메뉴 건너뛰기




Volumn 5, Issue OCT, 2015, Pages

Remodeling components of the tumor microenvironment to enhance cancer therapy

Author keywords

In vitro models; Stress alleviation; Tumor vessel permeability; Vascular normalization; Vessel compression

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84947049994     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00214     Document Type: Review
Times cited : (102)

References (165)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell (2000) 100:57-70. doi:10.1016/S0092-8674(00)81683-9
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 21:309-22. doi:10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 3
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9:162-74. doi:10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 4
    • 80355136629 scopus 로고    scopus 로고
    • Studying the mononuclear phagocyte system in the molecular age
    • Chow A, Brown BD, Merad M. Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 11:788-98. doi:10.1038/nri3087
    • (2011) Nat Rev Immunol , vol.11 , pp. 788-798
    • Chow, A.1    Brown, B.D.2    Merad, M.3
  • 5
    • 79960829290 scopus 로고    scopus 로고
    • Neutrophils in the activation and regulation of innate and adaptive immunity
    • Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 11:519-31. doi:10.1038/nri3024
    • (2011) Nat Rev Immunol , vol.11 , pp. 519-531
    • Mantovani, A.1    Cassatella, M.A.2    Costantini, C.3    Jaillon, S.4
  • 6
    • 84904323068 scopus 로고    scopus 로고
    • The role of mechanical forces in tumor growth and therapy
    • Jain RK, Martin JD, Stylianopoulos T. The role of mechanical forces in tumor growth and therapy. Annu Rev Biomed Eng (2014) 16:321-46. doi:10.1146/annurev-bioeng-071813-105259
    • (2014) Annu Rev Biomed Eng , vol.16 , pp. 321-346
    • Jain, R.K.1    Martin, J.D.2    Stylianopoulos, T.3
  • 7
    • 0022495733 scopus 로고
    • Microvascular permeability of normal and neoplastic tissues
    • Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissues. Microvasc Res (1986) 31:288-305. doi:10.1016/0026-2862(86)90018-X
    • (1986) Microvasc Res , vol.31 , pp. 288-305
    • Gerlowski, L.E.1    Jain, R.K.2
  • 8
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res (1986) 46:6387-92.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 9
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain RK. Transport of molecules across tumor vasculature. Cancer Metastasis Rev (1987) 6:559-93. doi:10.1007/BF00047468
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 10
    • 77956162919 scopus 로고    scopus 로고
    • Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability
    • Sarin H. Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. J Angiogenes Res (2010) 2:14. doi:10.1186/2040-2384-2-14
    • (2010) J Angiogenes Res , vol.2 , pp. 14
    • Sarin, H.1
  • 12
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H, Baluk P, Morikawa S, Mclean JW, Thurston G, Roberge S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol (2000) 156:1363-80. doi:10.1016/S0002-9440(10)65006-7
    • (2000) Am J Pathol , vol.156 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3    Mclean, J.W.4    Thurston, G.5    Roberge, S.6
  • 13
    • 84877870613 scopus 로고    scopus 로고
    • Vascular normalization as an emerging strategy to enhance cancer immunotherapy
    • Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res (2013) 73:2943-8. doi:10.1158/0008-5472.CAN-12-4354
    • (2013) Cancer Res , vol.73 , pp. 2943-2948
    • Huang, Y.1    Goel, S.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 14
    • 84912096468 scopus 로고    scopus 로고
    • Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
    • Jain RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell (2014) 26:605-22. doi:10.1016/j.ccell.2014.10.006
    • (2014) Cancer Cell , vol.26 , pp. 605-622
    • Jain, R.K.1
  • 15
    • 84861861104 scopus 로고    scopus 로고
    • Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
    • Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Res (2012) 72:2746-56. doi:10.1158/0008-5472.CAN-11-1272
    • (2012) Cancer Res , vol.72 , pp. 2746-2756
    • Calcinotto, A.1    Filipazzi, P.2    Grioni, M.3    Iero, M.4    De Milito, A.5    Ricupito, A.6
  • 17
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz G, Coukos G. Deciphering and reversing tumor immune suppression. Immunity (2013) 39:61-73. doi:10.1016/j.immuni.2013.07.005
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.1    Coukos, G.2
  • 19
    • 84897019542 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    • Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol (2014) 9:47-71. doi:10.1146/annurev-pathol-012513-104720
    • (2014) Annu Rev Pathol , vol.9 , pp. 47-71
    • Semenza, G.L.1
  • 20
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer (2011) 11:393-410. doi:10.1038/nrc3064
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 21
    • 0026350937 scopus 로고
    • Interstitial hypertension in superficial metastatic melanomas in humans
    • Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res (1991) 51:6691-4.
    • (1991) Cancer Res , vol.51 , pp. 6691-6694
    • Boucher, Y.1    Kirkwood, J.M.2    Opacic, D.3    Desantis, M.4    Jain, R.K.5
  • 22
    • 0026786660 scopus 로고
    • Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse
    • Boucher Y, Jain RK. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res (1992) 52:5110-4.
    • (1992) Cancer Res , vol.52 , pp. 5110-5114
    • Boucher, Y.1    Jain, R.K.2
  • 23
    • 84863655863 scopus 로고    scopus 로고
    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
    • Chauhan VP, Stylianopoulos T, Martin JD, Popovic Z, Chen O, Kamoun WS, et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat Nanotechnol (2012) 7:383-8. doi:10.1038/nnano.2012.45
    • (2012) Nat Nanotechnol , vol.7 , pp. 383-388
    • Chauhan, V.P.1    Stylianopoulos, T.2    Martin, J.D.3    Popovic, Z.4    Chen, O.5    Kamoun, W.S.6
  • 24
    • 84875962586 scopus 로고    scopus 로고
    • EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors
    • Stylianopoulos T. EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors. Ther Deliv (2013) 4:421-3. doi:10.4155/tde.13.8
    • (2013) Ther Deliv , vol.4 , pp. 421-423
    • Stylianopoulos, T.1
  • 25
    • 79959393938 scopus 로고    scopus 로고
    • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies
    • Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng (2011) 2:281-98. doi:10.1146/annurev-chembioeng-061010-114300
    • (2011) Annu Rev Chem Biomol Eng , vol.2 , pp. 281-298
    • Chauhan, V.P.1    Stylianopoulos, T.2    Boucher, Y.3    Jain, R.K.4
  • 26
    • 34047260282 scopus 로고    scopus 로고
    • Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
    • Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res (2007) 67:2729-35. doi:10.1158/0008-5472.CAN-06-4102
    • (2007) Cancer Res , vol.67 , pp. 2729-2735
    • Jain, R.K.1    Tong, R.T.2    Munn, L.L.3
  • 27
    • 0033178578 scopus 로고    scopus 로고
    • Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications
    • Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res (1999) 59:3776-82.
