J. Med. , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3    Fagan, A.M.4    Goate, A.5    Fox, N.C.6
  • 8
    • 84893754100 scopus 로고    scopus 로고
    • Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
    • doi: 10.1084/jem.20131660
    • Bien-Ly, N., Yu, Y. J., Bumbaca, D., Elstrott, J., Boswell, C. A., Zhang, Y., et al. (2014). Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. J. Exp. Med. 211, 233-244. doi: 10.1084/jem.20131660
    • (2014) J. Exp. Med. , vol.211 , pp. 233-244
    • Bien-Ly, N.1    Yu, Y.J.2    Bumbaca, D.3    Elstrott, J.4    Boswell, C.A.5    Zhang, Y.6
  • 9
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • doi: 10.1016/S0140-6736(06)69113-7
    • Blennow, K., De Leon, M. J., and Zetterberg, H. (2006). Alzheimer's disease. Lancet 368, 387-403. doi: 10.1016/S0140-6736(06)69113-7
    • (2006) Lancet , vol.368 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 10
    • 84863750982 scopus 로고    scopus 로고
    • Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease
    • doi: 10.1001/archneurol.2012.90
    • Blennow, K., Zetterberg, H., Rinne, J. O., Salloway, S., Wei, J., Black, R., et al. (2012). Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch. Neurol. 69, 1002-1010. doi: 10.1001/archneurol.2012.90
    • (2012) Arch. Neurol. , vol.69 , pp. 1002-1010
    • Blennow, K.1    Zetterberg, H.2    Rinne, J.O.3    Salloway, S.4    Wei, J.5    Black, R.6
  • 11
    • 84875544291 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor
    • doi: 10.1002/bit.24795
    • Boado, R. J., Lu, J. Z., Hui, E. K., Sumbria, R. K., and Pardridge, W. M. (2013). Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor. Biotechnol. Bioeng. 110, 1456-1465. doi: 10.1002/bit.24795
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 1456-1465
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Sumbria, R.K.4    Pardridge, W.M.5
  • 12
    • 34547644135 scopus 로고    scopus 로고
    • Genetic engineering, expression and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier
    • doi: 10.1002/bit.21369
    • Boado, R. J., Zhang, Y., Zhang, Y., and Pardridge, W. M. (2007). Genetic engineering, expression and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier. Biotechnol. Bioeng. 97, 1376-1386. doi: 10.1002/bit.21369
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 1376-1386
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 13
    • 77953872812 scopus 로고    scopus 로고
    • Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    • doi: 10.1007/s00401-010-0705-y
    • Boche, D., Donald, J., Love, S., Harris, S., Neal, J. W., Holmes, C., et al. (2010). Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta Neuropathol. 120, 13-20. doi: 10.1007/s00401-010-0705-y
    • (2010) Acta Neuropathol , vol.120 , pp. 13-20
    • Boche, D.1    Donald, J.2    Love, S.3    Harris, S.4    Neal, J.W.5    Holmes, C.6
  • 14
    • 84894433216 scopus 로고    scopus 로고
    • Comparison of five peptide vectors for improved brain delivery of the lysosomal enzyme arylsulfatase a
    • doi: 10.1523/jneurosci.4785-13.2014
    • Böckenhoff, A., Cramer, S., Wolte, P., Knieling, S., Wohlenberg, C., Gieselmann, V., et al. (2014). Comparison of five peptide vectors for improved brain delivery of the lysosomal enzyme arylsulfatase a. J. Neurosci. 34, 3122-3129. doi: 10.1523/jneurosci.4785-13.2014
    • (2014) J. Neurosci. , vol.34 , pp. 3122-3129
    • Böckenhoff, A.1    Cramer, S.2    Wolte, P.3    Knieling, S.4    Wohlenberg, C.5    Gieselmann, V.6
  • 15
