Immune activation by bacterial DNA: A new genetic code

Immunity

Volumn 5, Issue 4, 1996, Pages 303-310

  Pisetsky, David S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CYTOKINE; INTERFERON;

ANTIBODY RESPONSE; B LYMPHOCYTE; HUMAN; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0030273086     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80256-3     Document Type: Review

References (68)

1. Akhtar, S., and Juliano, R.L. (1992). Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell Biol. 2, 139-144.
2. Arnold, E.A., Yawn, D.H., Brown, D.G., Wyllie, R.C., and Coffey, D.S. (1972). Structural alteration in isolated liver nuclei after removal of template restriction by polyanions. J. Cell Biol. 53, 737-757.
3. Bennett, R.M. (1993). As nature intended? The uptake of DNA and oligonucleotides by eukaryotic cells. Antisense Res. Dev. 3, 235-241.
4. Bennett, R.M., Gabor, G.T., and Merritt, M.M. (1985). DNA binding to human leukocytes: evidence for a receptor-mediated association, internalization, and degradation of DNA. J. Clin. Invest. 76, 2182-2190.
5. Bird, A.P. (1987). CpG islands as gene markers in the vertebrate nucleus. Trends Genet. 3, 342-346.
6. Branda, R.F., Moore, A.L., Mathews, L., McCormack, J.J., and Zon, G. (1993). Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1. Biochem. Pharmacol. 45, 2037-2043.
7. Cowdery, J.S., Chace, J.H., Yi, A.-K., and Krieg, A.M. (1996). Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156, 4570-4575.
8. Diamond, B., Katz, J.B., Paul, E., Aranow, C., Lustgarten, D., and Scharff, M.D. (1992). The role of somatic mutation in the pathogenic anti-DNA response. Annu. Rev. Immunol. 10, 731-757.
9. Doerfler, W. (1991). Patterns of DNA methylation - evolutionary vestiges of foreign DNA inactivation as a host defense mechanism: a proposal. Biol. Chem. Hoppe Seyler 372, 557-564.
10. Emlen, W., Pisetsky, D.S., and Taylor, R.P. (1986). Antibodies to DNA: a perspective. Arthritis Rheum. 29, 1417-1426.
11. Field, A.K., Tytell, A.A., Lampson, G.P., and Hilleman, M.R. (1967). Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc. Natl. Acad. Sci. USA 58, 1004-1010.
12. Fredriksen, K., Skogsholm, A., Flaegstad, T., Traavik, T., and Rekvig, O.P. (1993). Antibodies to dsDNA are produced during primary BK virus infection in man, indicating that anti-dsDNA antibodies may be related to virus replication in vivo. Scand. J. Immunol. 38, 401-406.
13. Gilkeson, G.S., Grudier, J.P., and Pisetsky, D.S. (1989a). The antibody response of normal mice to immunization with single-stranded DNA of various species origin. Clin. Immunol. Immunopathol. 51, 362-371.
14. Gilkeson, G.S., Grudier, J.P., Karounos, D.G., and Pisetsky, D.S. (1989b). Induction of anti-dsDNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142, 1482-1486.
15. Gilkeson, G.S., Pritchard, A.J., and Pisetsky, D.S. (1991). Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Clin. Immunol. Immunopathol. 59, 288-300.
16. H CDR3 arginines. J. Immunol. 151, 1353-1364.
17. Gilkeson, G.S., Pippen, A.M.M., and Pisetsky, D.S. (1995). Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J. Clin. Invest. 95, 1398-1402.
18. Halpern, M.D., Kurlander, R.J., and Pisetsky, D.S. (1996). Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell. Immunol. 167, 72-78.
19. Hefeneider, S.H., McCoy, S.L., Morton, J.I., Bakke, A.C., Cornell, K.A., Brown, L.E., and Bennett, R.M. (1992). DNA binding to mouse cells is mediated by cell-surface molecules: the role of these DNA-binding molecules as target antigens in murine lupus. Lupus 1, 167-173.
20. Hergersberg, M. (1991). Biological aspects of cytosine methylation in eukaryotic cells. Experientia 47, 1171-1185.
21. Hovanessian, A.G. (1989). The double-stranded RNA-activated protein kinase induced by interferon: dsRNA-PK. J. Interferon Res. 9, 641-647.
22. Hovanessian, A.G., and Galabru, J. (1987). The double-stranded RNA-dependent protein kinase is also activated by heparin. Eur. J. Biochem. 167, 467-473.
