PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier

Journal of Controlled Release

Volumn 211, Issue , 2015, Pages 134-143

  Fornaguera, C ^a,b   Dols Perez, A ^a,b   Caldero G ^a,b   Garcia Celma M J ^b,c   Camarasa, J ^c   Solans, C ^a,b  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Active targeting; Blood brain barrier; Loperamide; Nano emulsions; Polymeric nanoparticles

Indexed keywords

ANTIBODIES; BIOCOMPATIBILITY; BIODEGRADATION; BLOOD; COPOLYMERS; EMULSIFICATION; EMULSIONS; MONOCLONAL ANTIBODIES; NEURODEGENERATIVE DISEASES; POLYMERS;

ACTIVE TARGETING; BLOOD-BRAIN BARRIER; LOPERAMIDE; NANO-EMULSIONS; POLYMERIC NANOPARTICLES;

NANOPARTICLES;

LOPERAMIDE; MONOCLONAL ANTIBODY; MORPHINE; NANOCARRIER; POLYGLACTIN; DRUG CARRIER; EMULSION; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ADULT; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BLOOD BRAIN BARRIER; CELL VIABILITY; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; ELECTROPHORETIC MOBILITY; EVAPORATION; HELA CELL LINE; HEMOLYSIS; HOT PLATE TEST; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; MOUSE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE CHARGE; WATER CONTENT; ZETA POTENTIAL; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; EMULSION; METABOLISM; PHYSIOLOGY; PROCEDURES; SYNTHESIS;

ANIMALS; BLOOD-BRAIN BARRIER; CELL SURVIVAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; HELA CELLS; HUMANS; LACTIC ACID; MALE; MICE; NANOPARTICLES; POLYGLYCOLIC ACID;

EID: 84931273562     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.06.002     Document Type: Article

References (67)

