-
1
-
-
0033516384
-
The scientific challenge of hepatitis C
-
Cohen J. The scientific challenge of hepatitis C. Science 1999; 285: 26-30
-
(1999)
Science
, vol.285
, pp. 26-30
-
-
Cohen, J.1
-
2
-
-
0036175179
-
Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: Is hepatic venous pressure gradient a better end point?
-
Burroughs AK, Groszmann R, Bosch J, Grace N, Garcia-Tsao G, Patch D, Garcia-Pagan J C, Dagher L. Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: is hepatic venous pressure gradient a better end point? Gut 2002; 50: 425-427
-
(2002)
Gut
, vol.50
, pp. 425-427
-
-
Burroughs, A.K.1
Groszmann, R.2
Bosch, J.3
Grace, N.4
Garcia-Tsao, G.5
Patch, D.6
Garcia-Pagan, J.C.7
Dagher, L.8
-
3
-
-
0036294003
-
Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
-
Hickman IJ, Clouston AD, Macdonald GA, Purdie DM, Prins JB, Ash S, Jonsson JR, Powell EE. Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut 2002; 51: 89-94
-
(2002)
Gut
, vol.51
, pp. 89-94
-
-
Hickman, I.J.1
Clouston, A.D.2
Macdonald, G.A.3
Purdie, D.M.4
Prins, J.B.5
Ash, S.6
Jonsson, J.R.7
Powell, E.E.8
-
4
-
-
0037372609
-
Cost effectiveness of peginterferon alpha-2b plus ribavirin versus interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C
-
Siebert U, Sroczynski G, Rossol S, Wasem J, Ravens-Sieberer U, Kurth BM, Manns MP, McHutchison JG, Wong JB. Cost effectiveness of peginterferon alpha-2b plus ribavirin versus interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C. Gut 2003; 52: 425-432
-
(2003)
Gut
, vol.52
, pp. 425-432
-
-
Siebert, U.1
Sroczynski, G.2
Rossol, S.3
Wasem, J.4
Ravens-Sieberer, U.5
Kurth, B.M.6
Manns, M.P.7
McHutchison, J.G.8
Wong, J.B.9
-
5
-
-
10744220759
-
Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C
-
Asselah T, Boyer N, Guimont MC, Cazals-Hatem D, Tubach F, Nahon K, Daikha H, Vidaud D, Martinot M, Vidaud M, Degott C, Valla D, Marcellin P. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Gut 2003; 52: 1638-1643
-
(2003)
Gut
, vol.52
, pp. 1638-1643
-
-
Asselah, T.1
Boyer, N.2
Guimont, M.C.3
Cazals-Hatem, D.4
Tubach, F.5
Nahon, K.6
Daikha, H.7
Vidaud, D.8
Martinot, M.9
Vidaud, M.10
Degott, C.11
Valla, D.12
Marcellin, P.13
-
6
-
-
0030928695
-
Hepatitis C: The clinical spectrum of disease
-
Hoofnagle JH. Hepatitis C: the clinical spectrum of disease. Hepatology 1997; 26: 15S-20S
-
(1997)
Hepatology
, vol.26
-
-
Hoofnagle, J.H.1
-
7
-
-
0032908398
-
Natural history of chronic hepatitis C
-
Pagliaro L, Peri V, Linea C, Camma C, Giunta M, Magrin S. Natural history of chronic hepatitis C. Ital J Gastroenterol Hepatol 1999; 31: 28-44
-
(1999)
Ital J Gastroenterol Hepatol
, vol.31
, pp. 28-44
-
-
Pagliaro, L.1
Peri, V.2
Linea, C.3
Camma, C.4
Giunta, M.5
Magrin, S.6
-
8
-
-
0028235641
-
Classification of chronic hepatitis: Diagnosis, grading and staging
-
Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-1520
-
(1994)
Hepatology
, vol.19
, pp. 1513-1520
-
-
Desmet, V.J.1
Gerber, M.2
Hoofnagle, J.H.3
Manns, M.4
Scheuer, P.J.5
-
9
-
-
0031004556
-
Long-term evolution of fibrosis from chronic hepatitis to cirrhosis in patients with hepatitis C: Morphometric analysis of repeated biopsies
-
Kage M, Shimamatu K, Nakashima E, Kojiro M, Inoue O, Yano M. Long-term evolution of fibrosis from chronic hepatitis to cirrhosis in patients with hepatitis C: morphometric analysis of repeated biopsies. Hepatology 1997; 25: 1028-1031
-
(1997)
Hepatology
, vol.25
, pp. 1028-1031
-
-
Kage, M.1
