Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats

Journal of Neuroscience

Volumn 19, Issue 24, 1999, Pages 11017-11026

  Baldo, Brian A ^b   Koob, George F ^c   Markou, Athina ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c NONE

Author keywords

Adenosine; Adenosine A(2A) receptor; APEC; Brain stimulation reward; CGS 21680; Chlorostyryl caffeine; Cocaine; DMPX; Dopamine; Nucleus accumbens; Withdrawal

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 3,7 DIMETHYL 1 PROPARGYLXANTHINE; 8 (3 CHLOROSTYRYL)CAFFEINE; ADENOSINE A2 RECEPTOR; ADENOSINE DERIVATIVE; COCAINE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG WITHDRAWAL; MALE; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REWARD;

EID: 0033573531     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-24-11017.1999     Document Type: Article

References (64)

1. Baldo BA, Markou A, Kooh GF (1999) Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology 141:135-144.
2. 2A receptors in the nucleus accumbens mediate locomotor depression. Brain Res Bull 31:397-404.
3. Bird M, Kornetsky C (1990) Dissociation of the attcntional and motivational effects of pimozide on the threshold for rewarding brain stimulation. Neuropsychopharmacology 3:33-40.
4. Brown SJ, Gill R, Evenden JL, Iversen SD, Richardson PJ (1991) Striatal A2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation. Psychopharmacology 103:78-82.
5. Collis MG, Hourani SMO (1993) Adenosine receptor subtypes. Trends Pharmacol Sci 14:360-366.
6. Damsma G, Pfaus JG, Wenkstern D, Phillips AG, Fibiger HC (1992) Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav Neurosci 106:181-191.
7. Dixon AK, Gubitz AK, Sirinathsinghji DJS, Richardson PJ, Freeman TC (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol 118:1461-1468.
8. Dunwiddie TV (1985) The physiological role of adenosine in the central nervous system. Int Rev Neurobiol 27:63-139.
9. Dunwiddie TV, Fredholm BB (1997) Adenosine neuromodulation. In: Purinergic approaches in experimental therapeutics (Jacobson KA, Jarvis MF, eds), pp 359-382. New York: Wiley-Liss.
10. Edmonds DE, Gallistel CR (1977) Reward versus performance in self-stimulation: electrode-specific effects of alpha-methyl-para tyrosine on reward in the rat. J Comp Physiol Psychol 91:962-974.
11. Ferré S (1997) Adenosine-dopamine interactions in the ventral striatum: implications for the treatment of schizophrenia. Psychopharmacology 133:107-120.
12. Ferré S, Rubio A, Fuxe K (1991a) Stimulation of adenosine A2 receptors induces catalepsy. Neurosci Lett 130:162-164.
13. Ferré S, von Euler G, Johansson B, Fredholm BB, Fuxe K (1991b) Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes. Proc Nat Acad Sci USA 88:7238-7241.
14. Ferré S, O'Connor WT, Fuxe K, Ungerstedt U (1993) The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain. J Neurosci 13:5402-5406.
15. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM (1992) Molecular cloning of the rat A2 adenosine receptor: selective co-expression with dopamine D2 receptors in rat striatum. Mol Brain Res 14:186-195.
16. Fiorino DF, Phillips AG (1999) Facilitation of sexual behavior and enhanced dopamine efflux in the nucleus accumbens of male rats after D-amphetamine-induced behavioral sensitization. J Neurosci 19: 456-463.
17. Fiorino DF, Coury A, Fibiger HC, Phillips AG (1993) Electrical stimulation of reward sites in the ventral tegmcntal area increases dopamine transmission in the nucleus accumbens of rat. Behav Brain Res 55:131-141.
18. Fouriezos G, Wise RA (1976) Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficits. Brain Res 103:377-380.
19. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994) Nomenclature and classification of purinoceptors: a report from the IUPHAR Subcommittee. Pharmacol Rev 46:143-156.
20. 2 receptors predicts neuroleptic potency in blocking the reinforcing effects of MFB stimulation. Pharmacol Biochem Behav 19:867-872.
21. Garris PA, Kilpatrick M, Bunin MA, Michael D, Walker DQ, Wightman RM (1999) Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation. Nature 398:67-69.
22. Hammer Jr RP, Pires WS, Markou A, Koob GF (1993) Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. Synapse 14:73-80.
23. 2A receptors in the nucleus accumbens and caudate-putamen. Eur J Pharmacol 323:127-131.
24. Heffner TG, Wiley JN, Williams AE, Bruns RF, Coughenour LL, Downs DA (1989) Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice. Psychopharmacology 98:31-37.
25. Jacobson KA, Nikodijevic O, Padgett WL, Gallo-Rodriguez C, Maillard M, and Daly JW (1993) 8-(3-Chlorostyryl) caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo. FEBS Lett 323:141-144.
26. Kaplan GB, Leite-Morris KA (1997) Up-regulation of adenosine transporter-binding sites in striatum and hypothalamus of opiate tolerant mice. Brain Res 25:215-220.
27. Koob GF (1992) Dopamine, addiction and reward. Semin Neurosci 4:139-148.
28. Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52-58.
29. Koob GF, Markou A, Weiss F, Schulteis G (1993) Opponent process and drug dependence: neurobiological mechanisms. Semin Neurosci 5:315-358.
