Purinergic receptors in psychiatric disorders

Neuropharmacology

Volumn 104, Issue , 2016, Pages 212-225

  Krügel, Ute ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Adenosine; ATP; Dopamine; GABA; Glutamate; Major depression; Mood; Purine receptors; Schizophrenia; Sensitization

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X5 RECEPTOR; PURINERGIC P2X6 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE TRIPHOSPHATE;

ASTROCYTE; DISEASE COURSE; GLIA CELL; HUMAN; LIMBIC SYSTEM; MAJOR DEPRESSION; NERVE CELL; NEUROMODULATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SCHIZOPHRENIA; SENSITIZATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANTIA NIGRA; ANIMAL; BRAIN; DISEASE MODEL; MENTAL DISEASE; METABOLISM;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; HUMANS; MENTAL DISORDERS; RECEPTORS, PURINERGIC; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 84947966694     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.10.032     Document Type: Review

References (233)

1. M.P. Abbracchio, G. Burnstock, A. Verkhratsky, and H. Zimmermann Purinergic signalling in the nervous system: an overview Trends Neurosci. 32 2009 19 29
2. C. Agulhon, J. Petravicz, A.B. McMullen, E.J. Sweger, S.K. Minton, S.R. Taves, K.B. Casper, T.A. Fiacco, and K.D. McCarthy What is the role of astrocyte calcium in neurophysiology? Neuron 59 2008 932 946
3. S. Akhondzadeh, E. Shasavand, H. Jamilian, O. Shabestari, and A. Kamalipour Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactions J. Clin. Pharm. Ther. 25 2000 131 137
4. E. Aliagas, I. Villar-Menendez, J. Sevigny, M. Roca, M. Romeu, I. Ferrer, M. Martin-Satue, and M. Barrachina Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis" Purinergic Signal 9 2013 599 608
5. C.M. Anderson, and R.A. Swanson Astrocyte glutamate transport: review of properties, regulation, and physiological functions Glia 32 2000 1 14
6. A. Araque, G. Carmignoto, P.G. Haydon, S.H. Oliet, R. Robitaille, and A. Volterra Gliotransmitters travel in time and space Neuron 81 2014 728 739
7. A.F. Arnsten Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia Int. J. Dev. Neurosci. 29 2011 215 223
8. A.F. Arnsten, M. Wang, and C.D. Paspalas Dopamine's actions in primate prefrontal cortex: challenges for treating cognitive disorders Pharmacol. Rev. 67 2015 681 696
9. K. Azdad, D. Gall, A.S. Woods, C. Ledent, S. Ferre, and S.N. Schiffmann Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization Neuropsychopharmacology 34 2009 972 986
10. L. Backlund, P. Nikamo, D.S. Hukic, I.R. Ek, L. Traskman-Bendz, M. Landen, G. Edman, M. Schalling, L. Frisen, and U. Osby Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder Bipolar Disord. 13 2011 500 508
11. B.A. Baldo, G.F. Koob, and A. Markou Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats J. Neurosci. 19 1999 11017 11026
12. O. Barret, J. Hannestad, C. Vala, D. Alagille, A. Tavares, M. Laruelle, D. Jennings, K. Marek, D. Russell, J. Seibyl, and G. Tamagnan Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptors J. Nucl. Med. 56 2015 586 591
13. A.M. Basso, N.A. Bratcher, R.R. Harris, M.F. Jarvis, M.W. Decker, and L.E. Rueter Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders Behav. Brain Res. 198 2009 83 90
14. E. Bastia, Y.H. Xu, A.C. Scibelli, Y.J. Day, J. Linden, J.F. Chen, and M.A. Schwarzschild A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization Neuropsychopharmacology 30 2005 891 900
15. V.L. Batalha, J.M. Pego, B.M. Fontinha, A.R. Costenla, J.S. Valadas, Y. Baqi, H. Radjainia, C.E. Muller, A.M. Sebastiao, and L.V. Lopes Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation Mol. Psychiatry 18 2013 320 331
16. I.E. Bauer, M.C. Pascoe, B. Wollenhaupt-Aguiar, F. Kapczinski, and J.C. Soares Inflammatory mediators of cognitive impairment in bipolar disorder J. Psychiatr. Res. 56 2014 18 27
17. M.R. Bennett Synaptic P2X7 receptor regenerative-loop hypothesis for depression Aust. N. Z. J. Psychiatry 41 2007 563 571
18. M.V. Bennett, J.M. Garre, J.A. Orellana, F.F. Bukauskas, M. Nedergaard, and J.C. Saez Connexin and pannexin hemichannels in inflammatory responses of glia and neurons Brain Res. 1487 2012 3 15
19. H.G. Bernstein, J. Steiner, P.C. Guest, H. Dobrowolny, and B. Bogerts Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy Schizophr. Res. 161 2015 4 18
20. K.C. Berridge, and M.L. Kringelbach Pleasure systems in the brain Neuron 86 2015 646 664
21. M.J. Besson, A.M. Graybiel, and B. Quinn Co-expression of neuropeptides in the cat's striatum: an immunohistochemical study of substance P, dynorphin B and enkephalin Neuroscience 39 1990 33 58
22. P. Bodin, and G. Burnstock Purinergic signalling: ATP release Neurochem. Res. 26 2001 959 969
23. D. Boison, and E. Aronica Comorbidities in Neurology: Is adenosine the common link? Neuropharmacology 97 2015 18 34
24. D. Boison, P. Singer, H.Y. Shen, J. Feldon, and B.K. Yee Adenosine hypothesis of schizophrenia-opportunities for pharmacotherapy Neuropharmacology 62 2012 1527 1543
25. A.A. Boucher, J.C. Arnold, G.E. Hunt, A. Spiro, J. Spencer, C. Brown, I.S. McGregor, M.R. Bennett, and M. Kassiou Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test Neuroscience 189 2011 170 177
26. D.N. Bowser, and B.S. Khakh Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes J. Gen. Physiol. 129 2007 485 491
