Targeting microbubbles-carrying TGFβ1 inhibitor combined with ultrasound sonication induce BBB/BTB disruption to enhance nanomedicine treatment for brain tumors

Journal of Controlled Release

Volumn 211, Issue , 2015, Pages 53-62

  Chen, Yung Chu ^a,b   Chiang, Chi Feng ^a   Wu, Sheng Kai ^a   Chen, Li Fang ^c   Hsieh, Wen Yuan ^b   Lin, Win Li ^a,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Bloodbrain bloodtumor barrier (BBB BTB); Des octanoyl ghrelin; Folate; Microbubbles; Targeted delivery; TGF 1 inhibitor; Ultrasound

Indexed keywords

CHEMOTHERAPY; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; SONICATION; TUMORS; ULTRASONICS;

BLOODBRAIN/BLOODTUMOR BARRIER (BBB/BTB); FOLATE; GHRELIN; MICROBUBBLES; TARGETED DELIVERY;

BRAIN;

DOXORUBICIN; FOLIC ACID; GHRELIN; LY 364947; PROTEIN INHIBITOR; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TRANSFORMING GROWTH FACTOR BETA 1 INHIBITOR; UNCLASSIFIED DRUG; LY-364947; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BLOOD TUMOR BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN TUMOR; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENDOTHELIUM; GLIOMA; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROBUBBLE; MOUSE; NANOMEDICINE; NONHUMAN; OVERALL SURVIVAL; PERICYTE; PRIORITY JOURNAL; RAT; SURVIVAL TIME; ULTRASOUND; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY; PROCEDURES; SCID MOUSE; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; DRUG DELIVERY SYSTEMS; MALE; MICE; MICE, INBRED ICR; MICE, SCID; MICROBUBBLES; NANOMEDICINE; PYRAZOLES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SONICATION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84930938169     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.05.288     Document Type: Article

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