Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

FASEB Journal

Volumn 24, Issue 8, 2010, Pages 2916-2927

  Stokes, Leanne ^a   Fuller, Stephen J ^a   Sluyter, Ronald ^a,b   Skarratt, Kristen K ^a   Gu, Ben J ^a,c   Wiley, James S ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Inflammation; Purinergic receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; ETHIDIUM; GLUTAMINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; RUBIDIUM; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD; CAUCASIAN; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; ERYTHROCYTE; EXON; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; INFLAMMATION; INHERITANCE; ION CURRENT; MONOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ALANINE; BLOOD CELLS; ERYTHROCYTES; ETHIDIUM; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-1BETA; ION TRANSPORT; MONOCYTES; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; RECEPTORS, PURINERGIC P2; THREONINE; UP-REGULATION;

EID: 77955776526     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-150862     Document Type: Article

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