    • (1999) Cancer Res , vol.59 , pp. 3776-3782
    • Griffon-Etienne, G.1    Boucher, Y.2    Brekken, C.3    Suit, H.D.4    Jain, R.K.5
  • 29
    • 84880079914 scopus 로고    scopus 로고
    • Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    • Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Res (2013) 73:3833-41. doi:10.1158/0008-5472.CAN-12-4521
    • (2013) Cancer Res , vol.73 , pp. 3833-3841
    • Stylianopoulos, T.1    Martin, J.D.2    Snuderl, M.3    Mpekris, F.4    Jain, S.R.5    Jain, R.K.6
  • 30
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell (2002) 110:673-87. doi:10.1016/S0092-8674(02)00971-6
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 31
    • 84933070290 scopus 로고    scopus 로고
    • Extracellular matrix-inspired growth factor delivery systems for skin wound healing
    • Briquez PS, Hubbell JA, Martino MM. Extracellular matrix-inspired growth factor delivery systems for skin wound healing. Adv Wound Care (New Rochelle) (2015) 4:479-89. doi:10.1089/wound.2014.0603
    • (2015) Adv Wound Care (New Rochelle) , vol.4 , pp. 479-489
    • Briquez, P.S.1    Hubbell, J.A.2    Martino, M.M.3
  • 32
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med (1986) 315:1650-9.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 33
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • Schafer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol (2008) 9:628-38. doi:10.1038/nrm2455
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 34
    • 84921916417 scopus 로고    scopus 로고
    • Role of TGFbeta in regulation of the tumor microenvironment and drug delivery (review)
    • Papageorgis P, Stylianopoulos T. Role of TGFbeta in regulation of the tumor microenvironment and drug delivery (review). Int J Oncol (2015) 46:933-43. doi:10.3892/ijo.2015.2816
    • (2015) Int J Oncol , vol.46 , pp. 933-943
    • Papageorgis, P.1    Stylianopoulos, T.2
  • 35
    • 79956064263 scopus 로고    scopus 로고
    • Desmoplastic stromal reaction in papillary thyroid microcarcinoma
    • Koperek O, Asari R, Niederle B, Kaserer K. Desmoplastic stromal reaction in papillary thyroid microcarcinoma. Histopathology (2011) 58:919-24. doi:10.1111/j.1365-2559.2011.03791.x
    • (2011) Histopathology , vol.58 , pp. 919-924
    • Koperek, O.1    Asari, R.2    Niederle, B.3    Kaserer, K.4
  • 36
    • 0031216358 scopus 로고    scopus 로고
    • Prognostic value of desmoplastic reaction and lymphocytic infiltration in the management of breast cancer
    • Cardone A, Tolino A, Zarcone R, Borruto Caracciolo G, Tartaglia E. Prognostic value of desmoplastic reaction and lymphocytic infiltration in the management of breast cancer. Panminerva Med (1997) 39:174-7.
    • (1997) Panminerva Med , vol.39 , pp. 174-177
    • Cardone, A.1    Tolino, A.2    Zarcone, R.3    Borruto Caracciolo, G.4    Tartaglia, E.5
  • 37
    • 84930757774 scopus 로고    scopus 로고
    • In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis
    • Ueno H, Shinto E, Hashiguchi Y, Shimazaki H, Kajiwara Y, Sueyama T, et al. In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis. Virchows Arch (2015) 466:655-63. doi:10.1007/s00428-015-1756-1
    • (2015) Virchows Arch , vol.466 , pp. 655-663
    • Ueno, H.1    Shinto, E.2    Hashiguchi, Y.3    Shimazaki, H.4    Kajiwara, Y.5    Sueyama, T.6
  • 38
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes-bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE. Friends or foes-bipolar effects of the tumour stroma in cancer. Nat Rev Cancer (2004) 4:839-49. doi:10.1038/nrc1477
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 39
    • 84901493119 scopus 로고    scopus 로고
    • The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance
    • Kharaishvili G, Simkova D, Bouchalova K, Gachechiladze M, Narsia N, Bouchal J. The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance. Cancer Cell Int (2014) 14:41. doi:10.1186/1475-2867-14-41
    • (2014) Cancer Cell Int , vol.14 , pp. 41
    • Kharaishvili, G.1    Simkova, D.2    Bouchalova, K.3    Gachechiladze, M.4    Narsia, N.5    Bouchal, J.6
  • 40
    • 0028111297 scopus 로고
    • The extracellular matrix in hepatocellular carcinoma shows different localization patterns depending on the differentiation and the histological pattern of tumors: immunohistochemical analysis
    • Torimura T, Ueno T, Inuzuka S, Kin M, Ohira H, Kimura Y, et al. The extracellular matrix in hepatocellular carcinoma shows different localization patterns depending on the differentiation and the histological pattern of tumors: immunohistochemical analysis. J Hepatol (1994) 21:37-46. doi:10.1016/S0168-8278(94)80134-7
    • (1994) J Hepatol , vol.21 , pp. 37-46
    • Torimura, T.1    Ueno, T.2    Inuzuka, S.3    Kin, M.4    Ohira, H.5    Kimura, Y.6
  • 41
    • 84863862833 scopus 로고    scopus 로고
    • Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression
    • Schedin P, Keely PJ. Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 3:a003228. doi:10.1101/cshperspect.a003228
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , pp. a003228
    • Schedin, P.1    Keely, P.J.2
  • 42
    • 0024379745 scopus 로고
    • Neoplastic modulation of extracellular matrix: stimulation of chondroitin sulfate proteoglycan and hyaluronic acid synthesis in co-cultures of human colon carcinoma and smooth muscle cells
    • Iozzo RV, Sampson PM, Schmitt GK. Neoplastic modulation of extracellular matrix: stimulation of chondroitin sulfate proteoglycan and hyaluronic acid synthesis in co-cultures of human colon carcinoma and smooth muscle cells. J Cell Biochem (1989) 39:355-78. doi:10.1002/jcb.240390403
    • (1989) J Cell Biochem , vol.39 , pp. 355-378
    • Iozzo, R.V.1    Sampson, P.M.2    Schmitt, G.K.3
  • 43
    • 0025854312 scopus 로고
    • Altered deposition of basement-membrane molecules in co-cultures of colonic cancer cells and fibroblasts
    • Bouziges F, Simo P, Simon-Assmann P, Haffen K, Kedinger M. Altered deposition of basement-membrane molecules in co-cultures of colonic cancer cells and fibroblasts. Int J Cancer (1991) 48:101-8. doi:10.1002/ijc.2910480119
    • (1991) Int J Cancer , vol.48 , pp. 101-108
    • Bouziges, F.1    Simo, P.2    Simon-Assmann, P.3    Haffen, K.4    Kedinger, M.5
  • 44
    • 0023102119 scopus 로고
    • Distribution of extracellular matrix proteins in primary human brain tumours: an immunohistochemical analysis
    • Rutka JT, Myatt CA, Giblin JR, Davis RL, Rosenblum ML. Distribution of extracellular matrix proteins in primary human brain tumours: an immunohistochemical analysis. Can J Neurol Sci (1987) 14:25-30.
