Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword

Virus Research

Volumn 209, Issue , 2015, Pages 100-117

  Vasallo, Claudia ^a   Gastaminza, Pablo ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Auto mitophagy; Hepatitis C virus; Oxidative stress; SIGMAR1; UPR

Indexed keywords

CHAPERONE; SIGMA 1 OPIATE RECEPTOR;

AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; DISEASE SEVERITY; FATTY LIVER; HEPATITIS C; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INSULIN RESPONSE; LIVER CELL CARCINOMA; LIVER DISEASE; MITOPHAGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROVIRUS; REVIEW; UNFOLDED PROTEIN RESPONSE; VIRUS PATHOGENESIS; VIRUS REPLICATION; HEPACIVIRUS; HOST PATHOGEN INTERACTION; LIVER CELL; PHYSIOLOGICAL STRESS; PHYSIOLOGY; VIROLOGY;

AUTOPHAGY; HEPACIVIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; MITOCHONDRIAL DEGRADATION; OXIDATIVE STRESS; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 84945947429     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2015.03.013     Document Type: Review

References (296)

1. Ait-Goughoulte M., Kanda T., Meyer K., Ryerse J.S., Ray R.B., Ray R. Hepatitis C virus genotype 1a growth and induction of autophagy. J. Virol. 2008, 82(5):2241-2249.
2. Al-Saif A., Al-Mohanna F., Bohlega S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 2011, 70:913-919.
3. Almansa C., Vela J.M. Selective sigma-1 receptor antagonists for the treatment of pain. Future Med. Chem. 2014, 6(10):1179-1199.
4. Alvisi G., Madan V., Bartenschlager R. Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol. 2011, 8(2):258-269.
5. Anderson P., Kedersha N. RNA granules. J. Cell Biol. 2006, 172(6):803-808.
6. Ando T., Imamura H., Suzuki R., Aizaki H., Watanabe T., Wakita T., Suzuki T. Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA. PLoS Pathog. 2012, 8(3):e1002561.
7. Araki K., Nagata K. Protein folding and quality control in the ER. Cold Spring Harb. Perspect. Biol. 2012, 4(8):a015438.
8. Arimoto K., Fukuda H., Imajoh-Ohmi S., Saito H., Takekawa M. Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat. Cell Biol. 2008, 10(11):1324-1332.
9. Ariumi Y., Kuroki M., Kushima Y., Osugi K., Hijikata M., Maki M., Ikeda M., Kato N. Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J. Virol. 2011, 85(14):6882-6892.
10. Arnoult D., Soares F., Tattoli I., Girardin S.E. Mitochondria in innate immunity. EMBO Rep. 2011, 12:901-910.
11. Asselah T., Bièche I., Mansouri A., Laurendeau I., Cazals-Hatem D., Feldmann G., Bedossa P., Paradis V., Martinot-Peignoux M., Lebrec D., Guichard C., Ogier-Denis E., Vidaud M., Tellier Z., Soumelis V., Marcellin P., Moreau R. In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. J. Pathol. 2010, 221:264-274.
12. Aydar E., Onganer P., Perrett R., Djamgoz M.B., Palmer C.P. The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell lines. Cancer Lett. 2006, 242:245-257.
13. Aydar E., Palmer C.P., Djamgoz M.B. Sigma receptors and cancer: possible involvement of ion channels. Cancer Res. 2004, 64(15):5029-5035.
14. B'Chir W., Chaveroux C., Carraro V., Averous J., Maurin A.C., Jousse C., Muranishi Y., Parry L., Fafournoux P., Bruhat A. Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. Cell. Signal. 2014, 26(7):1385-1391.
15. Ball J.K., Tarr A.W., McKeating J.A. The past, present and future of neutralizing antibodies for hepatitis C virus. Antiviral Res. 2014, 105:100-111.
16. Banerjee A., Meyer K., Mazumdar B., Ray R.B., Ray R. Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. J. Virol. 2010, 84(12):5936-5946.
17. Barbaro G., Di Lorenzo G., Asti A., Ribersani M., Belloni G., Grisorio B., Filice G., Barbarini G. Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am. J. Gastroenterol. 1999, 94(8):2198-2205.
18. Barbour J.A., Turner N. Mitochondrial stress signaling promotes cellular adaptations. Int. J. Cell Biol. 2014, 2014:156020.
19. Bartenschlager R., Lohmann V., Penin F. The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat. Rev. Microbiol. 2013, 11(7):482-496.
20. Bassendine M.F., Sheridan D.A., Bridge S.H., Felmlee D.J., Neely R.D. Lipids and HCV. Semin. Immunopathol. 2013, 35(1):87-100.
21. Basu A., Meyer K., Lai K.K., Saito K., Di Bisceglie A.M., Grosso L.E., Ray R.B., Ray R. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes. Virology 2006, 349:347-358.
22. Begriche K., Massart J., Robin M.A., Bonnet F., Fromenty B. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 2013, 58(4):1497-1507.
23. Benali-Furet N.L., Chami M., Houel L., De Giorgi F., Vernejoul F., Lagorce D., Buscail L., Bartenschlager R., Ichas F., Rizzuto R., Paterlini-Bréchot P. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene 2005, 24:4921-4933.
24. Bernsmeier C., Calabrese D., Heim M.H., Duong H.T. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1alpha and dephosphorylation of FoxO1. J. Viral Hepat. 2014, 21(1):9-18.
25. Biggins S.W., Bambha K.M., Terrault N.A., Inadomi J., Shiboski S., Dodge J.L., Gralla J., Rosen H.R., Roberts J.P. Projected future increase in aging hepatitis C virus-infected liver transplant candidates: a potential effect of hepatocellular carcinoma. Liver Transplant. 2012, 18(12):1471-1478.
26. Bishé B., Syed G., Siddiqui A. Phosphoinositides in the hepatitis C virus life cycle. Viruses 2012, 4:2340-2358.
27. Blazquez A.B., Escribano-Romero E., Merino-Ramos T., Saiz J.C., Martin-Acebes M.A. Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy. Front. Microbiol. 2014, 5:266.
28. Bockler S., Westermann B. Mitochondrial ER contacts are crucial for mitophagy in yeast. Dev. Cell 2014, 28(4):450-458.
29. Bose S.K., Kim H., Meyer K., Wolins N., Davidson N.O., Ray R. Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. J. Virol. 2014, 88(8):4195-4203.
30. Boudreau H.E., Emerson S.U., Korzeniowska A., Jendrysik M.A., Leto T.L. Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J. Virol. 2009, 83(24):12934-12946.
31. Bouman L., Schlierf A., Lutz A.K., Shan J., Deinlein A., Kast J., Galehdar Z., Palmisano V., Patenge N., Berg D., Gasser T., Augustin R., Trumbach D., Irrcher I., Park D.S., Wurst W., Kilberg M.S., Tatzelt J., Winklhofer K.F. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 2011, 18(5):769-782.
