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Volumn 23, Issue 17, 2015, Pages 1305-1315

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; CYTOKINE; DAMAGE ASSOCIATED MOLECULAR PATTERN; DEFENSIN; DNA; GALECTIN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; METHYL CPG BINDING PROTEIN; MITOCHONDRIAL DNA; NUCLEIC ACID; PEPTIDE; PROTEIN S 100; PURINERGIC P2X7 RECEPTOR; RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; URIC ACID; CARRIER PROTEIN; CRYOPYRIN; NLRP3 PROTEIN, HUMAN; P2XR RECEPTOR, HUMAN;

EID: 84952019428     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2015.6383     Document Type: Review
Times cited : (30)

References (106)
  • 1
    • 84929515613 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-atherogenic effects of the inflammasome NLRP3 inhibitor, arglabin, in ApoE2.Ki mice fed a high fat diet
    • Abderrazak A, Couchie D, Mahmood DF, et al. Anti-inflammatory and anti-atherogenic effects of the inflammasome NLRP3 inhibitor, arglabin, in ApoE2.Ki mice fed a high fat diet. Circulation 131: 1061-1070, 2015.
    • (2015) Circulation , vol.131 , pp. 1061-1070
    • Abderrazak, A.1    Couchie, D.2    Mahmood, D.F.3
  • 2
    • 84897491156 scopus 로고    scopus 로고
    • The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes
    • Abu El-Asrar AM, Mairaj Siddiquei M, Nawaz MI, Geboes K, Mohammad G. The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes. Mediat Inflamm 2014: 746415, 2014.
    • (2014) Mediat Inflamm , vol.2014 , pp. 746415
    • Abu El-Asrar, A.M.1    Mairaj Siddiquei, M.2    Nawaz, M.I.3    Geboes, K.4    Mohammad, G.5
  • 3
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser 307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275: 9047-9054, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 4
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • Biswas SK and Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 30: 475-487, 2009.
    • (2009) Trends Immunol , vol.30 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 5
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi T, Talamo F, Scaffidi P, et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 22: 5551-5560, 2003.
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1    Talamo, F.2    Scaffidi, P.3
  • 6
    • 31744441475 scopus 로고    scopus 로고
    • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    • Boyden ED and Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38: 240-244, 2006.
    • (2006) Nat Genet , vol.38 , pp. 240-244
    • Boyden, E.D.1    Dietrich, W.F.2
  • 7
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292: G518-G525, 2007.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G518-G525
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3
  • 8
    • 84888644812 scopus 로고    scopus 로고
    • Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: Evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition
    • Chen XL, Zhang XD, Li YY, Chen XM, Tang DR, Ran RJ. Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition. Br J Ophthalmol 97: 1598-1603, 2013.
    • (2013) Br J Ophthalmol , vol.97 , pp. 1598-1603
    • Chen, X.L.1    Zhang, X.D.2    Li, Y.Y.3    Chen, X.M.4    Tang, D.R.5    Ran, R.J.6
  • 9
    • 84887385152 scopus 로고    scopus 로고
    • The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis
    • Chen Y, Sun W, Gao R, et al. The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis. Rheumatology (Oxford) 52: 1739-1747, 2013.
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 1739-1747
    • Chen, Y.1    Sun, W.2    Gao, R.3
  • 10
    • 77249085646 scopus 로고    scopus 로고
    • Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
    • Cohen I, Rider P, Carmi Y, et al. Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc Natl Acad SciUS A 107: 2574-2579, 2010.
    • (2010) Proc Natl Acad SciUS A , vol.107 , pp. 2574-2579
    • Cohen, I.1    Rider, P.2    Carmi, Y.3
  • 12
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito DH, Mencin A, Gwak GY, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21: 504-516, 2012.
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1    Mencin, A.2    Gwak, G.Y.3
  • 13
    • 77953060025 scopus 로고    scopus 로고
    • Increased tolllike receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    • Dasu MR, Devaraj S, Park S, Jialal I. Increased tolllike receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 33: 861-868, 2010.