    • (1987) Can J Neurol Sci , vol.14 , pp. 25-30
    • Rutka, J.T.1    Myatt, C.A.2    Giblin, J.R.3    Davis, R.L.4    Rosenblum, M.L.5
  • 45
    • 77953497753 scopus 로고    scopus 로고
    • A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion
    • Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, et al. A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One (2010) 5:e9808. doi:10.1371/journal.pone.0009808
    • (2010) PLoS One , vol.5
    • Huijbers, I.J.1    Iravani, M.2    Popov, S.3    Robertson, D.4    Al-Sarraj, S.5    Jones, C.6
  • 46
    • 0031005920 scopus 로고    scopus 로고
    • Extracellular matrix composition and integrin expression in early hepatocarcinogenesis in human cirrhotic liver
    • Le Bail B, Faouzi S, Boussarie L, Balabaud C, Bioulac-Sage P, Rosenbaum J. Extracellular matrix composition and integrin expression in early hepatocarcinogenesis in human cirrhotic liver. J Pathol (1997) 181:330-7. doi:10.1002/(SICI)1096-9896(199703)181:3<330::AID-PATH765>3.0.CO;2-7
    • (1997) J Pathol , vol.181 , pp. 330-337
    • Le Bail, B.1    Faouzi, S.2    Boussarie, L.3    Balabaud, C.4    Bioulac-Sage, P.5    Rosenbaum, J.6
  • 47
    • 0025239162 scopus 로고
    • Extracellular matrix in preneoplastic lesions and early cancer of the lung
    • Fisseler-Eckhoff A, Prebeg M, Voss B, Muller KM. Extracellular matrix in preneoplastic lesions and early cancer of the lung. Pathol Res Pract (1990) 186:95-101. doi:10.1016/S0344-0338(11)81016-2
    • (1990) Pathol Res Pract , vol.186 , pp. 95-101
    • Fisseler-Eckhoff, A.1    Prebeg, M.2    Voss, B.3    Muller, K.M.4
  • 48
    • 84938648673 scopus 로고    scopus 로고
    • Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer
    • Whatcott CJ, Diep CH, Jiang P, Watanabe A, Lobello J, Sima C, et al. Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Clin Cancer Res (2015) 21:3561-8. doi:10.1158/1078-0432.CCR-14-1051
    • (2015) Clin Cancer Res , vol.21 , pp. 3561-3568
    • Whatcott, C.J.1    Diep, C.H.2    Jiang, P.3    Watanabe, A.4    Lobello, J.5    Sima, C.6
  • 49
    • 0034776908 scopus 로고    scopus 로고
    • Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma
    • Linder S, Castanos-Velez E, Von Rosen A, Biberfeld P. Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma. Hepatogastroenterology (2001) 48:1321-7.
    • (2001) Hepatogastroenterology , vol.48 , pp. 1321-1327
    • Linder, S.1    Castanos-Velez, E.2    Von Rosen, A.3    Biberfeld, P.4
  • 51
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med (1997) 3:177-82. doi:10.1038/nm0297-177
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 52
    • 23244437028 scopus 로고    scopus 로고
    • Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns
    • Kaufman LJ, Brangwynne CP, Kasza KE, Filippidi E, Gordon VD, Deisboeck TS, et al. Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns. Biophys J (2005) 89:635-50. doi:10.1529/biophysj.105.061994
    • (2005) Biophys J , vol.89 , pp. 635-650
    • Kaufman, L.J.1    Brangwynne, C.P.2    Kasza, K.E.3    Filippidi, E.4    Gordon, V.D.5    Deisboeck, T.S.6
  • 53
    • 84991885325 scopus 로고    scopus 로고
    • Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells
    • Cheng G, Tse J, Jain RK, Munn LL. Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. PLoS One (2009) 4:e4632. doi:10.1371/journal.pone.0004632
    • (2009) PLoS One , vol.4
    • Cheng, G.1    Tse, J.2    Jain, R.K.3    Munn, L.L.4
  • 54
    • 78149282625 scopus 로고    scopus 로고
    • Gene expression profiles in 3D tumor analogs indicate compressive strain differentially enhances metastatic potential
    • Demou ZN. Gene expression profiles in 3D tumor analogs indicate compressive strain differentially enhances metastatic potential. Ann Biomed Eng (2010) 38:3509-20. doi:10.1007/s10439-010-0097-0
    • (2010) Ann Biomed Eng , vol.38 , pp. 3509-3520
    • Demou, Z.N.1
  • 56
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol (2010) 7:653-64. doi:10.1038/nrclinonc.2010.139
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 57
    • 0028025011 scopus 로고
    • Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows
    • Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res (1994) 54:4564-8.
    • (1994) Cancer Res , vol.54 , pp. 4564-4568
    • Yuan, F.1    Salehi, H.A.2    Boucher, Y.3    Vasthare, U.S.4    Tuma, R.F.5    Jain, R.K.6
  • 59
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med (2004) 10:789-99. doi:10.1038/nm1087
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 60
    • 84872040888 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment for cancer therapy
    • Sounni NE, Noel A. Targeting the tumor microenvironment for cancer therapy. Clin Chem (2013) 59:85-93. doi:10.1373/clinchem.2012.185363
    • (2013) Clin Chem , vol.59 , pp. 85-93
    • Sounni, N.E.1    Noel, A.2
  • 61
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 91:1071-121. doi:10.1152/physrev.00038.2010
    • (2011) Physiol Rev , vol.91 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6
  • 62
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res (2004) 64:3731-6. doi:10.1158/0008-5472.CAN-04-0074
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 63
    • 33749004555 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance
    • Zhang L, Hannay JA, Liu J, Das P, Zhan M, Nguyen T, et al. Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance. Cancer Res (2006) 66:8770-8. doi:10.1158/0008-5472.CAN-06-1217
    • (2006) Cancer Res , vol.66 , pp. 8770-8778
    • Zhang, L.1    Hannay, J.A.2    Liu, J.3    Das, P.4    Zhan, M.5    Nguyen, T.6
  • 64
    • 79551605347 scopus 로고    scopus 로고
    • Smad4 inactivation promotes malignancy and drug resistance of colon cancer
    • Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert AW, Abdolmaleky HM, et al. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res (2011) 71:998-1008. doi:10.1158/0008-5472.CAN-09-3269
    • (2011) Cancer Res , vol.71 , pp. 998-1008
    • Papageorgis, P.1    Cheng, K.2    Ozturk, S.3    Gong, Y.4    Lambert, A.W.5    Abdolmaleky, H.M.6
  • 65
    • 84904461602 scopus 로고    scopus 로고
    • VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance
    • Cho HJ, Kim IK, Park SM, Baek KE, Nam IK, Park SH, et al. VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance. Int J Cancer (2014) 135:1553-63. doi:10.1002/ijc.28801
    • (2014) Int J Cancer , vol.135 , pp. 1553-1563
    • Cho, H.J.1    Kim, I.K.2    Park, S.M.3    Baek, K.E.4    Nam, I.K.5    Park, S.H.6
  • 66
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 30:393-402. doi:10.1016/j.molcel.2008.04.009
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 67
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, et al. Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 94:715-25. doi:10.1016/S0092-8674(00)81731-6
    • (1998) Cell , vol.94 , pp. 715-725
    • Fukumura, D.1    Xavier, R.2    Sugiura, T.3    Chen, Y.4    Park, E.C.5    Lu, N.6
  • 68
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 121:335-48. doi:10.1016/j.cell.2005.02.034
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6
  • 69
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell (2009) 15:21-34. doi:10.1016/j.ccr.2008.12.004
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6
  • 70
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med (2008) 5:e19. doi:10.1371/journal.pmed.0050019
    • (2008) PLoS Med , vol.5
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 71
    • 0346727319 scopus 로고    scopus 로고
    • What brings pericytes to tumor vessels?