27. K. Brebner, T.P. Wong, L. Liu, Y. Liu, P. Campsall, S. Gray, L. Phelps, A.G. Phillips, and Y.T. Wang Nucleus accumbens long-term depression and the expression of behavioral sensitization Science 310 2005 1340 1343
28. G. Burnstock, U. Krügel, M.P. Abbracchio, and P. Illes Purinergic signalling: from normal behaviour to pathological brain function Prog. Neurobiol. 95 2011 229 274
29. X. Cao, L.P. Li, Q. Wang, Q. Wu, H.H. Hu, M. Zhang, Y.Y. Fang, J. Zhang, S.J. Li, W.C. Xiong, H.C. Yan, Y.B. Gao, J.H. Liu, X.W. Li, L.R. Sun, Y.N. Zeng, X.H. Zhu, and T.M. Gao Astrocyte-derived ATP modulates depressive-like behaviors Nat. Med. 19 2013 773 777
30. S. Cappelletti, P. Daria, G. Sani, and M. Aromatario Caffeine: cognitive and physical performance Enhancer or psychoactive drug? Curr. Neuropharmacol. 13 2015 71 88
31. O. Cauli, A. Pinna, V. Valentini, and M. Morelli Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release Neuropsychopharmacology 28 2003 1752 1759
32. V. Chavan, J. Willis, S.K. Walker, H.R. Clark, X. Liu, M.A. Fox, S. Srivastava, and K. Mukherjee Central presynaptic terminals are enriched in ATP but the majority lack mitochondria PLoS One 10 2015 e0125185
33. J.F. Chen Adenosine receptor control of cognition in normal and disease Int. Rev. Neurobiol. 119 2014 257 307
34. J.F. Chen, C.F. Lee, and Y. Chern Adenosine receptor neurobiology: overview Int. Rev. Neurobiol. 119 2014 1 49
35. J.F. Chen, R. Moratalla, F. Impagnatiello, D.K. Grandy, B. Cuellar, M. Rubinstein, M.A. Beilstein, E. Hackett, J.S. Fink, M.J. Low, E. Ongini, and M.A. Schwarzschild The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 receptor knockout mice Proc. Natl. Acad. Sci. U. S. A. 98 2001 1970 1975
36. J.F. Chen, P.K. Sonsalla, F. Pedata, A. Melani, M.R. Domenici, P. Popoli, J. Geiger, L.V. Lopes, and M.A. de Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation Prog. Neurobiol. 83 2007 310 331
37. I.P. Chessell, J.P. Hatcher, C. Bountra, A.D. Michel, J.P. Hughes, P. Green, J. Egerton, M. Murfin, J. Richardson, W.L. Peck, C.B. Grahames, M.A. Casula, Y. Yiangou, R. Birch, P. Anand, and G.N. Buell Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain Pain 114 2005 386 396
38. R. Chesworth, R.M. Brown, J.H. Kim, C. Ledent, and A.J. Lawrence Adenosine 2A receptors modulate reward behaviours for methamphetamine Addict. Biol. 2015 10.1111/adb.12225 (in press)
39. G.S. Chiu, and G.G. Freund Modulation of neuroimmunity by adenosine and its receptors: metabolism to mental illness Metabolism 63 2014 1491 1498
40. Y. Chudasama Animal models of prefrontal-executive function Behav. Neurosci. 125 2011 327 343
41. F. Ciruela, V. Casado, R.J. Rodrigues, R. Lujan, J. Burgueno, M. Canals, J. Borycz, N. Rebola, S.R. Goldberg, J. Mallol, A. Cortes, E.I. Canela, J.F. Lopez-Gimenez, G. Milligan, C. Lluis, R.A. Cunha, S. Ferre, and R. Franco Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers J. Neurosci. 26 2006 2080 2087
42. S. Cristovao-Ferreira, G. Navarro, M. Brugarolas, K. Perez-Capote, S.H. Vaz, G. Fattorini, F. Conti, C. Lluis, J.A. Ribeiro, P.J. McCormick, V. Casado, R. Franco, and A.M. Sebastiao A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes Purinergic Signal 9 2013 433 449
43. C. Csölle, R.D. Ando, A. Kittel, F. Goloncser, M. Baranyi, K. Soproni, D. Zelena, J. Haller, T. Nemeth, A. Mocsai, and B. Sperlagh The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice Int. J. Neuropsychopharmacol. 16 2013 213 233
44. C. Csölle, M. Baranyi, G. Zsilla, A. Kittel, F. Goloncser, P. Illes, E. Papp, E.S. Vizi, and B. Sperlagh Neurochemical changes in the mouse Hippocampus Underlying the antidepressant effect of genetic deletion of P2X7 receptors PLoS One 8 2013 e66547
45. G.M. Cunha, P.M. Canas, C.R. Oliveira, and R.A. Cunha Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress Neuroscience 141 2006 1775 1781
46. R.A. Cunha, and P.M. Agostinho Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline J. Alzheimers Dis. 20 Suppl. 1 2010 S95 S116
47. R.A. Cunha, S. Ferre, J.M. Vaugeois, and J.F. Chen Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders Curr. Pharm. Des. 14 2008 1512 1524
48. S.R. Dager, S.D. Friedman, A. Parow, C. Demopulos, A.L. Stoll, I.K. Lyoo, D.L. Dunner, and P.F. Renshaw Brain metabolic alterations in medication-free patients with bipolar disorder Arch. Gen. Psychiatry 61 2004 450 458
49. S. Dallaspezia, and F. Benedetti Sleep deprivation therapy for depression Curr. Top. Behav. Neurosci. 25 2015 483 502
50. E. Dare, G. Schulte, O. Karovic, C. Hammarberg, and B.B. Fredholm Modulation of glial cell functions by adenosine receptors Physiol. Behav. 92 2007 15 20
51. D. De Berardis, S. Marini, N. Serroni, G. Rapini, F. Iasevoli, A. Valchera, M. Signorelli, E. Aguglia, G. Perna, A. Salone, I.G. Di, G. Martinotti, and G.M. Di S-Adenosyl-L-Methionine augmentation in patients with stage II treatment-resistant major depressive disorder: an open label, fixed dose, single-blind study ScientificWorldJournal 2013 2013 204649
52. A. de Mendonca, A.M. Sebastiao, and J.A. Ribeiro Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation Neuroreport 6 1995 1097 1100
53. J. Deckert, M. Brenner, N. Durany, R. Zochling, W. Paulus, G. Ransmayr, T. Tatschner, W. Danielczyk, K. Jellinger, and P. Riederer Up-regulation of striatal adenosine A(2A) receptors in schizophrenia Neuroreport 14 2003 313 316
