메뉴 건너뛰기




Volumn 33, Issue 14, 2014, Pages 1743-1754

Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment

Author keywords

Angiogenesis; CAF; Cancer progression; Hypoxia; TAM; Tumor stroma

Indexed keywords

B LYMPHOCYTE; BLOOD CELL; BONE MARROW CELL; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GROWTH; CANCER THERAPY; CELL HYPOXIA; DENDRITIC CELL; ENDOTHELIUM CELL; FIBROBLAST; HEMATOPOIETIC CELL; HUMAN; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; NATURAL KILLER CELL; NATURAL KILLER T CELL; NEUTROPHIL; NONHUMAN; OXYGEN TENSION; PERICYTE; PHASE 2 CLINICAL TRIAL (TOPIC); PHENOTYPE; PRIORITY JOURNAL; REVIEW; STROMA; T LYMPHOCYTE; THROMBOCYTE; TISSUE OXYGENATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR INFILTRATING MYELOID CELL; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR RESISTANCE; TUMOR STROMA;

EID: 84897990135     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.121     Document Type: Review
Times cited : (202)

References (153)
  • 1
    • 0029033810 scopus 로고
    • Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation
    • Goda F, O-Hara JA, Rhodes ES, Liu KJ, Dunn JF, Bacic G, et al. Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation. Cancer Res 1995; 55: 2249-2252
    • (1995) Cancer Res , vol.55 , pp. 2249-2252
    • Goda, F.1    O-Hara, J.A.2    Rhodes, E.S.3    Liu, K.J.4    Dunn, J.F.5    Bacic, G.6
  • 2
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation. Nature Med 1997; 3: 177-182
    • (1997) Nature Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 3
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS. Effect of p53 status on tumor response to antiangiogenic therapy. Science 2002; 295: 1526-1528
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 4
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not
    • De Bock K, Mazzone M, Carmeliet P. Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not? Nat Rev Clin Oncol 2011; 8: 393-404
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 5
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011; 10: 417-427
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite De Oliveira R, Loges S, Schmidt T, Jonckx B, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136: 839-851
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    Leite De Oliveira, R.3    Loges, S.4    Schmidt, T.5    Jonckx, B.6
  • 8
    • 79957921039 scopus 로고    scopus 로고
    • Growing tumor vessels: More than one way to skin a cat - implications for angiogenesis targeted cancer therapies
    • Leite De Oliveira R, Hamm A, Mazzone M. Growing tumor vessels: More than one way to skin a cat - implications for angiogenesis targeted cancer therapies. Mol Aspects Med 2011; 32: 71-87
    • (2011) Mol Aspects Med , vol.32 , pp. 71-87
    • Leite De Oliveira, R.1    Hamm, A.2    Mazzone, M.3
  • 9
    • 79955705786 scopus 로고    scopus 로고
    • Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors using (immuno-)fluorescence techniques
    • Maftei CA, Bayer C, Shi K, Astner ST, Vaupel P. Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors using (immuno-)fluorescence techniques. Strahlenther Onkol 2011; 184: 260-266
    • (2011) Strahlenther Onkol , vol.184 , pp. 260-266
    • Maftei, C.A.1    Bayer, C.2    Shi, K.3    Astner, S.T.4    Vaupel, P.5
  • 10
    • 79960360368 scopus 로고    scopus 로고
    • Changes in the fraction of total hypoxia and hypoxia subtypes in human squamous cell carcinomas upon fractionated irradiation: Evaluation using pattern recognition in microcirculatory supply units
    • Maftei CA, Bayer C, Shi K, Astner ST, Vaupel P. Changes in the fraction of total hypoxia and hypoxia subtypes in human squamous cell carcinomas upon fractionated irradiation: Evaluation using pattern recognition in microcirculatory supply units. Radiother Oncol 2011; 101: 209-216
    • (2011) Radiother Oncol , vol.101 , pp. 209-216
    • Maftei, C.A.1    Bayer, C.2    Shi, K.3    Astner, S.T.4    Vaupel, P.5
  • 11
    • 69949139925 scopus 로고    scopus 로고
    • Local guidance of emerging vessel sprouts requires soluble Flt-1
    • Chappell JC, Taylor SM, Ferrara N, Bautch VL. Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev Cell 2009; 17: 377-386
    • (2009) Dev Cell , vol.17 , pp. 377-386
    • Chappell, J.C.1    Taylor, S.M.2    Ferrara, N.3    Bautch, V.L.4
  • 12
    • 84859700702 scopus 로고    scopus 로고
    • Endothelial HIF-2alpha regulates murine pathological angiogenesis and revascularization processes
    • Skuli N, Majmundar AJ, Krock BL, Mesquita RC, Mathew LK, Quinn ZL, et al. Endothelial HIF-2alpha regulates murine pathological angiogenesis and revascularization processes. J Clin Invest 2012; 122: 1427-1443
    • (2012) J Clin Invest , vol.122 , pp. 1427-1443
    • Skuli, N.1    Majmundar, A.J.2    Krock, B.L.3    Mesquita, R.C.4    Mathew, L.K.5    Quinn, Z.L.6
  • 13
    • 0031029458 scopus 로고    scopus 로고
    • Endothelial hypoxic stress proteins
    • Graven KK, Farber HW. Endothelial hypoxic stress proteins. Kidney Int 1997; 51: 426-437
    • (1997) Kidney Int , vol.51 , pp. 426-437
    • Graven, K.K.1    Farber, H.W.2
  • 14
    • 84872534173 scopus 로고    scopus 로고
    • Endothelial cell metabolism and tumour angiogenesis: Glucose and glutamine as essential fuels and lactate as the driving force
    • Polet F, Feron O. Endothelial cell metabolism and tumour angiogenesis: Glucose and glutamine as essential fuels and lactate as the driving force. J Intern Med 2013; 273: 156-165