    • (2010) Diabetes Care , vol.33 , pp. 861-868
    • Dasu, M.R.1    Devaraj, S.2    Park, S.3    Jialal, I.4
  • 14
  • 15
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P, Kono H, Rayner KJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464: 1357-1361, 2010.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1    Kono, H.2    Rayner, K.J.3
  • 16
    • 34249941913 scopus 로고    scopus 로고
    • Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, requires ATP binding to mediate inflammatory signaling
    • Duncan JA, Bergstralh DT, Wang Y, et al. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci USA 104: 8041-8046, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8041-8046
    • Duncan, J.A.1    Bergstralh, D.T.2    Wang, Y.3
  • 17
    • 33847376042 scopus 로고    scopus 로고
    • Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
    • Faustin B, Lartigue L, Bruey JM, et al. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25: 713-724, 2007.
    • (2007) Mol Cell , vol.25 , pp. 713-724
    • Faustin, B.1    Lartigue, L.2    Bruey, J.M.3
  • 18
    • 0242552753 scopus 로고    scopus 로고
    • Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex
    • Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 100: 171-194, 2003.
    • (2003) Pharmacol Ther , vol.100 , pp. 171-194
    • Fujihara, M.1    Muroi, M.2    Tanamoto, K.3    Suzuki, T.4    Azuma, H.5    Ikeda, H.6
  • 19
    • 65649140025 scopus 로고    scopus 로고
    • Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    • Gasse P, Riteau N, Charron S, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 179: 903-913, 2009.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 903-913
    • Gasse, P.1    Riteau, N.2    Charron, S.3
  • 20
    • 79957526145 scopus 로고    scopus 로고
    • The role of uric acid as an endogenous danger signal in immunity and inflammation
    • Ghaemi-Oskouie F and Shi Y. The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep 13: 160-166, 2011.
    • (2011) Curr Rheumatol Rep , vol.13 , pp. 160-166
    • Ghaemi-Oskouie, F.1    Shi, Y.2
  • 22
    • 80755126873 scopus 로고    scopus 로고
    • Cell death in the maintenance and abrogation of tolerance: The five Ws of dying cells
    • Griffith TS and Ferguson TA. Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells. Immunity 35: 456-466, 2011.
    • (2011) Immunity , vol.35 , pp. 456-466
    • Griffith, T.S.1    Ferguson, T.A.2
  • 23
    • 77953488157 scopus 로고    scopus 로고
    • Regulation of inflammasome activity
    • Guarda G and So A. Regulation of inflammasome activity. Immunology 130: 329-336, 2010.
    • (2010) Immunology , vol.130 , pp. 329-336
    • Guarda, G.1    So, A.2
  • 24
    • 84883556650 scopus 로고    scopus 로고
    • Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity
    • Gunasekaran MK, Viranaicken W, Girard AC, et al. Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity. Cytokine 64: 103-111, 2013.
    • (2013) Cytokine , vol.64 , pp. 103-111
    • Gunasekaran, M.K.1    Viranaicken, W.2    Girard, A.C.3
  • 25
    • 84925773113 scopus 로고    scopus 로고
    • Alarmin highmobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in beta-cells
    • Guzman-RuizR,Ortega F,Rodriguez A, et al. Alarmin highmobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in beta-cells. Int J Obes (Lond) 38: 1545-1554, 2014.
    • (2014) Int J Obes (Lond) , vol.38 , pp. 1545-1554
    • Guzman-Ruizrortega Frodriguez, A.1
  • 26
    • 84859440796 scopus 로고    scopus 로고
    • HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
    • Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol 8: 195-202, 2012.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 195-202
    • Harris, H.E.1    Andersson, U.2    Pisetsky, D.S.3
  • 27
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Hasko G, Linden J, Cronstein B, Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 7: 759-770, 2008.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 759-770
    • Hasko, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 28
    • 43349085701 scopus 로고    scopus 로고
    • A2A receptors in inflammation and injury: Lessons learned from transgenic animals
    • Hasko G and Pacher P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol 83: 447-455, 2008.