30. Kornetsky C, Bain G (1990) Brain stimulation reward: a model for drug-induced euphoria. In: Modern methods in pharmacology. Vol 6, Testing and evaluation of drugs of abuse (Adler MW, Cowan A, eds), pp 211-231. New York: Wiley-Liss.
31. Kornetsky C, Esposito RU (1979) Euphorigenic drugs: effects on the reward pathways of the brain. Fed Proc 38:2473-2476.
32. Manzoni O, Pujalte D, Williams J, Bockaert J (1998) Decreased presynaptic sensitivity to adenosine after cocaine withdrawal. J Neurosci 18:7996-8002.
33. Markou A, Koob GF (1991) Postcocaine anhedonia: an animal model of cocaine withdrawal. Neuropsychopharmacology 4:17-26.
34. Markou A, Koob GF (1992a) Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiol Behav 51:111-119.
35. Markou A, Koob GF (1992b) Bromocriptine reverses the elevations in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal. Neuropsychopharmacology 7:213-224.
36. Markou A, Koob GF (1993) Intracranial self-stimulation thresholds as a measure of reward. In: Behavioral neuroscience. Vol II, A practical approach (Saghal A, ed), pp 93-115. New York: Oxford UP.
37. 2A/D2 receptor interaction in globus pallidus. Synapse 22:132-138.
38. Mirenowicz J, Schultz W (1996) Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. Nature 379:449-451.
39. Morelli M, Fenu S, Pinna A, Di Chiara G (1994) Adenosine A2a receptors interact negatively with D1 and D2 receptors in unilaterally 6-hydroxydopamine lcsioncd rats. Eur J Pharmacol 251:21-25.
40. 2A receptors in regulating GABA-ergic synaptic transmission in striatal medium spiny neurons. J Neurosci 16:605-611.
41. Mumford GK, Holtzman SG (1990) Methylxanthines elevate reinforcement threshold for electrical brain stimulation: role for adenosine receptors and phosphodiesterase inhibition. Brain Res 528:32-38.
42. Mumford GK, Holtzman SG (1991a) Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat? Brain Res 550: 172-178.
43. Mumford GK, Holtzman SG (1991b) Qualitative differences in the discriminative stimulus effects of low and high doses of caffeine in the rat. J Pharmacol Exp Ther 258:857-865.
44. Nehlig A, Daval J-L, Boyet S (1994) Effects of selective A1 and A2 receptor antagonists on local rates of energy metabolism in the rat brain. Eur J Pharmacol 258:57-66.
45. Parsons LH, Koob GF, Weiss F (1995) Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. J Pharmacol Exp Ther 274:1182-1191.
46. nd edition. New York: Plenum.
47. Pettit HO, Pettit AJ (1994) Disposition of cocaine in blood and brain after a single pretreatment. Brain Res 651:261-268.
48. Porrino LJ (1993) Functional consequences of acute cocaine treatment depend on route of administration. Psychopharmacology 112:343-351.
49. 2A agonists: a potential new type of atypical antipsychotic. Neuropsychopharmacology 17:82-91.
50. Robbins TW, Everitt BJ (1996) Neurobehavioral mechanisms of reward and motivation. Curr Opin Neurobiol 6:228-236.
51. Rossetti ZL, Hmaidan Y, Gessa, GL (1992) Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine, and amphetamine abstinence in rats. Eur J Pharmacol 221:227-234.
52. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB (1992) Adenosine and brain ischemia. Cerebrovasc Brain Metab Rev 4:346-369.
53. Schiffmann SN, Jacobs O, Vanderhaeghen J-J (1991) Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J Neurochem 57:1062-1067.
54. Snyder SH (1985) Adenosine as a neuromodulator. Annu Rev Neurosci 8:103-124.
55. Stellar JR, Corbett D (1989) Regional neuroleptic microinjections indicate a role for nucleus accumbens in lateral hypothalamic self-stimulation reward. Brain Res 477:126-143.
56. 2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience 80:1171-1185.
57. Svenningson P, Fourreau L, Bloch B, Fredholm BB, Gonon F, Le Moine C (1999) Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons. Neuroscience 89:827-837.
58. Weiss F, Markou A, Lorang MT, Koob GF (1992) Basal extracellular dopamine levels in the nucleus accumbens arc decreased during cocaine withdrawal after unlimited-access self-administration. Brain Res 593:314-318.
59. Williams M, Burnstock G (1997) Purinergic neurotransmission and neuromodulation: a historical perspective. In: Purinergic approaches in experimental therapeutics (Jacobson KA, Jarvis MF, eds), pp 3-26. New York: Wiley-Liss.
60. Winer BJ (1971) Statistical principles in experimental design. Ed 2. New York: McGraw Hill.
61. Wise RA (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22.
62. Yang S-N, Dasgupta S, Lledo P-M, Vincent J-D, Fuxe K (1995) Reduction of dopamine D2 receptor transduction by activation of adenosine A2A receptors in stably A2A/D2 (long form) receptor co-transfected mouse fibroblast cell lines: studies on intracellular calcium levels. Neuroscience 68:729-736.
63. Yates F (1933) The analysis of replicated experiments when field results are incomplete. Emp J Exp Agric 1:129-142.
64. Zarrindast MR, Modabber M, Sabetkasai M (1993) Influences of different adenosine receptor subtypes on catalepsy in mice. Psychopharmacology 113:257-261.