    • 84855780598 scopus 로고    scopus 로고
    • Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta
    • doi: 10.3233/JAD-2011-110977
    • Bohrmann, B., Baumann, K., Benz, J., Gerber, F., Huber, W., Knoflach, F., et al. (2012). Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta. J. Alzheimers Dis. 28, 49-69. doi: 10.3233/JAD-2011-110977
    • (2012) J. Alzheimers Dis. , vol.28 , pp. 49-69
    • Bohrmann, B.1    Baumann, K.2    Benz, J.3    Gerber, F.4    Huber, W.5    Knoflach, F.6
  • 16
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • doi: 10.1007/bf00308809
    • Braak, H., and Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239-259. doi: 10.1007/bf00308809
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 17
    • 0029686696 scopus 로고    scopus 로고
    • Evolution of the neuropathology of Alzheimer's disease
    • doi: 10.1111/j.1600-0404.1996.tb05866.x
    • Braak, H., and Braak, E. (1996). Evolution of the neuropathology of Alzheimer's disease. Acta Neurol. Scand. Suppl. 165, 3-12. doi: 10.1111/j.1600-0404.1996.tb05866.x
    • (1996) Acta Neurol. Scand. Suppl. , vol.165 , pp. 3-12
    • Braak, H.1    Braak, E.2
  • 18
    • 84872970450 scopus 로고    scopus 로고
    • Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease
    • doi: 10.1097/wnf.0b013e318279bcfa
    • Burstein, A. H., Zhao, Q., Ross, J., Styren, S., Landen, J. W., Ma, W. W., et al. (2013). Safety and pharmacology of ponezumab (PF-04360365) after a single 10-minute intravenous infusion in subjects with mild to moderate Alzheimer disease. Clin. Neuropharmacol. 36, 8-13. doi: 10.1097/wnf.0b013e318279bcfa
    • (2013) Clin. Neuropharmacol. , vol.36 , pp. 8-13
    • Burstein, A.H.1    Zhao, Q.2    Ross, J.3    Styren, S.4    Landen, J.W.5    Ma, W.W.6
  • 19
    • 27144511230 scopus 로고    scopus 로고
    • Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
    • doi: 10.1523/jneurosci.1697-05.2005
    • Buttini, M., Masliah, E., Barbour, R., Grajeda, H., Motter, R., Johnson-Wood, K., et al. (2005). Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J. Neurosci. 25, 9096-9101. doi: 10.1523/jneurosci.1697-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 9096-9101
    • Buttini, M.1    Masliah, E.2    Barbour, R.3    Grajeda, H.4    Motter, R.5    Johnson-Wood, K.6
  • 20
    • 84875369200 scopus 로고    scopus 로고
    • Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease
    • doi: 10.1016/j.jalz.2012.12.004
    • Carrillo, M. C., Brashear, H. R., Logovinsky, V., Ryan, J. M., Feldman, H. H., Siemers, E. R., et al. (2013). Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimers Dement. 9, 123-131.e1. doi: 10.1016/j.jalz.2012.12.004
    • (2013) Alzheimers Dement , vol.9
    • Carrillo, M.C.1    Brashear, H.R.2    Logovinsky, V.3    Ryan, J.M.4    Feldman, H.H.5    Siemers, E.R.6
  • 21
    • 84878276906 scopus 로고    scopus 로고
    • Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
    • doi: 10.1126/scitranslmed.3005338 183ra57
    • Couch, J. A., Yu, Y. J., Zhang, Y., Tarrant, J. M., Fuji, R. N., Meilandt, W. J., et al. (2013). Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Sci. Transl. Med. 5, 183ra57, 1-12. doi: 10.1126/scitranslmed.3005338
    • (2013) Sci. Transl. Med. , vol.5 , pp. 1-12
    • Couch, J.A.1    Yu, Y.J.2    Zhang, Y.3    Tarrant, J.M.4    Fuji, R.N.5    Meilandt, W.J.6
  • 22
    • 0034746897 scopus 로고    scopus 로고
    • Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
    • doi: 10.1016/s0197-4580(01)00245-7
    • Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2001). Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging 22, 721-727. doi: 10.1016/s0197-4580(01)00245-7
    • (2001) Neurobiol. Aging , vol.22 , pp. 721-727
    • Das, P.1    Murphy, M.P.2    Younkin, L.H.3    Younkin, S.G.4    Golde, T.E.5
  • 23
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • doi: 10.1038/nn842
    • Dodart, J. C., Bales, K. R., Gannon, K. S., Greene, S. J., Demattos, R. B., Mathis, C., et al. (2002). Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 5, 452-457. doi: 10.1038/nn842
    • (2002) Nat. Neurosci. , vol.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3    Greene, S.J.4    Demattos, R.B.5    Mathis, C.6
  • 24
    • 84892748542 scopus 로고    scopus 로고
    • Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
    • doi: 10.1056/NEJMoa1312889
    • Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., et al. (2014). Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 311-321. doi: 10.1056/NEJMoa1312889
    • (2014) N. Engl. J. Med. , vol.370 , pp. 311-321
    • Doody, R.S.1    Thomas, R.G.2    Farlow, M.3    Iwatsubo, T.4    Vellas, B.5    Joffe, S.6
  • 25
    • 84870162666 scopus 로고    scopus 로고
    • Chronic administration of an aglycosylated murine antibody of ponezumab does not worsen microhemorrhages in aged Tg2576 mice
    • doi: 10.2174/156720512803569064
    • Freeman, G. B., Brown, T. P., Wallace, K., and Bales, K. R. (2012a). Chronic administration of an aglycosylated murine antibody of ponezumab does not worsen microhemorrhages in aged Tg2576 mice. Curr. Alzheimer Res. 9, 1059-1068. doi: 10.2174/156720512803569064
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 1059-1068
    • Freeman, G.B.1    Brown, T.P.2    Wallace, K.3    Bales, K.R.4
  • 26
    • 84863245510 scopus 로고    scopus 로고
    • 39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period
    • doi: 10.3233/JAD-2011-110869
    • Freeman, G. B., Lin, J. C., Pons, J., and Raha, N. M. (2012b). 39-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period. J. Alzheimers Dis. 28, 531-541. doi: 10.3233/JAD-2011-110869
    • (2012) J. Alzheimers Dis. , vol.28 , pp. 531-541
    • Freeman, G.B.1    Lin, J.C.2    Pons, J.3    Raha, N.M.4
  • 27
    • 0035925634 scopus 로고    scopus 로고
    • Generation of auto-antibodies towards Alzheimer's disease vaccination
    • doi: 10.1016/s0264-410x(00)00501-6
    • Frenkel, D., Kariv, N., and Solomon, B. (2001). Generation of auto-antibodies towards Alzheimer's disease vaccination. Vaccine 19, 2615-2619. doi: 10.1016/s0264-410x(00)00501-6
    • (2001) Vaccine , vol.19 , pp. 2615-2619
    • Frenkel, D.1    Kariv, N.2    Solomon, B.3
  • 28
    • 0025828176 scopus 로고
    • Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier
    • doi: 10.1073/pnas.88.11.4771
    • Friden, P. M., Walus, L. R., Musso, G. F., Taylor, M. A., Malfroy, B., and Starzyk, R. M. (1991). Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc. Natl. Acad. Sci. U S A 88, 4771-4775. doi: 10.1073/pnas.88.11.4771
    • (1991) Proc. Natl. Acad. Sci. U S A , vol.88 , pp. 4771-4775
    • Friden, P.M.1    Walus, L.R.2    Musso, G.F.3    Taylor, M.A.4    Malfroy, B.5    Starzyk, R.M.6
  • 29
    • 33646064717 scopus 로고    scopus 로고
    • Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model
    • doi: 10.1016/j.bbrc.2006.03.145
    • Fukuchi, K., Accavitti-Loper, M. A., Kim, H. D., Tahara, K., Cao, Y., Lewis, T. L., et al. (2006). Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model. Biochem. Biophys. Res. Commun. 344, 79-86. doi: 10.1016/j.bbrc.2006.03.145
