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Volumn 16, Issue 2, 2015, Pages 223-233

Targeting Therapeutics Across the Blood Brain Barrier (BBB), Prerequisite Towards Thrombolytic Therapy for Cerebrovascular Disorders—an Overview and Advancements

Author keywords

blood brain barrier (BBB); cerebral ischemic disorders; drug delivery; earthworm protease; neurodegenerative disorder; thrombolytic

Indexed keywords

DRUG;

EID: 84939967150     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-015-0287-z     Document Type: Article
Times cited : (51)

References (139)
  • 1
    • 33646450620 scopus 로고    scopus 로고
    • Physiology of the blood–brain barrier and its consequences for drug transport to the brain
    • COI: 1:CAS:528:DC%2BD1cXhvVOhtb4%3D
    • Abbott NJ. Physiology of the blood–brain barrier and its consequences for drug transport to the brain. Int Congr Ser. 2005;1277:3–18.
    • (2005) Int Congr Ser , vol.1277 , pp. 3-18
    • Abbott, N.J.1
  • 2
    • 34547642139 scopus 로고    scopus 로고
    • Blood–brain barrier transport of therapeutics via receptor mediation
    • COI: 1:CAS:528:DC%2BD2sXosVKgt74%3D, PID: 17619996
    • Jones AR, Shusta EV. Blood–brain barrier transport of therapeutics via receptor mediation. Pharm Res. 2007;24:1759–71.
    • (2007) Pharm Res , vol.24 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 3
    • 2342471420 scopus 로고    scopus 로고
    • The blood–brain barrier: an overview: structure, regulation, and clinical implications
    • COI: 1:CAS:528:DC%2BD2cXjs1altL8%3D, PID: 15207256
    • Ballabh P, Braun A, Nedergaard M. The blood–brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis. 2004;16(1):1–13.
    • (2004) Neurobiol Dis , vol.16 , Issue.1 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 4
    • 77956344034 scopus 로고    scopus 로고
    • Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches
    • COI: 1:CAS:528:DC%2BC3cXhtFWqtLnJ, PID: 20685221
    • Cardoso FL, Brites D, Brito MA. Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches. Brain Res Rev. 2010;64:328–63.
    • (2010) Brain Res Rev , vol.64 , pp. 328-363
    • Cardoso, F.L.1    Brites, D.2    Brito, M.A.3
  • 5
    • 0042899083 scopus 로고    scopus 로고
    • Blood–brain barrier drug targeting: the future of brain drug development
    • COI: 1:CAS:528:DC%2BD3sXjsVWhsrk%3D, PID: 14993430
    • Pardridge WM. Blood–brain barrier drug targeting: the future of brain drug development. Mol Interv. 2003;3:90–105.
    • (2003) Mol Interv , vol.3 , pp. 90-105
    • Pardridge, W.M.1
  • 6
    • 65749100582 scopus 로고    scopus 로고
    • Drug interactions at the blood–brain barrier: fact or fantasy?
    • COI: 1:CAS:528:DC%2BD1MXms1ahsb0%3D, PID: 19393264
    • Eyal S, Hsiao P, Unadkat JD. Drug interactions at the blood–brain barrier: fact or fantasy? Pharmacol Ther. 2009;123:80–104.
    • (2009) Pharmacol Ther , vol.123 , pp. 80-104
    • Eyal, S.1    Hsiao, P.2    Unadkat, J.D.3
  • 7
    • 84893287460 scopus 로고    scopus 로고
    • Transport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications
    • COI: 1:CAS:528:DC%2BC2cXhsFakurg%3D, PID: 24362586
    • Shilo M, Motiei M, Hana P, Popovtzer R. Transport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications. Nanoscale. 2014;6(4):2146–52.
    • (2014) Nanoscale , vol.6 , Issue.4 , pp. 2146-2152
    • Shilo, M.1    Motiei, M.2    Hana, P.3    Popovtzer, R.4
  • 8
    • 22944483792 scopus 로고    scopus 로고
    • The blood–brain barrier/neurovascular unit in health and disease
    • COI: 1:CAS:528:DC%2BD2MXlsFejtL0%3D, PID: 15914466
    • Hawkins BT, Davis TP. The blood–brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 2005;57:173–85.
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 9
    • 48049091363 scopus 로고    scopus 로고
    • Mechanisms of lumbrokinase in protection of cerebral ischemia
    • COI: 1:CAS:528:DC%2BD1cXpt1KntLw%3D, PID: 18597751
    • Ji H, Wang L, Bi H, Sun L, Cai B, Wang Y, et al. Mechanisms of lumbrokinase in protection of cerebral ischemia. Eur J Pharmacol. 2008;590:281–9.
    • (2008) Eur J Pharmacol , vol.590 , pp. 281-289
    • Ji, H.1    Wang, L.2    Bi, H.3    Sun, L.4    Cai, B.5    Wang, Y.6
  • 10
    • 0036362078 scopus 로고    scopus 로고
    • The role of recombinant pro-urokinase (r-pro-UK) and intraarterial thrombolysis in acute ischemic stroke: the PROACT trials. Prolyse in acute cerebral thromboembolism
    • Furlan AJ, Abou-Chebi A. The role of recombinant pro-urokinase (r-pro-UK) and intraarterial thrombolysis in acute ischemic stroke: the PROACT trials. Prolyse in acute cerebral thromboembolism. Curr Med Res Opin. 2002;18 Suppl 2:44–7.
    • (2002) Curr Med Res Opin , vol.18 , pp. 44-47
    • Furlan, A.J.1    Abou-Chebi, A.2
  • 11
    • 18444386848 scopus 로고    scopus 로고
    • Molecular mechanisms of fibrinolysis
    • COI: 1:CAS:528:DC%2BD2MXltlWnt7c%3D, PID: 15842654
    • Cesarman-Maus G, Hajjar KA. Molecular mechanisms of fibrinolysis. Br J Haematol. 2005;129(3):307–21.
    • (2005) Br J Haematol , vol.129 , Issue.3 , pp. 307-321
    • Cesarman-Maus, G.1    Hajjar, K.A.2
  • 12
    • 31944447012 scopus 로고    scopus 로고
    • Structure of human urokinase plasminogen activator in complex with its receptor
    • COI: 1:CAS:528:DC%2BD28XptVyltA%3D%3D, PID: 16456079
    • Huai Q, Mazar A, Kuo A, Parry GC, Shaw DE, Callahan J, et al. Structure of human urokinase plasminogen activator in complex with its receptor. Science. 2006;311:656–9.
    • (2006) Science , vol.311 , pp. 656-659
    • Huai, Q.1    Mazar, A.2    Kuo, A.3    Parry, G.C.4    Shaw, D.E.5    Callahan, J.6
  • 13
    • 71049180369 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: therapeutic approaches
    • PID: 19919699
    • Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med. 2009;7:97.
    • (2009) J Transl Med , vol.7 , pp. 97
    • Lakhan, S.E.1    Kirchgessner, A.2    Hofer, M.3
  • 14
    • 0032723531 scopus 로고    scopus 로고
    • Intraarterial cerebral thrombolysis for acute ischemic stroke in a community hospital
    • COI: 1:STN:280:DC%2BD3c%2FgvV2rtA%3D%3D, PID: 10543641
    • Edwards MT, Murphy MM, Geraghty JJ, Wulf JA, Konzen JP. Intraarterial cerebral thrombolysis for acute ischemic stroke in a community hospital. AJNR Am J Neuroradiol. 1999;20(9):1682–7.
    • (1999) AJNR Am J Neuroradiol , vol.20 , Issue.9 , pp. 1682-1687
    • Edwards, M.T.1    Murphy, M.M.2    Geraghty, J.J.3    Wulf, J.A.4    Konzen, J.P.5
  • 15
    • 0029070798 scopus 로고
    • Tissue plasminogen activator (t-PA) inhibits plasmin degradation of fibrin. A mechanism that slows t-PA-mediated fibrinolysis but does not require alpha 2-antiplasmin or leakage of intrinsic plasminogen
    • COI: 1:CAS:528:DyaK2MXmtV2qsr8%3D, PID: 7769094
    • Wu JH, Diamond SL. Tissue plasminogen activator (t-PA) inhibits plasmin degradation of fibrin. A mechanism that slows t-PA-mediated fibrinolysis but does not require alpha 2-antiplasmin or leakage of intrinsic plasminogen. J Clin Invest. 1995;95(6):2483–90.