54. J. Deckert, M.M. Nothen, S.P. Bryant, S. Schuffenhauer, P.R. Schofield, N.K. Spurr, and P. Propping Mapping of the human adenosine A2a receptor gene: relationship to potential schizophrenia loci on chromosome 22q and exclusion from the CATCH 22 region Hum. Genet. 99 1997 326 328
55. R.F. Deicken, M.P. Pegues, S. Anzalone, R. Feiwell, and B. Soher Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder Am. J. Psychiatry 160 2003 873 882
56. J.M. Deniau, P. Mailly, N. Maurice, and S. Charpier The pars reticulata of the substantia nigra: a window to basal ganglia output Prog. Brain Res. 160 2007 151 172
57. F. Di Virgilio P2X receptors and inflammation Curr. Med. Chem. 22 2015 866 877
58. R.B. Dias, D.M. Rombo, J.A. Ribeiro, J.M. Henley, and A.M. Sebastiao Adenosine: setting the stage for plasticity Trends Neurosci. 36 2013 248 257
59. Y. Dou, H.J. Wu, H.Q. Li, S. Qin, Y.E. Wang, J. Li, H.F. Lou, Z. Chen, X.M. Li, Q.M. Luo, and S. Duan Microglial migration mediated by ATP-induced ATP release from lysosomes Cell Res. 22 2012 1022 1033
60. T.V. Dunwiddie, and S.A. Masino The role and regulation of adenosine in the central nervous system Annu. Rev. Neurosci. 24 2001 31 55
61. G.P. Dutra, G.L. Ottoni, D.R. Lara, and M.R. Bogo Lower frequency of the low activity adenosine deaminase allelic variant (ADA1∗2) in schizophrenic patients Rev. Bras. Psiquiatr. 32 2010 275 278
62. M. El Yacoubi, J. Costentin, and J.M. Vaugeois Adenosine A2A receptors and depression Neurology 61 2003 S82 S87
63. D. Elmenhorst, R. Basheer, R.W. McCarley, and A. Bauer Sleep deprivation increases A(1) adenosine receptor density in the rat brain Brain Res. 1258 2009 53 58
64. L. Erb, and G.A. Weisman Coupling of P2Y receptors to G proteins and other signaling pathways Wiley Interdiscip. Rev. Membr. Transp. Signal 1 2012 789 803
65. A. Erhardt, S. Lucae, P.G. Unschuld, M. Ising, N. Kern, D. Salyakina, R. Lieb, M. Uhr, E.B. Binder, M.E. Keck, B. Muller-Myhsok, and F. Holsboer Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders J. Affect Disord. 101 2007 159 168
66. S. Ferre Adenosine-dopamine interactions in the ventral striatum. Implications for the treatment of schizophrenia Psychopharmacol. Berl. 133 1997 107 120
67. S. Ferre, F. Ciruela, C. Quiroz, R. Lujan, P. Popoli, R.A. Cunha, L.F. Agnati, K. Fuxe, A.S. Woods, C. Lluis, and R. Franco Adenosine receptor heteromers and their integrative role in striatal function ScientificWorldJournal 7 2007 74 85
68. S. Ferre, I. Diamond, S.R. Goldberg, L. Yao, S.M. Hourani, Z.L. Huang, Y. Urade, and I. Kitchen Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain Prog. Neurobiol. 83 2007 332 347
69. S. Ferre, B.B. Fredholm, M. Morelli, P. Popoli, and K. Fuxe Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia Trends Neurosci. 20 1997 482 487
70. R.D. Fields Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron-glia signaling Semin. Cell Dev. Biol. 22 2011 214 219
71. R.D. Fields, and G. Burnstock Purinergic signalling in neuron-glia interactions Nat. Rev. Neurosci. 7 2006 423 436
72. M. Filip, M. Frankowska, M. Zaniewska, E. Przegalinski, C.E. Muller, L. Agnati, R. Franco, D.C. Roberts, and K. Fuxe Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine Brain Res. 1077 2006 67 80
73. W. Fischer, and U. Krügel P2Y receptors: focus on structural, pharmacological and functional aspects in the brain Curr. Med. Chem. 14 2007 2429 2455
74. H. Franke, and P. Illes Involvement of P2 receptors in the growth and survival of neurons in the CNS Pharmacol. Ther. 109 2006 297 324
75. H. Franke, H. Kittner, J. Grosche, and P. Illes Enhanced P2Y1 receptor expression in the brain after sensitisation with d-amphetamine Psychopharmacol. Berl. 167 2003 187 194
76. B.B. Fredholm Rethinking the purinergic neuron-glia connection Proc. Natl. Acad. Sci. U. S. A. 109 2012 5913 5914
77. B.B. Fredholm, J.F. Chen, R.A. Cunha, P. Svenningsson, and J.M. Vaugeois Adenosine and brain function Int. Rev. Neurobiol. 63 2005 191 270
78. B.B. Fredholm, A.P. IJzerman, K.A. Jacobson, J. Linden, and C.E. Muller International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors - an update Pharmacol. Rev. 63 2011 1 34
79. T. Fujita, M.J. Chen, B. Li, N.A. Smith, W. Peng, W. Sun, M.J. Toner, B.T. Kress, L. Wang, A. Benraiss, T. Takano, S. Wang, and M. Nedergaard Neuronal transgene expression in dominant-negative SNARE mice J. Neurosci. 34 2014 16594 16604
80. K. Fuxe, L.F. Agnati, and D.O. Borroto-Escuela The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity Expert Rev. Neurother. 14 2014 719 721
81. K. Fuxe, S. Ferre, S. Genedani, R. Franco, and L.F. Agnati Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function Physiol. Behav. 92 2007 210 217
82. J. George, F.Q. Goncalves, G. Cristovao, L. Rodrigues, J.R. Meyer Fernandes, T. Goncalves, R.A. Cunha, and C.A. Gomes Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism Glia 63 2015 1636 1645
83. G. Gonzalez-Burgos, and D.A. Lewis GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia Schizophr. Bull. 34 2008 944 961
84. L. Gotoh, H. Mitsuyasu, Y. Kobayashi, N. Oribe, A. Takata, H. Ninomiya, V.P. Stanton Jr., G.M. Springett, H. Kawasaki, and S. Kanba Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population Psychiatr. Genet. 19 2009 328 335