    • (2008) J Leukoc Biol , vol.83 , pp. 447-455
    • Hasko, G.1    Pacher, P.2
  • 29
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasomemediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C, et al. Inflammasomemediated dysbiosis regulates progression of NAFLD and obesity. Nature 482: 179-185, 2012.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 31
    • 84906870036 scopus 로고    scopus 로고
    • Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance
    • Henriksbo BD, Lau TC, Cavallari JF, et al. Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance. Diabetes 63: 3742-3747, 2014.
    • (2014) Diabetes , vol.63 , pp. 3742-3747
    • Henriksbo, B.D.1    Lau, T.C.2    Cavallari, J.F.3
  • 32
    • 84888087172 scopus 로고    scopus 로고
    • HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9
    • Hirata Y, Kurobe H, Higashida M, et al. HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9. Atherosclerosis 231: 227-233, 2013.
    • (2013) Atherosclerosis , vol.231 , pp. 227-233
    • Hirata, Y.1    Kurobe, H.2    Higashida, M.3
  • 33
    • 84914132421 scopus 로고    scopus 로고
    • Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation
    • Honda H, Nagai Y, Matsunaga T, et al. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leukoc Biol 96: 1087-1100, 2014.
    • (2014) J Leukoc Biol , vol.96 , pp. 1087-1100
    • Honda, H.1    Nagai, Y.2    Matsunaga, T.3
  • 34
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 444: 860-867, 2006.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 35
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95: 2409-2415, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 36
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesityinduced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R,White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesityinduced insulin resistance. Science 271: 665-668, 1996.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis Rwhite, M.F.4    Spiegelman, B.M.5
  • 37
    • 73949118676 scopus 로고    scopus 로고
    • Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    • Iyer SS, Pulskens WP, Sadler JJ, et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 106: 20388-20393, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20388-20393
    • Iyer, S.S.1    Pulskens, W.P.2    Sadler, J.J.3
  • 38
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine receptors as therapeutic targets
    • Jacobson KA and Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5: 247-264, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 39
    • 0037298948 scopus 로고    scopus 로고
    • Anti-DNA antibodies: Aspects of structure and pathogenicity
    • Jang YJ and Stollar BD. Anti-DNA antibodies: aspects of structure and pathogenicity. Cell Mol Life Sci 60: 309-320, 2003.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 309-320
    • Jang, Y.J.1    Stollar, B.D.2
  • 40
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, relationship to lipoprotein lipase. J Clin Invest 95: 2111-2119, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 41
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H and Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 8: 279-289, 2008.
    • (2008) Nat Rev Immunol , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 42
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptorinduced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk CM, Holowka T, Sun J, et al. Toll-like receptorinduced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115: 4742-4749, 2010.
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1    Holowka, T.2    Sun, J.3
  • 43
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM: CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20: 709-760, 2002.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 44
    • 79953068336 scopus 로고    scopus 로고
    • Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
    • Krysko DV, Agostinis P, Krysko O, et al. Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol 32: 157-164, 2011.
    • (2011) Trends Immunol , vol.32 , pp. 157-164
    • Krysko, D.V.1    Agostinis, P.2    Krysko, O.3
  • 45
    • 84865504141 scopus 로고    scopus 로고
    • Sterile inflammation in the liver
    • Kubes P and Mehal WZ. Sterile inflammation in the liver. Gastroenterology 143: 1158-1172, 2012.
    • (2012) Gastroenterology , vol.143 , pp. 1158-1172
    • Kubes, P.1    Mehal, W.Z.2
  • 46
    • 23044452084 scopus 로고    scopus 로고
    • NACHT-LRR proteins (NLRs) in bacterial infection and immunity
    • Kufer TA, Fritz JH, Philpott DJ. NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol 13: 381-388, 2005.
