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Bioorganic and Medicinal Chemistry
Volumn 23, Issue 12, 2015, Pages 2767-2780
Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR
Author keywords

Covalent Reversible Inhibitor; Kinases; Lung cancer; Medicinal chemistry; Receptor tyrosine kinases
Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYL 1 PIPERAZINYL)PHENYL]AMINO] 4 PYRIMIDINYL]OXY]PHENYL]ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (1H IMIDAZOL 5 YL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (3 NITROPHENYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (4 CYANOPHENYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (4 FLUOROPHENYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (4 NITROPHENYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (FURAN 3 YL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 (PYRIDIN 4 YL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 CYCLOPENTYLACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 CYCLOPROPYLACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 CYCLOPROPYLPROPANAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 [4 (DIMETHYLAMINO)PHENYL]ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 3 [4 (METHYLTHIO)PHENYL]ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 4 METHYLPENT 2 ENAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 2 CYANO 4,4 DIMETHYLPENT 2 ENAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 3 (4 FLUOROPHENYL) 2 (TRIFLUOROMETHYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 3 (4 METHOXYPHENYL) 2 (TRIFLUOROMETHYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 3 CYCLOPROPYLACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL] 3 [4 (DIMETHYLAMINO)PHENYL] 2 (TRIFLUOROMETHYL)ACRYLAMIDE; N [3 [[5 CHLORO 2 [[2 METHOXY 4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINO]PYRIMIDIN 4 YL]OXY]PHENYL]ACETAMIDE; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;
EID: 84930083960     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.038     Document Type: Article
Times cited : (39)
References (39)

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.