1. J.K. Sahni, S. Doggui, J. Ali, S. Baboota, L. Dao, and C. Ramassamy Neurotherapeutic applications of nanoparticles in Alzheimer's disease J. Control. Release 152 2011 208 231
2. M.R. Farlow Pharmacokinetic profiles of current therapies for Alzheimer's disease: implications for switching to galantamine Clin. Ther. 23 A 2001 13 24
3. G. Tosi, R.A. Fano, L. Bondioli, L. Badiali, R. Benassi, F. Rivasi, B. Ruozi, F. Forni, and A. Vandelli Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier Nanomedicine 6 3 2011 423 436
4. M. Gregori, M. Masserini, and S. Mancini Nanomedicine for the treatment of Alzheimer's disease Nanomedicine (Lond) 10 7 2015 1203 1218
5. S. Lilienfeld Galantamine - a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease CNS Drug Rev. 8 2 2006 159 176
6. M. Villaroya, A.G. García, J. Marco-Contelles, and M.G. López An update on the pharmacology of galantamine Expert Opin. Invest. Drugs 16 12 2007 1987 1998
7. M. Fazil, S. Baboota, J.K. Sahni, and J. Ali Nanotherapeutics for Alzheimer's disease (AD): past, present and future J. Drug Target. 20 2 2012 97 113
8. J. Todoroff, and R. Vanbever Fate of nanomedicines in the lungs Curr. Opin. Colloid Interface Sci. 16 2011 246 254
9. C. Pinto Reis, R.J. Neufeld, A.J. Ribeiro, and F. Veiga Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles Nanomed.: Nanotechnol., Biol. Med. 2 1 2006 8 21
10. B. Neha, B. Ganesh, and K. Preeti Drug delivery to the brain using polymeric nanoparticles: a review Int. J. Pharm. Life Sci. 2 3 2013 107 132
11. Y. Aktas, M. Yemisci, K. Andrieux, R.N. Gursoy, M.J. Alonso, and E. Fernandez-Megia Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26 Bioconjugate Chem. 16 2005 1503 1511
12. C. Vauthier, and K. Bouchemal Methods for the preparation and manufacture of polymeric nanoparticles Pharm. Res. 26 5 2009 1025 1058
13. V.P. Torchillin Multifunctional nanocarriers Adv. Drug Deliv. Rev. 64 2012 302 315
14. M. Willert, R. Rothe, K. Landfester, and M. Antonietti Synthesis of inorganic and metallic nanoparticles by miniemulsification of molten salts and metals Chem. Mater. 13 2001 4681 4685
15. N. Anton, J.P. Benoit, and P. Saulnier Design and production of nanoparticles formulated from nano-emulsion templates: a review J. Control. Release 128 2008 185 199
16. C. Solans, P. Izquierdo, J. Nolla, N. Azemar, and M.J. García-Celma Nano-emulsions Curr. Opin. Colloid Interface Sci. 10 2005 102 110
17. T. Tadros, P. Izquierdo, J. Esquena, and C. Solans Formation and stability of nano-emulsions Adv. Colloid Interface Sci. 108-109 2004 303 318
18. N. Anton, and T.F. Vandamme The universality of low-energy emulsification Int. J. Pharm. 377 2009 142 147
19. A. Forgiarini, J. Esquena, C. González, and C. Solans Formation of nano-emulsions by low-energy emulsification methods at constant temperature Langmuir 17 2001 2076 2083
20. I. Solè, A. Maestro, C.M. Pey, C. González, C. Solans, and J.M. Gutiérrez Nano-emulsions preparation by low energy methods in an ionic surfactant system Colloids Surf. A Physicochem. Eng. Asp. 288 2006 138 143
21. L. Wang, K.J. Mutch, J. Eastoe, R.K. Heenan, and J. Dong Nanoemulsions prepared by a two-step low-energy process Langmuir 24 2008 6092 6099
22. L. Wang, R. Tabor, J. Eastoe, X. Li, R.K. Heenan, and J. Dong Formation and stability of nanoemulsions with mixed ionic-nonionic surfactants Phys. Chem. Chem. Phys. 11 2009 9772 9778
23. H.J. Yang, W.G. Cho, and S.N. Park J. Ind. Eng. Chem. 15 2009 331 335
24. S. Desgouilles, C. Vauthier, D. Bazile, J. Vacus, J.L. Grossiord, M. Veillard, and P. Couvreur Langmuir 19 2003 9504
25. X. Song, Y. Zhao, S. Hou, F. Xu, R. Zhao, J. He, Z. Cai, Y. Li, and Q. Chen Eur. J. Pharm. Biopharm. 69 2008 445
26. M.C. Venier-Julienne, and J.P. Benoît Pharm. Acta Helv. 71 1996 121
27. D. Moinard-Chécot, Y. Chevalier, S. Briançon, L. Beney, and H. Fessi J. Colloid Interface Sci. 317 2008 458
28. G. Calderó, M.J. García-Celma, and C. Solans Formation of polymeric nano-emulsions by a low energy method and their use for nanoparticle preparation J. Colloid Interface Sci. 353 2011 406 411
29. R.N. Alyautdin, V.E. Petrov, K. Langer, A. Berthold, D.A. Kharkevich, and J. Kreuter Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanocrylate nanoparticles Pharm. Res. 14 3 1997 325 328
30. S. Gelperina, O. Maksimenko, A. Khalansky, L. Vanchugova, E. Shipulo, K. Abbasova, R. Berdiev, S. Wohlfart, N. Chepurnova, and J. Kreuter Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: influence of the formulation parameters Eur. J. Pharm. Biopharm. 74 2010 157 163
31. K. Ulbrich, T. Hekmatara, E. Herbert, and J. Kreuter Transferrin- and transferring-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur. J. Pharm. Biopharm. 71 2009 251 256
32. G. Tosi, L. Costantino, F. Rivasi, B. Ruozi, E. Leo, A.V. Vergoni, R. Tacchi, A. Bertolini, M.A. Vandelli, and F. Forni Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 J. Control. Release 122 2007 1 9
33. USP Pharmacopoeia On-line resource accessible at: http://www.usp.org/ 2014
34. W. Schärtl H. Pasch, Light Scattering From Polymer Solutions and Nanoparticle Dispersions 2006 Springer laboratory 978-3-540-71951-9 22
35. A.V. Delgado, F. González-Caballero, R.J. Hunter, and L.K. Koopal Measurement and interpretation of electrokinetic phenomena J. Colloids Interface Sci. 309 2007 194 224
36. I.I. Hewala Spectrofluorimetric and derivative absorption spectrophotometric techniques for the determination of loperamide hydrochloride in pharmaceutical formulations J. Pharm. Biomed. Anal. 13 6 1995 761 767