    • (1995) J Clin Invest , vol.95 , Issue.6 , pp. 2483-2490
    • Wu, J.H.1    Diamond, S.L.2
  • 16
    • 84883872986 scopus 로고    scopus 로고
    • Drug delivery systems for the treatment of ischemic stroke
    • COI: 1:CAS:528:DC%2BC3sXlvV2juw%3D%3D, PID: 23307348
    • Rhim T, Lee DY, Lee M. Drug delivery systems for the treatment of ischemic stroke. Pharm Res. 2013;30(10):2429–44.
    • (2013) Pharm Res , vol.30 , Issue.10 , pp. 2429-2444
    • Rhim, T.1    Lee, D.Y.2    Lee, M.3
  • 17
    • 13244271912 scopus 로고    scopus 로고
    • Prediction of blood–brain barrier permeation in drug discovery from in vivo, in vitro and in silico models
    • COI: 1:CAS:528:DC%2BD2MXhtlSqs7s%3D, PID: 24981621
    • Abbott NJ. Prediction of blood–brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discov Today Technol. 2004;1:407–16.
    • (2004) Drug Discov Today Technol , vol.1 , pp. 407-416
    • Abbott, N.J.1
  • 18
    • 79651475092 scopus 로고    scopus 로고
    • Emerging role for drug transporters at the blood brain barrier
    • PID: 21168226
    • Mruk DD, Su L, Cheng CY. Emerging role for drug transporters at the blood brain barrier. Trends Pharmacol Sci. 2010;32:99–106.
    • (2010) Trends Pharmacol Sci , vol.32 , pp. 99-106
    • Mruk, D.D.1    Su, L.2    Cheng, C.Y.3
  • 19
    • 70449718818 scopus 로고    scopus 로고
    • The role of the blood-CNS barrier in CNS disorders and their treatment
    • COI: 1:CAS:528:DC%2BD1MXhsVGms7vF, PID: 19664711
    • Palmer AM. The role of the blood-CNS barrier in CNS disorders and their treatment. Neurobiol Dis. 2010;37:3–12.
    • (2010) Neurobiol Dis , vol.37 , pp. 3-12
    • Palmer, A.M.1
  • 20
    • 84977771486 scopus 로고    scopus 로고
    • Introduction to the blood–brain barrier: methodology, biology, and pathology
    • Pardridge WM. Introduction to the blood–brain barrier: methodology, biology, and pathology. Cambridge University PRESS. 1998; 24(9):521–81.
    • (1998) Cambridge University PRESS , vol.24 , Issue.9 , pp. 521-581
    • Pardridge, W.M.1
  • 21
    • 33845784758 scopus 로고    scopus 로고
    • Blood–brain barrier delivery
    • COI: 1:CAS:528:DC%2BD2sXhsFOjsA%3D%3D, PID: 17198973
    • Pardridge WM. Blood–brain barrier delivery. Drug Discov Today. 2007;12:54–61.
    • (2007) Drug Discov Today , vol.12 , pp. 54-61
    • Pardridge, W.M.1
  • 22
    • 0036787074 scopus 로고    scopus 로고
    • Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole to-venous shunts
    • PID: 12357050
    • Anstrom JA, Brown WR, Moody DM, Thore CR, Challa VR, Block SM. Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole to-venous shunts. Pediatr Res. 2002;52:554–60.
    • (2002) Pediatr Res , vol.52 , pp. 554-560
    • Anstrom, J.A.1    Brown, W.R.2    Moody, D.M.3    Thore, C.R.4    Challa, V.R.5    Block, S.M.6
  • 23
    • 34547891114 scopus 로고    scopus 로고
    • Claudins and paracellular transport: an update
    • COI: 1:CAS:528:DC%2BD2sXhtV2rtr3M, PID: 17693762
    • Angelow S, Yu AS. Claudins and paracellular transport: an update. Curr Opin Nephrol Hypertens. 2007;16:459–64.
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , pp. 459-464
    • Angelow, S.1    Yu, A.S.2
  • 24
    • 67650348496 scopus 로고    scopus 로고
    • Regulation and roles for claudin-family tight junction proteins
    • COI: 1:CAS:528:DC%2BD1MXktVaitbk%3D, PID: 19319969
    • Findley MK, Koval M. Regulation and roles for claudin-family tight junction proteins. IUBMB Life. 2009;61(4):431–7.
    • (2009) IUBMB Life , vol.61 , Issue.4 , pp. 431-437
    • Findley, M.K.1    Koval, M.2
  • 25
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte–endothelial interactions at the blood brain barrier
    • COI: 1:CAS:528:DC%2BD2MXhtlaktbjP, PID: 16371949
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte–endothelial interactions at the blood brain barrier. Nat Rev Neurosci. 2006;7:41–53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 26
    • 26244456551 scopus 로고    scopus 로고
    • Molecular biology of the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD2MXktlyltrs%3D, PID: 15805577
    • Pardridge WM. Molecular biology of the blood–brain barrier. Mol Biotechnol. 2005;30:57–70.
    • (2005) Mol Biotechnol , vol.30 , pp. 57-70
    • Pardridge, W.M.1
  • 27
    • 0642311326 scopus 로고    scopus 로고
    • Measurement of blood–brain and blood-tumor barrier permeabilities with (14C)-labeled tracers
    • PID: 12958420
    • Asotra K, Ningaraj N, Black KL. Measurement of blood–brain and blood-tumor barrier permeabilities with (14C)-labeled tracers. Methods Mol Med. 2003;89:177–90.
    • (2003) Methods Mol Med , vol.89 , pp. 177-190
    • Asotra, K.1    Ningaraj, N.2    Black, K.L.3
  • 28
    • 12344273726 scopus 로고    scopus 로고
    • The blood–brain barrier: bottleneck in brain drug development
    • PID: 15717053
    • Pardridge WM. The blood–brain barrier: bottleneck in brain drug development. NeuroRx. 2005;2(1):3–14.
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 29
    • 28244432240 scopus 로고    scopus 로고
    • The blood–brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells
    • COI: 1:CAS:528:DC%2BD2MXht1OnsbrL, PID: 16271053
    • Abulrob A, Sprong H, Bergen Henegouwen PV, Stanimirovic D. The blood–brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J Neurochem. 2005;95:1201–14.
    • (2005) J Neurochem , vol.95 , pp. 1201-1214
    • Abulrob, A.1    Sprong, H.2    Bergen Henegouwen, P.V.3    Stanimirovic, D.4
  • 30
    • 0037004910 scopus 로고    scopus 로고
    • Comparative anatomy, physiology and in vitro models of the blood–brain and blood-retina barrier
    • Schlossauer B, Steuer H. Comparative anatomy, physiology and in vitro models of the blood–brain and blood-retina barrier. Curr Med Chem. 2002;2:175–86.
    • (2002) Curr Med Chem , vol.2 , pp. 175-186
    • Schlossauer, B.1    Steuer, H.2
  • 31
    • 81755174301 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in the brain: emerging evidence of biological significance
    • COI: 1:CAS:528:DC%2BC3MXhsV2mu7zN, PID: 21975165
    • Ferguson CS, Tyndale RF. Cytochrome P450 enzymes in the brain: emerging evidence of biological significance. Trends Pharmacol Sci. 2011;32:708–14.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 708-714
    • Ferguson, C.S.1    Tyndale, R.F.2
  • 32
    • 58149475254 scopus 로고    scopus 로고
    • Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition
    • COI: 1:CAS:528:DC%2BD1MXkvVartg%3D%3D, PID: 18668033
    • Miksys S, Tyndale RF. Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition. Neuropsychopharmacology. 2009;34(3):634–40.
    • (2009) Neuropsychopharmacology , vol.34 , Issue.3 , pp. 634-640
    • Miksys, S.1    Tyndale, R.F.2
  • 33
    • 85047698627 scopus 로고    scopus 로고
    • Sniffing neuropeptides a transnasal approach to the human brain
    • COI: 1:CAS:528:DC%2BD38XjvVygu7w%3D, PID: 11992114
    • Born J, Lange T, Kern W, Mc-Gregor GP, Bickel U, Fehm HL. Sniffing neuropeptides a transnasal approach to the human brain. Nat Neurosci. 2002;5:514–6.