85. F.G. Graeff, and H. Zangrossi Jr. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders Cent. Nerv. Syst. Agents Med. Chem. 10 2010 207 217
86. T.A. Green, and S. Schenk Dopaminergic mechanism for caffeine-produced cocaine seeking in rats Neuropsychopharmacology 26 2002 422 430
87. R.W. Greene, and H.L. Haas The electrophysiology of adenosine in the mammalian central nervous system Prog. Neurobiol. 36 1991 329 341
88. S.J. Guzman, H. Schmidt, H. Franke, U. Krügel, J. Eilers, P. Illes, and Z. Gerevich P2Y1 receptors inhibit long-term depression in the prefrontal cortex Neuropharmacology 59 2010 406 415
89. M.M. Halassa, and P.G. Haydon Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior Annu. Rev. Physiol. 72 2010 335 355
90. N.B. Hamilton, and D. Attwell Do astrocytes really exocytose neurotransmitters? Nat. Rev. Neurosci. 11 2010 227 238
91. J. Hannestad, N. DellaGioia, and M. Bloch The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis Neuropsychopharmacology 36 2011 2452 2459
92. C.J. Harmer, G.M. Goodwin, and P.J. Cowen Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action Br. J. Psychiatry 195 2009 102 108
93. J.J. Harris, R. Jolivet, and D. Attwell Synaptic energy use and supply Neuron 75 2012 762 777
94. K. Hejjas, A. Szekely, E. Domotor, Z. Halmai, G. Balogh, B. Schilling, A. Sarosi, G. Faludi, M. Sasvari-Szekely, and Z. Nemoda Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B 2009 295 299
95. U.M. Hemmeter, J. Hemmeter-Spernal, and J.C. Krieg Sleep deprivation in depression Expert Rev. Neurother. 10 2010 1101 1115
96. M.J. Higley, and B.L. Sabatini Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors Nat. Neurosci. 13 2010 958 966
97. D.J. Hines, and P.G. Haydon Astrocytic adenosine: from synapses to psychiatric disorders Philos. Trans. R. Soc. Lond B Biol. Sci. 369 2014 20130594
98. D.J. Hines, L.I. Schmitt, R.M. Hines, S.J. Moss, and P.G. Haydon Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling Transl. Psychiatry 3 2013 e212
99. T. Hirota, and T. Kishi Adenosine hypothesis in schizophrenia and bipolar disorder: a systematic review and meta-analysis of randomized controlled trial of adjuvant purinergic modulators Schizophr. Res. 149 2013 88 95
100. R.A. Hodgson, R. Bertorelli, G.B. Varty, J.E. Lachowicz, A. Forlani, S. Fredduzzi, M.E. Cohen-Williams, G.A. Higgins, F. Impagnatiello, E. Nicolussi, L.E. Parra, C. Foster, Y. Zhai, B.R. Neustadt, A.W. Stamford, E.M. Parker, A. Reggiani, and J.C. Hunter Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e ][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression J. Pharmacol. Exp. Ther. 330 2009 294 303
101. C. Hohoff, V. Garibotto, D. Elmenhorst, A. Baffa, T. Kroll, A. Hoffmann, K. Schwarte, W. Zhang, V. Arolt, J. Deckert, and A. Bauer Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain Neuropsychopharmacology 39 2014 2989 2999
102. C.J. Hong, H.C. Liu, T.Y. Liu, D.L. Liao, and S.J. Tsai Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson's disease and schizophrenia J. Neural Transm. 112 2005 1503 1510
103. M.A. Horowitz, and P.A. Zunszain Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin Ann. N. Y. Acad. Sci. 1351 2015 68 79
104. H. Houchi, W. Persyn, R. Legastelois, and M. Naassila The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals Addict. Biol. 18 2013 812 825
105. H. Houchi, V. Warnault, E. Barbier, C. Dubois, O. Pierrefiche, C. Ledent, M. Daoust, and M. Naassila Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice Genes Brain Behav. 7 2008 887 898
106. C.W. Hsu, C.S. Wang, and T.H. Chiu Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice J. Biomed. Sci. 17 2010 4
107. Z. Hu, C.I. Lee, J.Y. Han, E.H. Oh, J.H. Ryu, J.T. Hong, Y. Kim, and K.W. Oh Caffeine induces behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript peptides in mice Behav. Pharmacol. 25 2014 32 43
108. Y. Imura, Y. Morizawa, R. Komatsu, K. Shibata, Y. Shinozaki, H. Kasai, K. Moriishi, Y. Moriyama, and S. Koizumi Microglia release ATP by exocytosis Glia 61 2013 1320 1330
109. K. Inoue, S. Koizumi, and S. Ueno Implication of ATP receptors in brain functions Prog. Neurobiol. 50 1996 483 492
110. P.N. Jayakumar, B.N. Gangadhar, G. Venkatasubramanian, S. Desai, L. Velayudhan, D. Subbakrishna, and M.S. Keshavan High energy phosphate abnormalities normalize after antipsychotic treatment in schizophrenia: a longitudinal 31P MRS study of basal ganglia Psychiatry Res. 181 2010 237 240
111. M.P. Kaster, N.J. Machado, H.B. Silva, A. Nunes, A.P. Ardais, M. Santana, Y. Baqi, C.E. Muller, A.L. Rodrigues, L.O. Porciuncula, J.F. Chen, A.R. Tome, P. Agostinho, P.M. Canas, and R.A. Cunha Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress Proc. Natl. Acad. Sci. U. S. A. 112 2015 7833 7838
112. K.A. Kavanagh, D.C. Schreiner, S.C. Levis, C.E. O'Neill, and R.K. Bachtell Role of adenosine receptor subtypes in methamphetamine reward and reinforcement Neuropharmacology 89 2015 265 273
113. B.S. Khakh, D. Gittermann, D.A. Cockayne, and A. Jones ATP modulation of excitatory synapses onto interneurons J. Neurosci. 23 2003 7426 7437
114. G.M. Khandaker, and R. Dantzer Is there a role for immune-to-brain communication in schizophrenia? Psychopharmacol. Berl. 2015 10.1007/s00213-015-3975-1
