The role of purinergic signaling in depressive disorders;A purinerg jelátviteli rendszer szerepe depressziós kórképekben

Neuropsychopharmacologia Hungarica

Volumn 14, Issue 4, 2012, Pages 231-238

  Sperlagh, Beata ^a   Csolle, Cecilia ^a   Ando, Romeo D ^a   Goloncser, Flora ^a   Kittel, Agnes ^a   Baranyi, Maria ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Adenosine; ATP; Bipolar disorder; Depressive disorder; P2X7 receptor; Purinergic receptors

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE; ADENOSINE TRIPHOSPHATE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; DEAMINASE; INTERLEUKIN 1BETA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROTRANSMITTER; NUCLEOSIDE TRANSPORTER; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT;

BEHAVIORAL SCIENCE; BIPOLAR DISORDER; DEPRESSION; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HEMATOPOIETIC SYSTEM; HUMAN; INFLAMMATION; KNOCKOUT MOUSE; MONOAMINERGIC NERVE; MOOD DISORDER; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; POSTTRAUMATIC STRESS DISORDER; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; BIPOLAR DISORDER; DEPRESSIVE DISORDER; DEPRESSIVE DISORDER, MAJOR; HUMANS; MOOD DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84874083128     PISSN: 14198711     EISSN: None     Source Type: Journal    
DOI: 10.5706/nph201212003     Document Type: Review

References (44)