    • (2005) Trends Microbiol , vol.13 , pp. 381-388
    • Kufer, T.A.1    Fritz, J.H.2    Philpott, D.J.3
  • 47
    • 58149287750 scopus 로고    scopus 로고
    • Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
    • Lamkanfi M, Kanneganti TD, Van Damme P, et al. Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics 7: 2350-2363, 2008.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 2350-2363
    • Lamkanfi, M.1    Kanneganti, T.D.2    Van Damme, P.3
  • 48
    • 70449727077 scopus 로고    scopus 로고
    • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
    • Lamkanfi M, Mueller JL, Vitari AC, et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol 187: 61-70, 2009.
    • (2009) J Cell Biol , vol.187 , pp. 61-70
    • Lamkanfi, M.1    Mueller, J.L.2    Vitari, A.C.3
  • 49
    • 80055043169 scopus 로고    scopus 로고
    • Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
    • Li L, Chen L, Hu L, et al. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 54: 1620-1630, 2011.
    • (2011) Hepatology , vol.54 , pp. 1620-1630
    • Li, L.1    Chen, L.2    Hu, L.3
  • 50
    • 0028984948 scopus 로고
    • Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
    • Li P, Allen H, Banerjee S, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80: 401-411, 1995.
    • (1995) Cell , vol.80 , pp. 401-411
    • Li, P.1    Allen, H.2    Banerjee, S.3
  • 51
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1: 361-370, 2005.
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 52
    • 84877048917 scopus 로고    scopus 로고
    • The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy
    • Lin M, Yiu WH, Li RX, et al. The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int 83: 887-900, 2013.
    • (2013) Kidney Int , vol.83 , pp. 887-900
    • Lin, M.1    Yiu, W.H.2    Li, R.X.3
  • 53
    • 0141672181 scopus 로고    scopus 로고
    • Hyperuricemia and gout
    • Liote F. Hyperuricemia and gout. Curr Rheumatol Rep 5: 227-234, 2003.
    • (2003) Curr Rheumatol Rep , vol.5 , pp. 227-234
    • Liote, F.1
  • 54
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT and Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5: 331-342, 2005.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 55
    • 84896816054 scopus 로고    scopus 로고
    • JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation
    • Lu B, Antoine DJ, Kwan K, et al. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci USA 111: 3068-3073, 2014.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 3068-3073
    • Lu, B.1    Antoine, D.J.2    Kwan, K.3
  • 56
    • 84874418376 scopus 로고    scopus 로고
    • TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice
    • Lu Z, Zhang X, Li Y, Jin J, Huang Y. TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice. J Endocrinol 216: 61-71, 2013.
    • (2013) J Endocrinol , vol.216 , pp. 61-71
    • Lu, Z.1    Zhang, X.2    Li, Y.3    Jin, J.4    Huang, Y.5
  • 57
    • 84898831401 scopus 로고    scopus 로고
    • Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model
    • Luo B, Li B, Wang W, et al. Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model. Cardiovasc Drugs Ther 28: 33-43, 2014.
    • (2014) Cardiovasc Drugs Ther , vol.28 , pp. 33-43
    • Luo, B.1    Li, B.2    Wang, W.3
  • 58
    • 77955591462 scopus 로고    scopus 로고
    • Hepatocyte death: A clear and present danger
    • Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol Rev 90: 1165-1194, 2010.
    • (2010) Physiol Rev , vol.90 , pp. 1165-1194
    • Malhi, H.1    Guicciardi, M.E.2    Gores, G.J.3
  • 59
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • Mariathasan S, Weiss DS, Newton K, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232, 2006.
    • (2006) Nature , vol.440 , pp. 228-232
    • Mariathasan, S.1    Weiss, D.S.2    Newton, K.3
  • 60
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10: 417-426, 2002.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 61
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241, 2006.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 62
    • 33845497181 scopus 로고    scopus 로고
    • Inflammatory caspases and inflammasomes: Master switches of inflammation
    • Martinon F and Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ 14: 10-22, 2007.