    • (2013) J Intern Med , vol.273 , pp. 156-165
    • Polet, F.1    Feron, O.2
  • 15
    • 59349098621 scopus 로고    scopus 로고
    • Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
    • Fraisl P, Aragones J, Carmeliet P. Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 2009; 8: 139-152
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 139-152
    • Fraisl, P.1    Aragones, J.2    Carmeliet, P.3
  • 16
    • 84871475998 scopus 로고    scopus 로고
    • Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
    • Wong BW, Kuchnio A, Bruning U, Carmeliet P. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. Trends Biochem Sci 2013; 38: 3-11
    • (2013) Trends Biochem Sci , vol.38 , pp. 3-11
    • Wong, B.W.1    Kuchnio, A.2    Bruning, U.3    Carmeliet, P.4
  • 18
    • 54449087511 scopus 로고    scopus 로고
    • Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis
    • Dutta D, Ray S, Vivian JL, Paul S. Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem 2008; 283: 25404-25413
    • (2008) J Biol Chem , vol.283 , pp. 25404-25413
    • Dutta, D.1    Ray, S.2    Vivian, J.L.3    Paul, S.4
  • 19
    • 36349033527 scopus 로고    scopus 로고
    • HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites
    • Le Bras A, Lionneton F, Mattot V, Lelievre E, Caetano B, Spruyt N, et al. HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites. Oncogene 2007; 26: 7480-7489
    • (2007) Oncogene , vol.26 , pp. 7480-7489
    • Le Bras, A.1    Lionneton, F.2    Mattot, V.3    Lelievre, E.4    Caetano, B.5    Spruyt, N.6
  • 20
    • 67651098992 scopus 로고    scopus 로고
    • Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
    • Skuli N, Liu L, Runge A, Wang T, Yuan L, Patel S, et al. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 2009; 114: 469-477
    • (2009) Blood , vol.114 , pp. 469-477
    • Skuli, N.1    Liu, L.2    Runge, A.3    Wang, T.4    Yuan, L.5    Patel, S.6
  • 21
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004; 6: 485-495
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6
  • 23
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007; 445: 776-780
    • (2007) Nature , vol.445 , pp. 776-780
    • Hellstrom, M.1    Phng, L.K.2    Hofmann, J.J.3    Wallgard, E.4    Coultas, L.5    Lindblom, P.6
  • 25
    • 1642315195 scopus 로고    scopus 로고
    • Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
    • Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 2004; 279: 9899-9904
    • (2004) J Biol Chem , vol.279 , pp. 9899-9904
    • Koivunen, P.1    Hirsila, M.2    Gunzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 27
    • 0035149320 scopus 로고    scopus 로고
    • Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer
    • Schoppmann SF, Birner P, Studer P, Breiteneder-Geleff S. Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer. Anticancer Res 2001; 21: 2351-2355
    • (2001) Anticancer Res , vol.21 , pp. 2351-2355
    • Schoppmann, S.F.1    Birner, P.2    Studer, P.3    Breiteneder-Geleff, S.4
  • 28
    • 77955512358 scopus 로고    scopus 로고
    • Lymphangiogenesis and lymphatic metastasis in breast cancer
    • Ran S, Volk L, Hall K, Flister MJ. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 2010; 17: 229-251
    • (2010) Pathophysiology , vol.17 , pp. 229-251
    • Ran, S.1    Volk, L.2    Hall, K.3    Flister, M.J.4
  • 29
    • 84867087464 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
    • Schito L, Rey S, Tafani M, Zhang H, Wong CC, Russo A, et al. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. Proc Natl Acad Sci USA 2012; 109: E2707-E2716
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Schito, L.1    Rey, S.2    Tafani, M.3    Zhang, H.4    Wong, C.C.5    Russo, A.6
  • 31
    • 0032829875 scopus 로고    scopus 로고
    • Vegf and vegf type c play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours
    • Ohta Y, Shridhar V, Bright RK, Kalemkerian GP, Du W, Carbone M, et al. VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours. Br J Cancer 1999; 81: 54-61
    • (1999) Br J Cancer , vol.81 , pp. 54-61
    • Ohta, Y.1    Shridhar, V.2    Bright, R.K.3    Kalemkerian, G.P.4    Du, W.5    Carbone, M.6
  • 32
    • 45949094637 scopus 로고    scopus 로고
    • Hypoxia inducible factor-Alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma
    • Liang X, Yang D, Hu J, Hao X, Gao J, Mao Z. Hypoxia inducible factor-Alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma. Anticancer Res 2008; 28: 1659-1666
    • (2008) Anticancer Res , vol.28 , pp. 1659-1666
    • Liang, X.1    Yang, D.2    Hu, J.3    Hao, X.4    Gao, J.5    Mao, Z.6
  • 33
    • 65549118866 scopus 로고    scopus 로고
    • Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade
    • Spinella F, Garrafa E, Di Castro V, Rosano L, Nicotra MR, Caruso A, et al. Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. Cancer Res 2009; 69: 2669-2676
    • (2009) Cancer Res , vol.69 , pp. 2669-2676
    • Spinella, F.1    Garrafa, E.2    Di Castro, V.3    Rosano, L.4    Nicotra, M.R.5    Caruso, A.6
  • 34
    • 34249650289 scopus 로고    scopus 로고
    • Hypoxia alters the adhesive properties of lymphatic endothelial cells a transcriptional and functional study
    • Irigoyen M, Anso E, Martinez E, Garayoa M, Martinez-Irujo JJ, Rouzaut A. Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study. Biochim Biophys Acta 2007; 1773: 880-890
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 880-890