    • (2002) Nat Neurosci , vol.5 , pp. 514-516
    • Born, J.1    Lange, T.2    Kern, W.3    Mc-Gregor, G.P.4    Bickel, U.5    Fehm, H.L.6
  • 34
    • 77951741583 scopus 로고    scopus 로고
    • The role of insulin receptor signalling in synaptic plasticity and cognitive function
    • PID: 20438663
    • Huang CC, Lee CC, Hsu KS. The role of insulin receptor signalling in synaptic plasticity and cognitive function. Chang Gung Med J. 2010;33(2):115–25.
    • (2010) Chang Gung Med J , vol.33 , Issue.2 , pp. 115-125
    • Huang, C.C.1    Lee, C.C.2    Hsu, K.S.3
  • 35
    • 0035092097 scopus 로고    scopus 로고
    • Rapid transferrin efflux from brain to blood across the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD3MXhvVCju7g%3D, PID: 11238745
    • Zhang Y, Pardridge WM. Rapid transferrin efflux from brain to blood across the blood–brain barrier. J Neurochem. 2001;76:1597–600.
    • (2001) J Neurochem , vol.76 , pp. 1597-1600
    • Zhang, Y.1    Pardridge, W.M.2
  • 37
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos T, Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol. 2001;20:77–95.
    • (2001) Cell Mol Neurobiol , vol.20 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 38
    • 0037369812 scopus 로고    scopus 로고
    • Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood–brain barrier choline transporter
    • COI: 1:CAS:528:DC%2BD3sXit1eisLo%3D, PID: 12604705
    • Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood–brain barrier choline transporter. J Pharmacol Exp Ther. 2003;304:1268–74.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1268-1274
    • Allen, D.D.1    Lockman, P.R.2    Roder, K.E.3    Dwoskin, L.P.4    Crooks, P.A.5
  • 39
    • 0642311333 scopus 로고    scopus 로고
    • A review of blood brain barrier transport techniques
    • COI: 1:CAS:528:DC%2BD3sXntlKnsbo%3D, PID: 12958421
    • Smith QR. A review of blood brain barrier transport techniques. Methods Mol Med. 2003;89:193–208.
    • (2003) Methods Mol Med , vol.89 , pp. 193-208
    • Smith, Q.R.1
  • 40
    • 31544481841 scopus 로고    scopus 로고
    • Structure of the blood–brain barrier and its role in the transport of amino acids
    • COI: 1:CAS:528:DC%2BD28XivFSjtg%3D%3D, PID: 16365086
    • Hawkins RA, O’Kane RL, Simpson IA, Viña JR. Structure of the blood–brain barrier and its role in the transport of amino acids. J Nutr. 2006;136(1):218S–26.
    • (2006) J Nutr , vol.136 , Issue.1 , pp. 218-226
    • Hawkins, R.A.1    O’Kane, R.L.2    Simpson, I.A.3    Viña, J.R.4
  • 41
    • 34247842999 scopus 로고    scopus 로고
    • Functional properties and genomics of glucose transporters
    • COI: 1:CAS:528:DC%2BD2sXht1Kntb7O, PID: 18660845
    • Zhao F-Q, Keating AF. Functional properties and genomics of glucose transporters. Curr Genomics. 2007;8:113–28.
    • (2007) Curr Genomics , vol.8 , pp. 113-128
    • Zhao, F.-Q.1    Keating, A.F.2
  • 42
    • 1942437498 scopus 로고    scopus 로고
    • Identification and characterization of human glucose transporter-like protein-9 (GLUT9)
    • COI: 1:CAS:528:DC%2BD2cXivF2qsbs%3D, PID: 14739288
    • Augustin R, Carayannopoules MO, Dowd LO, Phay JE, Moley JF, Moley KH. Identification and characterization of human glucose transporter-like protein-9 (GLUT9). J Biol Chem. 2004;279:16229–36.
    • (2004) J Biol Chem , vol.279 , pp. 16229-16236
    • Augustin, R.1    Carayannopoules, M.O.2    Dowd, L.O.3    Phay, J.E.4    Moley, J.F.5    Moley, K.H.6
  • 43
    • 66149130750 scopus 로고    scopus 로고
    • Differential receptor-mediated drug targeting to the diseased brain
    • COI: 1:CAS:528:DC%2BD1MXjslajs7k%3D, PID: 19327042
    • Rip J, Schenk GJ, Boer AG. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin Drug Deliv. 2009;6:227–37.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 227-237
    • Rip, J.1    Schenk, G.J.2    Boer, A.G.3
  • 44
    • 39749166269 scopus 로고    scopus 로고
    • Large neutral amino acid transporter enables brain drug delivery via prodrugs
    • COI: 1:CAS:528:DC%2BD1cXhtVaiurY%3D, PID: 18217702
    • Gynther M, Laine K, Ropponen J, Leppanen J, Mannila A, Nevalainen T, et al. Large neutral amino acid transporter enables brain drug delivery via prodrugs. J Med Chem. 2008;51(4):932–6.
    • (2008) J Med Chem , vol.51 , Issue.4 , pp. 932-936
    • Gynther, M.1    Laine, K.2    Ropponen, J.3    Leppanen, J.4    Mannila, A.5    Nevalainen, T.6
  • 45
    • 84883865879 scopus 로고    scopus 로고
    • Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine
    • COI: 1:CAS:528:DC%2BC3sXntlKruw%3D%3D, PID: 24137801
    • Peura L, Malmioja K, Huttunen K, Leppanen J, Hamalainen M, Forsberg MM, et al. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. Pharm Res. 2013;30(10):2523–37.
    • (2013) Pharm Res , vol.30 , Issue.10 , pp. 2523-2537
    • Peura, L.1    Malmioja, K.2    Huttunen, K.3    Leppanen, J.4    Hamalainen, M.5    Forsberg, M.M.6
  • 46
    • 80053517788 scopus 로고    scopus 로고
    • Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery
    • COI: 1:CAS:528:DC%2BC3MXpvFSns70%3D, PID: 21770378
    • Peura L, Malmioja K, Laine K, Leppanen J, Gynther M, Isotalo A, et al. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery. Mol Pharm. 2011;8(5):1857–66.
    • (2011) Mol Pharm , vol.8 , Issue.5 , pp. 1857-1866
    • Peura, L.1    Malmioja, K.2    Laine, K.3    Leppanen, J.4    Gynther, M.5    Isotalo, A.6
  • 47
    • 84880161805 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis and brain delivery of therapeutic biologics
    • PID: 23840214, 14 pages
    • Xiao G, Gan L-S. Receptor-mediated endocytosis and brain delivery of therapeutic biologics. Int J Cell Biol. 2013;2013, 703545. 14 pages.
    • (2013) Int J Cell Biol , vol.2013
    • Xiao, G.1    Gan, L.-S.2
  • 48
    • 19444381236 scopus 로고    scopus 로고
    • Delivery of β-galactosidase to mouse brain via the blood–brain barrier transferrin receptor
    • COI: 1:CAS:528:DC%2BD2MXkslekt7s%3D, PID: 15718287
    • Zhang Y, Pardridge WM. Delivery of β-galactosidase to mouse brain via the blood–brain barrier transferrin receptor. J Pharmacol Exp Ther. 2005;313:1075–81.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1075-1081
    • Zhang, Y.1    Pardridge, W.M.2
  • 50
    • 0035947033 scopus 로고    scopus 로고
    • In vitro demonstration of a saturable transport system for leptin across the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD3MXktFOqtbc%3D, PID: 11411806
    • Maresh GA, Maness LM, Zadina JE, Kastin AJ. In vitro demonstration of a saturable transport system for leptin across the blood–brain barrier. Life Sci. 2001;69(1):67–73.
    • (2001) Life Sci , vol.69 , Issue.1 , pp. 67-73
    • Maresh, G.A.1    Maness, L.M.2    Zadina, J.E.3    Kastin, A.J.4
  • 51
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor mediated endocytosis pathway
    • COI: 1:CAS:528:DC%2BD38Xps1Grs7k%3D, PID: 12429868
    • Qian ZM, Li H, Sun H, Ho K. Targeted drug delivery via the transferrin receptor mediated endocytosis pathway. Pharmacol Rev. 2002;54(4):561–87.
    • (2002) Pharmacol Rev , vol.54 , Issue.4 , pp. 561-587
    • Qian, Z.M.1    Li, H.2    Sun, H.3    Ho, K.4
  • 52
    • 0036238011 scopus 로고    scopus 로고
    • Transferrin/transferrin receptor-mediated drug delivery
    • COI: 1:CAS:528:DC%2BD38XjslGru78%3D, PID: 11933019
    • Li H, Qian ZM. Transferrin/transferrin receptor-mediated drug delivery. Med Res Rev. 2002;22(3):225–50.
