Deletion of Adenosine A2A Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Biological Psychiatry

Volumn 78, Issue 11, 2015, Pages 763-774

  Matos, Marco ^a,b,c   Shen, Hai Ying ^d   Augusto, Elisabete ^a,b,c   Wang, Yumei ^a   Wei, Catherine J ^a   Wang, Yu Tian ^a,e   Agostinho, Paula ^b,c   Boison, Detlev ^d   Cunha, Rodrigo A ^b,c   Chen, Jiang Fan ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d LEGACY RESEARCH   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

A2AR; Adenosine; Astrocytes; GLT I; NMDA R; Schizophrenia

Indexed keywords

ADENOSINE A2 RECEPTOR; AMPA RECEPTOR; DIZOCILPINE; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; VESICULAR GLUTAMATE TRANSPORTER 1; 5-AMINO-7-(2-PHENYLETHYL)-2-(2-FURYL)PYRAZOLO(4,3-E)-1,2,4-TRIAZOLO(1,5-C)PYRIMIDINE; ADENOSINE A2A RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; DIHYDROKAINIC ACID; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CLINICAL FEATURE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOPHENOTYPE; ENZYME INHIBITION; HEREDITY; HOMEOSTASIS; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; UPREGULATION; WORKING MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COGNITIVE DEFECT; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LOCOMOTION; METABOLISM; PATHOLOGY; PSYCHOMOTOR DISORDER; SYNAPTOSOME; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; ASTROCYTES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACID TRANSPORTER 2; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; HOMEOSTASIS; KAINIC ACID; LOCOMOTION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PSYCHOMOTOR DISORDERS; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTOSOMES; TIME FACTORS; TRIAZOLES;

EID: 84957928612     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.02.026     Document Type: Article

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