32. Brault C., Levy P.L., Bartosch B. Hepatitis C virus-induced mitochondrial dysfunctions. Viruses 2013, 5(3):954-980.
33. Bravo R., Vicencio J.M., Parra V., Troncoso R., Munoz J.P., Bui M., Quiroga C., Rodriguez A.E., Verdejo H.E., Ferreira J., Iglewski M., Chiong M., Simmen T., Zorzano A., Hill J.A., Rothermel B.A., Szabadkai G., Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J. Cell Sci. 2011, 124:2143-2152.
34. Burdette D., Olivarez M., Waris G. Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway. J. Gen. Virol. 2010, 91:681-690.
35. Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002, 415(6867):92-96.
36. Carvajal-Yepes M., Himmelsbach K., Schaedler S., Ploen D., Krause J., Ludwig L., Weiss T., Klingel K., Hildt E. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. J. Biol. Chem. 2011, 286(11):8941-8951.
37. Chan S.-W. Unfolded protein response in hepatitis C virus infection. Front. Microbiol. 2014, 5:233.
38. Chen W.C., Wang S.Y., Chiu C.C., Tseng C.K., Lin C.K., Wang H.C., Lee J.C. Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction. Antimicrob. Agents Chemother. 2013, 57(3):1180-1191.
39. Cheng G., Zhong J., Chisari F.V. Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(22):8499-8504.
40. Cheng Y., Dharancy S., Malapel M., Desreumaux P. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A. World J. Gastroenterol. 2005, 11(48):7591-7596.
41. Choi J., Lee K.J., Zheng Y., Yamaga A.K., Lai M.M.C., Ou J.-H. Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology 2004, 39:81-89.
42. Cullinan S.B., Zhang D., Hannink M., Arvisais E., Kaufman R.J., Diehl J.A. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 2003, 23(20):7198-7209.
43. Darling N.J., Cook S.J. The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Biochim. Biophys. Acta 2014, 1843(10):2150-2163.
44. de Mochel N.S.R., Seronello S., Wang S.H., Ito C., Zheng J.X., Liang T.J., Lambeth J.D., Choi J. Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection. Hepatology (Baltimore, MD) 2010, 52:47-59.
45. Deng L., Shoji I., Ogawa W., Kaneda S., Soga T., Jiang D.P., Ide Y.H., Hotta H. Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J. Virol. 2011, 85(17):8556-8568.
46. Deretic V., Saitoh T., Akira S. Autophagy in infection, inflammation and immunity. Nat. Rev. Immunol. 2013, 13(10):722-737.
47. Dharancy S., Malapel M., Perlemuter G., Roskams T., Cheng Y., Dubuquoy L., Podevin P., Conti F., Canva V., Philippe D., Gambiez L., Mathurin P., Paris J.C., Schoonjans K., Calmus Y., Pol S., Auwerx J., Desreumaux P. Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Gastroenterology 2005, 128(2):334-342.
48. Diamond D.L., Jacobs J.M., Paeper B., Proll S.C., Gritsenko M.A., Carithers R.L., Larson A.M., Yeh M.M., Camp D.G., Smith R.D., Katze M.G. Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Hepatology 2007, 46:649-657.
49. Diamond D.L., Syder A.J., Jacobs J.M., Sorensen C.M., Walters K.-A., Proll S.C., McDermott J.E., Gritsenko M.A., Zhang Q., Zhao R., Metz T.O., Camp D.G., Waters K.M., Smith R.D., Rice C.M., Katze M.G. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog. 2010, 6:e1000719.
50. Diamond D.L., Syder A.J., Jacobs J.M., Sorensen C.M., Walters K.A., Proll S.C., McDermott J.E., Gritsenko M.A., Zhang Q., Zhao R., Metz T.O., Camp D.G., Waters K.M., Smith R.D., Rice C.M., Katze M.G. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog. 2010, 6(1):e1000719.
51. Dreux M., Chisari F.V. Impact of the autophagy machinery on hepatitis C virus infection. Viruses 2011, 3:1342-1357.
52. Dreux M., Gastaminza P., Wieland S.F., Chisari F.V. The autophagy machinery is required to initiate hepatitis C virus replication. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14046-14051.
53. Dreux M., Gastaminza P., Wieland S.F., Chisari F.V. The autophagy machinery is required to initiate hepatitis C virus replication. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(33):14046-14051.
54. Estrabaud E., De Muynck S., Asselah T. Activation of unfolded protein response and autophagy during HCV infection modulates innate immune response. J. Hepatol. 2011, 55:1150-1153.
55. Farber S.A., Slack B.E., Blusztajn J.K. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J. 2000, 14(14):2198-2206.
56. Fecto F., Siddique T. SIGMAR1 mutations, genetic heterogeneity at the chromosome 9p locus, and the expanding etiological diversity of amyotrophic lateral sclerosis. Ann. Neurol. 2011, 70:867-870.
57. Feher A., Juhasz A., Laszlo A., Kalman J., Pakaski M., Kalman J., Janka Z. Association between a variant of the sigma-1 receptor gene and Alzheimer's disease. Neurosci. Lett. 2012, 517(2):136-139.
58. Felmlee D., Hafirassou M., Lefevre M., Baumert T., Schuster C. Hepatitis C virus, cholesterol and lipoproteins - impact for the viral life cycle and pathogenesis of liver disease. Viruses 2013, 5:1292-1324.
59. Ferraris P., Beaumont E., Uzbekov R., Brand D., Gaillard J., Blanchard E., Roingeard P. Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection. Cell. Mol. Life Sci.: CMLS 2013, 70(7):1297-1306.
60. Ferraris P., Blanchard E., Roingeard P. Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes. J. Gen. Virol. 2010, 91(Pt 9):2230-2237.
61. Filomeni G., De Zio D., Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015, 22(3):377-388. 10.1038/cdd.2014.150.
62. Forns X., Bukh J. The molecular biology of hepatitis C virus. Genotypes and quasispecies. Clin. Liver Dis. 1999, 3(4):693-716. vii.
63. Friesland M., Mingorance L., Chung J., Chisari F.V., Gastaminza P. Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. J. Virol. 2013, 87(11):6377-6390.
64. Fujimoto M., Hayashi T., Urfer R., Mita S., Su T.-P. Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. Synapse 2012, 66(7):630-639. 10.1002/syn.21549.
65. Fujita N., Sugimoto R., Ma N., Tanaka H., Iwasa M., Kobayashi Y., Kawanishi S., Watanabe S., Kaito M., Takei Y. Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C. J. Viral Hepat. 2008, 15(7):498-507.
66. Gao L., Tu H., Shi S.T., Lee K.J., Asanaka M., Hwang S.B., Lai M.M. Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. J. Virol. 2003, 77(7):4149-4159.
67. Garaigorta U., Chisari F.V. Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe 2009, 6(6):513-522.
68. Garaigorta U., Heim M.H., Boyd B., Wieland S., Chisari F.V. Hepatitis C virus induces the formation of stress granules whose proteins regulate HCV RNA replication, virus assembly and egress. J. Virol. 2012, 86(20):11043-11056. 10.1128/JVI.07101-11.
69. Garcia-Mediavilla M.V., Sanchez-Campos S., Gonzalez-Perez P., Gomez-Gonzalo M., Majano P.L., Lopez-Cabrera M., Clemente G., Garcia-Monzon C., Gonzalez-Gallego J. Differential contribution of hepatitis C virus NS5A and core proteins to the induction of oxidative and nitrosative stress in human hepatocyte-derived cells. J. Hepatol. 2005, 43(4):606-613.
