HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9

Atherosclerosis

Volumn 231, Issue 2, 2013, Pages 227-233

  Hirata, Yoichiro ^a,b   Kurobe, Hirotsugu ^a   Higashida, Mayuko ^a   Fukuda, Daiju ^a   Shimabukuro, Michio ^a   Tanaka, Kimie ^b   Higashikuni, Yasutomi ^b   Kitagawa, Tetsuya ^a   Sata, Masataka ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Atherosclerosis; HMGB1; Inflammation; Toll like receptor; Vascular remodeling

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GELATIN; HIGH MOBILITY GROUP B1 PROTEIN; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL INJURY; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HYDROGEL; IMMUNE RESPONSE; IN VITRO STUDY; MACROPHAGE; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; VASCULAR LESION; VASCULITIS; WILD TYPE;

ATHEROSCLEROSIS; HMGB1; INFLAMMATION; TOLL-LIKE RECEPTOR; VASCULAR REMODELING;

ANIMALS; ATHEROSCLEROSIS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL LINE; HMGB1 PROTEIN; INFLAMMATION; LIGANDS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOINTIMA; OLIGODEOXYRIBONUCLEOTIDES; TOLL-LIKE RECEPTOR 9;

EID: 84888087172     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.09.010     Document Type: Article

References (29)

1. Sata M., Saiura A., Kunisato A., et al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002, 8:403-409.
2. Weber C., Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011, 17:1410-1422.
3. Stott K., Tang G.S., Lee K.B., et al. Structure of a complex of tandem HMG boxes and DNA. JMol Biol 2006, 360:90-104.
4. Wang H., Bloom O., Zhang M., et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999, 285:248-251.
5. de Souza A.W., Westra J., Limburg P.C., et al. HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis. Autoimmun Rev 2012, 11:909-917.
6. Yanai H., Ban T., Wang Z., et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 2009, 462:99-103.
7. Kalinina N., Agrotis A., Antropova Y., et al. Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines. Arterioscler Thromb Vasc Biol 2004, 24:2320-2325.
8. Kanellakis P., Agrotis A., Kyaw T.S., et al. High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thromb Vasc Biol 2011, 31:313-319.
9. Biscetti F., Straface G., De Cristofaro R., et al. High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism. Diabetes 2010, 59:1496-1505.
10. Andrassy M., Volz H.C., Igwe J.C., et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008, 117:3216-3226.
11. Sims G.P., Rowe D.C., Rietdijk S.T., et al. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 2010, 28:367-388.
12. Kawai T., Akira S. TLR signaling. Semin Immunol 2007, 19:24-32.
13. Rouhiainen A., Imai S., Rauvala H., et al. Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation. Thromb Haemost 2000, 84:1087-1094.
14. Tian J., Avalos A.M., Mao S.Y., et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007, 8:487-496.
15. Ivanov S., Dragoi A.M., Wang X., et al. Anovel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood 2007, 110:1970-1981.
16. Bamboat Z.M., Balachandran V.P., Ocuin L.M., et al. Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury. Hepatology 2010, 51:621-632.
17. Tanaka K., Sata M., Hirata Y., et al. Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res 2003, 93:783-790.
18. Sata M., Maejima Y., Adachi F., et al. Amouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia. JMol Cell Cardiol 2000, 32:2097-2104.
19. Tabata Y., Ikada Y. Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 1999, 20:2169-2175.
20. Takaoka M., Nagata D., Kihara S., et al. Periadventitial adipose tissue plays a critical role in vascular remodeling. Circ Res 2009, 105:906-911.
21. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol Cell Biol 1999, 19:5237-5246.
22. Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195.
23. Bianchi M.E., Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007, 220:35-46.
24. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
25. Barton G.M., Kagan J.C., Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2006, 7:49-56.
26. Shishido T., Nozaki N., Takahashi H., et al. Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun 2006, 345:1446-1453.
27. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007, 7:179-190.
28. Yan Z.Q., Hansson G.K. Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 2007, 219:187-203.
29. Mann D.L. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res 2011, 108:1133-1145.