Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants

Virology

Volumn 405, Issue 2, 2010, Pages 361-369

  Mishima, Kako ^a   Sakamoto, Naoya ^a   Sekine Osajima, Yuko ^a   Nakagawa, Mina ^a   Itsui, Yasuhiro ^a,b   Azuma, Seishin ^a   Kakinuma, Sei ^a   Kiyohashi, Kei ^a   Kitazume, Akiko ^a   Tsuchiya, Kiichiro ^a   Imamura, Michio ^c   Hiraga, Nobuhiko ^c   Chayama, Kazuaki ^c   Wakita, Takaji ^d   Watanabe, Mamoru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Soka Municipal Hospital   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Adaptive mutations; Cytopathic effect; HCV JFH1 cell culture; Human hepatocyte chimeric mice; Plaque assay

Indexed keywords

ARGININE; CYSTEINE; HEAT SHOCK PROTEIN; NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5B; PROLINE; SERINE; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERTANT; STRAIN DIFFERENCE; VIRUS MUTANT; VIRUS PLAQUE; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE, TUMOR; CYTOPATHOGENIC EFFECT, VIRAL; HEPACIVIRUS; HEPATOCYTES; HUMANS; MICE; MUTATION; PLAQUE ASSAY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; MUS;

EID: 77955655615     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.06.020     Document Type: Article

References (35)

