Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Cheng, Gang ^a   Tse, Janet ^a,b   Jain, Rakesh K ^a   Munn, Lance L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CELL; CELL PROLIFERATION; DORMANCY; GENE OVEREXPRESSION; MECHANICAL STRESS; MORPHOLOGY; TUMOR GROWTH; TUMOR SPHEROID;

EID: 84991885325     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004632     Document Type: Article

References (27)

1. Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
2. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
3. Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186.
4. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257.
5. Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62.
6. Gieni RS, Hendzel MJ (2008) Mechanotransduction from the ECM to the genome: are the pieces now in place? J Cell Biochem 104: 1964-1987.
7. Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, et al. (2004) Pathology: cancer cells compress intratumour vessels. Nature 427: 695.
8. Eaves G (1973) The invasive growth of malignant tumours as a purely mechanical process. J Pathol 109: 233-237.
9. Gartner MF, Fearns C, Wilson EL, Campbell JA, Dowdle EB (1992) Unusual growth characteristics of human melanoma xenografts in the nude mouse: a model for desmoplasia, dormancy and progression. Br J Cancer 65: 487-490.
10. Vaage J (1992) Fibrosis in immune control of mammary-tumor growth. Int J Cancer 51: 325-328.
11. Young JS (1959) The invasive growth of malignant tumours: an experimental interpretation based on elastic-jelly models. J Pathol Bacteriol 77: 321-339.
12. Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK (1997) Solid stress inhibits the growth of multicellular tumor spheroids. Nat Biotechnol 15: 778-783.
13. Deryugina EI, Quigley JP (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34.
14. Scandiucci de Freitas P, Wirz D, Stolz M, Gopfert B, Friederich NF, et al. (2006) Pulsatile dynamic stiffness of cartilage-like materials and use of agarose gels to validate mechanical methods and models. J Biomed Mater Res B Appl Biomater 78: 347-357.
15. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290.
16. Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, et al. (1997) Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 272: 7797-7800.
17. Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-ordeath switch. Nat Rev Cancer 2: 647-656.
18. Haykal J, Fernainy P, Itani W, Haddadin M, Geara F, et al. (2008) Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide. Radiother Oncol 86: 412-418.
19. Laird AK (1964) Dynamics of Tumor Growth. Br J Cancer 13: 490-502.
20. Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS (2003) Does tumor growth follow a "universal law"? J Theor Biol 225: 147-151.
21. Martin M (2003) Researchers suggest that universal 'law' governs tumor growth. J Natl Cancer Inst 95: 704-705.
22. Retsky M (2004) Universal law of tumor growth. J Theor Biol 229: 289.
23. Holmgren L, O'Reilly MS, Folkman J (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1: 149-153.
24. Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305-1308.
25. Lohmann I, McGinnis N, Bodmer M, McGinnis W (2002) The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper. Cell 110: 457-466.
26. Farge E (2003) Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium. Curr Biol 13: 1365-1377.
27. Toyama Y, Peralta XG, Wells AR, Kiehart DP, Edwards GS (2008) Apoptotic force and tissue dynamics during Drosophila embryogenesis. Science 321: 1683-1686.