70. Goldstein J.L., DeBose-Boyd R.A., Brown M.S. Protein sensors for membrane sterols. Cell 2006, 124(1):35-46.
71. Gong G., Waris G., Tanveer R., Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:9599-9604.
72. Gordy C., He Y.W. The crosstalk between autophagy and apoptosis: where does this lead?. Protein Cell 2012, 3(1):17-27.
73. Gosert R., Egger D., Lohmann V., Bartenschlager R., Blum H.E., Bienz K., Moradpour D. Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J. Virol. 2003, 77:5487-5492.
74. Grégoire I.P., Richetta C., Meyniel-Schicklin L., Borel S., Pradezynski F., Diaz O., Deloire A., Azocar O., Baguet J., Le Breton M., Mangeot P.E., Navratil V., Joubert P.-E., Flacher M., Vidalain P.-O., André P., Lotteau V., Biard-Piechaczyk M., Rabourdin-Combe C., Faure M. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog. 2011, 7:e1002422.
75. Guevin C., Manna D., Belanger C., Konan K.V., Mak P., Labonte P. Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection. Virology 2010, 405(1):1-7.
76. Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 2006, 1:23-61.
77. Hamamoto I., Nishimura Y., Okamoto T., Aizaki H., Liu M., Mori Y., Abe T., Suzuki T., Lai M.M., Miyamura T., Moriishi K., Matsuura Y. Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. J. Virol. 2005, 79(21):13473-13482.
78. Hara Y., Yanatori I., Ikeda M., Kiyokage E., Nishina S., Tomiyama Y., Toida K., Kishi F., Kato N., Imamura M., Chayama K., Hino K. Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization. Am. J. Pathol. 2014, 184(11):3026-3039. 10.1016/j.ajpath.2014.07.024.
79. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6(5):1099-1108.
80. Hayashi T., Fujimoto M. Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. Mol. Pharmacol. 2010, 77:517-528.
81. Hayashi T., Hayashi E., Fujimoto M., Sprong H., Su T.-P. The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones. J. Biol. Chem. 2012, 1-26.
82. Hayashi T., Rizzuto R., Hajnoczky G., Su T. MAM: more than just a housekeeper. Trends Cell Biol. 2009, 8.
83. Hayashi T., Su T.-P. Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:14949-14954.
84. 2+ signaling and cell survival. Cell 2007, 131:596-610.
85. Hayashi T., Su T.-P. Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. Subcell. Biochem. 2010, 51:381-398.
86. Hayashi T., Su T.P. Regulating ankyrin dynamics: roles of sigma-1 receptors. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:491-496.
87. Hayashi T., Su T.P. The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse. Life Sci. 2005, 77(14):1612-1624.
88. He Y., Nakao H., Tan S.L., Polyak S.J., Neddermann P., Vijaysri S., Jacobs B.L., Katze M.G. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J. Virol. 2002, 76(18):9207-9217.
89. Heo J.M., Rutter J. Ubiquitin-dependent mitochondrial protein degradation. Int. J. Biochem. Cell Biol. 2011, 43(10):1422-1426.
90. Herker E., Ott M. Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol. Metab. 2011, 22(6):241-248.
91. Hirao K., Natsuka Y., Tamura T., Wada I., Morito D., Natsuka S., Romero P., Sleno B., Tremblay L.O., Herscovics A., Nagata K., Hosokawa N. EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. J. Biol. Chem. 2006, 281(14):9650-9658.
92. Hollien J., Weissman J.S. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 2006, 313(5783):104-107.
93. Hollville E., Carroll R.G., Cullen S.P., Martin S.J. Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. Mol. Cell 2014, 55(3):451-466.
94. Horner S.M. Activation and evasion of antiviral innate immunity by hepatitis C virus. J. Mol. Biol. 2014, 426(6):1198-1209. 10.1016/j.jmb.2013.10.032.
95. Horner S.M., Liu H.M., Park H.S., Briley J., Gale M. Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(35):14590-14595.
96. Huang H., Chen Y., Ye J. Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(47):18666-18670.
97. Huang H., Kang R., Wang J., Luo G., Yang W., Zhao Z. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. Autophagy 2013, 9:175-195.
98. Ichimura Y., Waguri S., Sou Y.S., Kageyama S., Hasegawa J., Ishimura R., Saito T., Yang Y., Kouno T., Fukutomi T., Hoshii T., Hirao A., Takagi K., Mizushima T., Motohashi H., Lee M.S., Yoshimori T., Tanaka K., Yamamoto M., Komatsu M. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol. Cell 2013, 51(5):618-631.
99. Inoue Y., Aizaki H., Hara H., Matsuda M., Ando T., Shimoji T., Murakami K., Masaki T., Shoji I., Homma S., Matsuura Y., Miyamura T., Wakita T., Suzuki T. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. Virology 2011, 410(1):38-47.
100. Ivanov A.V., Bartosch B., Smirnova O.A., Isaguliants M.G., Kochetkov S.N. HCV and oxidative stress in the liver. Viruses 2013, 5:439-469.
101. Ivanov A.V., Smirnova O.A., Ivanova O.N., Masalova O.V., Kochetkov S.N., Isaguliants M.G. Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells. PLoS ONE 2011, 6:e24957.
102. Jacobs J.M., Diamond D.L., Chan E.Y., Gritsenko M.A., Qian W., Stastna M., Baas T., Camp D.G., Carithers R.L., Smith R.D., Katze M.G. Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients. J. Virol. 2005, 79(12):7558-7569.
103. Jheng J.-R., Ho J.-Y., Horng J.-T. ER stress, autophagy, and RNA viruses. Front. Microbiol. 2014, 5:1-13.
104. Johnson B.N., Berger A.K., Cortese G.P., Lavoie M.J. The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(16):6283-6288.
105. Jones C.T., Catanese M.T., Law L.M., Khetani S.R., Syder A.J., Ploss A., Oh T.S., Schoggins J.W., MacDonald M.R., Bhatia S.N., Rice C.M. Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat. Biotechnol. 2010, 28(2):167-171.
106. Jounai N., Takeshita F., Kobiyama K., Sawano A., Miyawaki A., Xin K.Q., Ishii K.J., Kawai T., Akira S., Suzuki K., Okuda K. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(35):14050-14055.
107. Joyce M.A., Walters K.-A., Lamb S.-E., Yeh M.M., Zhu L.-F., Kneteman N., Doyle J.S., Katze M.G., Tyrrell D.L. HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog. 2009, 5:e1000291.
108. Joyce M.A., Walters K.A., Lamb S.E., Yeh M.M., Zhu L.F., Kneteman N., Doyle J.S., Katze M.G., Tyrrell D.L. HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog. 2009, 5(2):e1000291.
109. Kageyama Y., Zhang Z., Roda R., Fukaya M., Wakabayashi J., Wakabayashi N., Kensler T.W., Reddy P.H., Iijima M., Sesaki H. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J. Cell Biol. 2012, 197(4):535-551.