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 79-86
    • Fukuchi, K.1    Accavitti-Loper, M.A.2    Kim, H.D.3    Tahara, K.4    Cao, Y.5    Lewis, T.L.6
  • 30
    • 84873487586 scopus 로고    scopus 로고
    • Genentech's Alzheimer's antibody trial to study disease prevention
    • doi: 10.1038/nbt0812-731
    • Garber, K. (2012). Genentech's Alzheimer's antibody trial to study disease prevention. Nat. Biotechnol. 30, 731-732. doi: 10.1038/nbt0812-731
    • (2012) Nat. Biotechnol. , vol.30 , pp. 731-732
    • Garber, K.1
  • 31
    • 34248172449 scopus 로고    scopus 로고
    • Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts
    • doi: 10.1016/j.pneurobio.2007.02.001
    • Gralle, M., and Ferreira, S. T. (2007). Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts. Prog. Neurobiol. 82, 11-32. doi: 10.1016/j.pneurobio.2007.02.001
    • (2007) Prog. Neurobiol. , vol.82 , pp. 11-32
    • Gralle, M.1    Ferreira, S.T.2
  • 32
    • 78049283756 scopus 로고    scopus 로고
    • Transsynaptic progression of amyloid-beta-induced neuronal dysfunction within the entorhinal-hippocampal network
    • doi: 10.1016/j.neuron.2010.10.020
    • Harris, J. A., Devidze, N., Verret, L., Ho, K., Halabisky, B., Thwin, M. T., et al. (2010). Transsynaptic progression of amyloid-beta-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron 68, 428-441. doi: 10.1016/j.neuron.2010.10.020
    • (2010) Neuron , vol.68 , pp. 428-441
    • Harris, J.A.1    Devidze, N.2    Verret, L.3    Ho, K.4    Halabisky, B.5    Thwin, M.T.6
  • 33
    • 0032802253 scopus 로고    scopus 로고
    • The mammalian low-density lipoprotein receptor family
    • doi: 10.1146/annurev.nutr.19.1.141
    • Hussain, M. M., Strickland, D. K., and Bakillah, A. (1999). The mammalian low-density lipoprotein receptor family. Annu. Rev. Nutr. 19, 141-172. doi: 10.1146/annurev.nutr.19.1.141
    • (1999) Annu. Rev. Nutr. , vol.19 , pp. 141-172
    • Hussain, M.M.1    Strickland, D.K.2    Bakillah, A.3
  • 34
    • 69149096041 scopus 로고    scopus 로고
    • Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments
    • doi: 10.1002/btpr.190
    • Kasturirangan, S., Brune, D., and Sierks, M. (2009). Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments. Biotechnol. Prog. 25, 1054-1063. doi: 10.1002/btpr.190
    • (2009) Biotechnol. Prog. , vol.25 , pp. 1054-1063
    • Kasturirangan, S.1    Brune, D.2    Sierks, M.3
  • 35
    • 77952524168 scopus 로고    scopus 로고
    • Targeted hydrolysis of Beta-amyloid with engineered antibody fragment
    • doi: 10.2174/156720510791050876
    • Kasturirangan, S., and Sierks, M. (2010). Targeted hydrolysis of Beta-amyloid with engineered antibody fragment. Curr. Alzheimer Res. 7, 214-222. doi: 10.2174/156720510791050876
    • (2010) Curr. Alzheimer Res. , vol.7 , pp. 214-222
    • Kasturirangan, S.1    Sierks, M.2
  • 36
    • 15944413832 scopus 로고    scopus 로고
    • The non-amyloidogenic pathway: structure and function of alpha-secretases
    • doi: 10.1007/0-387-23226-5_5
    • Kojro, E., and Fahrenholz, F. (2005). The non-amyloidogenic pathway: structure and function of alpha-secretases. Subcell. Biochem. 38, 105-127. doi: 10.1007/0-387-23226-5_5
    • (2005) Subcell. Biochem. , vol.38 , pp. 105-127
    • Kojro, E.1    Fahrenholz, F.2
  • 38
    • 84864286560 scopus 로고    scopus 로고
    • Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease
    • doi: 10.1016/j.jmb.2011.11.047