    • (2002) Med Res Rev , vol.22 , Issue.3 , pp. 225-250
    • Li, H.1    Qian, Z.M.2
  • 53
    • 0037022588 scopus 로고    scopus 로고
    • Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis
    • COI: 1:CAS:528:DC%2BD38Xit1Cqs7w%3D, PID: 11867720
    • Waheed A, Grubb JH, Zhou XY, Tomatsu S, Fleming RE, Costaldi ME, et al. Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci. 2002;99(5):3117–22.
    • (2002) Proc Natl Acad Sci , vol.99 , Issue.5 , pp. 3117-3122
    • Waheed, A.1    Grubb, J.H.2    Zhou, X.Y.3    Tomatsu, S.4    Fleming, R.E.5    Costaldi, M.E.6
  • 54
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin- and transferrin-receptor antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)
    • Karsten U, Telli H, Elisabeth H, Jorg K. Transferrin- and transferrin-receptor antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB). Eur J Pharm Biopharm. 2009;71(2):251–6.
    • (2009) Eur J Pharm Biopharm , vol.71 , Issue.2 , pp. 251-256
    • Karsten, U.1    Telli, H.2    Elisabeth, H.3    Jorg, K.4
  • 55
    • 12544256444 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis and intracellular trafficking of lipoproteins and transferrin in insect cells
    • PID: 15681222
    • Van Hoof D, Rodenburg KW, Van der Horst DJ. Receptor-mediated endocytosis and intracellular trafficking of lipoproteins and transferrin in insect cells. Insect Biochem Mol Biol. 2005;35(2):117–28.
    • (2005) Insect Biochem Mol Biol , vol.35 , Issue.2 , pp. 117-128
    • Van Hoof, D.1    Rodenburg, K.W.2    Van der Horst, D.J.3
  • 56
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood–brain barrier
    • COI: 1:CAS:528:DC%2BD2sXpsFShtA%3D%3D, PID: 16937408
    • Boado RJ, Zhang Y, Zhang Y, Pardridge WM. Humanization of anti-human insulin receptor antibody for drug targeting across the human blood–brain barrier. Biotechnol Bioeng. 2007;96(2):381–91.
    • (2007) Biotechnol Bioeng , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 57
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood–brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • COI: 1:CAS:528:DC%2BD3cXivVKls7c%3D, PID: 10801214
    • Coloma MJ, Lee HJ, Landaw EM, Boado RJ, Morrison SL, Pardridge WM. Transport across the primate blood–brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm Res. 2000;17(3):266–74.
    • (2000) Pharm Res , vol.17 , Issue.3 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Landaw, E.M.3    Boado, R.J.4    Morrison, S.L.5    Pardridge, W.M.6
  • 58
    • 44449128659 scopus 로고    scopus 로고
    • GDNF fusion protein for targeted-drug delivery across the human blood–brain barrier
    • Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM. GDNF fusion protein for targeted-drug delivery across the human blood–brain barrier. Biotech Bioeng. 2007;100:387–96.
    • (2007) Biotech Bioeng , vol.100 , pp. 387-396
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Wang, Y.4    Pardridge, W.M.5
  • 59
    • 1942453793 scopus 로고    scopus 로고
    • Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
    • COI: 1:CAS:528:DC%2BD2cXjtl2ktrc%3D, PID: 15109771
    • Chung NS, Wasan KM. Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake. Adv Drug Deliv Rev. 2004;56(9):1315–34.
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.9 , pp. 1315-1334
    • Chung, N.S.1    Wasan, K.M.2
  • 60
    • 48749095941 scopus 로고    scopus 로고
    • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
    • COI: 1:CAS:528:DC%2BD1cXhtVegtL3L, PID: 18489712
    • Demeule M, Currie JC, Bertrand Y, Che C, Regina A, Gabathuler R, et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J Neurochem. 2008;106(4):1534–44.
    • (2008) J Neurochem , vol.106 , Issue.4 , pp. 1534-1544
    • Demeule, M.1    Currie, J.C.2    Bertrand, Y.3    Che, C.4    Regina, A.5    Gabathuler, R.6
  • 61
    • 34247557490 scopus 로고    scopus 로고
    • The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions
    • COI: 1:CAS:528:DC%2BD2sXmt1Cqs7w%3D, PID: 17457719
    • May P, Woldt E, Matz RL, Boucher P. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann Med. 2007;39(3):219–28.
    • (2007) Ann Med , vol.39 , Issue.3 , pp. 219-228
    • May, P.1    Woldt, E.2    Matz, R.L.3    Boucher, P.4
  • 62
    • 34548496491 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway
    • COI: 1:CAS:528:DC%2BD2sXhtVehu77P, PID: 17463224
    • Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, et al. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J. 2007;21:2742–52.
    • (2007) FASEB J , vol.21 , pp. 2742-2752
    • Yoon, I.S.1    Chen, E.2    Busse, T.3    Repetto, E.4    Lakshmana, M.K.5    Koo, E.H.6
  • 63
    • 26844507074 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related proteins (LRPs), Alzheimer’s and cognition
    • COI: 1:CAS:528:DC%2BD2MXhtV2gsL3N, PID: 16266282
    • Harris-White ME, Frautschy SA. Low density lipoprotein receptor-related proteins (LRPs), Alzheimer’s and cognition. Curr Drug Targets CNS Neurol Disord. 2005;4(5):469–80.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , Issue.5 , pp. 469-480
    • Harris-White, M.E.1    Frautschy, S.A.2
  • 64
    • 33646438600 scopus 로고    scopus 로고
    • Diphtheria toxin receptor-targeted brain drug delivery
    • COI: 1:CAS:528:DC%2BD1cXhvVOhurs%3D
    • Gaillard PJ, Brink A, Boer AG. Diphtheria toxin receptor-targeted brain drug delivery. Int Congr Ser. 2005;1277:185–95.
    • (2005) Int Congr Ser , vol.1277 , pp. 185-195
    • Gaillard, P.J.1    Brink, A.2    Boer, A.G.3
  • 65
    • 0028298886 scopus 로고
    • Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neuron
    • COI: 1:CAS:528:DyaK2cXksl2itb4%3D
    • Bu G, Maksymovitch EA, Nerbonne JM, Schwartz AL. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neuron. J Biochem. 1994;269:18521–8.
    • (1994) J Biochem , vol.269 , pp. 18521-18528
    • Bu, G.1    Maksymovitch, E.A.2    Nerbonne, J.M.3    Schwartz, A.L.4
  • 66
    • 0031561480 scopus 로고    scopus 로고
    • Heparin-binding EGF like growth factor
    • COI: 1:CAS:528:DyaK2sXnsFyrsrk%3D, PID: 9426203
    • Raab G, Klagsbrun M. Heparin-binding EGF like growth factor. Biochim Biophys Acta. 1997;1333:F179–99.
    • (1997) Biochim Biophys Acta , vol.1333 , pp. 179-199
    • Raab, G.1    Klagsbrun, M.2
  • 67
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (t-PA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
    • COI: 1:STN:280:DyaK1c7itFSqtA%3D%3D, PID: 9461198
    • Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA. Tissue plasminogen activator (t-PA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998;4(2):228–31.
    • (1998) Nat Med , vol.4 , Issue.2 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3    Stieg, P.E.4    Soriano, S.G.5    Lipton, S.A.6
  • 68
    • 77951731600 scopus 로고    scopus 로고
    • Safety of t-PA in stroke mimics and neuroimaging-negative cerebral ischemia
    • COI: 1:CAS:528:DC%2BC3cXlsVOgsL4%3D, PID: 20335564
    • Chernyshev OY, Martin-Schild S, Albright KC, Barreto A, Misra V, Acosta Grotta JC, et al. Safety of t-PA in stroke mimics and neuroimaging-negative cerebral ischemia. Neurology. 2010;74(17):1340–5.