Shimamatu, K.2
Nakashima, E.3
Kojiro, M.4
Inoue, O.5
Yano, M.6
-
10
-
-
15844431546
-
The long-term pathological evolution of chronic hepatitis C
-
Yano M, Kumada H, Kage M, Ikeda K, Shimamatsu K, Inoue O, Hashimoto E, Lefkowitch JH, Ludwig J, Okuda K. The long-term pathological evolution of chronic hepatitis C. Hepatology 1996; 23: 1334-1340
-
(1996)
Hepatology
, vol.23
, pp. 1334-1340
-
-
Yano, M.1
Kumada, H.2
Kage, M.3
Ikeda, K.4
Shimamatsu, K.5
Inoue, O.6
Hashimoto, E.7
Lefkowitch, J.H.8
Ludwig, J.9
Okuda, K.10
-
11
-
-
0034987686
-
Quantitative assessment of fibrosis and steatosis in liver biopsies from patients with chronic hepatitis C
-
Zaitoun AM, Al Mardini H, Awad S, Ukabam S, Makadisi S, Record CO. Quantitative assessment of fibrosis and steatosis in liver biopsies from patients with chronic hepatitis C. J Clin Pathol 2001; 54: 461-465
-
(2001)
J Clin Pathol
, vol.54
, pp. 461-465
-
-
Zaitoun, A.M.1
Al Mardini, H.2
Awad, S.3
Ukabam, S.4
Makadisi, S.5
Record, C.O.6
-
12
-
-
0031712813
-
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
-
Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, Matsuura Y, Kimura S, Miyamura T, Koike K. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998; 4: 1065-1067
-
(1998)
Nat Med
, vol.4
, pp. 1065-1067
-
-
Moriya, K.1
Fujie, H.2
Shintani, Y.3
Yotsuyanagi, H.4
Tsutsumi, T.5
Ishibashi, K.6
Matsuura, Y.7
Kimura, S.8
Miyamura, T.9
Koike, K.10
-
13
-
-
18244365866
-
Hepatitis C: Virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
-
Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chretien Y, Koike K, Pessayre D, Chapman J, Barba G, Brechot C. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J 2002; 16: 185-194
-
(2002)
FASEB J
, vol.16
, pp. 185-194
-
-
Perlemuter, G.1
Sabile, A.2
Letteron, P.3
Vona, G.4
Topilco, A.5
Chretien, Y.6
Koike, K.7
Pessayre, D.8
Chapman, J.9
Barba, G.10
Brechot, C.11
-
14
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-650
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
15
-
-
1542335555
-
Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast
-
Bandsma RH, Van Dijk TH, Harmsel At A, Kok T, Reijngoud DJ, Staels B, Kuipers F. Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast. J Biol Chem 2004; 279: 8930-8937
-
(2004)
J Biol Chem
, vol.279
, pp. 8930-8937
-
-
Bandsma, R.H.1
Van Dijk, T.H.2
Harmsel, A.A.3
Kok, T.4
Reijngoud, D.J.5
Staels, B.6
Kuipers, F.7
-
16
-
-
0037459358
-
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
-
Gilde AJ, van der Lee KA, Willemsen PH, Chinetti G, van der Leij FR, van der Vusse GJ, Staels B, van Bilsen M. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Circ Res 2003; 92: 518-524
-
(2003)
Circ Res
, vol.92
, pp. 518-524
-
-
Gilde, A.J.1
van der Lee, K.A.2
Willemsen, P.H.3
Chinetti, G.4
van der Leij, F.R.5
van der Vusse, G.J.6
Staels, B.7
van Bilsen, M.8
-
17
-
-
0037178796
-
Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
-
van der Leij FR, Cox KB, Jackson VN, Huijkman NC, Bartelds B, Kuipers JR, Dijkhuizen T, Terpstra P, Wood PA, Zammit VA, Price NT. Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals, J Biol Chem 2002; 277: 26994-27005
-
(2002)
J Biol Chem
, vol.277
, pp. 26994-27005
-
-
van der Leij, F.R.1
Cox, K.B.2
Jackson, V.N.3
Huijkman, N.C.4
Bartelds, B.5
Kuipers, J.R.6
Dijkhuizen, T.7
Terpstra, P.8
Wood, P.A.9
Zammit, V.A.10
Price, N.T.11
-
18
-
-
0346749506
-
Functional and structural basis of carnitine palmitoyltransferase 1A deficiency