    • Jain RK, Booth MF. What brings pericytes to tumor vessels? J Clin Invest (2003) 112:1134-6. doi:10.1172/JCI200320087
    • (2003) J Clin Invest , vol.112 , pp. 1134-1136
    • Jain, R.K.1    Booth, M.F.2
  • 72
    • 78649737455 scopus 로고    scopus 로고
    • The extracellular matrix at a glance
    • Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci (2010) 123:4195-200. doi:10.1242/jcs.023820
    • (2010) J Cell Sci , vol.123 , pp. 4195-4200
    • Frantz, C.1    Stewart, K.M.2    Weaver, V.M.3
  • 73
    • 72449147268 scopus 로고    scopus 로고
    • Proteoglycans: from structural compounds to signaling molecules
    • Schaefer L, Schaefer RM. Proteoglycans: from structural compounds to signaling molecules. Cell Tissue Res (2010) 339:237-46. doi:10.1007/s00441-009-0821-y
    • (2010) Cell Tissue Res , vol.339 , pp. 237-246
    • Schaefer, L.1    Schaefer, R.M.2
  • 74
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: a dynamic niche in cancer progression
    • Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 196:395-406. doi:10.1083/jcb.201102147
    • (2012) J Cell Biol , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 75
    • 77951234989 scopus 로고    scopus 로고
    • The extracellular matrix in development and morphogenesis: a dynamic view
    • Rozario T, DeSimone DW. The extracellular matrix in development and morphogenesis: a dynamic view. Dev Biol (2010) 341:126-40. doi:10.1016/j.ydbio.2009.10.026
    • (2010) Dev Biol , vol.341 , pp. 126-140
    • Rozario, T.1    DeSimone, D.W.2
  • 76
    • 0032794692 scopus 로고    scopus 로고
    • Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model
    • Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J Cell Physiol (1999) 181:153-9. doi:10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K
    • (1999) J Cell Physiol , vol.181 , pp. 153-159
    • Mori, T.1    Kawara, S.2    Shinozaki, M.3    Hayashi, N.4    Kakinuma, T.5    Igarashi, A.6
  • 77
    • 0347418197 scopus 로고    scopus 로고
    • Collagens, modifying enzymes and their mutations in humans, flies and worms
    • Myllyharju J, Kivirikko KI. Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet (2004) 20:33-43. doi:10.1016/j.tig.2003.11.004
    • (2004) Trends Genet , vol.20 , pp. 33-43
    • Myllyharju, J.1    Kivirikko, K.I.2
  • 78
    • 84890122149 scopus 로고    scopus 로고
    • The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging
    • Egbert M, Ruetze M, Sattler M, Wenck H, Gallinat S, Lucius R, et al. The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. J Dermatol Sci (2014) 73:40-8. doi:10.1016/j.jdermsci.2013.08.010
    • (2014) J Dermatol Sci , vol.73 , pp. 40-48
    • Egbert, M.1    Ruetze, M.2    Sattler, M.3    Wenck, H.4    Gallinat, S.5    Lucius, R.6
  • 79
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 15:786-801. doi:10.1038/nrm3904
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 80
    • 0034161922 scopus 로고    scopus 로고
    • Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
    • Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res (2000) 60:1254-60.
    • (2000) Cancer Res , vol.60 , pp. 1254-1260
    • Barcellos-Hoff, M.H.1    Ravani, S.A.2
  • 81
    • 84874710060 scopus 로고    scopus 로고
    • Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: potential impact on angiogenesis and tumor growth
    • Hellevik T, Pettersen I, Berg V, Bruun J, Bartnes K, Busund LT, et al. Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: potential impact on angiogenesis and tumor growth. Transl Oncol (2013) 6:66-74. doi:10.1593/tlo.12349
    • (2013) Transl Oncol , vol.6 , pp. 66-74
    • Hellevik, T.1    Pettersen, I.2    Berg, V.3    Bruun, J.4    Bartnes, K.5    Busund, L.T.6
  • 82
    • 84890812467 scopus 로고    scopus 로고
    • Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
    • Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, Mace A, et al. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med (2013) 210:2851-72. doi:10.1084/jem.20131195
    • (2013) J Exp Med , vol.210 , pp. 2851-2872
    • Lotti, F.1    Jarrar, A.M.2    Pai, R.K.3    Hitomi, M.4    Lathia, J.5    Mace, A.6
  • 83
    • 84890549535 scopus 로고    scopus 로고
    • Combination antiangiogenic therapy and radiation in head and neck cancers
    • Hsu HW, Wall NR, Hsueh CT, Kim S, Ferris RL, Chen CS, et al. Combination antiangiogenic therapy and radiation in head and neck cancers. Oral Oncol (2014) 50:19-26. doi:10.1016/j.oraloncology.2013.10.003
    • (2014) Oral Oncol , vol.50 , pp. 19-26
    • Hsu, H.W.1    Wall, N.R.2    Hsueh, C.T.3    Kim, S.4    Ferris, R.L.5    Chen, C.S.6
  • 84
    • 84890282335 scopus 로고    scopus 로고
    • Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment
    • Kershaw MH, Devaud C, John LB, Westwood JA, Darcy PK. Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment. Oncoimmunology (2013) 2:e25962. doi:10.4161/onci.25962
    • (2013) Oncoimmunology , vol.2
    • Kershaw, M.H.1    Devaud, C.2    John, L.B.3    Westwood, J.A.4    Darcy, P.K.5
  • 85
    • 84922021366 scopus 로고    scopus 로고
    • Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy
    • Shahabi V, Postow MA, Tuck D, Wolchok JD. Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol (2015) 38:90-7. doi:10.1097/COC.0b013e3182868ec8
    • (2015) Am J Clin Oncol , vol.38 , pp. 90-97
    • Shahabi, V.1    Postow, M.A.2    Tuck, D.3    Wolchok, J.D.4
  • 86
    • 84887478772 scopus 로고    scopus 로고
    • Combining two strategies to improve perfusion and drug delivery in solid tumors
    • Stylianopoulos T, Jain RK. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proc Natl Acad Sci U S A (2013) 110:18632-7. doi:10.1073/pnas.1318415110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 18632-18637
    • Stylianopoulos, T.1    Jain, R.K.2
  • 87
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 285:1182-6. doi:10.1056/NEJM197111182852108
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 88
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 307:58-62. doi:10.1126/science.1104819
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 89
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med (2001) 7:987-9. doi:10.1038/nm0901-987
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 91
    • 84896031643 scopus 로고    scopus 로고
    • Phase I study of anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers
    • Wheler JJ, Janku F, Falchook GS, Jackson TL, Fu S, Naing A, et al. Phase I study of anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers. Cancer Chemother Pharmacol (2014) 73:495-501. doi:10.1007/s00280-014-2384-1
    • (2014) Cancer Chemother Pharmacol , vol.73 , pp. 495-501
    • Wheler, J.J.1    Janku, F.2    Falchook, G.S.3    Jackson, T.L.4    Fu, S.5    Naing, A.6
  • 92
    • 84922569615 scopus 로고    scopus 로고
    • Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer
    • Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, et al. Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proc Natl Acad Sci U S A (2015) 112:1547-52. doi:10.1073/pnas.1424024112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1547-1552
    • Heist, R.S.1    Duda, D.G.2    Sahani, D.V.3    Ancukiewicz, M.4    Fidias, P.5    Sequist, L.V.6
  • 93
    • 84903194653 scopus 로고    scopus 로고
    • Can bevacizumab prolong survival for glioblastoma patients through multiple lines of therapy?