110. Kandathil A.J., Graw F., Quinn J., Hwang H.S., Torbenson M., Perelson A.S., Ray S.C., Thomas D.L., Ribeiro R.M., Balagopal A. Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. Gastroenterology 2013, 145(6):1404-1413. e1401-1410.
111. Kasahara A., Scorrano L. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol. 2014, 24(12):761-770.
112. Kasai D., Adachi T., Deng L., Nagano-Fujii M., Sada K., Ikeda M., Kato N., Ide Y.H., Shoji I., Hotta H. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters. J. Hepatol. 2009, 50(5):883-894.
113. Kasprzak A., Biczysko W., Adamek A., Zabel M. Morphological lesions detected by light and electron microscopies in chronic type C hepatitis. Pol. J. Pathol. 2003, 54:129-142.
114. Kasprzak A., Seidel J., Biczysko W., Wysocki J., Spachacz R., Zabel M. Intracellular localization of NS3 and C proteins in chronic hepatitis C. Liver Int. 2005, 25(4):896-903.
115. Kaufman R.J., Malhotra J.D. Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim. Biophys. Acta 2014, 1843:2233-2239.
116. Ke P.-Y., Chen S.S.-L. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J. Clin. Invest. 2011, 121(1):37-56. 10.1172/JCI41474.
117. Ke P.-Y., Chen S.S.-L. Autophagy: a novel guardian of HCV against innate immune response. Autophagy 2011, 7:533-535.
118. Ke P.Y., Chen S.S. Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases. World J. Gastroenterol. 2014, 20(19):5773-5793.
119. Kim F.J., Schrock J.M., Spino C.M., Marino J.C., Pasternak G.W. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem. Biophys. Res. Commun. 2012, 426(2):177-182.
120. Kim S.J., Syed G.H., Khan M., Chiu W.W., Sohail M.A., Gish R.G., Siddiqui A. Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(17):6413-6418.
121. Kim S.J., Syed G.H., Siddiqui A. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013, 9(3):e1003285.
122. Kim T.Y., Kim E., Yoon S.K., Yoon J.B. Herp enhances ER-associated protein degradation by recruiting ubiquilins. Biochem. Biophys. Res. Commun. 2008, 369(2):741-746.
123. Kirkin V., Lamark T., Johansen T., Dikic I. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009, 5(5):732-733.
124. Kitada T., Seki S., Iwai S., Yamada T., Sakaguchi H., Wakasa K. In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease. J. Hepatol. 2001, 35:613-618.
125. Kobayashi A., Ohta T., Yamamoto M. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Methods Enzymol. 2004, 378:273-286.
126. Korenaga M., Wang T., Li Y., Showalter L.A., Chan T., Sun J., Weinman S.A. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J. Biol. Chem. 2005, 280(45):37481-37488.
127. Kuo Y.C., Chen I.Y., Chang S.C., Wu S.C., Hung T.M., Lee P.H., Shimotohno K., Chang M.F. Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways. Liver Int. 2014, 34(9):1358-1368.
128. Lamark T., Johansen T. Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int. J. Cell Biol. 2012, 2012:736905.
129. Lamb C.A., Yoshimori T., Tooze S.A. The autophagosome: origins unknown, biogenesis complex. Nat. Rev. Mol. Cell Biol. 2013, 14(12):759-774.
130. Lange C.M., Jacobson I.M., Rice C.M., Zeuzem S. Emerging therapies for the treatment of hepatitis C. EMBO Mol. Med. 2014, 6(1):4-15.
131. Lee A.H., Scapa E.F., Cohen D.E., Glimcher L.H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008, 320(5882):1492-1496.
132. Lee J.C., Tseng C.K., Young K.C., Sun H.Y., Wang S.W., Chen W.C., Lin C.K., Wu Y.H. Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. Br. J. Pharmacol. 2014, 171(1):237-252.
133. Lee S.J., Zhang J., Choi A.M., Kim H.P. Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress. Oxid. Med. Cell. Longev. 2013, 2013:327167.
134. Lehmann E., El-Tantawy W.H., Ocker M., Bartenschlager R., Lohmann V., Hashemolhosseini S., Tiegs G., Sass G. The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology 2010, 51(2):398-404.
135. Li K., Prow T., Lemon S.M., Beard M.R. Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells. Hepatology 2002, 35(5):1237-1246.
136. 2+ uniporter activity. FASEB J. 2007, 21(10):2474-2485.
137. Li Y., Zhang Q., Liu Y., Luo Z., Kang L., Qu J., Liu W., Xia X., Liu Y., Wu K., Wu J. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J. Virol. 2012, 86(23):12531-12543.
138. Liang Y., Shilagard T., Xiao S.Y., Snyder N., Lau D., Cicalese L., Weiss H., Vargas G., Lemon S.M. Visualizing hepatitis C virus infections in human liver by two-photon microscopy. Gastroenterology 2009, 137(4):1448-1458.
139. Lim P.J., Danner R., Liang J., Doong H., Harman C., Srinivasan D., Rothenberg C., Wang H., Ye Y., Fang S., Monteiro M.J. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J. Cell Biol. 2009, 187(2):201-217.
140. Lin C.C., Tsai P., Sun H.Y., Hsu M.C., Lee J.C., Wu I.C., Tsao C.W., Chang T.T., Young K.C. Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production. J. Hepatol. 2014, 61(5):984-993.
141. Lindenbach B.D., Rice C.M. The ins and outs of hepatitis C virus entry and assembly. Nat. Rev. Microbiol. 2013, 11:688-700.
142. Liu Z., Yang F., Robotham J.M., Tang H. Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex. J. Virol. 2009, 83(13):6554-6565.
143. Machida K., Cheng K.T.-H., Lai C.-K., Jeng K.-S., Sung V.M.-H., Lai M.M.C. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J. Virol. 2006, 80:7199-7207.
144. Malhi H., Kaufman R.J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 2011, 54(4):795-809.
145. Mankouri J., Tedbury P.R., Gretton S., Hughes M.E., Griffin S.D., Dallas M.L., Green K.A., Hardie D.G., Peers C., Harris M. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(25):11549-11554.
146. Mannova P., Beretta L. Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication. J. Virol. 2005, 79(14):8742-8749.
147. Marcu M.G., Doyle M., Bertolotti A., Ron D., Hendershot L., Neckers L. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol. Cell. Biol. 2002, 22(24):8506-8513.
148. Marriott K.-S.C., Prasad M., Thapliyal V., Bose H.S. σ-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation. J. Pharmacol. Exp. Ther. 2012, 343:578-586.
149. Mast S.W., Diekman K., Karaveg K., Davis A., Sifers R.N., Moremen K.W. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Glycobiology 2005, 15(4):421-436.
150. Matsumoto T., Rauskolb S., Polack M., Klose J., Kolbeck R., Korte M., Barde Y.A. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat. Neurosci. 2008, 11(2):131-133.
151. Maurel M., Chevet E., Tavernier J., Gerlo S. Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem. Sci. 2014, 39(5):245-254.
152. Mavlyutov T.A., Epstein M.L., Verbny Y.I., Huerta M.S., Zaitoun I., Ziskind-Conhaim L., Ruoho A.E. Lack of sigma-1 receptor exacerbates ALS progression in mice. Neuroscience 2013, 240:129-134.