115. H. Kittner, H. Franke, W. Fischer, N. Schultheis, U. Krügel, and P. Illes Stimulation of P2Y1 receptors causes anxiolytic-like effects in the rat elevated plus-maze: implications for the involvement of P2Y1 receptor-mediated nitric oxide production Neuropsychopharmacology 28 2003 435 444
116. H. Kittner, U. Krügel, E. Hoffmann, and P. Illes Effects of intra-accumbens injection of 2-methylthio ATP: a combined open field and electroencephalographic study in rats Psychopharmacol. Berl. 150 2000 123 131
117. H. Kittner, U. Krügel, and P. Illes The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural senstization caused by repeated amphetamine injections in rats Neuroscience 102 2001 241 243
118. C.M. Knapp, M.M. Foye, N. Cottam, D.A. Ciraulo, and C. Kornetsky Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration Pharmacol. Biochem. Behav. 68 2001 797 803
119. H. Koch, A. Bespalov, K. Drescher, H. Franke, and U. Krugel Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex Neuropsychopharmacology 40 2015 305 314
120. S. Koizumi Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes FEBS J. 277 2010 286 292
121. R. Kongsui, S.B. Beynon, S.J. Johnson, J. Mayhew, P. Kuter, M. Nilsson, and F.R. Walker Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: a cumulative threshold spectra analysis Brain Behav. Immun. 42 2014 69 80
122. U. Krügel, H. Kittner, H. Franke, and P. Illes Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo Neuropharmacology 40 2001 1084 1093
123. U. Krügel, H. Kittner, and P. Illes Adenosine 5'-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo Neurosci. Lett. 265 1999 49 52
124. J.H. Krystal, E.B. Perry Jr., R. Gueorguieva, A. Belger, S.H. Madonick, A. Abi-Dargham, T.B. Cooper, L. Macdougall, W. Abi-Saab, and D.C. D'Souza Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function Arch. Gen. Psychiatry 62 2005 985 994
125. A. Kurumaji, and M. Toru An increase in [3H] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics Brain Res. 808 1998 320 323
126. U. Lalo, O. Palygin, S. Rasooli-Nejad, J. Andrew, P.G. Haydon, and Y. Pankratov Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex PLoS Biol. 12 2014 e1001747
127. D. Langer, K. Hammer, P. Koszalka, J. Schrader, S. Robson, and H. Zimmermann Distribution of ectonucleotidases in the rodent brain revisited Cell Tissue Res. 334 2008 199 217
128. D.R. Lara, O. Pinto, K. Akiskal, and H.S. Akiskal Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications J. Affect Disord. 94 2006 67 87
129. D. Lindberg, D. Shan, J. Ayers-Ringler, A. Oliveros, J. Benitez, M. Prieto, R. McCullumsmith, and D.S. Choi Purinergic signaling and energy homeostasis in psychiatric disorders Curr. Mol. Med. 15 2015 275 295
130. J. Listos, S. Talarek, and S. Fidecka Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice Eur. J. Pharmacol. 588 2008 72 77
131. D. Lovatt, Q. Xu, W. Liu, T. Takano, N.A. Smith, J. Schnermann, K. Tieu, and M. Nedergaard Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity Proc. Natl. Acad. Sci. U. S. A. 109 2012 6265 6270
132. S. Lucae, D. Salyakina, N. Barden, M. Harvey, B. Gagne, M. Labbe, E.B. Binder, M. Uhr, M. Paez-Pereda, I. Sillaber, M. Ising, T. Bruckl, R. Lieb, F. Holsboer, and B. Muller-Myhsok P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder Hum. Mol. Genet. 15 2006 2438 2445
133. M. Lucas, F. Mirzaei, A. Pan, O.I. Okereke, W.C. Willett, E.J. O'Reilly, K. Koenen, and A. Ascherio Coffee, caffeine, and risk of depression among women Arch. Intern Med. 171 2011 1571 1578
134. J. Luthardt, S.J. Borvendeg, B. Sperlagh, W. Poelchen, K. Wirkner, and P. Illes P2Y1 receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex Neurochem. Int. 42 2003 161 172
135. M. Ma, Q. Ren, J.C. Zhang, and K. Hashimoto Effects of brilliant blue g on serum tumor necrosis factor-alpha levels and depression-like behavior in mice after lipopolysaccharide administration Clin. Psychopharmacol. Neurosci. 12 2014 31 36
136. R. Machado-Vieira, and C.A. Zarate Jr. Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments Depress Anxiety 28 2011 267 281
137. M. Maes The immunoregulatory effects of antidepressants Hum. Psychopharmacol. 16 2001 95 103
138. K. Martinowich, and B. Lu Interaction between BDNF and serotonin: role in mood disorders Neuropsychopharmacology 33 2008 73 83
139. M. Masin, C. Young, K. Lim, S.J. Barnes, X.J. Xu, V. Marschall, W. Brutkowski, E.R. Mooney, D.C. Gorecki, and R. Murrell-Lagnado Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts Br. J. Pharmacol. 165 2012 978 993
140. M. Matos, E. Augusto, A.D. Santos-Rodrigues, M.A. Schwarzschild, J.F. Chen, R.A. Cunha, and P. Agostinho Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes Glia 60 2012 702 716
141. M. Matos, H.Y. Shen, E. Augusto, Y. Wang, C.J. Wei, Y.T. Wang, P. Agostinho, D. Boison, R.A. Cunha, and J.F. Chen Deletion of adenosine a receptors from astrocytes Disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia Biol. Psychiatry 2015 10.1016/j.biopsych.2015.02.026 (in press)
142. C. Matute, M. Melone, A. Vallejo-Illarramendi, and F. Conti Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics Glia 49 2005 451 455
143. C.E. May, H.L. Haun, and W.C. Griffin III Sensitization and tolerance following repeated exposure to caffeine and alcohol in mice Alcohol Clin. Exp. Res. 39 2015 1443 1452
144. B.S. McEwen Physiology and neurobiology of stress and adaptation: central role of the brain Physiol. Rev. 87 2007 873 904