1. Backlund, L, Nikamo, P, Hukic, D.S., Ek, I.R., Traskman-Bendz, L, et al. (2011) Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder. Bipolar Disord, 13: 500-508.
2. Barden, N, Harvey, M, Gagne, B, Shink, E, et al. (2006). Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141: 374-82.
3. Basso, A.M., Bratcher, N.A., Harris, R.R., Jarvis, M.F. et al. (2009). Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders. Behavioral Brain Research, 198: 83-90.
4. Boucher, A.A., Arnold, J.C., Hunt, G.E., Spiro, A., et al. (2011). Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test. Neuroscience, 189: 170-7.
5. Burnstock, G (1972) Purinergic nerves. Pharmacol Rev, 24: 509-81.
6. Burnstock, G (2008). Purinergic signalling and disorders of the central nervous system. Nature Reviews Drug Discovery, 7: 575-90.
7. Burnstock, G, Krügel, U, Abbracchio, M.P., Illes, P (2011) Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol., 95(2):229-74.
8. Chen, L, Brosnan, C.F. (2006). Regulation of immune response by P2X7 receptor. Critical Reviews in Immunology, 26: 499-513.
9. Csölle, C, Andó, R.D., Kittel, A, Gölöncsér, F, Baranyi, M, Soproni, K, Zelena, D, Haller, J, Németh, T, Mócsai, A, Sperlágh, B (2012a) The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in moodrelated behaviour with dysregulated gene expression and stress reactivity in mice. Int J Neuropsychopharmacol, 16:1-21.
10. Csölle, C, Baranyi, M, Zsilla G, Kittel Á, Gölöncsér F, Illes P, Papp E, Vizi E.S. and Sperlágh B, (2012b) Neurochemical changes in the mouse hippocampus underlying the antidepressant effect of genetic deletion of P2X7 receptors. Plos ONE (under revision).
11. Dantzer, R, O'Connor, J.C., Freund, G.G., Johnson, R.W., et al. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience, 9: 46-56.
12. Deussing, J.M., Walser, S.M., Aprile-Garcia, F, Dedic, N, Jakubcakova, V, Kimura, M, Schmidt, M.V., Stühmer, W, Holsboer, F, Wurst, W, Arzt, E (2012) Validating P2RX7 as a susceptibility marker for depression using humanized mouse models. Abstracts of the FENS Forum 2012, Abstract No. 5123.
13. Drury, A.N., Szent-Györgyi, A (1929) The physiological action of adenine compounds with especial reference to their action on the mammalian heart. J. Physiol.(Lond), 68: 214-237.
14. El Yacoubi, M., Costentin, J, Vaugeois, J.M. (2003) Adenosine A2A receptors and depression. Neurology, 61: pp. S82-S87.
15. Erhardt, A, Lucae, S, Unschuld, P.G., Ising, M, Kern, N, Salyakina, D, Lieb, R, Uhr, M, Binder, E.B., Keck, M.E., Muller-Myhsok, B, Holsboer, F (2007) Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. J. Affect. Disord., 101: pp. 159-168.
16. Friedle, S.A., Curet, M.A., Watters, J.J. (2010) Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation. Recent Pat CNS Drug Discov. 5:35-45.
17. Green, E.K., Grozeva, D, Raybould, R, Elvidge, G, et al. (2009). P2RX7: A bipolar and unipolar disorder candidate susceptibility gene? American Journal of Medical Genetics B Neuropsychiatric Genetics, 150B: 1063-9.
18. Grigoroiu-Serbanescu, M, Herms, S, Mühleisen, T.W., Georgi, A, et al. (2010). Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples. American Journal of Medical Genetics B Neuropsychiatric Genetics, 150B. 1017-21.
19. Harvey, M, Belleau, P, Barden, N (2007). Gene interactions in depression: pathways out of darkness. Trends in Genetics, 23: 547-56.
20. Hejjas, K, Szekely, A, Domotor, E, Halmai, Z, et al. (2009). Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. American Journal of Medical Genetics B Neuropsychiatric Genetics, 150B: 295-9.
21. Hodgson, R.A., Bertorelli, R, Varty, G.B., Lachowicz,J.E., Forlani, A, Fredduzzi,S, Cohen-Williams, M.E., Higgins, G.A., Impagnatiello, F, Nicolussi, E, Parra, L.E., Foster, C, Zhai, Y, Neustadt, B.R., Stamford, A.W., Parker, E.M., Reggiani, A, Hunter, J.C. (2009) Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine in rodent models of movement disorders and depression. J. Pharmacol. Exp. Ther., 330: pp. 294-303.
22. Kaster, M.P., Rosa, A.O., Rosso, M.M., Goulart, E.C., Santos, A.R., Rodrigues, A.L. (2004) Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors Neurosci. Lett., 355: pp. 21-24.
23. Lavebratt, C, Aberg, E, Sjöholm, L.K., Forsell, Y (2010). Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. Journal of Affective Disorders, 125: 249-55.
24. Lucae, S, Salyakina, D, Barden, N, Harvey, M, et al. (2006). P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Human Molecular Genetics, 15: 2438-45.
25. Mantere, O, Soronen, P, Uher, R, Ketokivi, M, Jylhä, P, Melartin, T, Paunio, T, Isometsä, E (2012) Neuroticishm Mediates The Effects of P2RX7 on outcomes of Mood Disorders. Depress Anxiety, 10:1002/da.21945.
26. Masin, M, Young, C, Lim, K, Barnes, S.J., Xu, X, et al. (2012) Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts. Br J Pharmacol, 165: 978-993.
27. McQuillin, A, Bass, N.J., Choudhury, K, Puri, V, et al. (2009). Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolaraffective disorders. Molecular Psychiatry, 14: 614-20.
28. Nagy, G, Ronai, Z, Somogyi, A, Sasvari-Szekely, M, et al. (2008). P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32: 1884-8.
29. Nicke, A, Kuan, Y.H., Masin, M, Rettinger, J, et al. (2009). A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. Journal of Biological Chemistry, 284: 25813-22.
30. Roger, S, Mei, Z.Z., Baldwin, J.M., Dong, L, et al. (2010) Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. Journal of Psychiatric Research, 44: 347-55.
31. Sanacora, G, Zarate, C.A., Krystal, J.H., Manji, H.K. (2008). Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews Drug Discovery, 7: 426-37.
32. Saul, M.C., Gessay, G.M., Gammie, S.C. (2012) A new mouse model for mania shares genetic correlates with human bipolar disorder. PLoS One, 7(6):e38128.
33. Sikora, A, Liu, J, Brosnan, C, Buell, G, Chessel, I, Bloom, B.R. (1999) Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol, 15:163(2):558-61.
34. Skaper, S.D., Debetto, P, Giusti, P (2010). The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB Journal, 24: 337-345.
35. Sluyter, R, Stokes, L, Fuller, S.J., Skarratt, K.K., et al. (2010). Functional significance of P2RX7 polymorphisms associated with affective mood disorders. Journal of Psychiatric Research, 44: 1116-7.
36. Solle, M, Labasi, J, Perregaux, D.G., Stam, E, et al. (2001). Altered cytokine production in mice lacking P2X(7) receptors. Journal of Biological Chemistry, 276: 125-32.
37. Soronen, P, Mantere, O, Melartin, T, Suominen, K, Vuorilehto, M, et al. (2011) P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts. Am J Med Genet B Neuropsychiatr Genet, 156B: 435-447.
38. Sperlagh, B, Kofalvi, A, Deuchars, J, Atkinson, L, et al. (2002). Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus. Journal of Neurochemistry, 81: 1196-211.
39. Sperlagh, B, Vizi, E.S., Wirkner, K, Illes, P (2006). P2X7 receptors in the nervous system. Progress in Neurobiology, 78: 327-46.
40. Stokes, L, Fuller, S.J., Sluyter, R, Skarratt, K.K., et al. (2010). Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1{beta} secretion. FASEB Journal, 24: 2916-27.
41. Surprenant, A, Rassendren, F, Kawashima, E, North, R.A., et al. (1996). The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science, 272: 735-8.
42. Viikki, M, Kampman, O, Anttila, S, Illi, A, et al., (2011). P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT. Neurosci Lett, 493: 127-30.
43. Zhang, L, Su, T.P., Choi, K, Maree, W, Li, C.T., et al. (2011) P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res, 45: 435-441.
44. Woodson, J.C., Minor, T.R., Job, R.F. (1998) Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats. Behav. Neurosci., 112: pp. 399-409.