    • (2007) Cell Death Differ , vol.14 , pp. 10-22
    • Martinon, F.1    Tschopp, J.2
  • 63
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease
    • Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (∗). Annu Rev Immunol 27: 621-668, 2009.
    • (2009) Annu Rev Immunol , vol.27 , pp. 621-668
    • Masters, S.L.1    Simon, A.2    Aksentijevich, I.3    Kastner, D.L.4
  • 64
    • 78651300299 scopus 로고    scopus 로고
    • TAK-242 (resatorvid), a small-molecule inhibitor of Tolllike receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules
    • Matsunaga N, Tsuchimori N, Matsumoto T, Ii M. TAK-242 (resatorvid), a small-molecule inhibitor of Tolllike receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol 79: 34-41, 2011.
    • (2011) Mol Pharmacol , vol.79 , pp. 34-41
    • Matsunaga, N.1    Tsuchimori, N.2    Matsumoto, T.3    Ii, M.4
  • 65
    • 0028201732 scopus 로고
    • Tolerance, danger, the extended family
    • Matzinger P. Tolerance, danger, the extended family. Annu Rev Immunol 12: 991-1045, 1994.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 66
    • 84965089938 scopus 로고    scopus 로고
    • The TLR4 antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of HMGB1 signaling
    • McDonald KA, Huang H, Tohme S, et al. The TLR4 antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of HMGB1 signaling. Mol Med 20: 639-648, 2014.
    • (2014) Mol Med , vol.20 , pp. 639-648
    • McDonald, K.A.1    Huang, H.2    Tohme, S.3
  • 67
    • 84883542301 scopus 로고    scopus 로고
    • NLRP3 and IL-1beta in macrophages as critical regulators of metabolic diseases
    • McGettrick AF and O'Neill LA. NLRP3 and IL-1beta in macrophages as critical regulators of metabolic diseases. Diabetes Obes Metab 15 Suppl 3: 19-25, 2013.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 19-25
    • McGettrick, A.F.1    O'Neill, L.A.2
  • 68
    • 66349110620 scopus 로고    scopus 로고
    • Toll-like receptors as targets in chronic liver diseases
    • Mencin A, Kluwe J, Schwabe RF. Toll-like receptors as targets in chronic liver diseases. Gut 58: 704-720, 2009.
    • (2009) Gut , vol.58 , pp. 704-720
    • Mencin, A.1    Kluwe, J.2    Schwabe, R.F.3
  • 69
    • 84858786676 scopus 로고    scopus 로고
    • Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation
    • Menzel CL, Sun Q, Loughran PA, Pape HC, Billiar TR, Scott MJ. Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation. Mol Med 17: 1031-1038, 2011.
    • (2011) Mol Med , vol.17 , pp. 1031-1038
    • Menzel, C.L.1    Sun, Q.2    Loughran, P.A.3    Pape, H.C.4    Billiar, T.R.5    Scott, M.J.6
  • 70
    • 83455182149 scopus 로고    scopus 로고
    • Neutrophil extracellular trap formation is associated with IL-1beta and autophagy-related signaling in gout
    • Mitroulis I, Kambas K, Chrysanthopoulou A, et al. Neutrophil extracellular trap formation is associated with IL-1beta and autophagy-related signaling in gout. PLoS One 6: e29318, 2011.
    • (2011) PLoS One , vol.6 , pp. e29318
    • Mitroulis, I.1    Kambas, K.2    Chrysanthopoulou, A.3
  • 71
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel 'alarmin
    • Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin' PLoS One 3: e3331, 2008.
    • (2008) PLoS One , vol.3 , pp. e3331
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 72
    • 79959338922 scopus 로고    scopus 로고
    • AMPK is a direct adenylate charge-regulated protein kinase
    • Oakhill JS, Steel R, Chen ZP, et al. AMPK is a direct adenylate charge-regulated protein kinase. Science 332: 1433-1435, 2011.
    • (2011) Science , vol.332 , pp. 1433-1435
    • Oakhill, J.S.1    Steel, R.2    Chen, Z.P.3
  • 73
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • Ohta A and Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414: 916-920, 2001.
