Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders

Journal of Affective Disorders

Volumn 101, Issue 1-3, 2007, Pages 159-168

  Erhardt, Angelika ^a   Lucae, Susanne ^a   Unschuld, Paul G ^a   Ising, Marcus ^a   Kern, Nikola ^b   Salyakina, Daria ^a   Lieb, Roselind ^a   Uhr, Manfred ^a   Binder, Elisabeth B ^a   Keck, Martin E ^a   Müller Myhsok, Bertram ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Anxiety disorders; Association; Bipolar disorder; CaMKKb; P2RX7; SNP

Indexed keywords

CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; PROTEIN DERIVATIVE; PROTEIN KINASE; PROTEIN P2RX4; PROTEIN P2RX7; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADULT; AGORAPHOBIA; ANXIETY DISORDER; ARTICLE; BIPOLAR DEPRESSION; CASE CONTROL STUDY; CHROMOSOME 12; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD DISORDER; PANIC; PRIORITY JOURNAL;

ADULT; AGORAPHOBIA; ANXIETY DISORDERS; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PANIC DISORDER; PHENOTYPE; PHOBIC DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, PURINERGIC P2;

EID: 34249934942     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2006.11.016     Document Type: Article

References (41)

1. Anderson K.A., Means R.L., Huang Q.H., Kemp B.E., Goldstein E.G., Selbert M.A., Edelman A.M., Fremeau R.T., and Means A.R. Components of a calmodulin-dependent protein kinase cascade - molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J. Biol. Chem. 273 48 (1998) 31880-31889
2. Atkinson L., Milligan C.J., Buckley N.J., and Deuchars J. Purinergic receptors - An ATP-gated ion channel at the cell nucleus. Nature 420 6911 (2002) 42-42
3. Ballas C.A., and Staab J.P. Medically unexplained physical symptoms: toward an alternative paradigm for diagnosis and treatment. CNS Spectr. 8 12 (2003) 20-26
4. Bandelow B., Brunner E., Broocks A., Beinroth D., Hajak G., Pralle L., and Ruther E. The use of the panic and agoraphobia scale in a clinical trial. Psychiatry Res. 77 1 (1998) 43-49
5. Barden N., Harvey M., Gagne B., Shink E., Tremblay M., Raymond C., Labbe M., Villeneuve A., Rochette D., Bordeleau L., Stadler H., Holsboer F., and Müller-Myhsok B. Analysis of single nucleotide polymorphisms in genes in the chromosome 12q24.31 regions points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 4 (2006) 374-382
6. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Putz B., Papiol S., Seaman S., Lucae S., Kohli M.A., Nickel T., Kunzel H.E., Fuchs B., Majer M., Pfennig A., Kern N., Brunner J., Modell S., Baghai T., Deiml T., Zill P., Bondy B., Rupprecht R., Messer T., Kohnlein O., Dabitz H., Bruckl T., Muller N., Pfister H., Lieb R., Mueller J.C., Lohmussaar E., Strom T.M., Bettecken T., Meitinger T., Uhr M., Rein T., Holsboer F., and Muller-Myhsok B. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet. 36 12 (2004) 1319-1325
7. Chen Y.W., and Dilsaver S.C. Comorbidity of panic disorder in bipolar illness - evidence from the epidemiologic catchment-area survey. Am. J. Psychiatry 152 2 (1995) 280-282
8. Chessell I.P., Hatcher J.P., Bountra C., Michel A.D., Hughes J.P., Green P., Egerton J., Murfin M., Richardson J., Peck W.L., Grahames C.B.A., Casula M.A., Yiangou Y., Birch R., Anand P., and Buell G.N. Disruption of the P2X(7) purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114 3 (2005) 386-396
9. Cryan J.F., and Kaupmann K. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends Pharmacol. Sci. 26 1 (2005) 36-43
10. Curtis D., Kalsi G., Brynjolfsson J., McInnis M., O'Neill J., Smyth C., Moloney E., Murphy P., McQuillin A., Petursson H., and Gurling H. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr. Genet. 13 2 (2003) 77-84
11. Di Virgilio F., Sanz J.H., Chiozzi P., and Falzoni S. The P2Z/P2X(7) receptor of microglial cells: a novel immunomodulatory receptor. Prog. Brain Res. 120 (1999) 355-368
12. Feske U., Frank E., Mallinger A.G., Houck P.R., Fagiolini A., Shear M.K., Grochocinski V.J., and Kupfer D.J. Anxiety as a correlate of response to the acute treatment of bipolar I disorder. Am. J. Psychiatry 157 6 (2000) 956-962
13. Frank E., Cyranowski J.M., Rucci P., Shear M.K., Fagiolini A., Thase M.E., Cassano G.B., Grochocinski V.J., Kostelnik B., and Kupfer D.J. Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder. Arch. Gen. Psychiatry 59 10 (2002) 905-911
14. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., Higgins J., DeFelice M., Lochner A., Faggart M., Liu-Cordero S.N., Rotimi C., Adeyemo A., Cooper R., Ward R., Lander E.S., Daly M.J., and Altshuler D. The structure of haplotype blocks in the human genome. Science 296 5576 (2002) 2225-2229
15. Gorwood P. Generalized anxiety disorder and major depressive disorder comorbidity: an example of genetic pleiotropy?. Eur. Psychiatr. 19 1 (2004) 27-33
16. Hettema J.M., Neale M.C., and Kendler K.S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 158 10 (2001) 1568-1578