153. McCartney E.M., Helbig K.J., Narayana S.K., Eyre N.S., Aloia A.L., Beard M.R. Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus. Hepatology 2013, 58(5):1558-1568.
154. McLelland G.L., Soubannier V., Chen C.X., McBride H.M., Fon E.A. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 2014, 33(4):282-295.
155. McPherson S., Powell E.E., Barrie H.D., Clouston A.D., McGuckin M., Jonsson J.R. No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. J. Gastroenterol. Hepatol. 2011, 26(2):319-327.
156. Merquiol E., Uzi D., Mueller T., Goldenberg D., Nahmias Y., Xavier R.J., Tirosh B., Shibolet O. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS ONE 2011, 6:e24660.
157. Meunier J., Hayashi T. Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB. J. Pharmacol. Exp. Ther. 2010, 332(2):388-397.
158. Mishima K., Sakamoto N., Sekine-Osajima Y., Nakagawa M., Itsui Y., Azuma S., Kakinuma S., Kiyohashi K., Kitazume A., Tsuchiya K., Imamura M., Hiraga N., Chayama K., Wakita T., Watanabe M. Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants. Virology 2010, 405:361-369.
159. Mishina M., Ishiwata K., Ishii K., Kitamura S., Kimura Y., Kawamura K., Oda K., Sasaki T., Sakayori O., Hamamoto M., Kobayashi S., Katayama Y. Function of sigma1 receptors in Parkinson's disease. Acta Neurol. Scand. 2005, 112:103-107.
160. Mishina M., Ohyama M., Ishii K., Kitamura S., Kimura Y., Oda K.-i., Kawamura K., Sasaki T., Kobayashi S., Katayama Y., Ishiwata K. Low density of sigma1 receptors in early Alzheimer's disease. Ann. Nucl. Med. 2008, 22:151-156.
161. Mitsuda T., Omi T., Tanimukai H., Sakagami Y., Tagami S., Okochi M., Kudo T., Takeda M. Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress. Biochem. Biophys. Res. Commun. 2011, 415:519-525.
162. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., Bartenschlager R., Wakita T., Hijikata M., Shimotohno K. The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell Biol. 2007, 9:1089-1097.
163. Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 2010, 22(2):132-139.
164. Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011, 147(4):728-741.
165. Mohl B.-P., Tedbury P.R., Griffin S., Harris M. Hepatitis C virus-induced autophagy is independent of the unfolded protein response. J. Virol. 2012, 86:10724-10732.
166. Moradpour D., Penin F. Hepatitis C virus proteins: from structure to function. Curr. Top. Microbiol. Immunol. 2013, 369:113-142.
167. Mori T., Hayashi T., Hayashi E., Su T.P. Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLOS ONE 2013, 8(10):e76941.
168. Mori T., Hayashi T., Su T.-P. Compromising sigma-1 receptors at the ER renders cytotoxicity to physiologically relevant concentrations of dopamine in a NF-(B/Bcl-2-dependent mechanism: potential relevance to Parkinson's disease. J. Pharmacol. Exp. Ther. 2012, 341(3):663-671. 10.1124/jpet.111.190868.
169. Moriya K., Fujie H., Shintani Y., Yotsuyanagi H., Tsutsumi T., Ishibashi K., Matsuura Y., Kimura S., Miyamura T., Koike K. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat. Med. 1998, 4(9):1065-1067.
170. Moriya K., Nakagawa K., Santa T., Shintani Y., Fujie H., Miyoshi H., Tsutsumi T., Miyazawa T., Ishibashi K., Horie T., Imai K., Todoroki T., Kimura S., Koike K. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res. 2001, 61(11):4365-4370.
171. Motohashi H., Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 2004, 10:549-557.
172. Mottola G., Cardinali G., Ceccacci A., Trozzi C., Bartholomew L., Torrisi M.R., Pedrazzini E., Bonatti S., Migliaccio G. Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons. Virology 2002, 293(1):31-43.
173. Nakagawa S., Umehara T., Matsuda C., Kuge S., Sudoh M., Kohara M. Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice. Biochem. Biophys. Res. Commun. 2007, 353(4):882-888.
174. Nasimuzzaman M., Waris G., Mikolon D., Stupack D.G., Siddiqui A. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J. Virol. 2007, 81(19):10249-10257.
175. Negro F. Abnormalities of lipid metabolism in hepatitis C virus infection. Gut 2010, 59(9):1279-1287.
176. Negro F., Sanyal A.J. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int. 2009, 29(Suppl. 2):26-37.
177. Neufeldt C.J., Joyce M.A., Levin A., Steenbergen R.H., Pang D., Shields J., Tyrrell D.L.J., Wozniak R.W. Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication. PLoS Pathog. 2013, 9:e1003744.
178. Neumann-Haefelin C., Thimme R. Adaptive immune responses in hepatitis C virus infection. Curr. Top. Microbiol. Immunol. 2013, 369:243-262.
179. Nguyen L.N., Lim Y.S., Pham L.V., Shin H.Y., Kim Y.S., Hwang S.B. Stearoyl coenzyme a desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication. J. Virol. 2014, 88(21):12311-12325.
180. Niepmann M. Hepatitis C virus RNA translation. Curr. Top. Microbiol. Immunol. 2013, 369:143-166.
181. Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., Shiosaka S., Hammarback J.A., Urano F., Imaizumi K. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26(24):9220-9231.
182. Okamoto T., Nishimura Y., Ichimura T., Suzuki K., Miyamura T., Suzuki T., Moriishi K., Matsuura Y. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J. 2006, 25(20):5015-5025.
183. Okamoto T., Omori H., Kaname Y., Abe T., Nishimura Y., Suzuki T., Miyamura T., Yoshimori T., Moriishi K., Matsuura Y. A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication. J. Virol. 2008, 82(7):3480-3489.
184. Okuda M., Li K., Beard M.R., Showalter L.A., Scholle F., Lemon S.M., Weinman S.A. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002, 122(2):366-375.
185. Olivari S., Molinari M. Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins. FEBS Lett. 2007, 581(19):3658-3664.
186. Olmstead A.D., Knecht W., Lazarov I., Dixit S.B., Jean F. Human subtilase SKI-1/S1P is a master regulator of the HCV lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog. 2012, 8:e1002468.
187. Pager C.T., Schutz S., Abraham T.M., Luo G., Sarnow P. Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules. Virology 2013, 435(2):472-484.
188. Pal A., Fontanilla D., Gopalakrishnan A., Chae Y.-K., Markley J.L., Ruoho A.E. The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur. J. Pharmacol. 2012, 682:12-20.
189. Palam L.R., Baird T.D., Wek R.C. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J. Biol. Chem. 2011, 286(13):10939-10949.
190. Palmer C.P., Mahen R., Schnell E., Djamgoz M.B., Aydar E. Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. Cancer Res. 2007, 67(23):11166-11175.
191. Panteva M., Korkaya H., Jameel S. Hepatitis viruses and the MAPK pathway: is this a survival strategy?. Virus Res. 2003, 92(2):131-140.