    • La Porte, S. L., Bollini, S. S., Lanz, T. A., Abdiche, Y. N., Rusnak, A. S., Ho, W. H., et al. (2012). Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease. J. Mol. Biol. 421, 525-536. doi: 10.1016/j.jmb.2011.11.047
    • (2012) J. Mol. Biol. , vol.421 , pp. 525-536
    • La Porte, S.L.1    Bollini, S.S.2    Lanz, T.A.3    Abdiche, Y.N.4    Rusnak, A.S.5    Ho, W.H.6
  • 39
    • 84872960603 scopus 로고    scopus 로고
    • Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study
    • doi: 10.1097/WNF.0b013e31827db49b
    • Landen, J. W., Zhao, Q., Cohen, S., Borrie, M., Woodward, M., Billing, C. B. Jr., et al. (2013). Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study. Clin. Neuropharmacol. 36, 14-23. doi: 10.1097/WNF.0b013e31827db49b
    • (2013) Clin. Neuropharmacol. , vol.36 , pp. 14-23
    • Landen, J.W.1    Zhao, Q.2    Cohen, S.3    Borrie, M.4    Woodward, M.5    Billing Jr., C.B.6
  • 40
    • 76849091134 scopus 로고    scopus 로고
    • Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat
    • doi: 10.1038/nrneurol.2009.219
    • Lemere, C. A., and Masliah, E. (2010). Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat. Rev. Neurol. 6, 108-119. doi: 10.1038/nrneurol.2009.219
    • (2010) Rev. Neurol. , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 41
    • 3543054598 scopus 로고    scopus 로고
    • Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity
    • doi: 10.1021/bi0492354
    • Liu, R., Mcallister, C., Lyubchenko, Y., and Sierks, M. R. (2004). Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity. Biochemistry 43, 9999-10007. doi: 10.1021/bi0492354
    • (2004) Biochemistry , vol.43 , pp. 9999-10007
    • Liu, R.1    Mcallister, C.2    Lyubchenko, Y.3    Sierks, M.R.4
  • 42
    • 19944429065 scopus 로고    scopus 로고
    • Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    • doi: 10.1212/01.wnl.0000148590.39911.df
    • Masliah, E., Hansen, L., Adame, A., Crews, L., Bard, F., Lee, C., et al. (2005). Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 64, 129-131. doi: 10.1212/01.wnl.0000148590.39911.df
    • (2005) Neurology , vol.64 , pp. 129-131
    • Masliah, E.1    Hansen, L.2    Adame, A.3    Crews, L.4    Bard, F.5    Lee, C.6
  • 43
    • 84862868531 scopus 로고    scopus 로고
    • Spreading of neurodegenerative pathology via neuron-to-neuron transmission of beta-amyloid
    • doi: 10.1523/JNEUROSCI.0615-12.2012
    • Nath, S., Agholme, L., Kurudenkandy, F. R., Granseth, B., Marcusson, J., and Hallbeck, M. (2012). Spreading of neurodegenerative pathology via neuron-to-neuron transmission of beta-amyloid. J. Neurosci. 32, 8767-8777. doi: 10.1523/JNEUROSCI.0615-12.2012
    • (2012) J. Neurosci. , vol.32 , pp. 8767-8777
    • Nath, S.1    Agholme, L.2    Kurudenkandy, F.R.3    Granseth, B.4    Marcusson, J.5    Hallbeck, M.6
  • 44
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • doi: 10.1016/j.neuron.2013.10.061
    • Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P., et al. (2014). Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 81, 49-60. doi: 10.1016/j.neuron.2013.10.061
    • (2014) Neuron , vol.81 , pp. 49-60
    • Niewoehner, J.1    Bohrmann, B.2    Collin, L.3    Urich, E.4    Sade, H.5    Maier, P.6
  • 45
    • 84904581177 scopus 로고    scopus 로고
    • Amyloid Imaging And Safety Study Of ACC-001
    • NIH. Subjects With Mild to Moderate Alzheimer's Disease (ACCTION) [Online]. Available [Accessed]
    • NIH. (2014a). Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease (ACCTION) [Online]. Available: http://clinicaltrials.gov/ct2/show/NCT01284387 [Accessed].