    • Irigoyen, M.1    Anso, E.2    Martinez, E.3    Garayoa, M.4    Martinez-Irujo, J.J.5    Rouzaut, A.6
  • 35
    • 35548943960 scopus 로고    scopus 로고
    • Hypoxia/Notch signaling in primary culture of rat lymphatic endothelial cells
    • Ota H, Katsube K, Ogawa J, Yanagishita M. Hypoxia/Notch signaling in primary culture of rat lymphatic endothelial cells. FEBS Lett 2007; 581: 5220-5226
    • (2007) FEBS Lett , vol.581 , pp. 5220-5226
    • Ota, H.1    Katsube, K.2    Ogawa, J.3    Yanagishita, M.4
  • 41
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441: 437-443
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 42
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111: 1287-1295
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 43
    • 84855912001 scopus 로고    scopus 로고
    • Pericyte depletion results in hypoxia-Associated epithelial-To- mesenchymal transition and metastasis mediated by met signaling pathway
    • Cooke VG, LeBleu VS, Keskin D, Khan Z, O-Connell JT, Teng Y, et al. Pericyte depletion results in hypoxia-Associated epithelial-To-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 2012; 21: 66-81
    • (2012) Cancer Cell , vol.21 , pp. 66-81
    • Cooke, V.G.1    LeBleu, V.S.2    Keskin, D.3    Khan, Z.4    O-Connell, J.T.5    Teng, Y.6
  • 44
    • 31944432534 scopus 로고    scopus 로고
    • Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer
    • Ozerdem U. Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer. Prostate 2006; 66: 294-304
    • (2006) Prostate , vol.66 , pp. 294-304
    • Ozerdem, U.1
  • 46
    • 84867646045 scopus 로고    scopus 로고
    • Novel molecular targets for the therapy of renal cell carcinoma
    • Elfiky AA, Sonpavde G. Novel molecular targets for the therapy of renal cell carcinoma. Discov Med 2012; 13: 461-471
    • (2012) Discov Med , vol.13 , pp. 461-471
    • Elfiky, A.A.1    Sonpavde, G.2
  • 47
    • 84856694670 scopus 로고    scopus 로고
    • Targeting the angiopoietin/Tie2 pathway cutting tumor vessels with a double-edged sword
    • Cascone T, Heymach JV. Targeting the angiopoietin/Tie2 pathway: Cutting tumor vessels with a double-edged sword? J Clin Oncol 2012; 30: 441-444
    • (2012) J Clin Oncol , vol.30 , pp. 441-444
    • Cascone, T.1    Heymach, J.V.2
  • 48
    • 33747859659 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer: A novel tumor-promoting cell type
    • Orimo A, Weinberg RA. Stromal fibroblasts in cancer: A novel tumor-promoting cell type. Cell Cycle 2006; 5: 1597-1601
    • (2006) Cell Cycle , vol.5 , pp. 1597-1601
    • Orimo, A.1    Weinberg, R.A.2
  • 49
    • 0037989982 scopus 로고    scopus 로고
    • A Phase I doseescalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
    • Scott AM, Wiseman G, Welt S, Adjei A, Lee FT, Hopkins W, et al. A Phase I doseescalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res 2003; 9: 1639-1647
    • (2003) Clin Cancer Res , vol.9 , pp. 1639-1647
    • Scott, A.M.1    Wiseman, G.2    Welt, S.3    Adjei, A.4    Lee, F.T.5    Hopkins, W.6
  • 50
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-Associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N, Truitt M, Olson P, Arron ST, Hanahan D. Cancer-Associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010; 17: 135-147
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 52
    • 49249120549 scopus 로고    scopus 로고
    • Carcinoma-Associated fibroblast-like differentiation of human mesenchymal stem cells
    • Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP, Ganesan S, et al. Carcinoma-Associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res 2008; 68: 4331-4339
    • (2008) Cancer Res , vol.68 , pp. 4331-4339
    • Mishra, P.J.1    Humeniuk, R.2    Medina, D.J.3    Alexe, G.4    Mesirov, J.P.5    Ganesan, S.6
  • 53
    • 36349034540 scopus 로고    scopus 로고
    • Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment
    • Mueller L, Goumas FA, Affeldt M, Sandtner S, Gehling UM, Brilloff S, et al. Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment. Am J Pathol 2007; 171: 1608-1618
    • (2007) Am J Pathol , vol.171 , pp. 1608-1618
    • Mueller, L.1    Goumas, F.A.2    Affeldt, M.3    Sandtner, S.4    Gehling, U.M.5    Brilloff, S.6
  • 54
    • 0037331707 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
    • Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rank F, Niebuhr E, et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol 2003; 162: 391-402
    • (2003) Am J Pathol , vol.162 , pp. 391-402
    • Petersen, O.W.1    Nielsen, H.L.2    Gudjonsson, T.3    Villadsen, R.4    Rank, F.5    Niebuhr, E.6
  • 55
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-Associated fibroblasts
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-Associated fibroblasts. Cancer Res 2007; 67: 10123-10128
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 56
    • 77956400210 scopus 로고    scopus 로고
    • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia HIF1 induction and NFkappaB activation in the tumor stromal microenvironment
    • Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. Cell Cycle 2010; 9: 3515-3533
    • (2010) Cell Cycle , vol.9 , pp. 3515-3533
    • Martinez-Outschoorn, U.E.1    Trimmer, C.2    Lin, Z.3    Whitaker-Menezes, D.4    Chiavarina, B.5    Zhou, J.6
  • 57
    • 77956399348 scopus 로고    scopus 로고
    • HIF1-Alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis
    • Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, et al. HIF1-Alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle 2010; 9: 3534-3551