    • (2010) Neurology , vol.74 , Issue.17 , pp. 1340-1345
    • Chernyshev, O.Y.1    Martin-Schild, S.2    Albright, K.C.3    Barreto, A.4    Misra, V.5    Acosta Grotta, J.C.6
  • 69
    • 79952663249 scopus 로고    scopus 로고
    • Role of tissue plasminogen activator in acute ischemic stroke
    • COI: 1:CAS:528:DC%2BC3MXksVGktL8%3D, PID: 21386027
    • Hatcher MA, Starr JA. Role of tissue plasminogen activator in acute ischemic stroke. Ann Pharmacother. 2011;45(3):364–71.
    • (2011) Ann Pharmacother , vol.45 , Issue.3 , pp. 364-371
    • Hatcher, M.A.1    Starr, J.A.2
  • 70
    • 74149095001 scopus 로고    scopus 로고
    • Intravenous tissue plasminogen activator for stroke: a review of the ECASS III results in relation to prior clinical trials
    • PID: 19765940
    • Cronin CA. Intravenous tissue plasminogen activator for stroke: a review of the ECASS III results in relation to prior clinical trials. J Emerg Med. 2010;38(1):99–105.
    • (2010) J Emerg Med , vol.38 , Issue.1 , pp. 99-105
    • Cronin, C.A.1
  • 71
    • 70350228571 scopus 로고    scopus 로고
    • Prospects of thrombolytic therapy for acute ischemic stroke
    • PID: 19803399
    • Nakashima T, Minematsu K. Prospects of thrombolytic therapy for acute ischemic stroke. Brain Nerve. 2009;61(9):1003–12.
    • (2009) Brain Nerve , vol.61 , Issue.9 , pp. 1003-1012
    • Nakashima, T.1    Minematsu, K.2
  • 72
    • 0023616913 scopus 로고
    • Development and evaluation of anisoylated plasminogen streptokinase activator complex (APSAC) as a second generation thrombolytic agent
    • COI: 1:CAS:528:DyaL1cXkvVGisg%3D%3D, PID: 3312369
    • Anderson JL. Development and evaluation of anisoylated plasminogen streptokinase activator complex (APSAC) as a second generation thrombolytic agent. J Am Coll Cardiol. 1987;10(5 Suppl B):22B–7.
    • (1987) J Am Coll Cardiol , vol.10 , pp. 22-27
    • Anderson, J.L.1
  • 73
    • 0023180607 scopus 로고
    • Anisoylated plasminogen streptokinase activator complex (APSAC). A review of its mechanism of action, clinical pharmacology and therapeutic use in acute myocardial infarction
    • COI: 1:STN:280:DyaL1c%2FgsVWrug%3D%3D, PID: 3308411
    • Monk JP, Heel RC. Anisoylated plasminogen streptokinase activator complex (APSAC). A review of its mechanism of action, clinical pharmacology and therapeutic use in acute myocardial infarction. Drugs. 1987;34(1):25–49.
    • (1987) Drugs , vol.34 , Issue.1 , pp. 25-49
    • Monk, J.P.1    Heel, R.C.2
  • 74
    • 0031941584 scopus 로고    scopus 로고
    • Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent
    • COI: 1:CAS:528:DyaK1cXhs1Gqu7k%3D, PID: 9500599
    • Collen D. Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent. Nat Med. 1998;4(3):279–84.
    • (1998) Nat Med , vol.4 , Issue.3 , pp. 279-284
    • Collen, D.1
  • 75
    • 0345283158 scopus 로고    scopus 로고
    • Clinical development of PEGylated recombinant staphylokinase (PEG-Sak) for bolus thrombolytic treatment of patients with acute myocardial infarction
    • COI: 1:CAS:528:DC%2BD3sXnt1yqtro%3D, PID: 14499711
    • Moreadith RW, Collen D. Clinical development of PEGylated recombinant staphylokinase (PEG-Sak) for bolus thrombolytic treatment of patients with acute myocardial infarction. Adv Drug Deliv Rev. 2003;55(10):1337–45.
    • (2003) Adv Drug Deliv Rev , vol.55 , Issue.10 , pp. 1337-1345
    • Moreadith, R.W.1    Collen, D.2
  • 76
    • 8344247667 scopus 로고    scopus 로고
    • Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules
    • COI: 1:CAS:528:DC%2BD2cXhtFCqu7bK, PID: 15461857
    • Cooper EL, Hrzenjak TM, Grdisa T. Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules. Int J Immunopathol Pharmacol. 2004;17:237–44.
    • (2004) Int J Immunopathol Pharmacol , vol.17 , pp. 237-244
    • Cooper, E.L.1    Hrzenjak, T.M.2    Grdisa, T.3
  • 77
    • 0042861787 scopus 로고    scopus 로고
    • Purification, characterization and crystallization of a group of earthworm fibrinolytic enzymes from Eisenia fetida
    • COI: 1:CAS:528:DC%2BD3sXksFWnu7k%3D, PID: 12889822
    • Wang F, Wang C, Li M, Gui L, Zhang J, Chang W. Purification, characterization and crystallization of a group of earthworm fibrinolytic enzymes from Eisenia fetida. Biotechnol Lett. 2003;25:1105–9.
    • (2003) Biotechnol Lett , vol.25 , pp. 1105-1109
    • Wang, F.1    Wang, C.2    Li, M.3    Gui, L.4    Zhang, J.5    Chang, W.6
  • 78
    • 79960734368 scopus 로고    scopus 로고
    • A new thrombolytic agent, monteplase, is independent of plasminogen activator inhibitor in patients with acute myocardial infarction: comparison with native t-PA E 610
    • Inoue T, Yaguchi I, Takayangi K, Hayashi T, Moorrks S, Eguchi Y. A new thrombolytic agent, monteplase, is independent of plasminogen activator inhibitor in patients with acute myocardial infarction: comparison with native t-PA E 610. J Am Coll Cardiol. 1997;29:1447–53.
    • (1997) J Am Coll Cardiol , vol.29 , pp. 1447-1453
    • Inoue, T.1    Yaguchi, I.2    Takayangi, K.3    Hayashi, T.4    Moorrks, S.5    Eguchi, Y.6
  • 79
    • 33646442324 scopus 로고    scopus 로고
    • The cardio-protective effect and mechanism of lumbrokinase
    • COI: 1:CAS:528:DC%2BD2sXnsFGqtLc%3D, PID: 16758997
    • Sun HL, Jiao JD, Pan ZW, Dong DL, Yang FB. The cardio-protective effect and mechanism of lumbrokinase. Yao Xue Xue Bao. 2006;41(3):247–51.
    • (2006) Yao Xue Xue Bao , vol.41 , Issue.3 , pp. 247-251
    • Sun, H.L.1    Jiao, J.D.2    Pan, Z.W.3    Dong, D.L.4    Yang, F.B.5
  • 80
    • 0034013433 scopus 로고    scopus 로고
    • Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes
    • COI: 1:STN:280:DC%2BD3c3hvFSlsw%3D%3D, PID: 10756075
    • Justicia C, Gabriel C, Planas AM. Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes. Glia. 2000;30:253–70.
    • (2000) Glia , vol.30 , pp. 253-270
    • Justicia, C.1    Gabriel, C.2    Planas, A.M.3
  • 81
    • 0034617442 scopus 로고    scopus 로고
    • Antiplatelet mechanisms of TA-993 and its metabolite MB3 in ADP-induced platelet aggregation
    • COI: 1:CAS:528:DC%2BD3cXksFGitrw%3D, PID: 10884507
    • Katoh M, Karasawa T, Doi H, Odawara A, Takagi M, Ikeo T, et al. Antiplatelet mechanisms of TA-993 and its metabolite MB3 in ADP-induced platelet aggregation. Eur J Pharmacol. 2000;399:91–6.
    • (2000) Eur J Pharmacol , vol.399 , pp. 91-96
    • Katoh, M.1    Karasawa, T.2    Doi, H.3    Odawara, A.4    Takagi, M.5    Ikeo, T.6
  • 82
    • 0032510743 scopus 로고    scopus 로고
    • Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle
    • COI: 1:CAS:528:DyaK1cXjtFWktb0%3D, PID: 9576927
    • Mascareno E, Dhar M, Siddiqui MA. Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle. Proc Natl Acad Sci. 1998;95:5590–4.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 5590-5594
    • Mascareno, E.1    Dhar, M.2    Siddiqui, M.A.3
  • 83
    • 33846245504 scopus 로고    scopus 로고
    • Preventing stroke: saving lives around the world
    • PID: 17239805
    • Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world. Lancet Neurol. 2007;6:182–7.
