Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

Journal of Leukocyte Biology

Volumn 96, Issue 6, 2014, Pages 1087-1100

  Honda, Hiroe ^a,b   Nagai, Yoshinori ^b,c   Matsunaga, Takayuki ^a   Okamoto, Naoki ^b,d   Watanabe, Yasuharu ^b   Tsuneyama, Koichi ^b   Hayashi, Hiroaki ^e   Fujii, Isao ^e   Ikutani, Masashi ^b   Hirai, Yoshikatsu ^b   Muraguchi, Atsushi ^b   Takatsu, Kiyoshi ^a,b  

^a Toyama Prefectural Institute for Pharmaceutical Research   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Teika Pharmaceutical Co Ltd   (Japan)

^e IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

AIM2; Caspase 1; Diabetes; Glycyrrhizin; IL 1; Obesity

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; ADENOSINE TRIPHOSPHATE; AGLYCONE; AMYLIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHOLESTEROL; CRYOPYRIN; GLIBENCLAMIDE; GLYCYRRHIZIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; ISOLIQUIRITIGENIN; LEPTIN; LIPID A; LIPOPOLYSACCHARIDE; LIQUIRITIGENIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NIGERICIN; PARTHENOLIDE; PROTEIN; REACTIVE OXYGEN METABOLITE; SULFONYLUREA; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; ANTIINFLAMMATORY AGENT; CARRIER PROTEIN; CHALCONE DERIVATIVE; CIAS1 PROTEIN, MOUSE; DNA BINDING PROTEIN;

ADIPOSE TISSUE; ADIPOSE TISSUE INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE ACTIVATION AND RECRUITEMENT DOMAIN; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; GENE EXPRESSION; GLYCYRRHIZA URALENSIS; HISTOLOGY; HORMONE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; INFLAMMATION; INFLAMMATORY CELL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPID HOMEOSTASIS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OLIGOMERIZATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GERMFREE ANIMAL; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRIER PROTEINS; CELL LINE, TUMOR; CHALCONES; DIET, HIGH-FAT; DNA-BINDING PROTEINS; GLYBURIDE; GLYCYRRHIZA URALENSIS; GLYCYRRHIZIC ACID; HUMANS; HYPERCHOLESTEROLEMIA; INFLAMMASOMES; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-1BETA; ISLET AMYLOID POLYPEPTIDE; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; OBESITY; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84914132421     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.3A0114-005RR     Document Type: Article

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