    • (2001) Nature , vol.414 , pp. 916-920
    • Ohta, A.1    Sitkovsky, M.2
  • 74
    • 84890932260 scopus 로고    scopus 로고
    • Adenosine is required for sustained inflammasome activation via the A(2)A receptor and the HIF-1alpha pathway
    • Ouyang X,GhaniA,MalikA, et al.Adenosine is required for sustained inflammasome activation via the A(2)A receptor and the HIF-1alpha pathway. Nat Commun 4: 2909, 2013.
    • (2013) Nat Commun , vol.4 , pp. 2909
    • Ouyang, X.1    Ghani, A.2    Malik, A.3
  • 75
    • 77954566533 scopus 로고    scopus 로고
    • High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
    • Oyama Y, Hashiguchi T, Taniguchi N, et al. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Lab Invest 90: 853-866, 2010.
    • (2010) Lab Invest , vol.90 , pp. 853-866
    • Oyama, Y.1    Hashiguchi, T.2    Taniguchi, N.3
  • 76
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system
    • Pickup JC and Crook MA. Is type II diabetes mellitus a disease of the innate immune system Diabetologia 41: 1241-1248, 1998.
    • (1998) Diabetologia , vol.41 , pp. 1241-1248
    • Pickup, J.C.1    Ma, C.2
  • 77
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky DS. Immune activation by bacterial DNA: a new genetic code. Immunity 5: 303-310, 1996.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 78
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 47: 571-579, 2007.
    • (2007) J Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    Van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 80
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
    • Rubartelli A and Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 28: 429-436, 2007.
    • (2007) Trends Immunol , vol.28 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 81
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5¢-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D, Carling D, Stout RD, Suttles J. Adenosine 5¢-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 181: 8633-8641, 2008.
    • (2008) J Immunol , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 82
    • 84923364836 scopus 로고    scopus 로고
    • MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity
    • Salama A, Fichou N, Allard M, et al. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS One 9: e106153, 2014.
    • (2014) PLoS One , vol.9 , pp. e106153
    • Salama, A.1    Fichou, N.2    Allard, M.3
  • 83
    • 0034192082 scopus 로고    scopus 로고
    • Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells
    • Sanz JM and Di Virgilio F. Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol 164: 4893-4898, 2000.
    • (2000) J Immunol , vol.164 , pp. 4893-4898
    • Sanz, J.M.1    Di Virgilio, F.2
  • 84
    • 84860361435 scopus 로고    scopus 로고
    • HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
    • Schiraldi M, Raucci A, Munoz LM, et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 209: 551-563, 2012.
    • (2012) J Exp Med , vol.209 , pp. 551-563
    • Schiraldi, M.1    Raucci, A.2    Munoz, L.M.3
  • 85
    • 84920134906 scopus 로고    scopus 로고
    • Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy
    • Shahzad K, Bock F, Dong W, et al. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy. Kidney Int 87: 74-84, 2015.
    • (2015) Kidney Int , vol.87 , pp. 74-84
    • Shahzad, K.1    Bock, F.2    Dong, W.3
  • 86
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi Y, Evans JE, Rock KL. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521, 2003.
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 87
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada K, Crother TR, Karlin J, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36: 401-414, 2012.
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1    Crother, T.R.2    Karlin, J.3
  • 88
    • 78249253033 scopus 로고    scopus 로고
    • Secondary necrosis: The natural outcome of the complete apoptotic program
    • Silva MT. Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett 584: 4491-4499, 2010.
    • (2010) FEBS Lett , vol.584 , pp. 4491-4499
    • Silva, M.T.1
  • 89
    • 33644985564 scopus 로고    scopus 로고
    • Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    • Sutterwala FS, Ogura Y, Szczepanik M, et al. Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24: 317-327, 2006.