17. Holsboer F. Unipolar versus bipolar disorder: a distinction not helpful for studies of causality. Curr. Psychiatry Rep. 7 6 (2005) 405-407
18. Illes P., and Ribeiro J.A. Molecular physiology of P2 receptors in the central nervous system. Eur. J. Pharmacol. 483 1 (2004) 5-17
19. Ishii K., Kaneda M., Li H.B., Rockland K.S., and Hashikawa T. Neuron-specific distribution of P2X7 purinergic receptors in the monkey retina. J. Comp. Neurol. 459 3 (2003) 267-277
20. Kalsi G., McQuillin A., Degn B., Lundorf M.D., Bass N.J., Lawrence J., Choudhury K., Puri V., Nyegaard M., Curtis D., Mors O., Kruse T., Kerwin S., and Gurling H. Identification of the slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24. Am. J. Psychiatry 163 10 (2006) 1767-1776
21. Kessler R.C., McGonagle K.A., Zhao S.Y., Nelson C.B., Hughes M., Eshleman S., Wittchen H.U., and Kendler K.S. Lifetime and 12-month prevalence of dsm-iii-r psychiatric-disorders in the United-States - results from the national-comorbidity-survey. Arch. Gen. Psychiatry 51 1 (1994) 8-19
22. Kessler R.C., Stang P.E., Wittchen H.U., Ustun T.B., Roy-Burne P.P., and Walters E.E. Lifetime panic-depression comorbidity in the National Comorbidity Survey. Arch. Gen. Psychiatry 55 9 (1998) 801-808
23. Khakh B.S. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat. Rev., Neurosci. 2 3 (2001) 165-174
24. Le K.T., Villeneuve P., Ramjaun A.R., McPherson P.S., Beaudet A., and Seguela P. Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors. Neuroscience 83 1 (1998) 177-190
25. Lucae S., Salyakina D., Barden N., Harvey M., Gagne B., Labbe M., Binder E.B., Uhr M., Paez-Pereda M., Sillaber I., Ising M., Bruckl T., Lieb R., Holsboer F., and Muller-Myhsok B. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum. Mol. Genet. 15 16 (2006) 2438-2445
26. Lyons-Warren A., Chang J.J., Balkissoon R., Kamiya A., Garant M., Nurnberger J., Scheftner W., Reich T., McMahon F., Kelsoe J., Gershon E., Coryell W., Byerley W., Berrettini W., DePaulo R., McInnis M., and Sawa A. Evidence of association between bipolar disorder and Citron on chromosome 12q24. Mol. Psychiatry 10 9 (2005) 807-809
27. MacKinnon D.F., Xu J.F., McMahon F.J., Simpson S.G., Stine O.C., McInnis M.G., and DePaulo J.R. Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data. Am. J. Psychiatry 155 6 (1998) 829-831
28. Peters M., Mizuno K., Ris L., Angelo M., Godaux E., and Giese K.P. Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory. J. Neurosci. 23 30 (2003) 9752-9760
29. Reif A., Herterich S., Strobel A., Ehlis A.C., Saur D., Jacob C.P., Wienker T., Topner T., Fritzen S., Walter U., Schmitt A., Fallgatter A., and Lesch K.P. A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function. Mol. Psychiatry 11 3 (2006) 286-300
30. Robertson S.J., Ennion S.J., Evans R.J., and Edwards F.A. Synaptic P2X receptors. Curr. Opin. Neurobiol. 11 3 (2001) 378-386
31. Robins L.N., Wing J., Wittchen H.U., Helzer J.E., Babor T.F., Burke J., Farmer A., Jablenski A., Pickens R., Regier D.A., Sartorius N., and Towle L.H. The composite international diagnostic interview - an epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch. Gen. Psychiatry 45 12 (1988) 1069-1077
32. Rotondo A., Mazzanti C., Dell'Osso L., Rucci P., Sullivan P., Bouanani S., Gonnelli C., Goldman D., and Cassano G.B. Catechol O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am. J. Psychiatry 159 1 (2002) 23-29
33. Schmitt J.M., Guire E.S., Saneyoshi T., and Soderling T.R. Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation. J. Neurosci. 25 5 (2005) 1281-1290
34. Shink E., Morissette J., Sherrington R., and Barden N. A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. Mol. Psychiatry 10 6 (2005) 545-552
35. Smoller J.W., and Tsuang M.T. Panic and phobic anxiety: defining phenotypes for genetic studies. Am. J. Psychiatry 155 9 (1998) 1152-1162
36. Wang C.M., Chang Y.Y., Kuo J.S., and Sun S.H. Activation of P2X(7) receptors induced [H-3]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl-/HCO3--dependent mechanism. Glia 37 1 (2002) 8-18
37. Westfall P.H., and Young S.S. On adjusting P-values for multiplicity. Biometrics 49 3 (1993) 941-944
38. Wigginton J.E., Cutler D.J., and Abecasis G.R. A note on exact tests of Hardy-Weinberg equilibrium. Am. J. Hum. Genet. 76 5 (2005) 887-893
39. Williams J.B.W., Gibbon M., First M.B., Spitzer R.L., Davies M., Borus J., Howes M.J., Kane J., Pope H.G., Rounsaville B., and Wittchen H.U. The structured clinical interview for Dsm-III-R (Scid).2. Multisite test-retest reliability. Arch. Gen. Psychiatry 49 8 (1992) 630-636
40. Wittke-Thompson J.K., Pluzhnikov A., and Cox N.J. Rational inferences about departures from Hardy-Weinberg equilibrium. Am. J. Hum. Genet. 76 6 (2005) 967-986
41. Young L.T., Cooke R.G., Robb J.C., Levitt A.J., and Joffe R.T. Anxious and nonanxious bipolar disorder. J. Affect. Disord. 29 1 (1993) 49-52