37. C. Gómez-Gaete, N. Tsapis, M. Besnard, A. Bochot, and E. Fattal Int. J. Pharm. 331 2007 153
38. N. Schafroth, C. Arpagaus, U. Yadhav, S. Makne, and D. Doroumis Colloid Surf. B 90 2012 8 http://dx.doi.org/10.1016/j.colsurfb.2011.09.038
39. C. Fornaguera, M. Llinàs, C. Solans, and G. Calderó Design and in vitro evaluation of biocompatible dexamethasone-loaded nanoparticle dispersions, obtained from nano-emulsions, for inhalatory therapy Colloid Surf. B 125 1 2015 58 64 http://dx.doi.org/10.1016/j.colsurfb.2014.11.006
40. H. Edelhoch Spectroscopic determination of tryptophan and tyrosine in proteins Biochemistry 6 7 1967 1948 1954
41. D. Putnam, C.A. Gentry, D.W. Pack, and R. Langer Polymer-based gene delivery with low cytotoxicity by unique balance of side-chain termini PNAS 98 3 2001 1200 1205
42. Y.-C. Chen, W.-Y. Hsieh, W.-F. Lee, and D.-T. Zeng Effects of surface modification of PLGA-PEG-PLGA nanoparticles on loperamide delivery efficiency across the blood-brain barrier J. Biomater. Appl. 27 7 2011 909 922
43. B.P. Kirby, R. Pabari, C.N. Chen, Baharna M. Al, J. Walsh, and Z. Ramtoola Comparative evaluation of the degree of pegylation of poly(lactic-co-glycolic acid) nanoparticles in enhancing central nervous system delivery of loperamide J. Pharm. Pharmacol. 65 2013 1473 1481
44. Z. Chen, E. Davies, W.S. Miller, S. Shan, K.J. Valenzano, and D.J. Kyle Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor Bioorg. Med. Chem. Lett. 14 21 2004 5275 5279
45. A. Goldstein, and A. Naidu Multiple opioid receptors: ligand selectivity profiles and binding site signatures Mol. Pharmacol. 36 2 1989 265 272
46. C. Fornaguera, S. Grijalvo, M. Galán, E. Fuentes-Paniagua, F.J. de la Mata, R. Gómez, R. Eritja, G. Calderó, and C. Solans Novel non-viral gene delivery systems composed of carbosilane dendron functionalized nanoparticles prepared from nano-emulsions as non-viral carriers for antisense oligonucleotides Int. J. Pharm. 478 2015 113 123
47. C. Solans, and I. Solè Nano-emulsions: formation by low-energy methods Curr. Opin. Colloid Interface Sci. 17 2012 246 254
48. M. Jayne Lawrence Surfactant systems: their use in drug delivery Chem. Soc. Rev. 23 1994 417 424
49. J. Kreuter Nanoparticulate systems for brain delivery of drugs Adv. Drug Deliv. Rev. 64 2012 213 222
50. S. Wohlfart, S. Gelperina, and J. Kreuter Transport of drugs across the blood-brain barrier by nanoparticles J. Control. Release 161 2 2012 264 273
51. A.V. Kabanov, and H.E. Gendelman Nanomedicine in the diagnosis and therapy of neurodegenerative disorders Prog. Polym. Sci. 32 2007 1054 1082
52. S.K. Sahoo, and V. Labhasetwar Enhanced antiproliferative activity of transferrin conjugated, paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention Mol. Pharm. 2 2005 373 383
53. C. Fornaguera, G. Calderó, M. Mitjans, P. Vinardell, C. Solans, and C. Vauthier interaction of PLGA nanoparticles with blood components: protein adsorption, coagulation, activation of the complement system and hemolysis studies Nanoscale 2015 http://dx.doi.org/10.1039/c5nr00733j
54. J.L. Jiménez, M.I. Clemente, N.D. Weber, J. Sánchez, P. Ortega, F.J. de la Mata, R. Gómez, D. García, L.A. López-Fernández, and M.A. Muñoz-Fernández Carbosilane dendrimers to transfect human astrocytes with small interfering RNA targeting human immunodeficiency virus Biodrugs 24 5 2010 331 343
55. M.A. Dobrovolskaia, and S. McNeil Handbook of immunological properties of engineered nanomaterials Frontiers in Nanobiomedical Research 2013 SAIC-Frederick, Inc. USA
56. R. Gref, A. Domb, P. Quellec, T. Blunk, R.H. Müller, J.M. Verbavatz, and R. Langer The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres Adv. Drug Deliv. Rev. 64 2012 316 326
57. N. Anton, J.-P. Benoit, and P. Saulnier Design and production of nanoparticles formulated from nano-emulsions - a review J. Control. Release 128 3 2008 185 199
58. D. Morales, J.M. Gutiérrez, M.J. García-Celma, and C. Solans A study of the relation between bicontinuous microemulsions and oil/water nano-emulsion formation Langmuir 19 2003 7196 7200
59. A.A. Date, and M.S. Nagarsenker Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime poxetil Int. J. Pharm. 329 2007 166 172
60. A.A. Date, N. Desai, R. Dixit, and M. Nagarsenker Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances Nanomedicine 5 10 2010 1595 1616
61. G. Calderó, M. Llinàs, M.J. García-Celma, and C. Solans Studies on controlled release of hydrophilic drugs from W/O high internal phase ratio emulsions J. Pharm. Sci. 99 2 2010 701 711
62. R. Gabathuler Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases Neurobiol. Dis. 37 2010 48 57
63. J. Nicolas, S. Mura, D. Brambilla, N. Mackiewicz, and P. Couvreur Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery Chem. Soc. Rev. 42 2013 1147 1235
64. R. Alyautdin, I. Khalin, M.I. Nafeeza, M.H. Haron, and D. Kuznetsov Nanoscale drug delivery systems and the blood-brain barrier Int. J. Nanomedicine 9 2014 795 811
65. K. Rebolj, D. Pahovnik, and E. Zagar Characterization of a protein conjugate using an asymmetrical-flow flied-flow fractionation and a size-exclusion chromatography with multi-detection system Anal. Chem. 84 2012 7374 7383
66. E. Catiker, M. Gümüsderelioglu, and A. Güner Degradation of PLA, PLGA homo- and copolymers in the presence of serum albumin: a spectroscopic investigation Polym. Int. 49 2000 728 734
67. J. Kreuter Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB) J. Microencapsul. 30 1 2013 49 54