Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1

Microvascular Research

Volumn 81, Issue 1, 2011, Pages 103-107

  Dohgu, Shinya ^a   Takata, Fuyuko ^a,b   Matsumoto, Junichi ^a   Oda, Masatoshi ^a   Harada, Eriko ^a   Watanabe, Takuya ^a   Nishioku, Tsuyoshi ^a   Shuto, Hideki ^a   Yamauchi, Atsushi ^a   Kataoka, Yasufumi ^a,b  

^a FUKUOKA UNIVERSITY   (Japan)

^b PharmaCo Cell Co Ltd   (Japan)

Author keywords

Blood brain barrier; Brain endothelial cells; Co culture; Pericytes; Permeability; Plasminogen activator inhibitor 1; Transendothelial electrical resistance

Indexed keywords

FLUORESCEIN SODIUM; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; NONHUMAN; PARACRINE SIGNALING; PERICYTE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; TIGHT JUNCTION; UPREGULATION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES; AUTOCRINE COMMUNICATION; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, SERUM-FREE; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; FLUORESCEIN; PARACRINE COMMUNICATION; PERICYTES; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SERUM; UP-REGULATION;

RATTUS;

EID: 78650787293     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.10.004     Document Type: Article

References (41)

1. Abbott N.J., Ronnback L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 2006, 7:41-53.
2. Abu Fanne R., Nassar T., Yarovoi S., Rayan A., Lamensdorf I., Karakoveski M., Vadim P., Jammal M., Cines D.B., Higazi A.A. Blood-brain barrier permeability and tPA-mediated neurotoxicity. Neuropharmacology 2010, 58:972-980.
3. Adibhatla R.M., Hatcher J.F. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol. Disord. Drug Targets 2008, 7:243-253.
4. Agirbasli M. Pivotal role of plasminogen-activator inhibitor 1 in vascular disease. Int. J. Clin. Pract. 2005, 59:102-106.
5. Buisson A., Nicole O., Docagne F., Sartelet H., Mackenzie E.T., Vivien D. Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1. FASEB J. 1998, 12:1683-1691.
6. Cardoso F.L., Brites D., Brito M.A. Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res. Rev. 2010, 64:328-363.
7. Dehouck M.P., Jolliet-Riant P., Brée F., Fruchart J.C., Cecchelli R., Tillement J.P. Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 1992, 58:1790-1797.
8. Dohgu S., Yamauchi A., Nakagawa S., Takata F., Kai M., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes. Eur. J. Pharmacol. 2004, 505:51-59.
9. Dohgu S., Yamauchi A., Takata F., Naito M., Tsuruo T., Higuchi S., Sawada Y., Kataoka Y. Transforming growth factor-beta 1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell. Mol. Neurobiol. 2004, 24:491-497.
10. Dohgu S., Takata F., Yamauchi A., Nakagawa S., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res. 2005, 1038:208-215.
11. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173-185.
12. Hawkins B.T., Ocheltree S.M., Norwood K.M., Egleton R.D. Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Neurosci. Lett. 2007, 411:1-5.
13. Hiu T., Nakagawa S., Hayashi K., Kitagawa N., Tsutsumi K., Kawakubo J., Honda M., Suyama K., Nagata I., Niwa M. Tissue plasminogen activator enhances the hypoxia/reoxygenation-induced impairment of the blood-brain barrier in a primary culture of rat brain endothelial cells. Cell. Mol. Neurobiol. 2008, 28:1139-1146.
14. Hultman K., Bjorklund U., Hansson E., Jern C. Potentiating effect of endothelial cells on astrocytic plasminogen activator inhibitor type-1 gene expression in an in vitro model of the blood-brain barrier. Neuroscience 2010, 166:408-415.
15. Ingelsson E., Pencina M.J., Tofler G.H., Benjamin E.J., Lanier K.J., Jacques P.F., Fox C.S., Meigs J.B., Levy D., Larson M.G., Selhub J., D'Agostino R.B., Wang T.J., Vasan R.S. Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation 2007, 116:984-992.
16. Jacobsen J.S., Comery T.A., Martone R.L., Elokdah H., Crandall D.L., Oganesian A., Aschmies S., Kirksey Y., Gonzales C., Xu J., Zhou H., Atchison K., Wagner E., Zaleska M.M., Das I., Arias R.L., Bard J., Riddell D., Gardell S.J., Abou-Gharbia M., Robichaud A., Magolda R., Vlasuk G.P., Bjornsson T., Reinhart P.H., Pangalos M.N. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:8754-8759.