    • (2014)
  • 46
    • 84904565645 scopus 로고    scopus 로고
    • Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation
    • NIH. (DIAN-TU) [Online]. Available [Accessed]
    • NIH. (2014b). Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU) [Online]. Available: http://www.clinicaltrials.gov/ct2/show/NCT01760005 [Accessed].
    • (2014)
  • 47
    • 84904579504 scopus 로고    scopus 로고
    • Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo
    • (EXPEDITION 3) [Online]. Available[Accessed].NIH
    • NIH. (2014c). Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo (EXPEDITION 3) [Online]. Available: http://clinicaltrials.gov/ct2/show/NCT01900665?term=Solanezumab&rank=1 [Accessed].
    • (2014)
  • 48
    • 84904543437 scopus 로고    scopus 로고
    • Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy
    • [Online].NIH. Available [Accessed]
    • NIH. (2014d). Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy [Online]. Available: http://clinicaltrials.gov/ct2/show/NCT01821118 [Accessed].
    • (2014)
  • 49
    • 77956393132 scopus 로고    scopus 로고
    • Involvement of Fc receptors in disorders of the central nervous system
    • doi: 10.1007/s12017-009-8099-5
    • Okun, E., Mattson, M. P., and Arumugam, T. V. (2010). Involvement of Fc receptors in disorders of the central nervous system. Neuromolecular Med. 12, 164-178. doi: 10.1007/s12017-009-8099-5
    • (2010) Neuromolecular Med , vol.12 , pp. 164-178
    • Okun, E.1    Mattson, M.P.2    Arumugam, T.V.3
  • 50
    • 84863115941 scopus 로고    scopus 로고
    • Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab
    • doi: 10.1001/archneurol.2011.1538
    • Ostrowitzki, S., Deptula, D., Thurfjell, L., Barkhof, F., Bohrmann, B., Brooks, D. J., et al. (2012). Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch. Neurol. 69, 198-207. doi: 10.1001/archneurol.2011.1538
    • (2012) Arch. Neurol. , vol.69 , pp. 198-207
    • Ostrowitzki, S.1    Deptula, D.2    Thurfjell, L.3    Barkhof, F.4    Bohrmann, B.5    Brooks, D.J.6
  • 51
    • 84859070489 scopus 로고    scopus 로고
    • Neuronal receptors as targets for the action of amyloid-beta protein (Abeta) in the brain
    • doi: 10.1017/s1462399411002134
    • Patel, A. N., and Jhamandas, J. H. (2012). Neuronal receptors as targets for the action of amyloid-beta protein (Abeta) in the brain. Expert Rev. Mol. Med. 14:e2. doi: 10.1017/s1462399411002134
    • (2012) Expert Rev. Mol. Med. , vol.14
    • Patel, A.N.1    Jhamandas, J.H.2
  • 52
    • 80055034288 scopus 로고    scopus 로고
    • Alzheimer's prevention initiative: a plan to accelerate the evaluation of presymptomatic treatments
    • doi: 10.3233/JAD-2011-0059
    • Reiman, E. M., Langbaum, J. B., Fleisher, A. S., Caselli, R. J., Chen, K., Ayutyanont, N., et al. (2011). Alzheimer's prevention initiative: a plan to accelerate the evaluation of presymptomatic treatments. J. Alzheimers Dis. 26(Suppl. 3), 321-329. doi: 10.3233/JAD-2011-0059
    • (2011) J. Alzheimers Dis. , vol.26 , Issue.SUPPL. 3 , pp. 321-329
    • Reiman, E.M.1    Langbaum, J.B.2    Fleisher, A.S.3    Caselli, R.J.4    Chen, K.5    Ayutyanont, N.6
  • 53
    • 84892695519 scopus 로고    scopus 로고
    • Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
    • doi: 10.1056/NEJMoa1304839
    • Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., et al. (2014). Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 322-333. doi: 10.1056/NEJMoa1304839
    • (2014) N. Engl. J. Med. , vol.370 , pp. 322-333
    • Salloway, S.1    Sperling, R.2    Fox, N.C.3    Blennow, K.4    Klunk, W.5    Raskind, M.6
  • 54
    • 79955803502 scopus 로고    scopus 로고
    • Solanezumab for Alzheimer's disease
    • doi: 10.1517/14712598.2011.578573
    • Samadi, H., and Sultzer, D. (2011). Solanezumab for Alzheimer's disease. Expert Opin. Biol. Ther. 11, 787-798. doi: 10.1517/14712598.2011.578573
    • (2011) Expert Opin. Biol. Ther. , vol.11 , pp. 787-798
    • Samadi, H.1    Sultzer, D.2
  • 55
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • doi: 10.1038/22124
    • Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., et al. (1999). Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177. doi: 10.1038/22124
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 56
    • 63249137056 scopus 로고    scopus 로고
    • Development of AFFITOPE vaccines for Alzheimer's disease (AD)-from concept to clinical testing
    • doi: 10.1007/s12603-009-0070-5
    • Schneeberger, A., Mandler, M., Otawa, O., Zauner, W., Mattner, F., and Schmidt, W. (2009). Development of AFFITOPE vaccines for Alzheimer's disease (AD)-from concept to clinical testing. J. Nutr. Health Aging 13, 264-267. doi: 10.1007/s12603-009-0070-5
    • (2009) J. Nutr. Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3    Zauner, W.4    Mattner, F.5    Schmidt, W.6
  • 57
    • 77951893095 scopus 로고    scopus 로고
    • Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology
    • doi: 10.1093/brain/awq056
    • Serrano-Pozo, A., William, C. M., Ferrer, I., Uro-Coste, E., Delisle, M. B., Maurage, C. A., et al. (2010). Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain 133, 1312-1327. doi: 10.1093/brain/awq056
    • (2010) Brain , vol.133 , pp. 1312-1327
    • Serrano-Pozo, A.1    William, C.M.2    Ferrer, I.3    Uro-Coste, E.4    Delisle, M.B.5    Maurage, C.A.6
  • 58
    • 0028915964 scopus 로고
    • Transferrin-antibody fusion proteins are effective in brain targeting
    • doi: 10.1073/pnas.92.7.2820
    • Shin, S. U., Friden, P., Moran, M., Olson, T., Kang, Y. S., Pardridge, W. M., et al. (1995). Transferrin-antibody fusion proteins are effective in brain targeting. Proc. Natl. Acad. Sci. U S A 92, 2820-2824. doi: 10.1073/pnas.92.7.2820
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 2820-2824
    • Shin, S.U.1    Friden, P.2    Moran, M.3    Olson, T.4    Kang, Y.S.5    Pardridge, W.M.6
  • 59
    • 0036548070 scopus 로고    scopus 로고
    • γ-Secretase, notch Abeta and Alzheimer's disease: where do the presenilins fit in?
    • doi: 10.1038/nrn785
    • Sisodia, S. S., and St George-Hyslop, P. H. (2002). γ-Secretase, notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat. Rev. Neurosci. 3, 281-290. doi: 10.1038/nrn785
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 60
    • 34250665873 scopus 로고    scopus 로고
    • Targeted delivery of proteins across the blood-brain barrier
    • doi: 10.1073/pnas.0702170104
    • Spencer, B. J., and Verma, I. M. (2007). Targeted delivery of proteins across the blood-brain barrier. Proc. Natl. Acad. Sci. U S A 104, 7594-7599. doi: 10.1073/pnas.0702170104
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 7594-7599
    • Spencer, B.J.1    Verma, I.M.2
  • 61
    • 84878927746 scopus 로고    scopus 로고
    • Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive? Expert Opin
    • doi: 10.1517/14712598.2013.789856
    • Tayeb, H. O., Murray, E. D., Price, B. H., and Tarazi, F. I. (2013). Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive? Expert Opin. Biol. Ther. 13, 1075-1084. doi: 10.1517/14712598.2013.789856
    • (2013) Biol. Ther. , vol.13 , pp. 1075-1084
    • Tayeb, H.O.1    Murray, E.D.2    Price, B.H.3    Tarazi, F.I.4
  • 62
    • 84862806815 scopus 로고    scopus 로고
    • Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors
    • doi: 10.1016/j.pharmthera.2011.12.002
    • Tayeb, H. O., Yang, H. D., Price, B. H., and Tarazi, F. I. (2012). Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors. Pharmacol. Ther. 134, 8-25. doi: 10.1016/j.pharmthera.2011.12.002
    • (2012) Pharmacol. Ther. , vol.134 , pp. 8-25
    • Tayeb, H.O.1    Yang, H.D.2    Price, B.H.3    Tarazi, F.I.4
  • 63
    • 0000354585 scopus 로고
    • Structural basis of the cognitive alterations in Alzheimer disease
    • eds R. Terry and R. Katzman (New York: Raven Press)
    • Terry, R., Hansen, L., and Masliah, E. (1994). "Structural basis of the cognitive alterations in Alzheimer disease," in Alzheimer Disease, eds R. Terry and R. Katzman (New York: Raven Press), 179-196.
