Tumor induction of VEGF promoter activity in stromal cells

Cell

Volumn 94, Issue 6, 1998, Pages 715-725

  Fukumura, Dai ^a   Xavier, Ramnik ^a   Sugiura, Takeyuki ^a   Chen, Yi ^a   Park, Eun Chung ^a   Lu, Naifang ^a   Selig, Martin ^a   Nielsen, Gunnlaugur ^a   Taksir, Tatyana ^a   Jain, Rakesh K ^a   Seed, Brian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; FIBROBLAST; GRANULATION TISSUE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLID TUMOR; STROMA CELL; TRANSGENIC MOUSE; TUMOR VASCULARIZATION; ULCER; WOUND HEALING;

EID: 0032544686     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81731-6     Document Type: Article

References (39)

1. Berse, B., Brown, L.F., Van de Water, L., Dvorak, H.F., and Senger, D.R. (1992). Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 3, 211-220.
2. Boehm, T., Folkman, J., Browder, T., and O'Reilly, M.S. (1997). Anti-angiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390, 404-407.
3. Bondár, I., Uhl, E., Barker, J.H., Galla, T.J., Hammersen, F., and Messmer, K. (1991). A new model for studying microcirculatory changes during dermal wound healing. Res. Exp. Med. 191, 379-388.
4. Brown, L.F., Yeo, K.T., Berse, B., Yeo, T.K., Senger, D.R., Dvorak, H.F., and van de Water, L. (1992). Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176, 1375-1379.
5. Cerf-Bensussan, N., Schneeberger, E.E., and Bhan, A.K. (1983). Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J. Immunol. 130, 2615-2622.
6. Cormack, B.P., Valdivia, R.H., and Falkow, S. (1996). FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173, 33-38.
7. Damert, A., Machein, M., Breier, G., Fujita, M.Q., Hanahan, D., Risau, W., and Plate, K.H. (1997). Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms. Cancer Res. 57, 3860-3864.
8. Detmar, M., Brown, L.F., Schön, M.P., Elicker, B.M., Richard, L., Velasco, P., Fukumura, D., Monsky, W., Claffey, K.P., and Jain, R.K. (1998). Tortuous blood vessels and enhanced leukocyte-adhesion in VEGF transgenic mice. Invest. Dermatol. in press.
9. Dvorak, H.F. (1986). Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650-1659.
10. Dvorak, H.F., Brown, L.F., Detmar, M., and Dvorak, A.M. (1995). Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029-1039.
11. Ferrara, N., and Davis-Smyth, T. (1997). The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25.
12. Fidler, I.J. (1995). Modulation of the organ microenvironment for treatment of cancer metastasis. J. Natl. Cancer Inst. 87, 1588-1592.
13. Fleenor, D.E., and Kaufman, R.E. (1993). Characterization of the DNase I hypersensitive site 3′ of the human beta globin gene domain. Blood 81, 2781-2790.
14. Frank, S., Hubner, G., Breier, G., Longaker, M.T., Greenhalgh, D.G., and Werner, S. (1995). Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J. Biol. Chem. 270, 12607-12613.
15. Friesel, R.E., and Maciag, T. (1995). Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 9, 919-925.
16. Fukumura, D., Yuan, F., Endo, M., and Jain, R.K. (1997). Role of nitric oxide in tumor microcirculation: blood flow, vascular permeability, and leukocyte-endothelial interactions. Am. J. Pathol. 150, 713-725.
17. Gossen, M., and Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.
18. Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., Fornace, A.J., Jr., and Giaccia, A.J. (1994). Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264-6277.
19. Guy, C.T., Muthuswamy, S.K., Cardiff, R.D., Soriano, P., and Muller, W.J. (1994). Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev. 8, 23-32.
20. Haas, J., Park, E.C., and Seed, B. (1996). Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr. Biol. 6, 315-324.
21. Hanahan, D. (1997). Signaling vascular morphogenesis and maintenance. Science 277, 48-50.
22. Hanahan, D., and Folkman, J. (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364.
23. Heim, R., and Tsien, R.Y. (1996). Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr. Biol. 6, 178-182.
24. Helmlinger, G., Yuan, F., Dellian, M., and Jain, R.K. (1997). Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med. 3, 177-182.
25. Hlatky, L., Tsionou, C., Hahnfeldt, P., and Coleman, C.N. (1994). Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression. Cancer Res. 54, 6083-6086.
26. Hollander, G.A., Simpson, S.J., Mizoguchi, E., Nichogiannopoulou, A., She, J., Gutierrez-Ramos, J.C., Bhan, A.K., Burakoff, S.J., Wang, B., and Terhorst, C. (1995). Severe colitis in mice with aberrant thymic selection. Immunity 3, 27-38.
27. Jain, R.K. (1997). The Eugene M. Landis Award Lecture. Delivery of molecular and cellular medicine to solid tumors. Microcirculation 4, 1-23.
28. Kerbel, R.S. (1991). Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 13, 31-36.
29. Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S., and Ferrara, N. (1993). Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362, 841-844.
30. Leunig, M., Yuan, F., Menger, M.D., Boucher, Y., Goetz, A.E., Messmer, K., and Jain, R.K. (1992). Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 52, 6553-6560.
31. Levy, A.P., Levy, N.S., and Goldberg, M.A. (1996). Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271, 2746-2753.
32. Milstone, D.S., Fukumura, D., Padgen, B.C., O'Donnell, P.E., Davis, V.M., Benavidez, O.J., Monsky, W.L., Melder, R.J., Jain, R.K., and Gimbrone, J.M.A. (1998). Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation in press.
33. Parangi, S., O'Reilly, M., Christofori, G., Holmgren, L., Grosfeld, J., Folkman, J., and Hanahan, D. (1996). Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc. Natl. Acad. Sci. USA 93, 2002-2007.
34. Risau, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
35. Schmaltz, C., Hardenburgh, P.M., Wells, A., and Fisher, D.E. (1998). Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18, 2845-2854.
36. Shima, D.T., Deutsch, L.J., and D'Amore, P.A. (1995). Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability. FEBS Lett. 370, 203-208.
37. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845.
38. Stein, I., Neeman, M., Shweiki, D., Itin, A., and Keshet, E. (1995). Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol. Cell. Biol. 15, 5363-5368.
39. Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J.C., and Abraham, J.A. (1991). The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266, 11947-11954.