Adenosine is required for sustained inflammasome activation via the A 2A receptor and the HIF-1α pathway

Nature Communications

Volumn 4, Issue , 2013, Pages

  Ouyang, Xinshou ^a,b   Ghani, Ayaz ^a   Malik, Ahsan ^a   Wilder, Tuere ^c   Colegio, Oscar Rene ^d   Flavell, Richard Anthony ^d   Cronstein, Bruce Neil ^c   Mehal, Wajahat Zafar ^a,b  

^a YALE UNIVERSITY   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; CRYOPYRIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE;

DISEASE PREVALENCE; MOLECULAR ANALYSIS; POLYSACCHARIDE; SIGNALING;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME ACTIVATION; INFLAMMATION; LIVER INJURY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION;

EID: 84890932260     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3909     Document Type: Article

References (32)

1. Rock, K. L., Latz, E., Ontiveros, F. & Kono, H. The sterile inflammatory response. Annu. Rev. Immunol. 28, 321-342 (2010).
2. Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265 (2009).
3. Sanz, J. M. & Di Virgilio, F. Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J. Immunol. 164, 4893-4898 (2000). (Pubitemid 30238094)
4. McCall, C. E., Grosso-Wilmoth, L. M., LaRue, K., Guzman, R. N. & Cousart, S. L. Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome. J. Clin. Invest. 91, 853-861 (1993). (Pubitemid 23095259)
5. Biswas, S. K. & Lopez-Collazo, E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 30, 475-487 (2009).
6. Fujihara, M. et al. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol. Ther. 100, 171-194 (2003). (Pubitemid 37377912)
7. Costa-Junior, H. M. et al. ATP-induced apoptosis involves a Ca2\+independent phospholipase A2 and 5-lipoxygenase in macrophages. Prostaglandins. Other. Lipid. Mediat. 88, 51-61 (2009).
8. Jacobson, K. A. & Gao, Z. G. Adenosine receptors as therapeutic targets. Nat. Rev. Drug Discov. 5, 247-264 (2006). (Pubitemid 43336037)
9. Hasko, G. & Pacher, P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J. Leukoc. Biol. 83, 447-455 (2008). (Pubitemid 351966849)
10. Ohta, A. & Sitkovsky, M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414, 916-920 (2001). (Pubitemid 34024743)
11. Hasko, G., Linden, J., Cronstein, B. & Pacher, P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7, 759-770 (2008).
12. Bender, E. et al. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc. Natl Acad. Sci. USA 99, 8573-8578 (2002). (Pubitemid 34693603)
13. Franchi, L., Eigenbrod, T. & Nunez, G. Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J. Immunol. 183, 792-796 (2009).
14. Csoka, B. et al. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. Faseb J. 26, 376-386 (2012).
15. Sohail, M. A. et al. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology 49, 185-194 (2009).
16. Zhang, W. et al. Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J. Neuroimmunol. 174, 63-73 (2006).
17. Kvietikova, I., Wenger, R. H., Marti, H. H. & Gassmann, M. The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res. 23, 4542-4550 (1995). (Pubitemid 126003251)
18. Hu, C. J., Wang, L. Y., Chodosh, L. A., Keith, B. & Simon, M. C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell Biol. 23, 9361-9374 (2003). (Pubitemid 37499822)
19. Ahn, S. et al. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell Biol. 18, 967-977 (1998). (Pubitemid 28063431)
20. Roman, J., Ritzenthaler, J. D., Fenton, M. J., Roser, S. & Schuyler, W. Transcriptional regulation of the human interleukin 1beta gene by fibronectin: role of protein kinase C and activator protein 1 (AP-1). Cytokine 12, 1581-1596 (2000).
21. Hasko, G. et al. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol. 157, 4634-4640 (1996). (Pubitemid 126449386)
22. Nemeth, Z. H. et al. cDNA microarray analysis reveals a nuclear factor-kappaBindependent regulation of macrophage function by adenosine. J. Pharmacol. Exp. Ther. 306, 1042-1049 (2003). (Pubitemid 37025312)
23. Roth, S. et al. Concentrations of adenosine and its metabolites in the rat retina/choroid during reperfusion after ischemia. Curr. Eye Res. 16, 875-885 (1997). (Pubitemid 27410070)
24. Rodriguez-Nunez, A. et al. Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. J. Child. Neurol. 16, 704-706 (2001). (Pubitemid 32976398)
25. Malik, A. F. et al. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc. Natl Acad. Sci. USA 108, 20095-20100 (2011).
26. Watanabe, A. et al. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 46, 1509-1518 (2007). (Pubitemid 350155533)
27. Gasse, P. et al. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest. 117, 3786-3799 (2007). (Pubitemid 350224089)
28. Schulte, G. & Fredholm, B. B. Signalling from adenosine receptors to mitogenactivated protein kinases. Cell Signal. 15, 813-827 (2003). (Pubitemid 36776656)
29. De Ponti, C. et al. Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages. J. Leukoc. Biol. 82, 392-402 (2007). (Pubitemid 47230651)
30. Bauernfeind, F. G. et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791 (2009).
31. Lukashev, D., Ohta, A., Apasov, S., Chen, J. F. & Sitkovsky, M. Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs proteincoupled A2A adenosine receptor in vivo. J. Immunol. 173, 21-24 (2004). (Pubitemid 38797321)
32. Eltzschig, H. K., Sitkovsky, M. V. & Robson, S. C. Purinergic signaling during inflammation. N. Engl. J. Med. 367, 2322-2333 (2012).