    • (2010) Cell Cycle , vol.9 , pp. 3534-3551
    • Chiavarina, B.1    Whitaker-Menezes, D.2    Migneco, G.3    Martinez-Outschoorn, U.E.4    Pavlides, S.5    Howell, A.6
  • 58
    • 49749144117 scopus 로고    scopus 로고
    • Human breast cancer-Associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
    • Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, Minkeu A, et al. Human breast cancer-Associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy. Cancer Biol Ther 2008; 7: 1212-1225
    • (2008) Cancer Biol Ther , vol.7 , pp. 1212-1225
    • Mercier, I.1    Casimiro, M.C.2    Wang, C.3    Rosenberg, A.L.4    Quong, J.5    Minkeu, A.6
  • 59
    • 79959947008 scopus 로고    scopus 로고
    • Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
    • Goetz JG, Minguet S, Navarro-Lerida I, Lazcano JJ, Samaniego R, Calvo E, et al. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 2011; 146: 148-163
    • (2011) Cell , vol.146 , pp. 148-163
    • Goetz, J.G.1    Minguet, S.2    Navarro-Lerida, I.3    Lazcano, J.J.4    Samaniego, R.5    Calvo, E.6
  • 62
    • 24744451416 scopus 로고    scopus 로고
    • Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation
    • Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, et al. Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem 2005; 280: 31557-31563
    • (2005) J Biol Chem , vol.280 , pp. 31557-31563
    • Suzuki, A.1    Kusakai, G.2    Shimojo, Y.3    Chen, J.4    Ogura, T.5    Kobayashi, M.6
  • 63
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 2010; 107: 20009-20014
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20009-20014
    • Kojima, Y.1    Acar, A.2    Eaton, E.N.3    Mellody, K.T.4    Scheel, C.5    Ben-Porath, I.6
  • 64
    • 0023391364 scopus 로고
    • Wound healing: The effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization
    • Arnold F, West D, Kumar S. Wound healing: The effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization. Br J Exp Pathol 1987; 68: 569-574
    • (1987) Br J Exp Pathol , vol.68 , pp. 569-574
    • Arnold, F.1    West, D.2    Kumar, S.3
  • 65
    • 0035117937 scopus 로고    scopus 로고
    • Tumor hypoxia, the physiological link between Trousseau-s syndrome (carcinoma-induced coagulopathy) and metastasis
    • Denko NC, Giaccia AJ. Tumor hypoxia, the physiological link between Trousseau-s syndrome (carcinoma-induced coagulopathy) and metastasis. Cancer Res 2001; 61: 795-798
    • (2001) Cancer Res , vol.61 , pp. 795-798
    • Denko, N.C.1    Giaccia, A.J.2
  • 67
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegue E, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008; 13: 206-220
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegue, E.6
  • 68
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003; 425: 307-311
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 69
    • 9444226473 scopus 로고    scopus 로고
    • SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    • De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, et al. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 2004; 104: 3472-3482
    • (2004) Blood , vol.104 , pp. 3472-3482
    • De Falco, E.1    Porcelli, D.2    Torella, A.R.3    Straino, S.4    Iachininoto, M.G.5    Orlandi, A.6
  • 70
    • 30344437303 scopus 로고    scopus 로고
    • VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells
    • Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell 2006; 124: 175-189
    • (2006) Cell , vol.124 , pp. 175-189
    • Grunewald, M.1    Avraham, I.2    Dor, Y.3    Bachar-Lustig, E.4    Itin, A.5    Jung, S.6
  • 71
    • 0032887299 scopus 로고    scopus 로고
    • Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness
    • Kunz M, Hartmann A, Flory E, Toksoy A, Koczan D, Thiesen HJ, et al. Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. Am J Pathol 1999; 155: 753-763
    • (1999) Am J Pathol , vol.155 , pp. 753-763
    • Kunz, M.1    Hartmann, A.2    Flory, E.3    Toksoy, A.4    Koczan, D.5    Thiesen, H.J.6
  • 72
    • 0032712997 scopus 로고    scopus 로고
    • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
    • Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 1999; 5: 3711-3721
    • (1999) Clin Cancer Res , vol.5 , pp. 3711-3721
    • Shi, Q.1    Abbruzzese, J.L.2    Huang, S.3    Fidler, I.J.4    Xiong, Q.5    Xie, K.6
  • 74
    • 19944432390 scopus 로고    scopus 로고
    • Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity
    • Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 2005; 201: 105-115
    • (2005) J Exp Med , vol.201 , pp. 105-115
    • Walmsley, S.R.1    Print, C.2    Farahi, N.3    Peyssonnaux, C.4    Johnson, R.S.5    Cramer, T.6
  • 75
    • 33751168049 scopus 로고    scopus 로고
    • Neutrophils from patients with heterozygous germline mutations in the von hippel lindau protein (pvhl) display delayed apoptosis and enhanced bacterial phagocytosis
    • Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, et al. Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis. Blood 2006; 108: 3176-3178
    • (2006) Blood , vol.108 , pp. 3176-3178
    • Walmsley, S.R.1    Cowburn, A.S.2    Clatworthy, M.R.3    Morrell, N.W.4    Roper, E.C.5    Singleton, V.6
  • 77
    • 0012456681 scopus 로고
    • The nature of leukemic blood cells as determined by their metabolism
    • Kempner W. The nature of leukemic blood cells as determined by their metabolism. J Clin Invest 1939; 18: 291-300