    • (2007) Lancet Neurol , vol.6 , pp. 182-187
    • Strong, K.1    Mathers, C.2    Bonita, R.3
  • 84
    • 24144477985 scopus 로고    scopus 로고
    • The effect of lumbrokinase on P-selectin and E-selectin in cerebral ischemia model of rat
    • PID: 12875085
    • Zhang X, Zhang J, Kuang P, Lang S, Wu W, et al. The effect of lumbrokinase on P-selectin and E-selectin in cerebral ischemia model of rat. J Tradit Chin Med. 2003;23:141–6.
    • (2003) J Tradit Chin Med , vol.23 , pp. 141-146
    • Zhang, X.1    Zhang, J.2    Kuang, P.3    Lang, S.4    Wu, W.5
  • 85
    • 0034117736 scopus 로고    scopus 로고
    • Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging
    • COI: 1:STN:280:DC%2BD3c3it1yisw%3D%3D, PID: 10762157
    • Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47(4):462–9.
    • (2000) Ann Neurol , vol.47 , Issue.4 , pp. 462-469
    • Kidwell, C.S.1    Saver, J.L.2    Mattiello, J.3    Starkman, S.4    Vinuela, F.5    Duckwiler, G.6
  • 86
    • 0042282011 scopus 로고    scopus 로고
    • Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke
    • PID: 12869717
    • Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, et al. Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke. 2003;34(8):e109–37.
    • (2003) Stroke , vol.34 , Issue.8 , pp. 109-137
    • Higashida, R.T.1    Furlan, A.J.2    Roberts, H.3    Tomsick, T.4    Connors, B.5    Barr, J.6
  • 87
    • 0034035399 scopus 로고    scopus 로고
    • Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI
    • COI: 1:CAS:528:DC%2BD3cXkt1Cntrk%3D, PID: 10835451
    • Schellinger PD, Jansen O, Fiebach JB, Heiland S, Steiner T, Schwab S, et al. Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI. Stroke. 2000;31(6):1318–28.
    • (2000) Stroke , vol.31 , Issue.6 , pp. 1318-1328
    • Schellinger, P.D.1    Jansen, O.2    Fiebach, J.B.3    Heiland, S.4    Steiner, T.5    Schwab, S.6
  • 88
    • 84891833039 scopus 로고    scopus 로고
    • Stroke-induced brain parenchymal injury drives blood–brain barrier early leakage kinetics: a combined in vivo/in vitro study
    • PID: 24084699
    • Kuntz M, Mysiorek C, Pétrault O, Petrault M, Uzbekov R, Bordet R, et al. Stroke-induced brain parenchymal injury drives blood–brain barrier early leakage kinetics: a combined in vivo/in vitro study. J Cereb Blood Flow Metab. 2014;34:95–107.
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 95-107
    • Kuntz, M.1    Mysiorek, C.2    Pétrault, O.3    Petrault, M.4    Uzbekov, R.5    Bordet, R.6
  • 91
    • 84866527214 scopus 로고    scopus 로고
    • Pathobiology of injury after stroke: the neurovascular unit and beyond
    • PID: 22994217
    • Dirnagl U. Pathobiology of injury after stroke: the neurovascular unit and beyond. Ann N Y Acad Sci. 2012;1268:21–5.
    • (2012) Ann N Y Acad Sci , vol.1268 , pp. 21-25
    • Dirnagl, U.1
  • 92
    • 0035554149 scopus 로고    scopus 로고
    • Temporal kinetics of calcium in neocortical neuronal nuclei after global cerebral ischemia and reperfusion. An ultrastructural study
    • COI: 1:CAS:528:DC%2BD38Xjs1SqsLk%3D, PID: 12092097
    • Franko J, Pomfy M, Prosbova T, Kimakova T. Temporal kinetics of calcium in neocortical neuronal nuclei after global cerebral ischemia and reperfusion. An ultrastructural study. Sb Lek. 2001;102(2):149–52.
    • (2001) Sb Lek , vol.102 , Issue.2 , pp. 149-152
    • Franko, J.1    Pomfy, M.2    Prosbova, T.3    Kimakova, T.4
  • 93
    • 34250744722 scopus 로고    scopus 로고
    • Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction
    • COI: 1:CAS:528:DC%2BD2sXntl2jt7g%3D, PID: 17405866
    • Summerfield SG, Read K, Begley DJ, Obradovic T, Hidalgo IJ, Coggon S. Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction. J Pharmacol Exp Ther. 2007;322:205–13.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 205-213
    • Summerfield, S.G.1    Read, K.2    Begley, D.J.3    Obradovic, T.4    Hidalgo, I.J.5    Coggon, S.6
  • 94
    • 0035468033 scopus 로고    scopus 로고
    • Physicochemical profiling (solubility, permeability and charge state)
    • COI: 1:CAS:528:DC%2BD3MXms1Khs7o%3D, PID: 11899112
    • Avdeef A. Physicochemical profiling (solubility, permeability and charge state). Curr Top Med Chem. 2001;1:277–351.
    • (2001) Curr Top Med Chem , vol.1 , pp. 277-351
    • Avdeef, A.1
  • 95
    • 70349408777 scopus 로고    scopus 로고
    • New strategies to deliver anticancer drugs to brain tumors
    • COI: 1:CAS:528:DC%2BD1MXhtFGhurzI, PID: 19732031
    • Laquintana V. New strategies to deliver anticancer drugs to brain tumors. Expert Opin Drug Deliv. 2009;6(10):1017–32.
    • (2009) Expert Opin Drug Deliv , vol.6 , Issue.10 , pp. 1017-1032
    • Laquintana, V.1
  • 96
    • 0033526159 scopus 로고    scopus 로고
    • Vector mediated drug delivery to the brain
    • COI: 1:CAS:528:DyaK1MXhvVCnsrs%3D, PID: 10837722
    • Pardridge W. Vector mediated drug delivery to the brain. Adv Drug Deliv Rev. 1999;36:299–321.
    • (1999) Adv Drug Deliv Rev , vol.36 , pp. 299-321
    • Pardridge, W.1
  • 97
    • 0028821715 scopus 로고
    • New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA
    • COI: 1:CAS:528:DyaK28XitlSltw%3D%3D, PID: 7586274
    • Benedict CR, Refino CJ, Keyt BA, Pakala R, Paoni NF, Thomas GR, et al. New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA. Circulation. 1995;92:3032–40.
    • (1995) Circulation , vol.92 , pp. 3032-3040
    • Benedict, C.R.1    Refino, C.J.2    Keyt, B.A.3    Pakala, R.4    Paoni, N.F.5    Thomas, G.R.6
  • 98
    • 84861985853 scopus 로고    scopus 로고
    • TPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury
    • PID: 22435890
    • Armstead WM, Riley J, Yarovoi S, Cines DB, Smith DH, Higazi AA. TPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury. J Neurotrauma. 2012;29(9):1794–802.
    • (2012) J Neurotrauma , vol.29 , Issue.9 , pp. 1794-1802
    • Armstead, W.M.1    Riley, J.2    Yarovoi, S.3    Cines, D.B.4    Smith, D.H.5    Higazi, A.A.6
  • 99
    • 4444377604 scopus 로고    scopus 로고
    • Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury
    • COI: 1:CAS:528:DC%2BD2cXntlaru7c%3D, PID: 15350969
    • Graham EM, Sheldon RA, Flock DL, Ferriero DM, Martin LJ, O’Riordan DP, et al. Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury. Neurobiol Dis. 2004;17(1):89–98.
    • (2004) Neurobiol Dis , vol.17 , Issue.1 , pp. 89-98
    • Graham, E.M.1    Sheldon, R.A.2    Flock, D.L.3    Ferriero, D.M.4    Martin, L.J.5    O’Riordan, D.P.6
  • 100
    • 84880182010 scopus 로고    scopus 로고
    • LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
    • COI: 1:CAS:528:DC%2BC3sXht1ygurjI, PID: 23866919
    • Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, et al. LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Mol Neurodegener. 2013;8:25.
    • (2013) Mol Neurodegener , vol.8 , pp. 25
    • Maier, W.1    Bednorz, M.2    Meister, S.3    Roebroek, A.4    Weggen, S.5    Schmitt, U.6
  • 101
    • 84870309846 scopus 로고    scopus 로고
    • Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC38XhtVKkurjP, PID: 22848160
    • Kanwar JR, Sriramoju B, Kanwar RK. Neurological disorders and therapeutics targeted to surmount the blood–brain barrier. Int J Nanomedicine. 2012;7:3259–78.