145. A. McQuillin, N.J. Bass, K. Choudhury, V. Puri, M. Kosmin, J. Lawrence, D. Curtis, and H.M. Gurling Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders Mol. Psychiatry 14 2009 614 620
146. M. Melone, L. Vitellaro-Zuccarello, A. Vallejo-Illarramendi, A. Perez-Samartin, C. Matute, A. Cozzi, D.E. Pellegrini-Giampietro, J.D. Rothstein, and F. Conti The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine Mol. Psychiatry 6 2001 380 386
147. J.J. Miguel-Hidalgo, B.A. Wilson, S. Hussain, A. Meshram, G. Rajkowska, and C.A. Stockmeier Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression J. Psychiatr. Res. 55 2014 101 109
148. S. Mingote, L. Font, A.M. Farrar, R. Vontell, L.T. Worden, C.M. Stopper, R.G. Port, K.S. Sink, J.G. Bunce, J.J. Chrobak, and J.D. Salamone Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway J. Neurosci. 28 2008 9037 9046
149. T.R. Minor, and T.C. Hanff Adenosine signaling in reserpine-induced depression in rats Behav. Brain Res. 286 2015 184 191
150. T.R. Minor, J.L. Winslow, and W.C. Chang Stress and adenosine: II. Adenosine analogs mimic the effect of inescapable shock on shuttle-escape performance in rats Behav. Neurosci. 108 1994 265 276
151. D. Mischoulon, J.E. Alpert, E. Arning, T. Bottiglieri, M. Fava, and G.I. Papakostas Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder J. Clin. Psychiatry 73 2012 843 848
152. B. Moghaddam, and D. Javitt From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment Neuropsychopharmacology 37 2012 4 15
153. A. Monji, T. Kato, and S. Kanba Cytokines and schizophrenia: microglia hypothesis of schizophrenia Psychiatry Clin. Neurosci. 63 2009 257 265
154. M. Naganawa, M. Mishina, M. Sakata, K. Oda, M. Hiura, K. Ishii, and K. Ishiwata Test-retest variability of adenosine A2A binding in the human brain with (11)C-TMSX and PET EJNMMI Res. 4 2014 76
155. G. Nagy, Z. Ronai, A. Somogyi, M. Sasvari-Szekely, O.A. Rahman, A. Mate, T. Varga, and Z. Nemoda P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 1884 1888
156. M. Nedergaard, and A. Verkhratsky Artifact versus reality - how astrocytes contribute to synaptic events Glia 60 2012 1013 1023
157. D.J. Newport, L.L. Carpenter, W.M. McDonald, J.B. Potash, M. Tohen, and C.B. Nemeroff Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression Am. J. Psychiatry 172 2015 950 966
158. A. Nicke, Y.H. Kuan, M. Masin, J. Rettinger, B. Marquez-Klaka, O. Bender, D.C. Gorecki, R.D. Murrell-Lagnado, and F. Soto A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice J. Biol. Chem. 284 2009 25813 25822
159. T. Nishizaki, K. Nagai, T. Nomura, H. Tada, T. Kanno, H. Tozaki, X.X. Li, T. Kondoh, N. Kodama, E. Takahashi, N. Sakai, K. Tanaka, and N. Saito A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors Glia 39 2002 133 147
160. E.J. Nunes, P.A. Randall, E.E. Hart, C. Freeland, S.E. Yohn, Y. Baqi, C.E. Muller, L. Lopez-Cruz, M. Correa, and J.D. Salamone Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression J. Neurosci. 33 2013 19120 19130
161. M. Okada, D.J. Nutt, T. Murakami, G. Zhu, A. Kamata, Y. Kawata, and S. Kaneko Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release J. Neurosci. 21 2001 628 640
162. J.A. Orellana, R. Moraga-Amaro, R. Diaz-Galarce, S. Rojas, C.J. Maturana, J. Stehberg, and J.C. Saez Restraint stress increases hemichannel activity in hippocampal glial cells and neurons Front. Cell Neurosci. 9 2015 102 10.3389/fncel.2015.00102
163. M. Orru, C. Quiroz, X. Guitart, and S. Ferre Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum Neuropharmacology 61 2011 967 974
164. Y. Pankratov, U. Lalo, O.A. Krishtal, and A. Verkhratsky P2X receptors and synaptic plasticity Neuroscience 158 2009 137 148
165. Y. Pankratov, U. Lalo, A. Verkhratsky, and R.A. North Vesicular release of ATP at central synapses Pflugers Arch. 452 2006 589 597
166. Y. Pankratov, U. Lalo, A. Verkhratsky, and R.A. North Quantal release of ATP in mouse cortex J. Gen. Physiol. 129 2007 257 265
167. S. Paul, P.H. Elsinga, K. Ishiwata, R.A. Dierckx, and W.A. van Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging Curr. Med. Chem. 18 2011 4820 4835
168. P.J. Peng, K.T. Chiang, and C.S. Liang Low-dose caffeine may exacerbate psychotic symptoms in people with schizophrenia J. Neuropsychiatry Clin. Neurosci. 26 2014 E41
169. V.S. Pereira, P.C. Casarotto, V.A. Hiroaki-Sato, A.G. Sartim, F.S. Guimaraes, and S.R. Joca Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide Eur. Neuropsychopharmacol. 23 2013 1769 1778
170. A. Pintor, M. Galluzzo, R. Grieco, A. Pezzola, R. Reggio, and P. Popoli Adenosine A 2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors J. Neurochem. 89 2004 152 156
171. J. Pintor, A. Porras, F. Mora, and M.T. Miras-Portugal Amphetamine-induced release of diadenosine polyphosphates-Ap4A and Ap5A-from caudate putamen of conscious rat Neurosci. Lett. 150 1993 13 16
172. P. Popoli, and R. Pepponi Potential therapeutic relevance of adenosine A2B and A2A receptors in the central nervous system CNS Neurol. Disord. Drug Targets 11 2012 664 674
173. D. Preti, P.G. Baraldi, A.R. Moorman, P.A. Borea, and K. Varani History and Perspectives of A2A adenosine receptor antagonists as potential therapeutic agents Med. Res. Rev. 35 2015 790 848