192. Paradies G., Paradies V., Ruggiero F.M., Petrosillo G. Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J. Gastroenterol. 2014, 20(39):14205-14218.
193. Parent R., Qu X., Petit M.A., Beretta L. The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity. Hepatology 2009, 49(6):1798-1809.
194. Park K.J., Choi S.H., Choi D.H., Park J.M., Yie S.W., Lee S.Y., Hwang S.B. 1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2. J. Biol. Chem. 2003, 278(33):30711-30718.
195. Parvaiz F., Manzoor S., Iqbal J., McRae S., Javed F., Ahmed Q.L., Waris G. Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome. Arch. Virol. 2014, 159(5):1017-1025.
196. Patergnani S., Pinton P. Mitophagy and mitochondrial balance. Methods Mol. Biol. 2015, 1241:181-194.
197. Pena J., Harris E. Dengue virus modulates the unfolded protein response in a time-dependent manner. J. Biol. Chem. 2011, 286(16):14226-14236.
198. Piccoli C., Quarato G., Ripoli M., D'Aprile A., Scrima R., Cela O., Boffoli D., Moradpour D., Capitanio N. HCV infection induces mitochondrial bioenergetic unbalance: causes and effects. Biochim. Biophys. Acta 2009, 1787(5):539-546.
199. Piccoli C., Scrima R., Quarato G., D'Aprile A., Ripoli M., Lecce L., Boffoli D., Moradpour D., Capitanio N. Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress. Hepatology 2007, 46(1):58-65.
200. Pietschmann T., Bartenschlager R. The hepatitis C virus replicon system and its application to molecular studies. Curr. Opin. Drug Discov. Dev. 2001, 4(5):657-664.
201. Prause J., Goswami A., Katona I., Roos A., Schnizler M., Bushuven E., Dreier A., Buchkremer S., Johann S., Beyer C., Deschauer M., Troost D., Weis J. Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis. Hum. Mol. Genet. 2013, 22:1581-1600.
202. Quarato G., Scrima R., Agriesti F., Moradpour D., Capitanio N., Piccoli C. Targeting mitochondria in the infection strategy of the hepatitis C virus. Int. J. Biochem. Cell Biol. 2013, 45(1):156-166. 10.1016/j.biocel.2012.06.008.
203. Rainbolt T.K., Saunders J.M., Wiseman R.L. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends Endocrinol. Metab. 2014, 25(10):528-537.
204. Rakic B., Clarke J., Tremblay T.-L., Taylor J., Schreiber K., Nelson K.M., Abrams S.R., Pezacki J.P. A small-molecule probe for hepatitis C virus replication that blocks protein folding. Chem. Biol. 2006, 13:1051-1060.
205. Ramachandran S., Chu U.B., Mavlyutov T.A., Pal A., Pyne S., Ruoho A.E. The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. Eur. J. Pharmacol. 2009, 609(1-3):19-26.
206. Ramière C., Rodriguez J., Enache L.S., Lotteau V., André P., Diaz O. Activity of hexokinase is increased by its interaction with hepatitis C virus protein NS5A. J. Virol. 2014, 88:3246-3254.
207. Rautou P.E., Cazals-Hatem D., Feldmann G., Mansouri A., Grodet A., Barge S., Martinot-Peignoux M., Duces A., Bieche I., Lebrec D., Bedossa P., Paradis V., Marcellin P., Valla D., Asselah T., Moreau R. Changes in autophagic response in patients with chronic hepatitis C virus infection. Am. J. Pathol. 2011, 178(6):2708-2715.
208. Richards A.L., Jackson W.T. How positive-strand RNA viruses benefit from autophagosome maturation. J. Virol. 2013, 87(18):9966-9972.
209. Ripoli M., D'aprile A., Quarato G., Sarasin-Filipowicz M., Gouttenoire J., Scrima R., Cela O., Boffoli D., Heim M.H., Moradpour D., Capitanio N., Piccoli C. Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation. J. Virol. 2010, 84:647-660.
210. Roe B., Kensicki E., Mohney R., Hall W.W. Metabolomic profile of hepatitis C virus-infected hepatocytes. PLoS ONE 2011, 6:e23641.
211. Rojas A., del Campo J.A., Maraver M., Aparcero R., Garcia-Valdecasas M., Diago M., Carmona I., Andrade R.J., Sola R., Romero-Gomez M. Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro. J. Viral Hepat. 2014, 21(1):19-24.
212. Romero-Brey I., Merz A., Chiramel A., Lee J.Y., Chlanda P., Haselman U., Santarella-Mellwig R., Habermann A., Hoppe S., Kallis S., Walther P., Antony C., Krijnse-Locker J., Bartenschlager R. Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog. 2012, 8(12):e1003056.
213. Rouschop K.M., van den Beucken T., Dubois L., Niessen H., Bussink J., Savelkouls K., Keulers T., Mujcic H., Landuyt W., Voncken J.W., Lambin P., van der Kogel A.J., Koritzinsky M., Wouters B.G. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Invest. 2010, 120(1):127-141.
214. Ruggieri A., Anticoli S., Nencioni L., Sgarbanti R., Garaci E., Palamara A. Interplay between hepatitis C virus and redox cell signaling. Int. J. Mol. Sci. 2013, 14:4705-4721.
215. Ruggieri A., Dazert E., Metz P., Hofmann S., Bergeest J.P., Mazur J., Bankhead P., Hiet M.S., Kallis S., Alvisi G., Samuel C.E., Lohmann V., Kaderali L., Rohr K., Frese M., Stoecklin G., Bartenschlager R. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 2012, 12(1):71-85.
216. Ruggieri V., Mazzoccoli C., Pazienza V., Andriulli A., Capitanio N., Piccoli C. Hepatitis C virus, mitochondria and auto/mitophagy: exploiting a host defense mechanism. World J. Gastroenterol. 2014, 20:2624-2633.
217. Rutkowski D.T., Arnold S.M., Miller C.N., Wu J., Li J., Gunnison K.M., Mori K., Sadighi Akha A.A., Raden D., Kaufman R.J. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006, 4(11):e374.
218. Saeed M., Suzuki R., Watanabe N., Masaki T., Tomonaga M., Muhammad A., Kato T., Matsuura Y., Watanabe H., Wakita T., Suzuki T. Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles. J. Biol. Chem. 2011, 286:37264-37273.
219. Sano R., Reed J.C. ER stress-induced cell death mechanisms. Biochim. Biophys. Acta 2013, 1833(12):3460-3470.
220. Sato C., Saito T., Misawa K., Katsumi T., Tomita K., Ishii R., Haga H., Okumoto K., Nishise Y., Watanabe H., Ueno Y., Kawata S. Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance. BMC Gastroenterol. 2013, 13:112.
221. Schaefer E.A., Chung R.T. HCV and host lipids: an intimate connection. Semin. Liver Dis. 2013, 33(4):358-368.
222. Scheel T.K., Rice C.M. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nat. Med. 2013, 19(7):837-849.
223. Schroder M. Endoplasmic reticulum stress responses. Cell. Mol. Life Sci.: CMLS 2008, 65(6):862-894.
224. Schwer B., Ren S., Pietschmann T., Kartenbeck J., Kaehlcke K., Bartenschlager R., Yen T.S., Ott M. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J. Virol. 2004, 78(15):7958-7968.
