Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery

Acta Biomaterialia

Volumn 15, Issue , 2015, Pages 89-101

  Fan, Ching Hsiang ^a   Ting, Chien Yu ^a   Chang, Yuan Chih ^b   Wei, Kuo Chen ^c   Liu, Hao Li ^c   Yeh, Chih Kuang ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Blood brain barrier; Chemotherapy; Focused ultrasound; Inertial cavitation reduction; Intracerebral hemorrhage

Indexed keywords

ACOUSTIC EMISSION TESTING; BLOOD; BRAIN; CAVITATION; CONTROLLED DRUG DELIVERY; NATURAL FREQUENCIES; TARGETED DRUG DELIVERY; TUMORS; ULTRASONIC IMAGING;

% REDUCTIONS; BLOOD-BRAIN BARRIER; BRAIN TUMORS; FOCUSED ULTRASOUND; HAEMORRAGE; INERTIAL CAVITATION; INERTIAL CAVITATION REDUCTION; INTRACEREBRAL HEMORRHAGE; MICROBUBBLES; NITROSOUREAS;

CHEMOTHERAPY;

CARMUSTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HEMORRHAGE; BRAIN RADIOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG BRAIN LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; FEASIBILITY STUDY; GLIOMA; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROBUBBLE; NONHUMAN; PRIORITY JOURNAL; RAT; THERAPY EFFECT; ACOUSTICS; ANIMAL; BRAIN NEOPLASMS; CELL SURVIVAL; DRUG EFFECTS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; SIGNAL PROCESSING; SPRAGUE DAWLEY RAT; STAINING; TIME; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASOUND;

ANIMALIA; RATTUS;

ACOUSTICS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CARMUSTINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; MAGNETIC RESONANCE IMAGING; MALE; MICROBUBBLES; MICROSCOPY, ELECTRON, TRANSMISSION; RATS, SPRAGUE-DAWLEY; SIGNAL PROCESSING, COMPUTER-ASSISTED; STAINING AND LABELING; TIME FACTORS; ULTRASONICS;

EID: 84922688468     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.12.026     Document Type: Article

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