    • Brandes AA, Mason W, Pichler J, Nowak AK, Gil M, Saran F, et al. Can bevacizumab prolong survival for glioblastoma patients through multiple lines of therapy? Future Oncol (2014) 10:1137-45. doi:10.2217/fon.14.75
    • (2014) Future Oncol , vol.10 , pp. 1137-1145
    • Brandes, A.A.1    Mason, W.2    Pichler, J.3    Nowak, A.K.4    Gil, M.5    Saran, F.6
  • 94
    • 84862907876 scopus 로고    scopus 로고
    • Increased survival of glioblastoma patients who respond to anti-angiogenic therapy with elevated blood perfusion
    • Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, et al. Increased survival of glioblastoma patients who respond to anti-angiogenic therapy with elevated blood perfusion. Cancer Res (2012) 72:402-7. doi:10.1158/0008-5472.CAN-11-2464
    • (2012) Cancer Res , vol.72 , pp. 402-407
    • Sorensen, A.G.1    Emblem, K.E.2    Polaskova, P.3    Jennings, D.4    Kim, H.5    Ancukiewicz, M.6
  • 95
    • 84887419886 scopus 로고    scopus 로고
    • Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
    • Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A (2013) 110:19059-64. doi:10.1073/pnas.1318022110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 19059-19064
    • Batchelor, T.T.1    Gerstner, E.R.2    Emblem, K.E.3    Duda, D.G.4    Kalpathy-Cramer, J.5    Snuderl, M.6
  • 96
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 93:14765-70. doi:10.1073/pnas.93.25.14765
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 97
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell (2004) 6:553-63. doi:10.1016/S1535-6108(04)00305-8
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3    Chae, S.S.4    Booth, M.F.5    Garkavtsev, I.6
  • 98
    • 84890282284 scopus 로고    scopus 로고
    • Benefits of vascular normalization are dose and time dependent-letter
    • Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK. Benefits of vascular normalization are dose and time dependent-letter. Cancer Res (2013) 73:7144-6. doi:10.1158/0008-5472.CAN-13-1989
    • (2013) Cancer Res , vol.73 , pp. 7144-7146
    • Huang, Y.1    Stylianopoulos, T.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 99
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, Di Tomaso E, Duda DG, Munn LL, Tong RT, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med (2004) 10:145-7. doi:10.1038/nm988
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3    Duda, D.G.4    Munn, L.L.5    Tong, R.T.6
  • 100
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, Di Tomaso E, Zhang WT, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell (2007) 11:83-95. doi:10.1016/j.ccr.2006.11.021
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    Di Tomaso, E.3    Zhang, W.T.4    Duda, D.G.5    Cohen, K.S.6
  • 102
    • 67649921334 scopus 로고    scopus 로고
    • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
    • Willett CG, Duda DG, Di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol (2009) 27:3020-6. doi:10.1200/JCO.2008.21.1771
    • (2009) J Clin Oncol , vol.27 , pp. 3020-3026
    • Willett, C.G.1    Duda, D.G.2    Di Tomaso, E.3    Boucher, Y.4    Ancukiewicz, M.5    Sahani, D.V.6
  • 103
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, Mcintyre D, Honess D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 324:1457-61. doi:10.1126/science.1171362
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    Mcintyre, D.5    Honess, D.6
  • 104
    • 84904994417 scopus 로고    scopus 로고
    • Stromal response to Hedgehog signaling restrains pancreatic cancer progression
    • Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A (2014) 111:E3091-100. doi:10.1073/pnas.1411679111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E3091-E3100
    • Lee, J.J.1    Perera, R.M.2    Wang, H.3    Wu, D.C.4    Liu, X.S.5    Han, S.6
  • 105
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell (2014) 25:719-34. doi:10.1016/j.ccr.2014.04.005
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Özdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.C.5    Simpson, T.R.6
  • 106
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell (2014) 25:735-47. doi:10.1016/j.ccr.2014.04.021
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3    Mirek, E.T.4    Palermo, C.F.5    Sastra, S.A.6
  • 107
    • 79952594233 scopus 로고    scopus 로고
    • Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
    • Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A (2011) 108:2909-14. doi:10.1073/pnas.1018892108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2909-2914
    • Diop-Frimpong, B.1    Chauhan, V.P.2    Krane, S.3    Boucher, Y.4    Jain, R.K.5
  • 108
    • 84885129359 scopus 로고    scopus 로고
    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels
    • Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels. Nat Commun (2013) 4:2516. doi:10.1038/ncomms.3516
    • (2013) Nat Commun , vol.4 , pp. 2516
    • Chauhan, V.P.1    Martin, J.D.2    Liu, H.3    Lacorre, D.A.4    Jain, S.R.5    Kozin, S.V.6
  • 109
    • 84867362497 scopus 로고    scopus 로고
    • TGF-beta blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
    • Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, et al. TGF-beta blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A (2012) 109:16618-23. doi:10.1073/pnas.1117610109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 16618-16623
    • Liu, J.1    Liao, S.2    Diop-Frimpong, B.3    Chen, W.4    Goel, S.5    Naxerova, K.6
  • 110
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 62:112-20. doi:10.1136/gutjnl-2012-302529
    • (2012) Gut , vol.62 , pp. 112-120
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3    Bapiro, T.E.4    Cook, N.5    Frese, K.K.6
  • 111
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 21:418-29. doi:10.1016/j.ccr.2012.01.007
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 112
    • 84904244854 scopus 로고    scopus 로고
    • Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure
    • Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, et al. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell (2014) 26:14-5. doi:10.1016/j.ccr.2014.06.003
    • (2014) Cancer Cell , vol.26 , pp. 14-15
    • Chauhan, V.P.1    Boucher, Y.2    Ferrone, C.R.3    Roberge, S.4    Martin, J.D.5    Stylianopoulos, T.6
  • 113
    • 69049113864 scopus 로고    scopus 로고
    • Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy
    • Wilop S, Von Hobe S, Crysandt M, Esser A, Osieka R, Jost E. Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy. J Cancer Res Clin Oncol (2009) 135:1429-35. doi:10.1007/s00432-009-0587-3
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 1429-1435
    • Wilop, S.1    Von Hobe, S.2    Crysandt, M.3    Esser, A.4    Osieka, R.5    Jost, E.6
  • 114
    • 78650224339 scopus 로고    scopus 로고
    • Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine
    • Nakai Y, Isayama H, Ijichi H, Sasaki T, Sasahira N, Hirano K, et al. Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br J Cancer (2010) 103:1644-8. doi:10.1038/sj.bjc.6605955
    • (2010) Br J Cancer , vol.103 , pp. 1644-1648
    • Nakai, Y.1    Isayama, H.2    Ijichi, H.3    Sasaki, T.4    Sasahira, N.5    Hirano, K.6
  • 115
    • 80051889719 scopus 로고    scopus 로고
    • Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
    • Keizman D, Huang P, Eisenberger MA, Pili R, Kim JJ, Antonarakis ES, et al. Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination. Eur J Cancer (2011) 47:1955-61. doi:10.1016/j.ejca.2011.04.019
    • (2011) Eur J Cancer , vol.47 , pp. 1955-1961
    • Keizman, D.1    Huang, P.2    Eisenberger, M.A.3    Pili, R.4    Kim, J.J.5    Antonarakis, E.S.6
  • 116
    • 84906951532 scopus 로고    scopus 로고
    • Improving the distribution of Doxil® in the tumormatrix by depletion of tumor hyaluronan
    • Kohli AG, Kivimäe S, Tiffany MR, Szoka FC. Improving the distribution of Doxil® in the tumormatrix by depletion of tumor hyaluronan. J Control Release (2014) 191:105-14. doi:10.1016/j.jconrel.2014.05.019
    • (2014) J Control Release , vol.191 , pp. 105-114
    • Kohli, A.G.1    Kivimäe, S.2    Tiffany, M.R.3    Szoka, F.C.4
  • 118
    • 84861794046 scopus 로고    scopus 로고
    • Blood flow reprograms lymphatic vessels to blood vessels
    • Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, et al. Blood flow reprograms lymphatic vessels to blood vessels. J Clin Invest (2012) 122:2006-17. doi:10.1172/JCI57513
    • (2012) J Clin Invest , vol.122 , pp. 2006-2017
    • Chen, C.Y.1    Bertozzi, C.2    Zou, Z.3    Yuan, L.4    Lee, J.S.5    Lu, M.6
  • 119
    • 70350565505 scopus 로고    scopus 로고
    • Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    • Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, et al. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med (2009) 15:1219-23. doi:10.1038/nm.1971
    • (2009) Nat Med , vol.15 , pp. 1219-1223
    • Vakoc, B.J.1    Lanning, R.M.2    Tyrrell, J.A.3    Padera, T.P.4    Bartlett, L.A.5    Stylianopoulos, T.6
  • 120
    • 84862907562 scopus 로고    scopus 로고
    • Intravital multiphoton imaging of immune responses in the mouse ear skin
    • Li JL, Goh CC, Keeble JL, Qin JS, Roediger B, Jain R, et al. Intravital multiphoton imaging of immune responses in the mouse ear skin. Nat Protoc (2012) 7:221-34. doi:10.1038/nprot.2011.438
    • (2012) Nat Protoc , vol.7 , pp. 221-234
    • Li, J.L.1    Goh, C.C.2    Keeble, J.L.3    Qin, J.S.4    Roediger, B.5    Jain, R.6
  • 121
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models
    • Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (2010) 17:206-25. doi:10.1111/j.1549-8719.2010.00029.x
    • (2010) Microcirculation , vol.17 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 122
    • 84901034975 scopus 로고    scopus 로고
    • In vivo optical imaging of cancer metastasis using multiphoton microscopy: a short review
    • Tanaka K, Toiyama Y, Okugawa Y, Okigami M, Inoue Y, Uchida K, et al. In vivo optical imaging of cancer metastasis using multiphoton microscopy: a short review. Am J Transl Res (2014) 6:179-87.
    • (2014) Am J Transl Res , vol.6 , pp. 179-187
    • Tanaka, K.1    Toiyama, Y.2    Okugawa, Y.3    Okigami, M.4    Inoue, Y.5    Uchida, K.6
  • 123
    • 80053058993 scopus 로고    scopus 로고
    • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    • Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, Mclendon RE, et al. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One (2011) 6(9):e24807. doi:10.1371/journal.pone.0024807
    • (2011) PLoS One , vol.6 , Issue.9
    • Lathia, J.D.1    Gallagher, J.2    Myers, J.T.3    Li, M.4    Vasanji, A.5    Mclendon, R.E.6
  • 125
  • 127
    • 67749145233 scopus 로고    scopus 로고
    • Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension
    • Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, et al. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell (2009) 20:3224-38. doi:10.1091/mbc.E08-12-1186
    • (2009) Mol Biol Cell , vol.20 , pp. 3224-3238
    • Gehler, S.1    Baldassarre, M.2    Lad, Y.3    Leight, J.L.4    Wozniak, M.A.5    Riching, K.M.6
  • 128
    • 80051804176 scopus 로고    scopus 로고
    • 3D in vitro bioengineered tumors based on collagen I hydrogels
    • Szot CS, Buchanan CF, Freeman JW, Rylander MN. 3D in vitro bioengineered tumors based on collagen I hydrogels. Biomaterials (2011) 32:7905-12. doi:10.1016/j.biomaterials.2011.07.001
    • (2011) Biomaterials , vol.32 , pp. 7905-7912
    • Szot, C.S.1    Buchanan, C.F.2    Freeman, J.W.3    Rylander, M.N.4
  • 129
    • 84870237106 scopus 로고    scopus 로고
    • Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior
    • Mason BN, Starchenko A, Williams RM, Bonassar LJ, Reinhart-King CA. Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior. Acta Biomater (2013) 9:4635-44. doi:10.1016/j.actbio.2012.08.007
    • (2013) Acta Biomater , vol.9 , pp. 4635-4644
    • Mason, B.N.1    Starchenko, A.2    Williams, R.M.3    Bonassar, L.J.4    Reinhart-King, C.A.5
  • 130
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 139:891-906. doi:10.1016/j.cell.2009.10.027
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3    Lakins, J.N.4    Egeblad, M.5    Erler, J.T.6
  • 131
    • 72549107558 scopus 로고    scopus 로고
    • A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion
    • Brekhman V, Neufeld G. A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. BMC Cancer (2009) 9:415. doi:10.1186/1471-2407-9-415
    • (2009) BMC Cancer , vol.9 , pp. 415
    • Brekhman, V.1    Neufeld, G.2
  • 132
    • 3843084007 scopus 로고    scopus 로고
    • Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D
    • David L, Dulong V, Le Cerf D, Chauzy C, Norris V, Delpech B, et al. Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D. Matrix Biol (2004) 23:183-93. doi:10.1016/j.matbio.2004.05.005
    • (2004) Matrix Biol , vol.23 , pp. 183-193
    • David, L.1    Dulong, V.2    Le Cerf, D.3    Chauzy, C.4    Norris, V.5    Delpech, B.6
  • 133
    • 69249230753 scopus 로고    scopus 로고
    • Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
    • Gurski LA, Jha AK, Zhang C, Jia X, Farach-Carson MC. Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells. Biomaterials (2009) 30:6076-85. doi:10.1016/j.biomaterials.2009.07.054
    • (2009) Biomaterials , vol.30 , pp. 6076-6085
    • Gurski, L.A.1    Jha, A.K.2    Zhang, C.3    Jia, X.4    Farach-Carson, M.C.5
  • 135
    • 84899966772 scopus 로고    scopus 로고
    • The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer
    • 9-70
    • Weigelt B, Ghajar CM, Bissell MJ. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv Drug Deliv Rev (2014) 6(9-70):42-51. doi:10.1016/j.addr.2014.01.001
    • (2014) Adv Drug Deliv Rev , vol.6 , pp. 42-51
    • Weigelt, B.1    Ghajar, C.M.2    Bissell, M.J.3
  • 137
    • 84908267279 scopus 로고    scopus 로고
    • Compressive stress inhibits proliferation in tumor spheroids through a volume limitation
    • Delarue M, Montel F, Vignjevic D, Prost J, Joanny JF, Cappello G. Compressive stress inhibits proliferation in tumor spheroids through a volume limitation. Biophys J (2014) 107:1821-8. doi:10.1016/j.bpj.2014.08.031
    • (2014) Biophys J , vol.107 , pp. 1821-1828
    • Delarue, M.1    Montel, F.2    Vignjevic, D.3    Prost, J.4    Joanny, J.F.5    Cappello, G.6
  • 138
    • 0028918625 scopus 로고
    • Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells
    • Keely PJ, Fong AM, Zutter MM, Santoro SA. Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci (1995) 108(Pt 2):595-607.