1. Alter M.J. Epidemiology of hepatitis C. Hepatology 1997, 26:62S-65S.
2. Bartenschlager R., Lohmann V. Replication of hepatitis C virus. J. Gen. Virol. 2000, 81:1631-1648.
3. Bukh J., Pietschmann T., Lohmann V., Krieger N., Faulk K., Engle R.E., Govindarajan S., Shapiro M., Claire M.S., Bartenschlager R. Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(22):14416-14421.
4. Cerny A., Chisari F.V. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 1999, 30(3):595-601.
5. Delgrange D., Pillez A., Castelain S., Cocquerel L., Rouille Y., Dubuisson J., Wakita T., Duverlie G., Wychowski C. Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins. J. Gen. Virol. 2007, 88(Pt 9):2495-2503.
6. Delladetsima J.K., Boletis J.N., Makris F., Psichogiou M., Kostakis A., Hatzakis A. Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection. Liver Transpl. Surg. 1999, 5(4):294-300.
7. Dixon L.R., Crawford J.M. Early histologic changes in fibrosing cholestatic hepatitis C. Liver Transpl. 2007, 13(2):219-226.
8. Fried M.W., Shiffman M.L., Reddy K.R., Smith C., Marionos G., Goncales F.L., Häussinger D., Diago M., Garosi G., Dhumeaux D., Craxi A., Lin A., Hoffman J., Yu J. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 2002, 347:975-982.
9. Han Q., Xu C., Wu C., Zhu W., Yang R., Chen X. Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus. Virus Res. 2009, 145(1):63-73.
10. Itsui, Y., Sakamoto, N., Kakinuma, S., Nakagawa, M., Sekine-Osajima, Y., Tasaka-Fujita, M., Nishimura-Sakurai, Y., Suda, G., Karakama, Y., Yamamoto, M., Watanabe, T., Ueyama, M., Funaoka, Y., Azuma, S., and Watanabe, M. (2009). Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein. Hepatology 50 (6), 1727-1737.
11. Jordan R., Wang L., Graczyk T.M., Block T.M., Romano P.R. Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells. J. Virol. 2002, 76(19):9588-9599.
12. Kato N. Molecular virology of hepatitis C virus. Acta Med. Okayama 2001, 55(3):133-159.
13. Kato T., Date T., Miyamoto M., Furusaka A., Tokushige K., Mizokami M., Wakita T. Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology 2003, 125(6):1808-1817.
14. Kaul A., Woerz I., Meuleman P., Leroux-Roels G., Bartenschlager R. Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J. Virol. 2007, 81(23):13168-13179.
15. Koutsoudakis G., Herrmann E., Kallis S., Bartenschlager R., Pietschmann T. The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells. J. Virol. 2007, 81(2):588-598.
16. Leifeld L., Nattermann J., Fielenbach M., Schmitz V., Sauerbruch T., Spengler U. Intrahepatic activation of caspases in human fulminant hepatic failure. Liver Int. 2006, 26(7):872-879.
17. Lesburg C.A., Cable M.B., Ferrari E., Hong Z., Mannarino A.F., Weber P.C. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat. Struct. Biol. 1999, 6(10):937-943.
18. Lindenbach B.D., Evans M.J., Syder A.J., Wolk B., Tellinghuisen T.L., Liu C.C., Maruyama T., Hynes R.O., Burton D.R., McKeating J.A., Rice C.M. Complete replication of hepatitis C virus in cell culture. Science 2005, 309(5734):623-626.
19. Lohmann V., Korner F., Koch J., Herian U., Theilmann L., Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999, 285(5424):110-113.
20. Mercer D.F., Schiller D.E., Elliott J.F., Douglas D.N., Hao C., Rinfret A., Addison W.R., Fischer K.P., Churchill T.A., Lakey J.R., Tyrrell D.L., Kneteman N.M. Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 2001, 7(8):927-933.
21. Mita A., Hashikura Y., Tagawa Y., Nakayama J., Kawakubo M., Miyagawa S. Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure. Am. J. Gastroenterol. 2005, 100(11):2551-2559.
22. Mottola G., Cardinali G., Ceccacci A., Trozzi C., Bartholomew L., Torrisi M.R., Pedrazzini E., Bonatti S., Migliaccio G. Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons. Virology 2002, 293(1):31-43.
23. Russell R.S., Meunier J.C., Takikawa S., Faulk K., Engle R.E., Bukh J., Purcell R.H., Emerson S.U. Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(11):4370-4375.
24. Ryo K., Kamogawa Y., Ikeda I., Yamauchi K., Yonehara S., Nagata S., Hayashi N. Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure. Am. J. Gastroenterol. 2000, 95(8):2047-2055.
25. Sakamoto N., Watanabe M. New therapeutic approaches to hepatitis C virus. J. Gastroenterol. 2009, 44(7):643-649.
26. Sakamoto N., Yoshimura M., Kimura T., Toyama K., Sekine-Osajima Y., Watanabe M., Muramatsu M. Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon. Biochem. Biophys. Res. Commun. 2007, 357(2):467-473.
27. Sekine-Osajima Y., Sakamoto N., Mishima K., Nakagawa M., Itsui Y., Tasaka M., Nishimura-Sakurai Y., Chen C.H., Kanai T., Tsuchiya K., Wakita T., Enomoto N., Watanabe M. Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity. Virology 2008, 371(1):71-85.
28. Shuda M., Kondoh N., Imazeki N., Tanaka K., Okada T., Mori K., Hada A., Arai M., Wakatsuki T., Matsubara O., Yamamoto N., Yamamoto M. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 2003, 38(5):605-614.
29. Tanabe Y., Sakamoto N., Enomoto N., Kurosaki M., Ueda E., Maekawa S., Yamashiro T., Nakagawa M., Chen C.H., Kanazawa N., Watanabe M. Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha. J. Infect. Dis. 2004, 189:1129-1139.
30. Tasaka M., Sakamoto N., Itakura Y., Nakagawa M., Itsui Y., Sekine-Osajima Y., Nishimura-Sakurai Y., Chen C.H., Yoneyama M., Fujita T., Wakita T., Maekawa S., Enomoto N., Watanabe M. Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. J. Gen. Virol. 2007, 88(Pt 12):3323-3333.
31. Wakita T., Pietschmann T., Kato T., Date T., Miyamoto M., Zhao Z., Murthy K., Habermann A., Krausslich H.G., Mizokami M., Bartenschlager R., Liang T.J. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 2005, 11(7):791-796.
32. Yi M., Bodola F., Lemon S.M. Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein. Virology 2002, 304(2):197-210.
33. Yokota T., Sakamoto N., Enomoto N., Tanabe Y., Miyagishi M., Maekawa S., Yi L., Kurosaki M., Taira K., Watanabe M., Mizusawa H. Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep. 2003, 4(6):602-608.
34. Zhong J., Gastaminza P., Cheng G., Kapadia S., Kato T., Burton D.R., Wieland S.F., Uprichard S.L., Wakita T., Chisari F.V. Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(26):9294-9299.
35. Zhong J., Gastaminza P., Chung J., Stamataki Z., Isogawa M., Cheng G., McKeating J.A., Chisari F.V. Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J. Virol. 2006, 80(22):11082-11093.