A novel platform for engineering blood-brain barrier-crossing bispecific biologics

FASEB Journal

Volumn 28, Issue 11, 2014, Pages 4764-4778

  Farrington, Graham K ^a   Caram Salas, Nadia ^b   Haqqani, Arsalan S ^b   Brunette, Eric ^b   Eldredge, John ^a   Pepinsky, Blake ^a   Antognetti, Giovanna ^a   Baumann, Ewa ^b   Ding, Wen ^b   Garber, Ellen ^a   Jiang, Susan ^b   Delaney, Christie ^a   Boileau, Eve ^b   Sisk, William P ^a   Stanimirovic, Danica B ^b  

^a BIOGEN   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Drug delivery; Neuropeptides; Single domain antibody

Indexed keywords

BISPECIFIC ANTIBODY; FC5 FC FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE 6 ARGININE]; NANOBODY; NEUROPEPTIDE Y; UNCLASSIFIED DRUG; ANTIBODY CONJUGATE; BIOLOGICAL PRODUCT;

ADULT; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY ENGINEERING; ANTIBODY LIBRARY; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; CHRONIC PAIN; CISTERNA MAGNA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DELIVERY SYSTEM; DRUG POTENCY; HYPERALGESIA; IN VITRO STUDY; INFLAMMATORY PAIN; MALE; MEMBRANE PERMEABILITY; MONOLAYER CULTURE; NONHUMAN; PLASMA HALF LIFE; RAT; TRANSCYTOSIS; ANIMAL; BRAIN; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES; PROTEIN ENGINEERING; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; ANTIBODIES, BISPECIFIC; BIOLOGICAL PRODUCTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; IMMUNOCONJUGATES; MALE; PROTEIN ENGINEERING; RATS, WISTAR; RECOMBINANT FUSION PROTEINS;

EID: 84908002106     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-253369     Document Type: Article

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