-
Gobin S, Thuillier L, Jogl G, Faye A, Tong L, Chi M, Bonnefont JP, Girard J, Prip-Buus C. Functional and structural basis of carnitine palmitoyltransferase 1A deficiency. J Biol Chem 2003; 278: 50428-50434
-
(2003)
J Biol Chem
, vol.278
, pp. 50428-50434
-
-
Gobin, S.1
Thuillier, L.2
Jogl, G.3
Faye, A.4
Tong, L.5
Chi, M.6
Bonnefont, J.P.7
Girard, J.8
Prip-Buus, C.9
-
19
-
-
0029778988
-
An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group
-
Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996; 24: 289-293
-
(1996)
Hepatology
, vol.24
, pp. 289-293
-
-
Bedossa, P.1
Poynard, T.2
-
20
-
-
0035794293
-
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
-
Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001; 193: 827-838
-
(2001)
J Exp Med
, vol.193
, pp. 827-838
-
-
Desreumaux, P.1
Dubuquoy, L.2
Nutten, S.3
Peuchmaur, M.4
Englaro, W.5
Schoonjans, K.6
Derijard, B.7
Desvergne, B.8
Wahli, W.9
Chambon, P.10
Leibowitz, M.D.11
Colombel, J.F.12
Auwerx, J.13
-
21
-
-
11144357274
-
Hepatitis C: Virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
-
Barba G, Harper F, Harada T, Kohara M, Goulinet S, Matsuura Y, Eder G, Schaff Z, Chapman MJ, Miyamura T, Brechot C. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci USA 1997; 94: 1200-1205
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1200-1205
-
-
Barba, G.1
Harper, F.2
Harada, T.3
Kohara, M.4
Goulinet, S.5
Matsuura, Y.6
Eder, G.7
Schaff, Z.8
Chapman, M.J.9
Miyamura, T.10
Brechot, C.11
-
22
-
-
0030658022
-
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
-
Martin G, Schoonjans K, Lefebvre AM, Staels B, Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem 1997; 272: 28210-28217
-
(1997)
J Biol Chem
, vol.272
, pp. 28210-28217
-
-
Martin, G.1
Schoonjans, K.2
Lefebvre, A.M.3
Staels, B.4
Auwerx, J.5
-
23
-
-
0141542480
-
Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications
-
Bieche I, Onody P, Laurendeau I, Olivi M, Vidaud D, Lidereau R, Vidaud M. Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications. Clin Chem 1999; 45: 1148-1156
-
(1999)
Clin Chem
, vol.45
, pp. 1148-1156
-
-
Bieche, I.1
Onody, P.2
Laurendeau, I.3
Olivi, M.4
Vidaud, D.5
Lidereau, R.6
Vidaud, M.7
-
24
-
-
0037847511
-
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
-
Dubuquoy L, Jansson EA, Deeb S, Rakotobe S, Karoui M, Colombel JF, Auwerx J, Pettersson S, Desreumaux P. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 2003; 124: 1265-1276
-
(2003)
Gastroenterology
, vol.124
, pp. 1265-1276
-
-
Dubuquoy, L.1
Jansson, E.A.2
Deeb, S.3
Rakotobe, S.4
Karoui, M.5
Colombel, J.F.6
Auwerx, J.7
Pettersson, S.8
Desreumaux, P.9
-
25
-
-
0037651166
-
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation
-
Philippe D, Dubuquoy L, Groux H, Brun V, Chuoi-Mariot MT, Gaveriaux-Ruff C, Colombel JF, Kieffer BL, Desreumaux P. Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. J Clin Invest 2003; 111: 1329-1338
-
(2003)
J Clin Invest
, vol.111
, pp. 1329-1338
-
-
Philippe, D.1
Dubuquoy, L.2
Groux, H.3
Brun, V.4
Chuoi-Mariot, M.T.5
Gaveriaux-Ruff, C.6
Colombel, J.F.7
Kieffer, B.L.8
Desreumaux, P.9
-
26
-
-
11144342818
-
Hepatitis C: Virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells
-
Otani K, Korenaga M, Beard MR, Li K, Qian T, Showalter LA, Singh AK, Wang T, Weinman SA. Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology 2005; 128: 96-107
-
(2005)
Gastroenterology
, vol.128
, pp. 96-107
-
-
Otani, K.1
Korenaga, M.2
