P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 8, 2008, Pages 1884-1888

  Nagy, Geza ^a   Ronai, Zsolt ^a   Somogyi, Aniko ^a   Sasvari Szekely, Maria ^a   Rahman, Omar Abdul ^a   Mate, Attila ^a   Varga, Timea ^a   Nemoda, Zsofia ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Hospital Anxiety and Depression Scale; P2RX7; Serotonin transporter; TPH2

Indexed keywords

ARGININE; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMINE; HEMOGLOBIN A1C; PURINERGIC P2X7 RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE 2;

ALLELE; ANXIETY DISORDER; ARTICLE; BDNF GENE; CONTROLLED STUDY; DEPRESSION; DIABETES MELLITUS; DIABETIC PATIENT; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; HUNGARY; MAJOR CLINICAL STUDY; MALE; P2RX7 GENE; PROMOTER REGION; RECEPTOR GENE; SCORING SYSTEM; SYMPTOMATOLOGY; TPH2 GENE;

ARGININE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DIABETES COMPLICATIONS; DIABETES MELLITUS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTAMINE; HUMANS; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; RECEPTORS, PURINERGIC P2; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRYPTOPHAN HYDROXYLASE;

EID: 56449122703     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.08.021     Document Type: Article

References (36)

1. Anderson R.J., Freedland K.E., Clouse R.E., and Lustman P.J. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 24 (2001) 1069-1078
2. Barden N., Harvey M., Gagne B., Shink E., Tremblay M., Raymond C., et al. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet (Neuropsychiatr Genet) 141 (2006) 374-382
3. Benjamini Y., and Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57 (1995) 289-300
4. Brown S.M., Peet E., Manuck S.B., Williamson D.E., Dahl R.E., Ferrell R.E., et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10 (2005) 884-888
5. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
6. Ciechanowski P.S., Katon W.J., and Russo J.E. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med 160 (2000) 3278-3285
7. Denlinger L.C., Coursin D.B., Schell K., Angelini G., Green D.N., Guadarrama A.G., et al. Human P2X7 pore function predicts allele linkage disequilibrium. Clin Chem 52 (2006) 995-1004
8. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
9. Golden S.H., Lazo M., Carnethon M., Bertoni A.G., Schreiner P.J., Roux A.V., et al. Examining a bidirectional association between depressive symptoms and diabetes. JAMA 299 (2008) 2751-2759
10. Groves J.O. Is it time to reassess the BDNF hypothesis of depression?. Mol Psychiatry 12 (2007) 1079-1088
11. Gutknecht L., Jacob C., Strobel A., Kriegebaum C., Muller J., Zeng Y., et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol 10 (2007) 309-320
12. Hejjas K., Szekely A., Domotor E., Halmai Z., Balogh G., Schilling B., et al. Association between depression and the Gln460Argpolymorphism of P2RX7 gene: a dimensional approach. Am J Med Genet (Neuropsychiatr Genet) (2008) Electronic publication
13. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78 (2006) 815-826
14. Jans L.A., Riedel W.J., Markus C.R., and Blokland A. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 12 (2007) 522-543
15. Krabbe K., Nielsen A., Krogh-Madsen R., Plomgaard P., Rasmussen P., Erikstrup C., et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50 (2007) 431-438
16. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
17. Levinson D.F. The genetics of depression: a review. Biol Psychiatry 60 (2006) 84-92
18. Lotrich F.E., and Pollock B.G. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14 (2004) 121-129
19. Lucae S., Salyakina D., Barden N., Harvey M., Gagne B., Labbe M., et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet 15 (2006) 2438-2445
20. Lustman P., Carney R., and Amado H. Acute stress and metabolism in diabetes. Diabetes Care 4 (1981) 658-659
21. Lustman P.J., Griffith L.S., Freedland K.E., and Clouse R.E. The course of major depression in diabetes. Gen Hosp Psychiatry 19 (1997) 138-143
22. Lustman P.J., Anderson R.J., Freedland K.E., de Groot M., Carney R.M., and Clouse R.E. Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23 (2000) 934-942
23. McQuillin A., Bass N.J., Choudhury K., Puri V., Kosmin M., Lawrence J., et al. Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders. Mol Psychiatry (2008) Electronic publication
24. Muszbek K., Szekely A., Balogh E.M., Molnar M., Rohanszky M., Ruzsa A., et al. Validation of the hungarian translation of hospital anxiety and depression scale. Qual Life Res 15 (2006) 761-766
25. Offenbaecher M., Bondy B., de Jonge S., Glatzeder K., Kruger M., Schoeps P., et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 42 (1999) 2482-2488
26. Parsey R.V., Hastings R.S., Oquendo M.A., Hu X., Goldman D., Huang Y.Y., et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 163 (2006) 48-51
27. Post R.M. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J Psychiatr Res 41 (2007) 979-990
28. Reuter M., Kuepper Y., and Hennig J. Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. Int J Neuropsychopharmacol 10 (2007) 401-404
29. Snaith R.P. The Hospital Anxiety And Depression Scale. Health Qual Life Outcomes 1 (2003) 29
30. Sperlágh B., Vizi E.S., Wirkner K., and Illes P. P2X7 receptors in the nervous system. Prog Neurobiol 78 (2006) 327-346
31. Sperlágh B., Heinrich A., and Csölle C. P2 receptor-mediated modulation of neurotransmitter release - an update. Purinergic Signal 3 (2007) 269-284
32. Testa M.A., and Simonson D.C. Health economic benefits and quality of life during improved glycemic control in patients with type 2 diabetes mellitus: a randomized, controlled, double-blind trial. JAMA 280 (1998) 1490-1496
33. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
34. Wendland J.R., Martin B.J., Kruse M.R., Lesch K.P., and Murphy D.L. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11 (2006) 224-226
35. Zalsman G., Huang Y.Y., Oquendo M.A., Burke A.K., Hu X.Z., Brent D.A., et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163 (2006) 1588-1593
36. Zigmond A.S., and Snaith R.P. The hospital anxiety and depression scale. Acta Psychiatr Scand 67 (1983) 361-370