Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: Clinical implications

Cancer Research

Volumn 59, Issue 15, 1999, Pages 3776-3782

  Griffon Etienne, Geneviève ^b   Boucher, Yves ^a   Brekken, Christian ^c   Suit, Herman D ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DEBIOPHARM SA   (Switzerland)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DOCETAXEL; PACLITAXEL; TAXANE DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PENETRATION; GROWTH INHIBITION; INTERSTITIAL FLUID; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; TISSUE PRESSURE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOOD VESSELS; BRAIN NEOPLASMS; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PACLITAXEL; PRESSURE; SARCOMA, EXPERIMENTAL; SPECIFIC PATHOGEN-FREE ORGANISMS; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 0033178578     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Jain, R. K. Barriers to drug delivery in solid tumors. Sci. Am., 271: 58-65, 1994.
2. Jain. R. K. The next frontier of molecular medicine: delivery of therapeutics. Nat. Med., 4: 655-657, 1998.
3. Netti, P. A., Hamberg, L. M., Babich, J. W., Kierstead, D., Graham, W., Hunter, G. J., Wolf, G. L., Fishman, A., Boucher, Y., and Jain, R. K. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc. Natl. Acad. Sci. USA, 96: 3137-3142, 1999.
4. Netti, P. A., Roberge, S., Boucher, Y., Baxter, L. T., and Jain R. K. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc. Res., 52: 27-46, 1996.
5. Folkman, J. Clinical applications of research on angiogenesis. N. Engl. J. Med., 333: 1757-1763, 1995.
6. Wiig, H., Tveit, E., Hultborn, R., Reed, R. K., and Weiss, L. Interstitial fluid pressure in DMBA-induced rat mammary tumors. Scand. J. Clin. Lab. Investig., 42: 159-164, 1982.
7. Boucher, Y., and Jain, R. K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res., 52: 5110-5114, 1992.
8. Boucher, Y., Leunig, M., and Jain, R. K. Tumor angiogenesis and interstitial hypertension. Cancer Res., 50: 4264-4266, 1996.
9. Boucher, Y., Salehi, H., Witwer, B., Harsh, G. R., IV, and Jain, R. K. Interstitial fluid pressure in intracranial tumours in patients and rodents. Br. J. Cancer, 56: 829-836, 1997.
10. Helmlinger, G., Netti, P. A., Lichtenbeld, H. C., Melder R. J., and Jain, R. K. Solid stress inhibits the growth of multicellular tumor spheroids. Nat. Biotechnol., 15: 778-783, 1997.
11. Milross, C. G., Mason, K. A., Hunter, N. R., Ki Chung, W., Peters, L. J., and Milas, L., Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J. Natl. Cancer Inst., 88: 1308-1314, 1996.
12. Bissery, M. C., Guenard, D., Gueritte-Voegelein, F., and Lavelle, F. Experimental antitumor activity of Taxotere (RP 56976, NSC 628503) a Taxol analogue. Cancer Res., 51: 4845-4852, 1991.
13. Holmes, F. A., Walters, R. S., and Theriault, R. L. Phase II trial of Taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst., 83: 1797-1805, 1991.
14. Fossella, F. V., Lee, J. S., Murphy, W. K., Lippman, S. M., Calayag, M., Pang, A., Chasen, M., Shin, D. M., Glisson, B., and Benner, S. Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer. J. Clin. Oncol., 12: 1238-1244, 1994.
15. Milas, L., Hunter, N. R., Kurdoglu, B., Mason, K. A., Meyn, R. E., Stephens, L. C., and Peters, L. J. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with Taxol. Cancer Chemomer. Pharmacol., 35: 297-303, 1995.
16. Mason, K. A., Hunter, N. R., Milas, M., Abbruzzese, J. L., and Milas, L. Docetaxel enhances tumor radioresponse in vivo. Clin. Cancer Res., 3: 2431-2438, 1997.
17. Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., and Jain, R. K. Relationship between structure, composition, and macroscopic transport properties of tumor interstitium. In: Annual Meeting of The American Institute of Chemical Engineers, abstract 221g. Los Angeles, CA: 1997.
18. Boucher, Y., Kirkwood, J. M., Opacic, D., Desantis, M., and Jain R. K. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res., 51: 6691-6694, 1991.
19. Lee, I., Boucher, Y., and Jain, R. K. Nicotinamide can lower tumor interstitial pressure: mechanistic and therapeutic implications. Cancer Res., 52: 3237-3240, 1992.
20. Swabb, E. A., Wei, J., and Gullino, P. M. Diffusion and convection in normal and neoplastic tissues. Cancer Res., 34: 2814-2822, 1974.
21. Leunig, M., Yuan, F., Menger, M., Boucher, Y., Goetz, A. E., Messmer, K., and Jain, R. K. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early tumor growth of human adenocarcinoma LS174T in SCID mice. Cancer Res., 52; 6553-6560, 1992.
22. Bossi, P., Viale, G., Lee, A. K., Alfano, R., Coggi, G., and Bosari, S. Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res., 55; 5049-5053, 1995.
23. ®): a review of preclimcal and clinical experience. Part I: preclinical experience. Anticancer Drugs, 6: 339-368, 1995.
24. Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res., 37: 77-104, 1989.
25. Desjardins, L. M., and MacManus, J. P. An adherent cell model to study different stages of apoptosis. Exp. Cell Res., 216: 380-387, 1995.
26. Roh, H. D., Boucher, Y., Kalnicki, S., Buchsbaum, R., Bloomer, W. D., and Jain R. K. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res., 51: 6695-6698, 1991.
27. Znati, C. A., Karasek, K., Faul, C., Roh, H. D., Boucher, Y., Rosenstein, M., Kalnicki, S., Buchsbaum, B., Chen, A., Bloomer, W. D., and Jain, R. K. Interstitial fluid pressure changes in cervical carcinomas in patients undergoing radiation therapy. In: Annual Meeting of the Radiation Research Society, p. 172. Chicago, IL: 1996.
28. Curti, B. D., Urba, W. J., Alvord, G., Janik, J. E., Smith, J. W., II, Madara, K., and Longo D. L. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res., 55: 2204-2207, 1993.
29. Milas, L., Hunter, N. R., Mason, K. A., Milross, C. G., Saito, Y., and Peters, L. J. Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res., 55: 3564-3568, 1995.
30. Baselga, J., Norton, L., Albanell, J., Kim, Y. M., and Mendelsohn, J. Recombinant humanized anti-HER2 antibody (herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu-overexpressing human breast cancer xenografts. Cancer Res., 58: 2825-2831, 1998.
31. Perez-Atayde, A. R., Sallan, S. E., Tedrow, U., Connors, S., Allred, E., and Folkman, J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am. J. Pathol. 150: 815-821, 1997.
32. Tozer, G. M., Myers, R., and Cunningham, V. J. Radiation-induced modification of blood flow in a rat fibrosarcoma. Int. J. Radiat. Biol. 60: 327-334, 1991.
33. Baish, J. W., and Jain, R. K. Cancer, angiogenesis and fractals. Nat. Med., 4: 984, 1998.