174. K. Puchalowicz, M. Tarnowski, I. Baranowska-Bosiacka, D. Chlubek, and V. Dziedziejko P2X and P2Y receptors-role in the pathophysiology of the nervous system Int. J. Mol. Sci. 15 2014 23672 23704
175. G.C. Quintero Role of nucleus accumbens glutamatergic plasticity in drug addiction Neuropsychiatr. Dis. Treat. 9 2013 1499 1512
176. C. Quiroz, R. Lujan, M. Uchigashima, A.P. Simoes, T.N. Lerner, J. Borycz, A. Kachroo, P.M. Canas, M. Orru, M.A. Schwarzschild, D.L. Rosin, A.C. Kreitzer, R.A. Cunha, M. Watanabe, and S. Ferre Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway ScientificWorldJournal 9 2009 1321 1344
177. V. Ralevic, and G. Burnstock Receptors for purines and pyrimidines Pharmacol. Rev. 50 1998 413 492
178. P.A. Randall, E.J. Nunes, S.L. Janniere, C.M. Stopper, A.M. Farrar, T.N. Sager, Y. Baqi, J. Hockemeyer, C.E. Muller, and J.D. Salamone Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists Psychopharmacol. Berl. 216 2011 173 186
179. V. Rangaraju, N. Calloway, and T.A. Ryan Activity-driven local ATP synthesis is required for synaptic function Cell 156 2014 825 835
180. P.F. Renshaw, A.M. Parow, F. Hirashima, Y. Ke, C.M. Moore, B.B. Frederick, M. Fava, J. Hennen, and B.M. Cohen Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression Am. J. Psychiatry 158 2001 2048 2055
181. G.Z. Reus, G.R. Fries, L. Stertz, M. Badawy, I.C. Passos, T. Barichello, F. Kapczinski, and J. Quevedo The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders Neuroscience 300 2015 141 154
182. D. Rial, D.R. Lara, and R.A. Cunha The adenosine neuromodulation system in schizophrenia Int. Rev. Neurobiol. 119 2014 395 449
183. R. Rimondini, S. Ferre, S.O. Ogren, and K. Fuxe Adenosine A2A agonists: a potential new type of atypical antipsychotic Neuropsychopharmacology 17 1997 82 91
184. L.J. Robinson, and I.N. Ferrier Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence Bipolar Disord. 8 2006 103 116
185. R.J. Rodrigues, A.R. Tome, and R.A. Cunha ATP as a multi-target danger signal in the brain Front. Neurosci. 9 2015 148
186. S. Roger, Z.Z. Mei, J.M. Baldwin, L. Dong, H. Bradley, S.A. Baldwin, A. Surprenant, and L.H. Jiang Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions J. Psychiatr. Res. 44 2010 347 355
187. D.C. Rotaru, D.A. Lewis, and G. Gonzalez-Burgos The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia Rev. Neurosci. 23 2012 97 109
188. J.D. Salamone, and M. Correa Dopamine/adenosine interactions involved in effort-related aspects of food motivation Appetite 53 2009 422 425
189. K. Sarantis, E. Tsiamaki, S. Kouvaros, C. Papatheodoropoulos, and F. Angelatou Adenosine A receptors permit mGluR5-evoked tyrosine phosphorylation of NR2B (Tyr1472) in rat hippocampus: a possible key mechanism in NMDA receptor modulation J. Neurochem. 2015 10.1111/jnc.13291 (in press)
190. S. Scaccianoce, D. Navarra, S.A. Di, L. Angelucci, and E. Endroczi Adenosine and pituitary-adrenocortical axis activity in the rat Neuroendocrinology 50 1989 464 468
191. S.N. Schiffmann, G. Fisone, R. Moresco, R.A. Cunha, and S. Ferre Adenosine A2A receptors and basal ganglia physiology Prog. Neurobiol. 83 2007 277 292
192. J.K. Seamans, C.C. Lapish, and D. Durstewitz Comparing the prefrontal cortex of rats and primates: insights from electrophysiology Neurotox. Res. 14 2008 249 262
193. T. Serchov, H.W. Clement, M.K. Schwarz, F. Iasevoli, D.K. Tosh, M. Idzko, K.A. Jacobson, B.A. de, C. Normann, K. Biber, and C.D. van Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a Neuron 87 2015 549 562
194. D. Shan, V. Haroutunian, J.H. Meador-Woodruff, and R.E. McCullumsmith Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia Neuroreport 23 2012 224 227
195. H.Y. Shen, J.E. Coelho, N. Ohtsuka, P.M. Canas, Y.J. Day, Q.Y. Huang, N. Rebola, L. Yu, D. Boison, R.A. Cunha, J. Linden, J.Z. Tsien, and J.F. Chen A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs J. Neurosci. 28 2008 2970 2975
196. H.Y. Shen, P. Singer, N. Lytle, C.J. Wei, J.Q. Lan, R.L. Williams-Karnesky, J.F. Chen, B.K. Yee, and D. Boison Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia J. Clin. Invest 122 2012 2567 2577
197. T. Shimazoe, A. Yoshimatsu, A. Kawashimo, and S. Watanabe Roles of adenosine A(1) and A(2A) receptors in the expression and development of methamphetamine-induced sensitization Eur. J. Pharmacol. 388 2000 249 254
198. T.L. Sills, A. Azampanah, and P.J. Fletcher The adenosine A1 receptor agonist N6-cyclopentyladenosine blocks the disruptive effect of phencyclidine on prepulse inhibition of the acoustic startle response in the rat Eur. J. Pharmacol. 369 1999 325 329
199. M.D. Simpson, P. Slater, and J.F. Deakin Comparison of glutamate and gamma-aminobutyric acid uptake binding sites in frontal and temporal lobes in schizophrenia Biol. Psychiatry 44 1998 423 427
200. S.D. Skaper, P. Debetto, and P. Giusti The P2X7 purinergic receptor: from physiology to neurological disorders FASEB J. 24 2010 337 345
201. R. Sluyter, L. Stokes, S.J. Fuller, K.K. Skarratt, B.J. Gu, and J.S. Wiley Functional significance of P2RX7 polymorphisms associated with affective mood disorders J. Psychiatric Res. 44 2010 1116 1117
202. R.E. Smith, V. Haroutunian, K.L. Davis, and J.H. Meador-Woodruff Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia Am. J. Psychiatry 158 2001 1393 1399