    • (1939) J Clin Invest , vol.18 , pp. 291-300
    • Kempner, W.1
  • 79
    • 79952215345 scopus 로고    scopus 로고
    • Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
    • Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, et al. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest 2011; 121: 1053-1063
    • (2011) J Clin Invest , vol.121 , pp. 1053-1063
    • Walmsley, S.R.1    Chilvers, E.R.2    Thompson, A.A.3    Vaughan, K.4    Marriott, H.M.5    Parker, L.C.6
  • 80
    • 79251558091 scopus 로고    scopus 로고
    • Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils
    • McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AA, et al. Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils. J Immunol 2011; 186: 453-463
    • (2011) J Immunol , vol.186 , pp. 453-463
    • McGovern, N.N.1    Cowburn, A.S.2    Porter, L.3    Walmsley, S.R.4    Summers, C.5    Thompson, A.A.6
  • 81
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-Associated neutrophil phenotype by TGF-beta: N1- versus N2- TAN
    • Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-Associated neutrophil phenotype by TGF-beta: N1- versus N2- TAN. Cancer Cell 2009; 16: 183-194
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3    Kapoor, V.4    Cheng, G.5    Ling, L.6
  • 82
    • 0019507905 scopus 로고
    • Human neutrophil-mediated cytotoxicity to tumor cells
    • Gerrard TL, Cohen DJ, Kaplan AM. Human neutrophil-mediated cytotoxicity to tumor cells. J Natl Cancer Inst 1981; 66: 483-488
    • (1981) J Natl Cancer Inst , vol.66 , pp. 483-488
    • Gerrard, T.L.1    Cohen, D.J.2    Kaplan, A.M.3
  • 85
    • 84861190260 scopus 로고    scopus 로고
    • On the dual roles and polarized phenotypes of neutrophils in tumor development and progression
    • Piccard H, Muschel RJ, Opdenakker G. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression. Crit Rev Oncol Hematol 2012; 82: 296-309
    • (2012) Crit Rev Oncol Hematol , vol.82 , pp. 296-309
    • Piccard, H.1    Muschel, R.J.2    Opdenakker, G.3
  • 86
  • 87
    • 84865147481 scopus 로고    scopus 로고
    • Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-Associated macrophages
    • Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, et al. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-Associated macrophages. Cancer Res 2012; 72: 4165-4177
    • (2012) Cancer Res , vol.72 , pp. 4165-4177
    • Movahedi, K.1    Schoonooghe, S.2    Laoui, D.3    Houbracken, I.4    Waelput, W.5    Breckpot, K.6
  • 88
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxiainducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, Durham AC, Yuan LJ, et al. Hypoxiainducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 2010; 120: 2699-2714
    • (2010) J Clin Invest , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1    Williams, E.P.2    Hickey, M.M.3    Patel, S.A.4    Durham, A.C.5    Yuan, L.J.6
  • 89
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi K, Laoui D, Gysemans C, Baeten M, Stange G, Van Den Bossche J, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res 2010; 70: 5728-5739
    • (2010) Cancer Res , vol.70 , pp. 5728-5739
    • Movahedi, K.1    Laoui, D.2    Gysemans, C.3    Baeten, M.4    Stange, G.5    Van Den Bossche, J.6
  • 91
    • 27744603002 scopus 로고    scopus 로고
    • Hypoxia regulates macrophage functions in inflammation
    • Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 2005; 175: 6257-6263
    • (2005) J Immunol , vol.175 , pp. 6257-6263
    • Murdoch, C.1    Muthana, M.2    Lewis, C.E.3
  • 93
    • 0023241480 scopus 로고
    • Quantitative immunocytochemical characterization of mononuclear phagocytes II Monocytes and tissue macrophages
    • Nibbering PH, Leijh PC, van Furth R. Quantitative immunocytochemical characterization of mononuclear phagocytes. II. Monocytes and tissue macrophages. Immunology 1987; 62: 171-176
    • (1987) Immunology , vol.62 , pp. 171-176
    • Nibbering, P.H.1    Leijh, P.C.2    Van Furth, R.3
  • 94
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat Immunol 2010; 11: 889-896
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 95
    • 76349088502 scopus 로고    scopus 로고
    • FcRgamma activation regulates inflammation-Associated squamous carcinogenesis
    • Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, et al. FcRgamma activation regulates inflammation-Associated squamous carcinogenesis. Cancer Cell 2010; 17: 121-134
    • (2010) Cancer Cell , vol.17 , pp. 121-134
    • Andreu, P.1    Johansson, M.2    Affara, N.I.3    Pucci, F.4    Tan, T.5    Junankar, S.6
  • 96
    • 33845752914 scopus 로고    scopus 로고
    • P50 nuclear factor-kappaB overexpression in tumor-Associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    • Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, et al. p50 nuclear factor-kappaB overexpression in tumor-Associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 2006; 66: 11432-11440
    • (2006) Cancer Res , vol.66 , pp. 11432-11440
    • Saccani, A.1    Schioppa, T.2    Porta, C.3    Biswas, S.K.4    Nebuloni, M.5    Vago, L.6
  • 97
    • 68249140395 scopus 로고    scopus 로고
    • Hypoxiainducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
    • Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, et al. Hypoxiainducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009; 114: 844-859
    • (2009) Blood , vol.114 , pp. 844-859
    • Fang, H.Y.1    Hughes, R.2    Murdoch, C.3    Coffelt, S.B.4    Biswas, S.K.5    Harris, A.L.6
  • 99