    • (2012) Int J Nanomedicine , vol.7 , pp. 3259-3278
    • Kanwar, J.R.1    Sriramoju, B.2    Kanwar, R.K.3
  • 102
    • 77949375780 scopus 로고    scopus 로고
    • Biopharmaceutical drug targeting to the brain
    • COI: 1:CAS:528:DC%2BC3cXivFeks78%3D, PID: 20064077
    • Pardridge WM. Biopharmaceutical drug targeting to the brain. J Drug Target. 2010;18(3):157–67.
    • (2010) J Drug Target , vol.18 , Issue.3 , pp. 157-167
    • Pardridge, W.M.1
  • 103
    • 49149127640 scopus 로고    scopus 로고
    • Coordination of thrombolytic pro-ala-lys peptides with Cu (II): leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation
    • COI: 1:CAS:528:DC%2BD1cXntVyntL0%3D, PID: 18547100
    • Ren X, Cui G, Zhao M, Wang C, Peng S. Coordination of thrombolytic pro-ala-lys peptides with Cu (II): leading to nanoscale self-assembly, increase of thrombolytic activity and additional vasodilation. J Phys Chem B. 2008;112(27):8174–80.
    • (2008) J Phys Chem B , vol.112 , Issue.27 , pp. 8174-8180
    • Ren, X.1    Cui, G.2    Zhao, M.3    Wang, C.4    Peng, S.5
  • 104
    • 79959919390 scopus 로고    scopus 로고
    • A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke
    • COI: 1:CAS:528:DC%2BC3MXpsVajtrg%3D
    • Marsh JN, Hu G, Scott MJ, Zhang H, Goette MJ, Gaffney PJ, et al. A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke. Nanomedicine (London). 2011;6(4):605–15.
    • (2011) Nanomedicine (London) , vol.6 , Issue.4 , pp. 605-615
    • Marsh, J.N.1    Hu, G.2    Scott, M.J.3    Zhang, H.4    Goette, M.J.5    Gaffney, P.J.6
  • 105
    • 34249690076 scopus 로고    scopus 로고
    • Molecular imaging with targeted perfluorocarbon nanoparticles: quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes
    • PID: 17434667
    • Marsh JN, Partlow KC, Abendschein DR, Scott MJ, Lanza GM, Wickline SA. Molecular imaging with targeted perfluorocarbon nanoparticles: quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes. Ultrasound Med Biol. 2007;33(6):950–8.
    • (2007) Ultrasound Med Biol , vol.33 , Issue.6 , pp. 950-958
    • Marsh, J.N.1    Partlow, K.C.2    Abendschein, D.R.3    Scott, M.J.4    Lanza, G.M.5    Wickline, S.A.6
  • 107
    • 0036858484 scopus 로고    scopus 로고
    • Ultrasound-enhanced thrombolysis for stroke: clinical significance
    • PID: 12470858
    • Alexandrov AV. Ultrasound-enhanced thrombolysis for stroke: clinical significance. Eur J Ultrasound. 2002;16(1–2):131–40.
    • (2002) Eur J Ultrasound , vol.16 , Issue.1-2 , pp. 131-140
    • Alexandrov, A.V.1
  • 108
    • 33646714392 scopus 로고    scopus 로고
    • Ultrasound enhanced thrombolysis for stroke
    • Alexandrov AV. Ultrasound enhanced thrombolysis for stroke. Int J Stroke. 2005;1(1):26–9.
    • (2005) Int J Stroke , vol.1 , Issue.1 , pp. 26-29
    • Alexandrov, A.V.1
  • 110
    • 0037494727 scopus 로고    scopus 로고
    • Recent advances in adenovirus-mediated gene therapy for cerebral ischemia
    • PID: 12553534
    • Masumu M, Hata R. Recent advances in adenovirus-mediated gene therapy for cerebral ischemia. Curr Gene Ther. 2003;3(1):43–8.
    • (2003) Curr Gene Ther , vol.3 , Issue.1 , pp. 43-48
    • Masumu, M.1    Hata, R.2
  • 111
    • 0034942540 scopus 로고    scopus 로고
    • Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    • COI: 1:CAS:528:DC%2BD3MXlsV2ksLs%3D, PID: 11462790
    • Yenari MA, Dumas TC, Sapolsky RM, Steinberg GK. Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Ann N Y Acad Sci. 2001;939:340–57.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 340-357
    • Yenari, M.A.1    Dumas, T.C.2    Sapolsky, R.M.3    Steinberg, G.K.4
  • 113
    • 77956520638 scopus 로고    scopus 로고
    • Epidemiology and risk factors of cerebral ischemia and ischemic heart diseases: similarities and differences
    • PID: 21804773
    • Soler EP, Ruiz VC. Epidemiology and risk factors of cerebral ischemia and ischemic heart diseases: similarities and differences. Curr Cardiol Rev. 2010;6(3):138–49.
    • (2010) Curr Cardiol Rev , vol.6 , Issue.3 , pp. 138-149
    • Soler, E.P.1    Ruiz, V.C.2
  • 115
    • 0037315747 scopus 로고    scopus 로고
    • The impact of systemic infection on the progression of neurodegenerative disease
    • COI: 1:CAS:528:DC%2BD3sXot12itQ%3D%3D, PID: 12563281
    • Perry VH, Newman TA, Cunningham C. The impact of systemic infection on the progression of neurodegenerative disease. Nat Rev Neurosci. 2003;4(2):103–212.
    • (2003) Nat Rev Neurosci , vol.4 , Issue.2 , pp. 103-212
    • Perry, V.H.1    Newman, T.A.2    Cunningham, C.3
  • 116
    • 59349100950 scopus 로고    scopus 로고
    • Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms
    • COI: 1:CAS:528:DC%2BD1MXhsFKrtLo%3D, PID: 18706982
    • Teeling JL, Perry VH. Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience. 2009;158(3):1062–73.
    • (2009) Neuroscience , vol.158 , Issue.3 , pp. 1062-1073
    • Teeling, J.L.1    Perry, V.H.2
  • 117
    • 0035078659 scopus 로고    scopus 로고
    • Neurodegenerative disorders and ischemic brain diseases
    • COI: 1:CAS:528:DC%2BD3MXivVGrsL0%3D, PID: 11321043
    • Mattson MP, Duan W, Pedersen WA, Culmsee C. Neurodegenerative disorders and ischemic brain diseases. Apoptosis. 2001;6(1–2):69–81.
    • (2001) Apoptosis , vol.6 , Issue.1-2 , pp. 69-81
    • Mattson, M.P.1    Duan, W.2    Pedersen, W.A.3    Culmsee, C.4
  • 118
    • 84931261067 scopus 로고    scopus 로고
    • Modern medical management of acute ischemic stroke
    • PID: 25114761
    • Goldstein LB. Modern medical management of acute ischemic stroke. Methodist Debakey Cardiovasc J. 2014;10(2):99–104.
    • (2014) Methodist Debakey Cardiovasc J , vol.10 , Issue.2 , pp. 99-104
    • Goldstein, L.B.1
  • 119
    • 0035942303 scopus 로고    scopus 로고
    • Clinical carotid endarterectomy decision making: noninvasive vascular imaging versus angiography
    • COI: 1:STN:280:DC%2BD3M3jtFCkuw%3D%3D, PID: 11320170
    • Johnston DCC, Goldstein LB. Clinical carotid endarterectomy decision making: noninvasive vascular imaging versus angiography. Neurology. 2001;56(8):1009–15.
    • (2001) Neurology , vol.56 , Issue.8 , pp. 1009-1015
    • Johnston, D.C.C.1    Goldstein, L.B.2
  • 121
    • 42349095894 scopus 로고    scopus 로고
    • Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke
    • COI: 1:CAS:528:DC%2BD1cXkvVSrsLY%3D, PID: 18303253
    • Kidwell CS, Latour L, Saver JL, Alger JR, Starkman S, Duckwiler G, et al. Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke. Cerebrovasc Dis. 2008;25(4):338–43.
    • (2008) Cerebrovasc Dis , vol.25 , Issue.4 , pp. 338-343
    • Kidwell, C.S.1    Latour, L.2    Saver, J.L.3    Alger, J.R.4    Starkman, S.5    Duckwiler, G.6
  • 122
    • 49849089117 scopus 로고    scopus 로고
    • Early disruption of the blood–brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke
    • COI: 1:CAS:528:DC%2BD1cXos12iur4%3D, PID: 18556588
    • Kastrup A, Groschel K, Ringer TM, Redecker C, Cordesmeyer R, Witte OW, et al. Early disruption of the blood–brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke. Stroke. 2008;39(8):2385–7.
