An increase in [3H] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics

Brain Research

Volumn 808, Issue 2, 1998, Pages 320-323

  Kurumaji, Akeo ^a   Toru, Michio ^a  

^a Tokyo Med and Dent Univ S ^*  (Japan)

Author keywords

3H CGS21680; Adenosine 2a receptors; Basal ganglia; Postmortem brain; Schizophrenia

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; LIGAND; TRITIUM; ADENOSINE; ALPHA 2 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

ADULT; AGED; ARTICLE; BASAL GANGLION; BINDING AFFINITY; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; MALE; MENTAL DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR BINDING; SCHIZOPHRENIA; BRAIN LEVEL; CHEMISTRY; CHRONIC DISEASE; CORPUS STRIATUM; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RADIOASSAY;

ADENOSINE; ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BRAIN CHEMISTRY; CHRONIC DISEASE; CORPUS STRIATUM; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENETHYLAMINES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2; SCHIZOPHRENIA; TRITIUM;

EID: 0032547582     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00840-3     Document Type: Article

References (20)

1. Bridges A.J., Moos H.W., Szotek D.L., Trivedi B.K., Bristol J.A., Heffner T.G., Bruns R.F., Dow D.A. N6-(2-2-Diphenylethyl)-adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. J. Med. Chem. 30:1987;1709-1711.
2. Ferré S., Fredholm B.B., Morreli M., Popoli P., Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20:1997;482-487.
3. 2 dopamine receptors in the rat striatum. Mol. Brain Res. 14:1992;186-195.
4. Fredholm B.B., Abbracchio M.P., Burnstock G., Daly J.W., Harden T.K., Jacobson K.A., Leff P., Williams M. Nomenclature and classification of purinoreceptors. Pharmacol. Rev. 46:1994;143-156.
5. 2 receptor. Mol. Brain Res. 15:1995;62-66.
6. 2 receptors in rat brain J. Pharmacol. Exp. Ther. 251:1989;888-893.
7. 3H ] CGS21680 Eur. J. Pharmacol. 168:1989;243-246.
8. 2 receptor interactions in animal models of schizophrenia. Eur. J. Pharmacol. 295:1996;147-154.
9. 2a receptor. Nature. 388:1997;674-678.
10. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
11. Lucas P.B., Pickar D., Kelsoe J., Rapaport M., Pato C., Hommer D. Effects of the acute administration of caffeine in patients with schizophrenia. Biol. Psychiatry. 28:1990;35-40.
12. 2 receptors: selective localization in the human basal ganglia and alterations with disease. Neuroscience. 42:1991;697-706.
13. 2a receptors in rat striatum: implications for the mechanism and the treatment of tardive dyskinesia. J. Neurochem. 65:1994;2057-2064.
14. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J. Neurochem. 57:1991;1062-1067.
15. 2 receptor-mediated excitatory actions on the nervous system. Prog. Neurobiol. 48:1996;167-189.
16. Seeman P., Lee T., Chau-Wong M., Wong K. Antipsychotic drug doses and neuroleptic/dopmaine receptors. Nature. 365:1976;717-719.
17. Seeman P., Niznik H.B. Dopamine receptors and transporters in Parkinson's disease and schizophrenia. FASEB J. 4:1990;2737-2744.
18. 2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience. 80:1997;1171-1185.
19. Svenningsson P., Hall H., Sedvall G., Fredholm B.B. Distribution of adenosine receptors in the postmortem human brain: an extended autotadiographic study. Synapse. 27:1997;322-335.
20. Toru M., Watanabe S., Shibuya H., Nishikawa T., Noda K., Mitsushio H., Ichikawa H., Kurumaji A., Takashima M., Mataga N., Ogawa A. Neurotransmitters, receptors and neuropeptides in postmortem brains of chronic schizophrenic patients. Acta Psychiatr. Scand. 78:1988;121-137.