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008; 456: 814-818
    • (2008) Nature , vol.456 , pp. 814-818
    • Stockmann, C.1    Doedens, A.2    Weidemann, A.3    Zhang, N.4    Takeda, N.5    Greenberg, J.I.6
  • 100
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, et al. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res 2010; 70: 7465-7475
    • (2010) Cancer Res , vol.70 , pp. 7465-7475
    • Doedens, A.L.1    Stockmann, C.2    Rubinstein, M.P.3    Liao, D.4    Zhang, N.5    DeNardo, D.G.6
  • 101
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
    • Takeda N, O-Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev 2010; 24: 491-501
    • (2010) Genes Dev , vol.24 , pp. 491-501
    • Takeda, N.1    O-Dea, E.L.2    Doedens, A.3    Kim, J.W.4    Weidemann, A.5    Stockmann, C.6
  • 102
    • 64849087205 scopus 로고    scopus 로고
    • Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor
    • Acosta-Iborra B, Elorza A, Olazabal IM, Martin-Cofreces NB, Martin-Puig S, Miro M, et al. Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor. J Immunol 2009; 182: 3155-3164
    • (2009) J Immunol , vol.182 , pp. 3155-3164
    • Acosta-Iborra, B.1    Elorza, A.2    Olazabal, I.M.3    Martin-Cofreces, N.B.4    Martin-Puig, S.5    Miro, M.6
  • 103
    • 77957808350 scopus 로고    scopus 로고
    • Knockout of HIF-1alpha in tumor-Associated macrophages enhances M2 polarization and attenuates their pro-Angiogenic responses
    • Werno C, Menrad H, Weigert A, Dehne N, Goerdt S, Schledzewski K, et al. Knockout of HIF-1alpha in tumor-Associated macrophages enhances M2 polarization and attenuates their pro-Angiogenic responses. Carcinogenesis 2010; 31: 1863-1872
    • (2010) Carcinogenesis , vol.31 , pp. 1863-1872
    • Werno, C.1    Menrad, H.2    Weigert, A.3    Dehne, N.4    Goerdt, S.5    Schledzewski, K.6
  • 104
    • 80455122752 scopus 로고    scopus 로고
    • Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
    • Takeda Y, Costa S, Delamarre E, Roncal C, Leite De Oliveira R, Squadrito ML, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 2011; 479: 122-126
    • (2011) Nature , vol.479 , pp. 122-126
    • Takeda, Y.1    Costa, S.2    Delamarre, E.3    Roncal, C.4    Leite De Oliveira, R.5    Squadrito, M.L.6
  • 106
    • 70350055199 scopus 로고    scopus 로고
    • Arginase: An emerging key player in the mammalian immune system
    • Munder M. Arginase: An emerging key player in the mammalian immune system. Br J Pharmacol 2009; 158: 638-651
    • (2009) Br J Pharmacol , vol.158 , pp. 638-651
    • Munder, M.1
  • 107
    • 79955437235 scopus 로고    scopus 로고
    • Cancer: Macrophages limit chemotherapy
    • De Palma M, Lewis CE. Cancer: Macrophages limit chemotherapy. Nature 2011; 472: 303-304
    • (2011) Nature , vol.472 , pp. 303-304
    • De Palma, M.1    Lewis, C.E.2
  • 108
    • 0033998433 scopus 로고    scopus 로고
    • The macrophage -A novel system to deliver gene therapy to pathological hypoxia
    • Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, et al. The macrophage -A novel system to deliver gene therapy to pathological hypoxia. Gene Ther 2000; 7: 255-262
    • (2000) Gene Ther , vol.7 , pp. 255-262
    • Griffiths, L.1    Binley, K.2    Iqball, S.3    Kan, O.4    Maxwell, P.5    Ratcliffe, P.6
  • 110
    • 77952299622 scopus 로고    scopus 로고
    • Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells
    • Fainaru O, Almog N, Yung CW, Nakai K, Montoya-Zavala M, Abdollahi A, et al. Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J 2010; 24: 1411-1418
    • (2010) FASEB J , vol.24 , pp. 1411-1418
    • Fainaru, O.1    Almog, N.2    Yung, C.W.3    Nakai, K.4    Montoya-Zavala, M.5    Abdollahi, A.6
  • 111
    • 44449117540 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharideinduced dendritic cell activation and function
    • Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, et al. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharideinduced dendritic cell activation and function. J Immunol 2008; 180: 4697-4705
    • (2008) J Immunol , vol.180 , pp. 4697-4705
    • Jantsch, J.1    Chakravortty, D.2    Turza, N.3    Prechtel, A.T.4    Buchholz, B.5    Gerlach, R.G.6
  • 112
    • 40849124059 scopus 로고    scopus 로고
    • Hypoxia stimulus: An adaptive immune response during dendritic cell maturation
    • Rama I, Bruene B, Torras J, Koehl R, Cruzado JM, Bestard O, et al. Hypoxia stimulus: An adaptive immune response during dendritic cell maturation. Kidney Int 2008; 73: 816-825
    • (2008) Kidney Int , vol.73 , pp. 816-825
    • Rama, I.1    Bruene, B.2    Torras, J.3    Koehl, R.4    Cruzado, J.M.5    Bestard, O.6
  • 113
    • 82155192305 scopus 로고    scopus 로고
    • Hypoxia affects dendritic cell survival: Role of the hypoxia-inducible factor-1alpha and lipopolysaccharide
    • Naldini A, Morena E, Pucci A, Miglietta D, Riboldi E, Sozzani S, et al. Hypoxia affects dendritic cell survival: Role of the hypoxia-inducible factor-1alpha and lipopolysaccharide. J Cell Physiol 2012; 227: 587-595
    • (2012) J Cell Physiol , vol.227 , pp. 587-595
    • Naldini, A.1    Morena, E.2    Pucci, A.3    Miglietta, D.4    Riboldi, E.5    Sozzani, S.6
  • 114
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011; 475: 226-230
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3    Balint, K.4    Barchetti, A.5    Wang, L.P.6
  • 115
    • 0029112871 scopus 로고
    • A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes
    • Zhang H, Lake DF, Barbuto JA, Bernstein RM, Grimes WJ, Hersh EM. A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes. Cancer Res 1995; 55: 3584-3591
    • (1995) Cancer Res , vol.55 , pp. 3584-3591
    • Zhang, H.1    Lake, D.F.2    Barbuto, J.A.3    Bernstein, R.M.4    Grimes, W.J.5    Hersh, E.M.6
  • 117
    • 76149131356 scopus 로고    scopus 로고
    • Possible significance of differences in proportions of cytotoxic T cells and B-lineage cells in the tumourinfiltrating lymphocytes of typical and atypical medullary carcinomas of the breast
    • Lim KH, Telisinghe PU, Abdullah MS, Ramasamy R. Possible significance of differences in proportions of cytotoxic T cells and B-lineage cells in the tumourinfiltrating lymphocytes of typical and atypical medullary carcinomas of the breast. Cancer Immun 2010; 10: 3
    • (2010) Cancer Immun , vol.10 , pp. 3
    • Lim, K.H.1    Telisinghe, P.U.2    Abdullah, M.S.3    Ramasamy, R.4
  • 118
    • 68149141666 scopus 로고    scopus 로고
    • Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals cd20 foxp3 and tia-1 as positive prognostic factors
    • Milne K, Kobel M, Kalloger SE, Barnes RO, Gao D, Gilks CB, et al. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS One 2009; 4: E6412
    • (2009) PLoS One , vol.4
    • Milne, K.1    Kobel, M.2    Kalloger, S.E.3    Barnes, R.O.4    Gao, D.5    Gilks, C.B.6
  • 119
    • 78149488860 scopus 로고    scopus 로고
    • CD20 B cells: The other tumor-infiltrating lymphocytes
    • Nelson BH. CD20 B cells: The other tumor-infiltrating lymphocytes. J Immunol 2010; 185: 4977-4982
    • (2010) J Immunol , vol.185 , pp. 4977-4982
    • Nelson, B.H.1
  • 120
    • 70349240438 scopus 로고    scopus 로고
    • In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy
    • Li Q, Teitz-Tennenbaum S, Donald EJ, Li M, Chang AE. In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy. J Immunol 2009; 183: 3195-3203
    • (2009) J Immunol , vol.183 , pp. 3195-3203
    • Li, Q.1    Teitz-Tennenbaum, S.2    Donald, E.J.3    Li, M.4    Chang, A.E.5
  • 121
    • 0032445137 scopus 로고    scopus 로고
    • A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
    • Boes M, Prodeus AP, Schmidt T, Carroll MC, Chen J. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection J Exp Med 1998; 188: 2381-2386
    • (1998) J Exp Med , vol.188 , pp. 2381-2386
    • Boes, M.1    Prodeus, A.P.2    Schmidt, T.3    Carroll, M.C.4    Chen, J.5
  • 122
    • 0037133250 scopus 로고    scopus 로고
    • Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha-deficient chimeric mice
    • Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, et al. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha-deficient chimeric mice. Proc Natl Acad Sci USA 2002; 99: 2170-2174
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2170-2174
    • Kojima, H.1    Gu, H.2    Nomura, S.3    Caldwell, C.C.4    Kobata, T.5    Carmeliet, P.6
  • 123
    • 73949112134 scopus 로고    scopus 로고
    • Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow
    • Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, et al. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol 2010; 184: 154-163
    • (2010) J Immunol , vol.184 , pp. 154-163
    • Kojima, H.1    Kobayashi, A.2    Sakurai, D.3    Kanno, Y.4    Hase, H.5    Takahashi, R.6
  • 124
    • 34548742977 scopus 로고    scopus 로고
    • Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells
    • Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, et al. Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol 2007; 37: 2400-2404
    • (2007) Eur J Immunol , vol.37 , pp. 2400-2404
    • Zhong, X.1    Gao, W.2    Degauque, N.3    Bai, C.4    Lu, Y.5    Kenny, J.6
  • 126
  • 128
    • 0017123967 scopus 로고
    • Effects of tumor-like assay conditions, lonizing radiation, and hyperthermia on immune lysis of tumor cells by cytotoxic T-lymphocytes
    • Harris JW. Effects of tumor-like assay conditions, lonizing radiation, and hyperthermia on immune lysis of tumor cells by cytotoxic T-lymphocytes. Cancer Res 1976; 36: 2733-2739
    • (1976) Cancer Res , vol.36 , pp. 2733-2739
    • Harris, J.W.1
  • 130
    • 0026784913 scopus 로고
    • Influence of tumour physico-chemical conditions on interleukin-2- stimulated lymphocyte proliferation
    • Loeffler DA, Juneau PL, Masserant S. Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation. Br J Cancer 1992; 66: 619-622
    • (1992) Br J Cancer , vol.66 , pp. 619-622
    • Loeffler, D.A.1    Juneau, P.L.2    Masserant, S.3
  • 132
    • 77950350986 scopus 로고    scopus 로고
    • The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells
    • Naldini A, Morena E, Pucci A, Pellegrini M, Baldari CT, Pelicci PG, et al. The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells. J Leukoc Biol 2010; 87: 365-369
    • (2010) J Leukoc Biol , vol.87 , pp. 365-369
    • Naldini, A.1    Morena, E.2    Pucci, A.3    Pellegrini, M.4    Baldari, C.T.5    Pelicci, P.G.6
  • 133
    • 55249095393 scopus 로고    scopus 로고
    • Hypoxia controls CD4CD25 regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
    • Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J. Hypoxia controls CD4CD25 regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol 2008; 38: 2412-2418
    • (2008) Eur J Immunol , vol.38 , pp. 2412-2418
    • Ben-Shoshan, J.1    Maysel-Auslender, S.2    Mor, A.3    Keren, G.4    George, J.5
  • 134