17. Juhan-Vague I., Alessi M.C., Mavri A., Morange P.E. Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. J. Thromb. Haemost. 2003, 1:1575-1579.
18. Kim J.A., Tran N.D., Li Z., Yang F., Zhou W., Fisher M.J. Brain endothelial hemostasis regulation by pericytes. J. Cereb. Blood Flow Metab. 2006, 26:209-217.
19. Kimura M., Soeda S., Oda M., Ochiai T., Kihara T., Ono N., Shimeno H. Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. J. Neurosci. Res. 2000, 62:781-788.
20. Kose N., Asashima T., Muta M., Iizasa H., Sai Y., Terasaki T., Nakashima E. Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment. Drug Metab. Pharmacokinet. 2007, 22:255-266.
21. Kunz M., Ibrahim S.M. Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009, 2009:979258.
22. Lo E.H., Broderick J.P., Moskowitz M.A. tPA and proteolysis in the neurovascular unit. Stroke 2004, 35:354-356.
23. McIlroy M., O'Rourke M., McKeown S.R., Hirst D.G., Robson T. Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1). Cardiovasc. Res. 2006, 69:207-217.
24. Meltzer M.E., Lisman T., de Groot P.G., Meijers J.C., le Cessie S., Doggen C.J., Rosendaal F.R. Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. Blood 2010, 116:113-121.
25. Nagai N., De Mol M., Lijnen H.R., Carmeliet P., Collen D. Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation 1999, 99:2440-2444.
26. Nagai N., Suzuki Y., Van Hoef B., Lijnen H.R., Collen D. Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice. J. Thromb. Haemost. 2005, 3:1379-1384.
27. Nakagawa S., Deli M.A., Nakao S., Honda M., Hayashi K., Nakaoke R., Kataoka Y., Niwa M. Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell. Mol. Neurobiol. 2007, 27:687-694.
28. Ronaldson P.T., Demarco K.M., Sanchez-Covarrubias L., Solinsky C.M., Davis T.P. Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain. J. Cereb. Blood Flow Metab. 2009, 29:1084-1098.
29. Sobel B.E. Increased plasminogen activator inhibitor-1 and vasculopathy. A reconcilable paradox. Circulation 1999, 99:2496-2498.
30. Soeda S., Oda M., Ochiai T., Shimeno H. Deficient release of plasminogen activator inhibitor-1 from astrocytes triggers apoptosis in neuronal cells. Brain Res. Mol. Brain Res. 2001, 91:96-103.
31. Soeda S., Imatoh T., Ochiai T., Koyanagi S., Shimeno H. Plasminogen activator inhibitor-1 aids survival of neurites on neurons derived from pheochromocytoma (PC-12) cells. NeuroReport 2004, 15:855-858.
32. Soeda S., Shinomiya K., Ochiai T., Koyanagi S., Toda A., Eyanagi R., Shimeno H. Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways. Neuroscience 2006, 141:101-108.
33. Sumi N., Nishioku T., Takata F., Matsumoto J., Watanabe T., Shuto H., Yamauchi A., Dohgu S., Kataoka Y. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell. Mol. Neurobiol. 2010, 30:247-253.
34. Takata F., Sumi N., Nishioku T., Harada E., Wakigawa T., Shuto H., Yamauchi A., Kataoka Y. Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells. Neurosci. Lett. 2008, 441:163-166.
35. Takata F., Dohgu S., Nishioku T., Takahashi H., Harada E., Makino I., Nakashima M., Yamauchi A., Kataoka Y. Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. Neurosci. Lett. 2009, 449:71-75.
36. Verma S., Nakaoke R., Dohgu S., Banks W.A. Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide. Brain Behav. Immun. 2006, 20:449-455.
37. Wang Y.F., Tsirka S.E., Strickland S., Stieg P.E., Soriano S.G., Lipton S.A. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat. Med. 1998, 4:228-231.
38. Yang D., Nemkul N., Shereen A., Jone A., Dunn R.S., Lawrence D.A., Lindquist D., Kuan C.Y. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J. Neurosci. 2009, 29:8669-8674.
39. Yepes M., Sandkvist M., Moore E.G., Bugge T.H., Strickland D.K., Lawrence D.A. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest. 2003, 112:1483-1485.
40. Zhao R., Ma X., Shen G.X. Transcriptional regulation of plasminogen activator inhibitor-1 in vascular endothelial cells induced by oxidized very low density lipoproteins. Mol. Cell. Biochem. 2008, 317:197-204.
41. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.