225. Shepard C.W., Finelli L., Alter M.J. Global epidemiology of hepatitis C virus infection. Lancet. Infect. Dis. 2005, 5(9):558-567.
226. Shinohara Y., Imajo K., Yoneda M., Tomeno W., Ogawa Y., Kirikoshi H., Funakoshi K., Ikeda M., Kato N., Nakajima A., Saito S. Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy. Biochem. Biophys. Res. Commun. 2013, 432:326-332.
227. Shrivastava S., Bhanja Chowdhury J., Steele R., Ray R., Ray R.B. Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling. J. Virol. 2012, 86:8705-8712.
228. Shrivastava S., Raychoudhuri A., Steele R., Ray R., Ray R.B. Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology (Baltimore, MD) 2011, 53:406-414.
229. Shuda M., Kondoh N., Imazeki N., Tanaka K., Okada T., Mori K., Hada A., Arai M., Wakatsuki T., Matsubara O., Yamamoto N., Yamamoto M. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 2003, 38(5):605-614.
230. Silva L.M., Jung J.U. Modulation of the autophagy pathway by human tumor viruses. Semin. Cancer Biol. 2013, 23:323-328.
231. Singh S.B., Ornatowski W., Vergne I., Naylor J., Delgado M., Roberts E., Ponpuak M., Master S., Pilli M., White E., Komatsu M., Deretic V. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat. Cell Biol. 2010, 12:1154-1165.
232. Sir D., Chen W.-L., Choi J., Wakita T., Yen T.S.B., Ou J.-H.J. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology (Baltimore, MD) 2008, 48:1054-1061.
233. Sir D., Kuo C.-F., Tian Y., Liu H.M., Huang E.J., Jung J.U., Machida K., Ou J.-H.J. Replication of hepatitis C virus RNA on autophagosomal membranes. J. Biol. Chem. 2012, 287(22):18036-18043. 10.1074/jbc.M111.320085.
234. Sir D., Liang C., Chen W.-l., Jung J.U., Ou J.-h.J. Perturbation of autophagic pathway by hepatitis C virus. Autophagy 2008, 4:830-831.
235. Sriburi R., Jackowski S., Mori K., Brewer J.W. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 2004, 167(1):35-41.
236. Street A., Macdonald A., Crowder K., Harris M. The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 2004, 279(13):12232-12241.
237. Su W.-C., Chao T.-C., Huang Y.-L., Weng S.-C., Jeng K.-S., Lai M.M.C. Rab5 and class III PI-3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J. Virol. 2011, 85(20):10561-10571. 10.1128/JVI.00173-11.
238. Subramaniam A., Shanmugam M.K., Perumal E., Li F., Nachiyappan A., Dai X., Swamy S.N., Ahn K.S., Kumar A.P., Tan B.K., Hui K.M., Sethi G. Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochim. Biophys. Acta 2013, 1835(1):46-60.
239. Sugiyama K., Ebinuma H., Nakamoto N., Sakasegawa N., Murakami Y., Chu P.-S., Usui S., Ishibashi Y., Wakayama Y., Taniki N., Murata H., Saito Y., Fukasawa M., Saito K., Yamagishi Y., Wakita T., Takaku H., Hibi T., Saito H., Kanai T. Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus. PLOS ONE 2014, 9:e94460.
240. Sumida Y., Nakashima T., Yoh T., Nakajima Y., Ishikawa H., Mitsuyoshi H., Sakamoto Y., Okanoue T., Kashima K., Nakamura H., Yodoi J. Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection. J. Hepatol. 2000, 33:616-622.
241. Sun B., Kawahara M., Ehata S., Nagamune T. AAG8 promotes carcinogenesis by activating STAT3. Cell. Signal. 2014, 26(9):1863-1869. 10.1016/j.cellsig.2014.04.001.
242. Syed G.H., Amako Y., Siddiqui A. Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol. Metab. 2010, 21(1):33-40.
243. Taguwa S., Kambara H., Fujita N., Noda T., Yoshimori T., Koike K., Moriishi K., Matsuura Y. Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus. J. Virol. 2011, 85(24):13185-13194.
244. Taguwa S., Kambara H., Omori H., Tani H., Abe T., Mori Y., Suzuki T., Yoshimori T., Moriishi K., Matsuura Y. Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. J. Virol. 2009, 83(20):10427-10436.
245. Takebayashi M., Hayashi T., Su T.-P. Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution. Synapse 2004, 53:90-103.
246. Tal M.C., Iwasaki A. Autophagic control of RLR signaling. Autophagy 2009, 5(5):749-750.
247. Tanida I., Fukasawa M., Ueno T., Kominami E., Wakita T., Hanada K. Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy 2009, 5:937-945.
248. Tardif K.D., Mori K., Kaufman R.J., Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J. Biol. Chem. 2004, 279:17158-17164.
249. Tardif K.D., Mori K., Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J. Virol. 2002, 76:7453-7459.
250. Tardif K.D., Waris G., Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 2005, 13(4):159-163.
251. Tardif K.D., Waris G., Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 2005, 13:159-163.
252. Tatsuta T., Scharwey M., Langer T. Mitochondrial lipid trafficking. Trends Cell Biol. 2014, 24:44-52.
253. Taylor E.B., Rutter J. Mitochondrial quality control by the ubiquitin-proteasome system. Biochem. Soc. Trans. 2011, 39(5):1509-1513.
254. Tsai S.-Y., Rothman R.K., Su T.-P. Insights into the Sigma-1 receptor Chaperone's cellular functions: a microarray report. Synapse 2011, 66:42-51.
255. Tsai S.Y., Pokrass M.J., Klauer N.R., De Credico N.E., Su T.P. Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders. Expert Opin. Ther. Targets 2014, 18(12):1461-1476.
256. Tsutsumi T., Matsuda M., Aizaki H., Moriya K., Miyoshi H., Fujie H., Shintani Y., Yotsuyanagi H., Miyamura T., Suzuki T., Koike K. Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology 2009, 50(2):378-386.
257. Tu B.P., Weissman J.S. Oxidative protein folding in eukaryotes: mechanisms and consequences. J. Cell Biol. 2004, 164(3):341-346.
258. Twig G., Shirihai O.S. The interplay between mitochondrial dynamics and mitophagy. Antioxid. Redox Signal. 2011, 14(10):1939-1951.
259. Ujino S., Yamaguchi S., Shimotohno K., Takaku H. Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3. J. Biol. Chem. 2009, 284(11):6841-6846.
260. Vance J.E. MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond. Biochim. Biophys. Acta 2014, 1841(4):595-609.
261. Varadarajan S., Bampton E.T., Smalley J.L., Tanaka K., Caves R.E., Butterworth M., Wei J., Pellecchia M., Mitcheson J., Gant T.W., Dinsdale D., Cohen G.M. A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. Cell Death Differ. 2012, 19(12):1896-1907.