203. M. Solle, J. Labasi, D.G. Perregaux, E. Stam, N. Petrushova, B.H. Koller, R.J. Griffiths, and C.A. Gabel Altered cytokine production in mice lacking P2X(7) receptors J. Biol. Chem. 276 2001 125 132
204. P. Soronen, O. Mantere, T. Melartin, K. Suominen, M. Vuorilehto, H. Rytsala, P. Arvilommi, I. Holma, M. Holma, P. Jylha, H.M. Valtonen, J. Haukka, E. Isometsa, and T. Paunio P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B 2011 435 447
205. B. Sperlagh, C. Csolle, R.D. Ando, F. Goloncser, A. Kittel, and M. Baranyi The role of purinergic signaling in depressive disorders Neuropsychopharmacol. Hung 14 2012 231 238
206. B. Sperlagh, and P. Illes P2X7 receptor: an emerging target in central nervous system diseases Trends Pharmacol. Sci. 35 2014 537 547
207. B. Sperlagh, E.S. Vizi, K. Wirkner, and P. Illes P2X7 receptors in the nervous system Prog. Neurobiol. 78 2006 327 346
208. R. Srinivasan, B.S. Huang, S. Venugopal, A.D. Johnston, H. Chai, H. Zeng, P. Golshani, and B.S. Khakh Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo Nat. Neurosci. 18 2015 708 717
209. L. Stokes, S.J. Fuller, R. Sluyter, K.K. Skarratt, B.J. Gu, and J.S. Wiley Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion FASEB J. 24 2010 2916 2927
210. S.O. Suadicani, R. Iglesias, J. Wang, G. Dahl, D.C. Spray, and E. Scemes ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes Glia 60 2012 1106 1116
211. N. Takahashi, and T. Sakurai Roles of glial cells in schizophrenia: possible targets for therapeutic approaches Neurobiol. Dis. 53 2013 49 60
212. J.M. Tepper, F. Tecuapetla, T. Koos, and O. Ibanez-Sandoval Heterogeneity and diversity of striatal GABAergic interneurons Front. Neuroanat. 4 2010 150
213. S. Totterdell, and A.D. Smith Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat J. Chem. Neuroanat. 2 1989 285 298
214. D. van Calker, and K. Biber The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders Neurochem. Res. 30 2005 1205 1217
215. J. van Os, and S. Kapur Schizophrenia Lancet 374 2009 635 645
216. M. Viikki, O. Kampman, S. Anttila, A. Illi, E. Setala-Soikkeli, M. Huuhka, N. Mononen, T. Lehtimaki, and E. Leinonen P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT Neurosci. Lett. 493 2011 127 130
217. I. Villar-Menendez, S. Diaz-Sanchez, M. Blanch, J.L. Albasanz, T. Pereira-Veiga, A. Monje, L.M. Planchat, I. Ferrer, M. Martin, and M. Barrachina Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia J. Psychiatr. Res. 51 2014 49 59
218. J.H. Wang, J. Short, C. Ledent, A.J. Lawrence, and M. van den Buuse Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A2A receptor Behav. Brain Res. 143 2003 201 207
219. J.L. Warner-Schmidt, and R.S. Duman Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment Hippocampus 16 2006 239 249
220. M. Weiser, A.A. Gershon, K. Rubinstein, C. Petcu, M. Ladea, D. Sima, D. Podea, R.S. Keefe, and J.M. Davis A randomized controlled trial of allopurinol vs. placebo added on to antipsychotics in patients with schizophrenia or schizoaffective disorder Schizophr. Res. 138 2012 35 38
221. D. Weismann, and C.J. Binder The innate immune response to products of phospholipid peroxidation Biochim. Biophys. Acta 1818 2012 2465 2475
222. S. Wiese, S. Jablonka, B. Holtmann, N. Orel, R. Rajagopal, M.V. Chao, and M. Sendtner Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB Proc. Natl. Acad. Sci. U. S. A. 104 2007 17210 17215
223. P. Willner Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS Neuropsychobiology 52 2005 90 110
224. I. Wonodi, H.V. Gopinath, J. Liu, H. Adami, L.E. Hong, R. Allen-Emerson, R.P. McMahon, and G.K. Thaker Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signaling Psychopharmacol. Berl. 218 2011 341 345
225. J.C. Woodson, T.R. Minor, and R.F. Job Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats Behav. Neurosci. 112 1998 399 409
226. K. Yamada, M. Kobayashi, and T. Kanda Involvement of adenosine A2A receptors in depression and anxiety Int. Rev. Neurobiol. 119 2014 373 393
227. D.S. Zahm An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens Neurosci. Biobehav Rev. 24 2000 85 105
228. D. Zhang, Z.G. Gao, K. Zhang, E. Kiselev, S. Crane, J. Wang, S. Paoletta, C. Yi, L. Ma, W. Zhang, G.W. Han, H. Liu, V. Cherezov, V. Katritch, H. Jiang, R.C. Stevens, K.A. Jacobson, Q. Zhao, and B. Wu Two disparate ligand-binding sites in the human P2Y1 receptor Nature 520 2015 317 321
229. J. Zhang, C.G. Abdallah, J. Wang, X. Wan, C. Liang, L. Jiang, Y. Liu, H. Huang, X. Hong, Q. Huang, R. Wu, and C. Xu Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients Psychiatry Res. 200 2012 126 132
230. L. Zhang, T.P. Su, K. Choi, W. Maree, C.T. Li, M.Y. Chung, Y.S. Chen, Y.M. Bai, Y.H. Chou, J.L. Barker, J.E. Barrett, X.X. Li, H. Li, D.M. Benedek, and R. Ursano P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide J. Psychiatr. Res. 45 2011 435 441
231. Y.X. Zhang, H. Yamashita, T. Ohshita, N. Sawamoto, and S. Nakamura ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum Brain Res. 691 1995 205 212
232. Z. Zhang, G. Chen, W. Zhou, A. Song, T. Xu, Q. Luo, W. Wang, X.S. Gu, and S. Duan Regulated ATP release from astrocytes through lysosome exocytosis Nat. Cell Biol. 9 2007 945 953
233. F.F. Zimmermann, S. Altenhofen, L.W. Kist, C.E. Leite, M.R. Bogo, G.P. Cognato, and C.D. Bonan Unpredictable chronic stress alters adenosine metabolism in Zebrafish brain Mol. Neurobiol. 2015 10.1007/s12035-015-9270-7