23. Karounos, D.G., Grudier, J.P., and Pisetsky, D.S. (1988). Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus. J. Immunol. 140, 451-455.
24. Kimura, Y., Sonehara, K., Kuramoto, E., Makino, T., Yamamoto, S., Yamamoto, T., Kataoka, T., and Tokunaga, T. (1994). Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. J. Biochem. 116, 991-994.
25. Klinman, D.M., Yi, A.-K., Beaucage, S.L., Conover, J., and Krieg, A.M. (1996). CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ. Proc. Natl. Acad. Sci. USA 93, 2879-2883.
26. Krieg, A.M., Yi, A.-K., Matson, S., Waldschmidt, T.J., Bishop, G.A., Teasdale, R., Koretzky, G.A., and Klinman, D.M. (1995). CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549.
27. Krieger, M., and Herz, J. (1994). Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63, 601-637.
28. Kumar, A., Haque, J., Lacoste, J., Hiscott, J., and Williams, B.R.G. (1994). Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. USA 91, 6288-6292.
29. Lampson, G.P., Tytell, A.A., Field, A.K., Nemes, M.M., and Hilleman, M.R. (1967). Studies of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. Proc. Natl. Acad. Sci. USA 58, 782-789.
30. Mackworth-Young, C., and Schwartz, R.S. (1988). Autoantibodies to DNA. CRC Crit. Rev. Immunol. 8, 147-173.
31. Manche, L., Green, S.R., Schmedt, C., and Mathews, M.B. (1992). Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell. Biol. 12, 5238-5248.
32. Mashiba, H., Matsunaga, K., Tomoda, H., Furusawa, M., Jimi, S., and Tokunaga, T. (1988). In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG. Jpn. J. Med. Sci. Biol. 41, 197-202.
33. Messina, J.P., Gilkeson, G.S., and Pisetsky, D.S. (1991). Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147, 1759-1764.
34. Messina, J.P., Gilkeson, G.S., and Pisetsky, D.S. (1993). The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens. Cell. Immunol. 147, 148-157.
35. Mor, G., Klinman, D.M., Shapiro, S., Hagiwara, E., Sedegah, M., Norman, J.A., Hoffman, S.L., and Steinberg, A.D. (1995). Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J. Immunol. 155, 2039-2046.
36. Pardoll, D.M., and Beckerleg, A.M. (1995). Exposing the immunology of naked DNA vaccines. Immunity 3, 165-169.
37. Pearson, A.M., Rich, A., and Krieger, M. (1993). Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J. Biol. Chem. 268, 3546-3554.
38. Pisetsky, D.S. (1992). Anti-DNA antibodies in systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 18, 437-454.
39. Pisetsky, D.S. (1993). DNA vaccination: a clue to memory? Human Immunol. 38, 241-242.
40. Pisetsky, D.S., and Reich, C. (1993). Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. Mol. Biol. Rep. 18, 217-221.
41. Pisetsky, D.S., and Reich, C.F. (1994). Stimulation of murine lymphocyte proliferation by an oligonucleotide with antisense activity. Life Sci. 54, 101-107.
42. Radic, M.Z., and Weigert, M. (1994). Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12, 487-520.
43. Raz, E., Carson, D.A., Parker, S.E., Parr, T.B., Abai, A.M., Aichinger, G., Gromkowski, S.H., Singh, M., Lew, D., Yankauckas, M.A., Baird, S.M., and Rhodes, G.H. (1994). Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91, 9519-9523.
44. 1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl. Acad. Sci. USA 93, 5141-5145.
45. Robertson, C.R., Gilkeson, G.S., Ward, M.M., and Pisetsky, D.S. (1992). Patterns of heavy and light chain utilization in the antibody response to bacterial DNA in normal human subjects and patients with SLE. Clin. Immunol. Immunopathol. 62, 25-32.
46. Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M.-D., Silverman, G.J., Lotz, M., Carson, D.A., and Raz, E. (1996). Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354.
47. Sen, D., and Gilbert, W. (1991). The structure of telomeric DNA: DNA quadriplex formation. Curr. Opin. Struct. Biol. 1, 435-438.