    • (2008) Stroke , vol.39 , Issue.8 , pp. 2385-2387
    • Kastrup, A.1    Groschel, K.2    Ringer, T.M.3    Redecker, C.4    Cordesmeyer, R.5    Witte, O.W.6
  • 123
    • 0034645547 scopus 로고    scopus 로고
    • Short-term prognosis after emergency department diagnosis of TIA
    • COI: 1:STN:280:DC%2BD3M%2Fos1aktg%3D%3D, PID: 11147987
    • Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284(22):2901–6.
    • (2000) JAMA , vol.284 , Issue.22 , pp. 2901-2906
    • Johnston, S.C.1    Gress, D.R.2    Browner, W.S.3    Sidney, S.4
  • 124
    • 70349921190 scopus 로고    scopus 로고
    • The burden and management of TIA and stroke in government-funded healthcare programs
    • Gorelick PB. The burden and management of TIA and stroke in government-funded healthcare programs. Am J Manage Care. 2009;15(6 Suppl):S177–84.
    • (2009) Am J Manage Care , vol.15 , pp. 177-184
    • Gorelick, P.B.1
  • 125
    • 84875161421 scopus 로고    scopus 로고
    • Renal impairment reduces the efficacy of thrombolytic therapy in acute ischemic stroke
    • COI: 1:CAS:528:DC%2BC3sXjtFGisL8%3D, PID: 23428996
    • Power A, Epstein D, Cohen D, Bathula R, Devine J, Kar A, et al. Renal impairment reduces the efficacy of thrombolytic therapy in acute ischemic stroke. Cerebrovasc Dis. 2013;35(1):45–52.
    • (2013) Cerebrovasc Dis , vol.35 , Issue.1 , pp. 45-52
    • Power, A.1    Epstein, D.2    Cohen, D.3    Bathula, R.4    Devine, J.5    Kar, A.6
  • 127
    • 34547401424 scopus 로고    scopus 로고
    • Advancing stroke therapeutics through genetic understanding
    • COI: 1:CAS:528:DC%2BD2sXhtVSnsb%2FP, PID: 17630939
    • Ross OA, Worrall BB, Meschia JF. Advancing stroke therapeutics through genetic understanding. Curr Drug Targets. 2007;8(7):850–9.
    • (2007) Curr Drug Targets , vol.8 , Issue.7 , pp. 850-859
    • Ross, O.A.1    Worrall, B.B.2    Meschia, J.F.3
  • 128
    • 79960058709 scopus 로고    scopus 로고
    • Thrombolysis in acute ischaemic stroke: an update
    • PID: 23251746
    • Robinson T, Zaheer Z, Mistri AK. Thrombolysis in acute ischaemic stroke: an update. Ther Adv Chronic Dis. 2011;2(2):119–31.
    • (2011) Ther Adv Chronic Dis , vol.2 , Issue.2 , pp. 119-131
    • Robinson, T.1    Zaheer, Z.2    Mistri, A.K.3
  • 129
    • 84893713788 scopus 로고    scopus 로고
    • Nanoscale drug delivery systems and the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC2cXhs12lsbzM, PID: 24550672
    • Alyautdin R, Khalin I, Nafeeza MI, Haron MH, Kuznetsov D. Nanoscale drug delivery systems and the blood–brain barrier. Int J Nanomedicine. 2014;9:795–811.
    • (2014) Int J Nanomedicine , vol.9 , pp. 795-811
    • Alyautdin, R.1    Khalin, I.2    Nafeeza, M.I.3    Haron, M.H.4    Kuznetsov, D.5
  • 130
    • 84859996647 scopus 로고    scopus 로고
    • Modern methods for delivery of drugs across the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC38XlvFygtbc%3D, PID: 22154620
    • Chen Y, Liu L. Modern methods for delivery of drugs across the blood–brain barrier. Adv Drug Deliv Rev. 2012;64(7):640–65.
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.7 , pp. 640-665
    • Chen, Y.1    Liu, L.2
  • 131
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood–brain barrier, and central nervous system drug discovery
    • PID: 16489365
    • Alavijeh MS, Chishty M, Qaiser MZ, Palmer AM. Drug metabolism and pharmacokinetics, the blood–brain barrier, and central nervous system drug discovery. NeuroRx. 2005;2(4):554–71.
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 132
    • 41149121206 scopus 로고    scopus 로고
    • Mechanical thrombectomy for acute ischemic stroke: final results of the multi MERCI trial
    • PID: 18309168
    • Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the multi MERCI trial. Stroke. 2008;39:1205–12.
    • (2008) Stroke , vol.39 , pp. 1205-1212
    • Smith, W.S.1    Sung, G.2    Saver, J.3    Budzik, R.4    Duckwiler, G.5    Liebeskind, D.S.6
  • 133
    • 68249091754 scopus 로고    scopus 로고
    • The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease
    • Penumbra Pivotal Stroke Trial Investigators. The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke. 2009;40:2761–8.
    • (2009) Stroke , vol.40 , pp. 2761-2768
    • Penumbra Pivotal Stroke Trial Investigators1
  • 134
    • 84888320235 scopus 로고    scopus 로고
    • Prospective, multicenter, single-arm study of mechanical thrombectomy using solitaire flow restoration in acute ischemic stroke
    • PID: 23908066
    • Pereira VM, Gralla J, Davalos A, Bonafé A, Castaño C, Chapot R, et al. Prospective, multicenter, single-arm study of mechanical thrombectomy using solitaire flow restoration in acute ischemic stroke. Stroke. 2013;44(10):2802–7.
    • (2013) Stroke , vol.44 , Issue.10 , pp. 2802-2807
    • Pereira, V.M.1    Gralla, J.2    Davalos, A.3    Bonafé, A.4    Castaño, C.5    Chapot, R.6
  • 135
    • 33845404703 scopus 로고    scopus 로고
    • Mechanical thrombectomy for acute ischemic stroke, thrombus–device interaction, efficiency, and complications in vivo
    • PID: 17053185
    • Gralla J, Schroth G, Remonda L, Nedeltchev K, Slotboom J, Brekenfeld C. Mechanical thrombectomy for acute ischemic stroke, thrombus–device interaction, efficiency, and complications in vivo. Stroke. 2006;37:3019–24.
    • (2006) Stroke , vol.37 , pp. 3019-3024
    • Gralla, J.1    Schroth, G.2    Remonda, L.3    Nedeltchev, K.4    Slotboom, J.5    Brekenfeld, C.6
  • 137
    • 77149151217 scopus 로고    scopus 로고
    • Sonothrombolysis in the management of acute ischemic stroke
    • PID: 20104930
    • Rubiera M, Alexandrov AV. Sonothrombolysis in the management of acute ischemic stroke. Am J Cardiovasc Drugs. 2010;10(1):5–10.
    • (2010) Am J Cardiovasc Drugs , vol.10 , Issue.1 , pp. 5-10
    • Rubiera, M.1    Alexandrov, A.V.2
  • 138
    • 84881239240 scopus 로고    scopus 로고
    • Sonothrombolysis in ischemic stroke
    • PID: 23378229
    • Barlinn K, Alexandrov AV. Sonothrombolysis in ischemic stroke. Curr Treat Options Neurol. 2013;15(2):91–103.
    • (2013) Curr Treat Options Neurol , vol.15 , Issue.2 , pp. 91-103
    • Barlinn, K.1    Alexandrov, A.V.2
  • 139
    • 85013816949 scopus 로고    scopus 로고
    • Transcranial sonothrombolysis using high-intensity focused ultrasound: impact of increasing output power on clot fragmentation
    • PID: 25512864
    • Ahadi G, Welch CS, Grimm MJ, Fisher DJ, Zadicario E, Ernstrom K, et al. Transcranial sonothrombolysis using high-intensity focused ultrasound: impact of increasing output power on clot fragmentation. J Ther Ultrasound. 2013;1:22.
    • (2013) J Ther Ultrasound , vol.1 , pp. 22
    • Ahadi, G.1    Welch, C.S.2    Grimm, M.J.3    Fisher, D.J.4    Zadicario, E.5    Ernstrom, K.6


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