262. Vassilaki N., Kalliampakou K.I., Kotta-Loizou I., Befani C., Liakos P., Simos G., Mentis A.F., Kalliaropoulos A., Doumba P.P., Smirlis D., Foka P., Bauhofer O., Poenisch M., Windisch M.P., Lee M.E., Koskinas J., Bartenschlager R., Mavromara P. Low oxygen tension enhances hepatitis C virus replication. J. Virol. 2013, 87(5):2935-2948.
263. Vendemiale G., Grattagliano I., Portincasa P., Serviddio G., Palasciamo G., Altomare E. Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up. Eur. J. Clin. Invest. 2001, 31(1):54-63.
264. Vescovo T., Romagnoli A., Perdomo A.B., Corazzari M., Ciccosanti F., Alonzi T., Nardacci R., Ippolito G., Tripodi M., Garcia-Monzon C., Lo Iacono O., Piacentini M., Fimia G.M. Autophagy protects cells from HCV-induced defects in lipid metabolism. Gastroenterology 2012, 142(3):644-653. e643.
265. Vollrath J.T., Sechi A., Dreser A., Katona I., Wiemuth D., Vervoorts J., Dohmen M., Chandrasekar A., Prause J., Brauers E., Jesse C.M., Weis J., Goswami A. Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances. Cell Death Dis. 2014, 5:e1290.
266. von dem Bussche A., Machida R., Li K., Loevinsohn G., Khander A., Wang J., Wakita T., Wands J.R., Li J. Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication. J. Hepatol. 2010, 53(5):797-804.
267. Walter P., Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011, 334(6059):1081-1086.
268. Walters K.-A., Syder A.J., Lederer S.L., Diamond D.L., Paeper B., Rice C.M., Katze M.G. Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes. PLoS Pathog. 2009, 5:e1000269.
269. Walters K.A., Syder A.J., Lederer S.L., Diamond D.L., Paeper B., Rice C.M., Katze M.G. Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes. PLoS Pathog. 2009, 5(1):e1000269.
270. Wang J., Kang R., Huang H., Xi X., Wang B., Wang J., Zhao Z. Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression. Autophagy 2014, 10(5):766-784.
271. Wang T., Campbell R.V., Yi M.K., Lemon S.M., Weinman S.A. Role of hepatitis C virus core protein in viral-induced mitochondrial dysfunction. J. Viral Hepat. 2010, 17(11):784-793.
272. Wang T., Weinman S.A. Interactions between hepatitis C virus and mitochondria: impact on pathogenesis and innate immunity. Curr. Pathobiol. Rep. 2013, 1:179-187.
273. Wang T., Weinman S.A. Interactions between hepatitis C virus and mitochondria: impact on pathogenesis and innate immunity. Curr. Pathobiol. Rep. 2013, 1(3):179-187.
274. Waris G., Felmlee D.J., Negro F., Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J. Virol. 2007, 81:8122-8130.
275. Waris G., Siddiqui A. Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J. Virol. 2005, 79:9725-9734.
276. Waris G., Tardif K.D., Siddiqui A. Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem. Pharmacol. 2002, 64(10):1425-1430.
277. Waris G., Turkson J., Hassanein T., Siddiqui A. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J. Virol. 2005, 79:1569-1580.
278. Watashi K., Ishii N., Hijikata M., Inoue D., Murata T., Miyanari Y., Shimotohno K. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol. Cell 2005, 19(1):111-122.
279. Wei Y., Pattingre S., Sinha S., Bassik M., Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 2008, 30(6):678-688.
280. Weyemi U., Dupuy C. The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses. Mutat. Res. 2012, 751(2):77-81.
281. White E., DiPaola R.S. The double-edged sword of autophagy modulation in cancer. Clin. Cancer Res. 2009, 15(17):5308-5316.
282. Wieland S., Makowska Z., Campana B., Calabrese D., Dill M.T., Chung J., Chisari F.V., Heim M.H. Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver. Hepatology 2014, 59(6):2121-2130.
283. Wilson G.K., Brimacombe C.L., Rowe I.A., Reynolds G.M., Fletcher N.F., Stamataki Z., Bhogal R.H., Simoes M.L., Ashcroft M., Afford S.C., Mitry R.R., Dhawan A., Mee C.J., Hubscher S.G., Balfe P., McKeating J.A. A dual role for hypoxia inducible factor-1alpha in the hepatitis C virus lifecycle and hepatoma migration. J. Hepatol. 2012, 56(4):803-809.
284. Woodhouse S.D., Narayan R., Latham S., Lee S., Antrobus R., Gangadharan B., Luo S., Schroth G.P., Klenerman P., Zitzmann N. Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro. Hepatology 2010, 52:443-453.
285. Yamane D., McGivern D.R., Masaki T., Lemon S.M. Liver injury and disease pathogenesis in chronic hepatitis C. Curr. Top. Microbiol. Immunol. 2013, 369:263-288.
286. Yamane D., McGivern D.R., Wauthier E., Yi M., Madden V.J., Welsch C., Antes I., Wen Y., Chugh P.E., McGee C.E., Widman D.G., Misumi I., Bandyopadhyay S., Kim S., Shimakami T., Oikawa T., Whitmire J.K., Heise M.T., Dittmer D.P., Kao C.C., Pitson S.M., Merrill A.H., Reid L.M., Lemon S.M. Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation. Nat. Med. 2014, 20(8):927-935.
287. Yao W., Cai H., Li X., Li T., Hu L., Peng T. Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1alpha/liver-specific PGC-1alpha upregulation. J. Virol. 2014, 88(15):8361-8374.
288. Yi Z., Pan T., Wu X., Song W., Wang S., Xu Y., Rice C.M., Macdonald M.R., Yuan Z. Hepatitis C virus co-opts Ras-GTPase-activating protein-binding protein 1 for its genome replication. J. Virol. 2011, 85(14):6996-7004.
289. Yoshida H., Matsui T., Hosokawa N., Kaufman R.J., Nagata K., Mori K. A time-dependent phase shift in the mammalian unfolded protein response. Dev. Cell 2003, 4(2):265-271.
290. Yoshii S.R., Kishi C., Ishihara N., Mizushima N. Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 2011, 286(22):19630-19640.
291. Yu Y., Pierciey F.J., Maguire T.G., Alwine J.C. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog. 2013, 9(4):e1003266.
292. Zhao Y., Li X., Cai M.Y., Ma K., Yang J., Zhou J., Fu W., Wei F.Z., Wang L., Xie D., Zhu W.G. XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells. Cell Res. 2013, 23(4):491-507.
293. Zhao Y., Sun X., Nie X., Sun L., Tang T.S., Chen D., Sun Q. COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production. PLoS Pathog. 2012, 8(12):e1003086.
294. Zhong J., Gastaminza P., Chung J., Stamataki Z., Isogawa M., Cheng G., McKeating J.A., Chisari F.V. Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J. Virol. 2006, 80(22):11082-11093.
295. Zhu Z., Wilson A.T., Luxon B.A., Brown K.E., Mathahs M.M., Bandyopadhyay S., McCaffrey A.P., Schmidt W.N. Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase?. Hepatology 2010, 52(6):1897-1905.
296. Zhu Z., Wilson A.T., Mathahs M.M., Wen F., Brown K.E., Luxon B.A., Schmidt W.N. Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology 2008, 48(5):1430-1439.