The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity

Expert Review of Neurotherapeutics

Volumn 14, Issue 7, 2014, Pages 719-721

  Fuxe, Kjell ^a   Agnati, Luigi F ^b   Borroto Escuela, Dasiel O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b IRCCS SAN CAMILLO HOSPITAL   (Italy)

Author keywords

allosteric receptor receptor interaction; G protein coupled receptor; learning; long term depression; long term potentiation; memory plasticity; receptor heteromer; receptor tyrosine kinase; striatum

Indexed keywords

MEMBRANE RECEPTOR; CELL SURFACE RECEPTOR;

ALLOSTERISM; COMPLEX FORMATION; LEARNING; MEMORY; MOLECULAR RECOGNITION; NERVE CELL PLASTICITY; NEUROMODULATION; OLIGOMERIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; BRAIN; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; BRAIN; HUMANS; NEURONAL PLASTICITY; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 84903143050     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2014.922878     Document Type: Review

References (23)

1. Fuxe K, Agnati LF. Receptor-receptor interactions in the central nervous system. A new integrative mechanism in synapses. Med Res Rev 1985;5(4):441-82
2. Zoli M, Agnati LF, Hedlund PB, et al. Receptor-receptor interactions as an integrative mechanism in nerve cells. Mol Neurobiol 1993;7(3-4):293-334
3. Tarakanov AO, Fuxe KG. Triplet puzzle: homologies of receptor heteromers. J Mol Neurosci 2010;41(2):294-303
4. Fuxe K, Borroto-Escuela DO, Romero-Fernandez W, et al. Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the g protein-coupled receptor field. Neuropsychopharmacology 2014;39(1): 131-55
5. Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, et al. On the existence of a possible A2A-D2-beta-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced beta-arrestin2 recruitment. J Mol Biol 2011;406(5):687-99
6. Cristovao-Ferreira S, Navarro G, Brugarolas M, et al. A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes. Purinergic Signal 2013;9(3):433-49
7. Shen W, Flajolet M, Greengard P, et al. Dichotomous dopaminergic control of striatal synaptic plasticity. Science 2008; 321(5890):848-51
8. Cabello N, Gandia J, Bertarelli DC, et al. Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 2009;109(5):1497-507
9. Fuxe K, Borroto-Escuela DO, Romero-Fernandez W, et al. On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons. Brain Res 2012;1476:119-31
10. Surmeier DJ, Ding J, Day M, et al. D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci 2007;30(5):228-35
11. Liu XY, Chu XP, Mao LM, et al. Modulation of D2R-NR2B interactions in response to cocaine. Neuron 2006;52(5): 897-909
12. Fuxe K, Marcellino D, Rivera A, et al. Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology. Brain Res Rev 2008;58(2):415-52
13. Fuxe K, Marcellino D, Genedani S, et al. Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease. Mov Disord 2007; 22(14):1990-2017
14. Fuxe K, Agnati LF, Jacobsen K, et al. Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Neurology 2003;61(11 Suppl 6):S19-23
15. Metaxas A, Al-Hasani R, Farshim P, et al. Genetic deletion of the adenosine A(2A) receptor prevents nicotine-induced upregulation of alpha7, but not alpha4beta2* nicotinic acetylcholine receptor binding in the brain. Neuropharmacology 2013;71:228-36
16. Tanganelli S, Sandager Nielsen K, Ferraro L, et al. Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease. Parkinsonism Relat Disord 2004;10(5):273-80
17. Agnati LF, Franzen O, Ferre S, et al. Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia. J Neural Transm Suppl 2003(65):1-28
18. Ciccarelli A, Giustetto M. Role of ERK signaling in activity-dependent modifications of histone proteins. Neuropharmacology 2014;80C:34-44
19. Guzman-Karlsson MC, Meadows JP, Gavin CF, et al. Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity. Neuropharmacology 2014;80C:3-17
20. Flajolet M, Wang Z, Futter M, et al. FGF acts as a co-transmitter through adenosine A (2A) receptor to regulate synaptic plasticity. Nat Neurosci 2008;11(12):1402-9
21. Borroto-Escuela DO, Romero-Fernandez W, Mudo G, et al. Fibroblast growth factor receptor 1-5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Biol Psychiatry 2012;71(1):84-91
22. Assaife-Lopes N, Sousa VC, Pereira DB, et al. Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity. Purinergic Signal 2013. [Epub ahead of print]
23. Sebastiao AM, Colino-Oliveira M, Assaife-Lopes N, et al. Lipid rafts, synaptic transmission and plasticity: impact in age-related neurodegenerative diseases. Neuropharmacology 2013;64:97-107