NLRP3 (NALP3, cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways

Journal of Immunology

Volumn 183, Issue 3, 2009, Pages 2008-2015

  Willingham, Stephen B ^a   Allen, Irving C ^a   Bergstralh, Daniel T ^a   Brickey, Willie June ^b   Huang, Max Tze Han ^a   Taxman, Debra J ^b   Duncan, Joseph A ^b   Ting, Jenny P Y ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN; PROTEIN ASC; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOSKELETON PROTEIN; PYCARD PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; IMMUNE RESPONSE; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; MOLECULAR DYNAMICS; MONOCYTE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM; ANIMAL; DISEASE MODEL; INFLAMMATION; KLEBSIELLA; MACROPHAGE; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; NECROSIS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; HMGB1 PROTEIN; INFLAMMATION; INTERLEUKIN-1BETA; KLEBSIELLA; MACROPHAGES; MICE; MICE, KNOCKOUT; NECROSIS; PNEUMONIA;

EID: 68149100523     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900138     Document Type: Article

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