48. Shimada, S., Yano, O., Inoue, H., Kuramoto, E., Fukuda, T., Yamamoto, H., Kataoka, T., and Tokunaga, T. (1985). Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors. J. Natl. Cancer Inst. 74, 681-688.
49. Smith, R.C., Bement, W.M., Dersch, M.A., Dworkin-Rastl, E., Dworkin, M.B., and Capco, D.G. (1990). Nonspecific effects of oligodeoxynucleotide injection in Xenopus oocytes: a reevaluation of previous D7 mRNA ablation experiments. Development 110, 769-779.
50. Stein, C.A., and Cheng, Y.-C. (1993). Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science 261, 1004-1012.
51. Tang, D.-c., DeVit, M., and Johnston, S.A. (1992). Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152-154.
52. Taniguchi, T. (1989). Regulation of interferon-β gene: structure and function of cis-elements and frans-acting factors. J. Interferon Res. 9, 633-640.
53. Terada, K., Okuhara, E., and Kawarada, Y. (1991). Antigen DNA isolated from immune complexes in plasma of patients with systemic lupus erythematosus hybridizes with the Escherichia coli lac Z gene. Clin. Exp. Immunol. 85, 66-69.
54. Tokunaga, T., Yamamoto, H., Shimada, S., Abe, H., Fukuda, T., Fujisawa, Y., Furutani, Y., Yano, O., Kataoka, T., Sudo, T., Makiguchi, N., and Suganuma, T. (1984). Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer lnst. 72, 955-962.
55. Tokunaga, T., Yano, O., Kuramoto, E., Kimura, Y., Yamamoto, T., Kataoka, T., and Yamamoto, S. (1992). Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36, 55-66.
56. Ulmer, J.B., Donnelly, J.J., Parker, S.E., Rhodes, G.H., Felgner, P.L., Dwarki, V.J., Gromkowski, S.H., Deck, R.R., DeWitt, C.M., Friedman, A., Hawe, L.A., Leander, K.R., Martinez, D., Perry, H.C., Shiver, J.W., Montgomery, D.L, and Liu, M.A. (1993). Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1748.
57. Visvanathan, K.V., and Goodbourn, S. (1989). Double-stranded RNA activates binding of NF-κB to an inducible element in the human β-interferon promoter. EMBO J. 8, 1129-1138.
58. Vlassov, V.V., Balakireva, L.A., and Yakubov, L.A. (1994). Transport of oligonucleotides across natural and model membranes. Biochim. Biophys. Acta 1197, 95-108.
59. Vogt, W., Rühl, H., Wagner, B., and Diamantstein, T. (1973). Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions. Eur. J. Immunol. 3, 493-496.
60. Wagner, R.W. (1994). Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333-335.
61. Williamson, J.R., Raghuraman, M.K., and Cech, T.R. (1989). Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell 59, 871-880.
62. Yakubov, L.A., Deeva, E.A., Zarytova, V.F., Ivanova, E.M., Ryte, A.S., Yurchenko, L.V., and Vlassov, V.V. (1989). Mechanism of oligonucleotide uptake by cells: involvement of specific receptors. Proc. Natl. Acad. Sci. USA 86, 6454-6458.
63. Yamamoto, S., Kuramoto, E., Shimada, S., and Tokunaga, T. (1988). In vitro augmentation of natural killer cell activity and production of interferon-α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG. Jpn. J. Cancer Res. 79, 866-873.
64. Yamamoto, S., Yamamoto, T., Kataoka, T., Kuramoto, E., Yano, O., and Tokunaga, T. (1992a). Unique palindromic sequences in synthetic oligonucleotides are required to induce INF and augment INF-mediated natural killer activity. J. Immunol. 148, 4072-4076.
65. Yamamoto, S., Yamamoto, T., Shimada, S., Kuramoto, E., Yano, O., Kataoka, T., and Tokunaga, T. (1992b). DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36, 983-997.
66. Yamamoto, T., Yamamoto, S., Kataoka, T., Komuro, K., Kohase, M., and Tokunaga, T. (1994). Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro. Jpn. J. Cancer Res. 85, 775-779.
67. Yi, A.-K., Chace, J.H., Cowdery, J.S., and Krieg, A.M. (1996). IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156, 558-564.
68. Zhao, Q., Temsamani, J., Iadarola, P.L., Jiang, Z., and Agrawal, S. (1996). Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem. Pharmacol. 51, 173-182.