    • (1994) Alzheimer Disease , pp. 179-196
    • Terry, R.1    Hansen, L.2    Masliah, E.3
  • 64
    • 84903190262 scopus 로고    scopus 로고
    • Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
    • doi: 10.1111/jnc.12715.[Epub ahead of print]
    • Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., et al. (2014). Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J. Neurochem. doi: 10.1111/jnc.12715. [Epub ahead of print].
    • (2014) J. Neurochem.
    • Vassar, R.1    Kuhn, P.H.2    Haass, C.3    Kennedy, M.E.4    Rajendran, L.5    Wong, P.C.6
  • 65
    • 0037350545 scopus 로고    scopus 로고
    • Immunotherapy: past, present and future
    • doi: 10.1038/nm0303-269
    • Waldmann, T. A. (2003). Immunotherapy: past, present and future. Nat. Med. 9, 269-277. doi: 10.1038/nm0303-269
    • (2003) Nat. Med. , vol.9 , pp. 269-277
    • Waldmann, T.A.1
  • 66
    • 79959670013 scopus 로고    scopus 로고
    • The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
    • doi: 10.1523/jneurosci.0293-11.2011
    • Wiessner, C., Wiederhold, K. H., Tissot, A. C., Frey, P., Danner, S., Jacobson, L. H., et al. (2011). The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J. Neurosci. 31, 9323-9331. doi: 10.1523/jneurosci.0293-11.2011
    • (2011) J. Neurosci. , vol.31 , pp. 9323-9331
    • Wiessner, C.1    Wiederhold, K.H.2    Tissot, A.C.3    Frey, P.4    Danner, S.5    Jacobson, L.H.6
  • 67
    • 0035544150 scopus 로고    scopus 로고
    • Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation and congophilic plaque levels
    • doi: 10.1089/10445490152717596
    • Wilcock, D. M., Gordon, M. N., Ugen, K. E., Gottschall, P. E., Dicarlo, G., Dickey, C., et al. (2001). Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation and congophilic plaque levels. DNA Cell Biol. 20, 731-736. doi: 10.1089/10445490152717596
    • (2001) DNA Cell Biol , vol.20 , pp. 731-736
    • Wilcock, D.M.1    Gordon, M.N.2    Ugen, K.E.3    Gottschall, P.E.4    Dicarlo, G.5    Dickey, C.6
  • 68
    • 84862331908 scopus 로고    scopus 로고
    • Safety, tolerability and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study
    • doi: 10.1016/s1474-4422(12)70140-0
    • Winblad, B., Andreasen, N., Minthon, L., Floesser, A., Imbert, G., Dumortier, T., et al. (2012). Safety, tolerability and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurol. 11, 597-604. doi: 10.1016/s1474-4422(12)70140-0
    • (2012) Lancet Neurol , vol.11 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5    Dumortier, T.6
  • 69
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • doi: 10.3410/f.10855956.11773054
    • Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., et al. (2011). Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci. Transl. Med. 3:84. doi: 10.3410/f.10855956.11773054
    • (2011) Sci. Transl. Med. , vol.3 , pp. 84
    • Yu, Y.J.1    Zhang, Y.2    Kenrick, M.3    Hoyte, K.4    Luk, W.5    Lu, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.