Beard, M.R.3
Li, K.4
Qian, T.5
Showalter, L.A.6
Singh, A.K.7
Wang, T.8
Weinman, S.A.9
-
27
-
-
10044264310
-
Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation
-
McCarthy TC, Pollak PT, Hanniman EA, Sinal CJ. Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation. J Pharmacol Exp Ther 2004; 311: 864-873
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 864-873
-
-
McCarthy, T.C.1
Pollak, P.T.2
Hanniman, E.A.3
Sinal, C.J.4
-
28
-
-
0033799773
-
PPAR-alpha: A key to the mechanism of hepatoprotection by clofibrate
-
Mehendale HM. PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. Toxicol Sci 2000; 57: 187-190
-
(2000)
Toxicol Sci
, vol.57
, pp. 187-190
-
-
Mehendale, H.M.1
-
29
-
-
0035958960
-
Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells
-
Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem 2001; 276: 27950-27958
-
(2001)
J Biol Chem
, vol.276
, pp. 27950-27958
-
-
Hsu, M.H.1
Savas, U.2
Griffin, K.J.3
Johnson, E.F.4
-
30
-
-
4444307033
-
Carnitine palmitoyltransferases 1 and 2: Biochemical, molecular and medical aspects
-
Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med 2004; 25: 495-520
-
(2004)
Mol Aspects Med
, vol.25
, pp. 495-520
-
-
Bonnefont, J.P.1
Djouadi, F.2
Prip-Buus, C.3
Gobin, S.4
Munnich, A.5
Bastin, J.6
-
31
-
-
0037929468
-
Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: Residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
-
Price NT, Jackson VN, van der Leij FR, Cameron JM, Travers MT, Bartelds B, Huijkman NC, Zammit VA. Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme. Biochem J 2003; 372: 871-879
-
(2003)
Biochem J
, vol.372
, pp. 871-879
-
-
Price, N.T.1
Jackson, V.N.2
van der Leij, F.R.3
Cameron, J.M.4
Travers, M.T.5
Bartelds, B.6
Huijkman, N.C.7
Zammit, V.A.8
-
32
-
-
0035658444
-
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis
-
Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1333-G1339
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.281
-
-
Reddy, J.K.1
-
33
-
-
0142216121
-
Ragaglitazar: A novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models
-
Chakrabarti R, Vikramadithyan RK, Misra P, Hiriyan J, Raichur S, Damarla RK, Gershome C, Suresh J, Rajagopalan R. Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models. Br J Pharmacol 2003; 140: 527-537
-
(2003)
Br J Pharmacol
, vol.140
, pp. 527-537
-
-
Chakrabarti, R.1
Vikramadithyan, R.K.2
Misra, P.3
Hiriyan, J.4
Raichur, S.5
Damarla, R.K.6
Gershome, C.7
Suresh, J.8
Rajagopalan, R.9
-
34
-
-
0035984958
-
Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats
-
Rao MS, Papreddy K, Musunuri S, Okonkwo A. Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats. In Vivo 2002; 16: 145-152
-
(2002)
In Vivo
, vol.16
, pp. 145-152
-
-
Rao, M.S.1
Papreddy, K.2
Musunuri, S.3
Okonkwo, A.4
-
35
-
-
0036146821
-
Dietary 1-carnitine stimulates carnitine acyltransferases in the liver of aged rats
-
Karlic H, Lohninger S, Koeck T, Lohninger A. Dietary 1-carnitine stimulates carnitine acyltransferases in the liver of aged rats. J Histochem Cytochem 2002; 50: 205-12
-
(2002)
J Histochem Cytochem
, vol.50
, pp. 205-212
-
-
Karlic, H.1
Lohninger, S.2
Koeck, T.3
Lohninger, A.4
-
36
-
-
0037799205
-
Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2
-
Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem 2003; 278: 4467-4473
-
(2003)
J Biol Chem
, vol.278
, pp. 4467-4473
-
-
Sumanasekera, W.K.1
Tien, E.S.2
Turpey, R.3
Vanden Heuvel, J.P.4
Perdew, G.H.5
|