    • (2006) Immunity , vol.24 , pp. 317-327
    • Sutterwala, F.S.1    Ogura, Y.2    Szczepanik, M.3
  • 90
    • 34548434775 scopus 로고    scopus 로고
    • Differential regulation of caspase-1 activation, pyroptosis, autophagy via Ipaf and ASC in Shigella-infected macrophages
    • Suzuki T, Franchi L, Toma C, et al. Differential regulation of caspase-1 activation, pyroptosis, autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 3: e111, 2007.
    • (2007) PLoS Pathog , vol.3 , pp. e111
    • Suzuki, T.1    Franchi, L.2    Toma, C.3
  • 91
    • 84884227563 scopus 로고    scopus 로고
    • TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice
    • Tai N, Wong FS, Wen L. TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice. J Immunol 191: 2926-2937, 2013.
    • (2013) J Immunol , vol.191 , pp. 2926-2937
    • Tai, N.1    Wong, F.S.2    Wen, L.3
  • 92
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha
    • Tannahill GM, Curtis AM, Adamik J, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature 496: 238-242, 2013.
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1    Curtis, A.M.2    Adamik, J.3
  • 93
    • 84874247282 scopus 로고    scopus 로고
    • Implication of inflammatory signaling pathways in obesity-induced insulin resistance
    • Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) 3: 181, 2012.
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 181
    • Tanti, J.F.1    Ceppo, F.2    Jager, J.3    Berthou, F.4
  • 95
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17: 179-188, 2011.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3
  • 97
    • 84866378556 scopus 로고    scopus 로고
    • Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
    • Venereau E, Casalgrandi M, Schiraldi M, et al. Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med 209: 1519-1528, 2012.
    • (2012) J Exp Med , vol.209 , pp. 1519-1528
    • Venereau, E.1    Casalgrandi, M.2    Schiraldi, M.3
  • 98
    • 78649333667 scopus 로고    scopus 로고
    • HMGB1: The missing link between diabetes mellitus and heart failure
    • Volz HC, Seidel C, Laohachewin D, et al. HMGB1: the missing link between diabetes mellitus and heart failure. Basic Res Cardiol 105: 805-820, 2010.
    • (2010) Basic Res Cardiol , vol.105 , pp. 805-820
    • Volz, H.C.1    Seidel, C.2    Laohachewin, D.3
  • 99
    • 31044456529 scopus 로고    scopus 로고
    • CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    • Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115-124, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 115-124
    • Weisberg, S.P.1    Hunter, D.2    Huber, R.3
  • 100
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12: 408-415, 2011.
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3
  • 101
    • 68149100523 scopus 로고    scopus 로고
    • NLRP3 (NALP3, cryopyrin) facilitates in vivo caspase-1 activation, necrosis, HMGB1 release via inflammasomedependent and-independent pathways
    • Willingham SB, Allen IC, Bergstralh DT, et al. NLRP3 (NALP3, cryopyrin) facilitates in vivo caspase-1 activation, necrosis, HMGB1 release via inflammasomedependent and-independent pathways. J Immunol 183: 2008-2015, 2009.
    • (2009) J Immunol , vol.183 , pp. 2008-2015
    • Willingham, S.B.1    Allen, I.C.2    Bergstralh, D.T.3
  • 103
    • 77449142258 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    • Yao D and Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 59: 249-255, 2010.
    • (2010) Diabetes , vol.59 , pp. 249-255
    • Yao, D.1    Brownlee, M.2
  • 104
    • 77349087078 scopus 로고    scopus 로고
    • SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
    • Yoshizaki T, Schenk S, Imamura T, et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 298: E419-E428, 2010.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E419-E428
    • Yoshizaki, T.1    Schenk, S.2    Imamura, T.3
  • 105
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11: 136-140, 2010.
    • (2010) Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 106
    • 77950366886 scopus 로고    scopus 로고
    • Decoding cell death signals in inflammation and immunity
    • Zitvogel L, Kepp O, Kroemer G. Decoding cell death signals in inflammation and immunity. Cell 140: 798-804, 2010.
    • (2010) Cell , vol.140 , pp. 798-804
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3


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