    • (1995) J Cell Sci , vol.108 , pp. 595-607
    • Keely, P.J.1    Fong, A.M.2    Zutter, M.M.3    Santoro, S.A.4
  • 139
    • 84861486197 scopus 로고    scopus 로고
    • The advantages of co-culture over mono cell culture in simulating in vivo environment
    • Miki Y, Ono K, Hata S, Suzuki T, Kumamoto H, Sasano H. The advantages of co-culture over mono cell culture in simulating in vivo environment. J Steroid Biochem Mol Biol (2012) 131:68-75. doi:10.1016/j.jsbmb.2011.12.004
    • (2012) J Steroid Biochem Mol Biol , vol.131 , pp. 68-75
    • Miki, Y.1    Ono, K.2    Hata, S.3    Suzuki, T.4    Kumamoto, H.5    Sasano, H.6
  • 141
    • 84885720631 scopus 로고    scopus 로고
    • A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development
    • Girard YK, Wang C, Ravi S, Howell MC, Mallela J, Alibrahim M, et al. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PLoS One (2013) 8:e75345. doi:10.1371/journal.pone.0075345
    • (2013) PLoS One , vol.8
    • Girard, Y.K.1    Wang, C.2    Ravi, S.3    Howell, M.C.4    Mallela, J.5    Alibrahim, M.6
  • 142
    • 84863066952 scopus 로고    scopus 로고
    • Electrospun fibrous scaffolds promote breast cancer cell alignment and epithelial-mesenchymal transition
    • Saha S, Duan X, Wu L, Lo PK, Chen H, Wang Q. Electrospun fibrous scaffolds promote breast cancer cell alignment and epithelial-mesenchymal transition. Langmuir (2012) 28:2028-34. doi:10.1021/la203846w
    • (2012) Langmuir , vol.28 , pp. 2028-2034
    • Saha, S.1    Duan, X.2    Wu, L.3    Lo, P.K.4    Chen, H.5    Wang, Q.6
  • 143
    • 23744515305 scopus 로고    scopus 로고
    • Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    • Nelson CM, Bissell MJ. Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 15:342-52. doi:10.1016/j.semcancer.2005.05.001
    • (2005) Semin Cancer Biol , vol.15 , pp. 342-352
    • Nelson, C.M.1    Bissell, M.J.2
  • 145
    • 84932617660 scopus 로고    scopus 로고
    • 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways
    • DelNero P, Lane M, Verbridge SS, Kwee B, Kermani P, Hempstead B, et al. 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways. Biomaterials (2015) 55:110-8. doi:10.1016/j.biomaterials.2015.03.035
    • (2015) Biomaterials , vol.55 , pp. 110-118
    • DelNero, P.1    Lane, M.2    Verbridge, S.S.3    Kwee, B.4    Kermani, P.5    Hempstead, B.6
  • 146
    • 33747352316 scopus 로고    scopus 로고
    • Atomic force microscopy in biology: technology and techniques
    • Gadegaard N. Atomic force microscopy in biology: technology and techniques. Biotech Histochem (2006) 81:87-97. doi:10.1080/10520290600783143
    • (2006) Biotech Histochem , vol.81 , pp. 87-97
    • Gadegaard, N.1
  • 147
    • 84876670393 scopus 로고    scopus 로고
    • Surface nanoscale imaging of collagen thin films by atomic force microscopy
    • Stylianou A, Yova D. Surface nanoscale imaging of collagen thin films by atomic force microscopy. Mater Sci Eng C Mater Biol Appl (2013) 33:2947-57. doi:10.1016/j.msec.2013.03.029
    • (2013) Mater Sci Eng C Mater Biol Appl , vol.33 , pp. 2947-2957
    • Stylianou, A.1    Yova, D.2
  • 148
    • 84923194007 scopus 로고    scopus 로고
    • Assessing collagen nanoscale thin films heterogeneity by AFM multimode imaging and nanoindetation for nanobiomedical applications
    • Stylianou A, Kontomaris SV, Yova D. Assessing collagen nanoscale thin films heterogeneity by AFM multimode imaging and nanoindetation for nanobiomedical applications. Micro Nanosyst (2014) 6:95-102. doi:10.2174/187640290602141127114448
    • (2014) Micro Nanosyst , vol.6 , pp. 95-102
    • Stylianou, A.1    Kontomaris, S.V.2    Yova, D.3
  • 149
    • 84907842539 scopus 로고    scopus 로고
    • Investigation of the influence of UV irradiation on collagen thin films by AFM imaging
    • Stylianou A, Yova D, Alexandratou E. Investigation of the influence of UV irradiation on collagen thin films by AFM imaging. Mater Sci Eng C (2014) 45:455-68. doi:10.1016/j.msec.2014.09.006
    • (2014) Mater Sci Eng C , vol.45 , pp. 455-468
    • Stylianou, A.1    Yova, D.2    Alexandratou, E.3
  • 151
    • 84888042567 scopus 로고    scopus 로고
    • Nanotopography of collagen thin films in correlation with fibroblast response
    • Stylianou A, Yova D, Alexandratou E. Nanotopography of collagen thin films in correlation with fibroblast response. J Nanophotonics (2013) 7(1):073590. doi:10.1117/1.JNP.7.073590
    • (2013) J Nanophotonics , vol.7 , Issue.1 , pp. 073590
    • Stylianou, A.1    Yova, D.2    Alexandratou, E.3
  • 152
    • 84926962690 scopus 로고    scopus 로고
    • The effects of UV irradiation on collagen D-band revealed by atomic force microscopy
    • Kontomaris SV, Yova D, Stylianou A, Balogiannis G. The effects of UV irradiation on collagen D-band revealed by atomic force microscopy. Scanning (2015) 37:101-11. doi:10.1002/sca.21185
    • (2015) Scanning , vol.37 , pp. 101-111
    • Kontomaris, S.V.1    Yova, D.2    Stylianou, A.3    Balogiannis, G.4
  • 153
    • 84921508408 scopus 로고    scopus 로고
    • Biomechanics of TGFbeta-induced epithelial-mesenchymal transition: implications for fibrosis and cancer