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/ T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/ T(reg) balance by hypoxia-inducible factor 1. Cell 2011; 146: 772-784
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 135
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 2011; 208: 1367-1376
    • (2011) J Exp Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6
  • 136
    • 77953534607 scopus 로고    scopus 로고
    • Metabolism in T cell activation and differentiation
    • Pearce EL. Metabolism in T cell activation and differentiation. Curr Opin Immunol 2010; 22: 314-320
    • (2010) Curr Opin Immunol , vol.22 , pp. 314-320
    • Pearce, E.L.1
  • 137
    • 27744519400 scopus 로고    scopus 로고
    • Fuel feeds function: Energy metabolism and the T-cell response
    • Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: Energy metabolism and the T-cell response. Nat Rev Immunol 2005; 5: 844-852
    • (2005) Nat Rev Immunol , vol.5 , pp. 844-852
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 138
    • 84871861969 scopus 로고    scopus 로고
    • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells
    • Finlay DK, Rosenzweig E, Sinclair LV, Feijoo-Carnero C, Hukelmann JL, Rolf J, et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells. J Exp Med 2012; 209: 2441-2453
    • (2012) J Exp Med , vol.209 , pp. 2441-2453
    • Finlay, D.K.1    Rosenzweig, E.2    Sinclair, L.V.3    Feijoo-Carnero, C.4    Hukelmann, J.L.5    Rolf, J.6
  • 141
    • 0025739228 scopus 로고
    • Natural killer-cell activity under conditions reflective of tumor micro-environment
    • Loeffler DA, Juneau PL, Heppner GH. Natural killer-cell activity under conditions reflective of tumor micro-environment. Int J Cancer 1991; 48: 895-899
    • (1991) Int J Cancer , vol.48 , pp. 895-899
    • Loeffler, D.A.1    Juneau, P.L.2    Heppner, G.H.3
  • 142
    • 0346753956 scopus 로고    scopus 로고
    • Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions
    • Fink T, Ebbesen P, Koppelhus U, Zachar V. Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions. Scand J Immunol 2003; 58: 607-612
    • (2003) Scand J Immunol , vol.58 , pp. 607-612
    • Fink, T.1    Ebbesen, P.2    Koppelhus, U.3    Zachar, V.4
  • 143
    • 84861801527 scopus 로고    scopus 로고
    • IL-15 protects NKT cells from inhibition by tumor-Associated macrophages and enhances antimetastatic activity
    • Liu D, Song L, Wei J, Courtney AN, Gao X, Marinova E, et al. IL-15 protects NKT cells from inhibition by tumor-Associated macrophages and enhances antimetastatic activity. J Clin Invest 2012; 122: 2221-2233
    • (2012) J Clin Invest , vol.122 , pp. 2221-2233
    • Liu, D.1    Song, L.2    Wei, J.3    Courtney, A.N.4    Gao, X.5    Marinova, E.6
  • 144
    • 79251478398 scopus 로고    scopus 로고
    • Contribution of platelets to tumour metastasis
    • Gay LJ, Felding-Habermann B. Contribution of platelets to tumour metastasis. Nat Rev Cancer 2011; 11: 123-134
    • (2011) Nat Rev Cancer , vol.11 , pp. 123-134
    • Gay, L.J.1    Felding-Habermann, B.2
  • 146
    • 38949178835 scopus 로고    scopus 로고
    • Angiogenesis is regulated by a novel mechanism: Pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    • Italiano Jr. JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, et al. Angiogenesis is regulated by a novel mechanism: Pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008; 111: 1227-1233
    • (2008) Blood , vol.111 , pp. 1227-1233
    • Italiano Jr., J.E.1    Richardson, J.L.2    Patel-Hett, S.3    Battinelli, E.4    Zaslavsky, A.5    Short, S.6
  • 147
    • 79953825324 scopus 로고    scopus 로고
    • A novel role for platelet secretion in angiogenesis: Mediating bone marrowderived cell mobilization and homing
    • Feng W, Madajka M, Kerr BA, Mahabeleshwar GH, Whiteheart SW, Byzova TV. A novel role for platelet secretion in angiogenesis: Mediating bone marrowderived cell mobilization and homing. Blood 2011; 117: 3893-3902
    • (2011) Blood , vol.117 , pp. 3893-3902
    • Feng, W.1    Madajka, M.2    Kerr, B.A.3    Mahabeleshwar, G.H.4    Whiteheart, S.W.5    Byzova, T.V.6
  • 148
    • 77953951477 scopus 로고    scopus 로고
    • Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis
    • Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, et al. Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood 2010; 115: 4605-4613
    • (2010) Blood , vol.115 , pp. 4605-4613
    • Zaslavsky, A.1    Baek, K.H.2    Lynch, R.C.3    Short, S.4    Grillo, J.5    Folkman, J.6
  • 151
    • 84866460269 scopus 로고    scopus 로고
    • Will an aspirin a day keep cancer away
    • Kaiser J. Will an aspirin a day keep cancer away? Science 2012; 337: 1471-1473
    • (2012) Science , vol.337 , pp. 1471-1473
    • Kaiser, J.1
  • 152
    • 84864681003 scopus 로고    scopus 로고
    • Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B
    • Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci USA 2012; 109: E2165-E2172
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Sitia, G.1    Aiolfi, R.2    Di Lucia, P.3    Mainetti, M.4    Fiocchi, A.5    Mingozzi, F.6
  • 153
    • 36348974088 scopus 로고    scopus 로고
    • Inhibition of platelet function: Does it offer a chance of better cancer progression control
    • Sierko E, Wojtukiewicz MZ. Inhibition of platelet function: Does it offer a chance of better cancer progression control? Semin Thromb Hemost 2007; 33: 712-721.
    • (2007) Semin Thromb Hemost , vol.33 , pp. 712-721
    • Sierko, E.1    Wojtukiewicz, M.Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.