    • O'Connor J, Gomez E. Biomechanics of TGFbeta-induced epithelial-mesenchymal transition: implications for fibrosis and cancer. Clin Transl Med (2014) 3:23. doi:10.1186/2001-1326-3-23
    • (2014) Clin Transl Med , vol.3 , pp. 23
    • O'Connor, J.1    Gomez, E.2
  • 154
    • 84891909139 scopus 로고    scopus 로고
    • Tension monitoring during epithelial-to-mesenchymal transition links the switch of phenotype to expression of moesin and cadherins in NMuMG cells
    • Schneider D, Baronsky T, Pietuch A, Rother J, Oelkers M, Fichtner D, et al. Tension monitoring during epithelial-to-mesenchymal transition links the switch of phenotype to expression of moesin and cadherins in NMuMG cells. PLoS One (2013) 8(12):e80068. doi:10.1371/journal.pone.0080068
    • (2013) PLoS One , vol.8 , Issue.12
    • Schneider, D.1    Baronsky, T.2    Pietuch, A.3    Rother, J.4    Oelkers, M.5    Fichtner, D.6
  • 155
    • 42549106883 scopus 로고    scopus 로고
    • Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds
    • Pittet P, Lee K, Kulik AJ, Meister JJ, Hinz B. Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J Cell Sci (2008) 121:877-86. doi:10.1242/jcs.024877
    • (2008) J Cell Sci , vol.121 , pp. 877-886
    • Pittet, P.1    Lee, K.2    Kulik, A.J.3    Meister, J.J.4    Hinz, B.5
  • 157
    • 84860395096 scopus 로고    scopus 로고
    • Cytoskeletal re-arrangement in TGF-β1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
    • Buckley ST, Medina C, Davies AM, Ehrhardt C. Cytoskeletal re-arrangement in TGF-β1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis. Nanomedicine (2012) 8:355-64. doi:10.1016/j.nano.2011.06.021
    • (2012) Nanomedicine , vol.8 , pp. 355-364
    • Buckley, S.T.1    Medina, C.2    Davies, A.M.3    Ehrhardt, C.4
  • 158
    • 0038444006 scopus 로고    scopus 로고
    • Atomic force microscopy measurement of cytostructural elements involved in the nanodynamics of tumour cell invasion
    • Chasiotis I, Fillmore HL, Gillies GT. Atomic force microscopy measurement of cytostructural elements involved in the nanodynamics of tumour cell invasion. Nanotechnology (2003) 14:557-61. doi:10.1088/0957-4484/14/5/314
    • (2003) Nanotechnology , vol.14 , pp. 557-561
    • Chasiotis, I.1    Fillmore, H.L.2    Gillies, G.T.3
  • 159
    • 0037253822 scopus 로고    scopus 로고
    • Atomic force microscopy observations of tumour cell invadopodia: novel cellular nanomorphologies on collagen substrates
    • Fillmore HL, Chasiotis I, Cho SW, Gillies GT. Atomic force microscopy observations of tumour cell invadopodia: novel cellular nanomorphologies on collagen substrates. Nanotechnology (2003) 14:73-6. doi:10.1088/0957-4484/14/1/317
    • (2003) Nanotechnology , vol.14 , pp. 73-76
    • Fillmore, H.L.1    Chasiotis, I.2    Cho, S.W.3    Gillies, G.T.4
  • 160
    • 23244447185 scopus 로고    scopus 로고
    • Nanoscale imaging and quantification of local proteolytic activity
    • Kusick S, Bertram H, Oberleithner H, Ludwig T. Nanoscale imaging and quantification of local proteolytic activity. J Cell Physiol (2005) 204:767-74. doi:10.1002/jcp.20328
    • (2005) J Cell Physiol , vol.204 , pp. 767-774
    • Kusick, S.1    Bertram, H.2    Oberleithner, H.3    Ludwig, T.4
  • 161
    • 30444432840 scopus 로고    scopus 로고
    • Local proteolytic activity in tumor cell invasion and metastasis
    • Ludwig T. Local proteolytic activity in tumor cell invasion and metastasis. Bioessays (2005) 27:1181-91. doi:10.1002/bies.20306
    • (2005) Bioessays , vol.27 , pp. 1181-1191
    • Ludwig, T.1
  • 162
    • 43149087073 scopus 로고    scopus 로고
    • Challenges and approaches-probing tumor cell invasion by atomic force microscopy
    • Méndez-Vilas A, Díaz J, editors. Badajoz: Formatex
    • Ludwig T, Kirmse R, Poole K. Challenges and approaches-probing tumor cell invasion by atomic force microscopy. In: Méndez-Vilas A, Díaz J, editors. Modern Research and Educational Topics in Microscopy. Badajoz: Formatex (2007). p. 11-22.
    • (2007) Modern Research and Educational Topics in Microscopy , pp. 11-22
    • Ludwig, T.1    Kirmse, R.2    Poole, K.3
  • 163
    • 84905591082 scopus 로고    scopus 로고
    • AFM-based dual nano-mechanical phenotypes for cancer metastasis
    • Park S, Lee YJ. AFM-based dual nano-mechanical phenotypes for cancer metastasis. J Biol Phys (2014) 40:413-9. doi:10.1007/s10867-014-9353-0
    • (2014) J Biol Phys , vol.40 , pp. 413-419
    • Park, S.1    Lee, Y.J.2
  • 164
    • 84901445604 scopus 로고    scopus 로고
    • Atomic force microscopy reveals a role for endothelial cell ICAM-1 expression in bladder cancer cell adherence
    • Laurent VM, Duperray A, Sundar Rajan V, Verdier C. Atomic force microscopy reveals a role for endothelial cell ICAM-1 expression in bladder cancer cell adherence. PLoS One (2014) 9(5):e98034. doi:10.1371/journal.pone.0098034
    • (2014) PLoS One , vol.9 , Issue.5
    • Laurent, V.M.1    Duperray, A.2    Sundar Rajan, V.3    Verdier, C.4
  • 165
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
    • Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol (2013) 31:2205-18. doi:10.1200/JCO.2012.46.3653
    • (2013) J Clin Oncol , vol.31 , pp. 2205-2218
    • Jain, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.