-
1
-
-
0035856949
-
Insulin signaling and the regulation of glucose and lipid metabolism
-
doi:10.1038/414799a
-
Saltiel AR, Ronald Kahn C (2001) Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414: 799-806. doi: 10. 1038/414799a.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Ronald Kahn, C.2
-
2
-
-
0032214652
-
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
-
doi:10.1016/S1097-2765(00)80155-0
-
Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2: 559-569. doi: 10. 1016/S1097-2765(00)80155-0.
-
(1998)
Mol Cell
, vol.2
, pp. 559-569
-
-
Brüning, J.C.1
Michael, M.D.2
Winnay, J.N.3
Hayashi, T.4
Hörsch, D.5
Accili, D.6
Goodyear, L.J.7
Kahn, C.R.8
-
3
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
-
doi:10.1016/S0092-8674(00)80546-2
-
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-339. doi: 10. 1016/S0092-8674(00)80546-2.
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Brüning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
4
-
-
0032470252
-
The insulin receptor-a critical link in glucose homeostasis and insulin action
-
Patti ME, Kahn CR (1998) The insulin receptor-a critical link in glucose homeostasis and insulin action. J Basic Clin Physol Pharmacol 9: 89-109.
-
(1998)
J Basic Clin Physol Pharmacol
, vol.9
, pp. 89-109
-
-
Patti, M.E.1
Kahn, C.R.2
-
5
-
-
33845244172
-
Pathophysiology of insulin resistance
-
doi:10.1016/j.beem.2006.09.007
-
Sesti G (2006) Pathophysiology of insulin resistance. Best Pract Res Clin Endocrin Metab 20: 665-679. doi: 10. 1016/j. beem. 2006. 09. 007.
-
(2006)
Best Pract Res Clin Endocrin Metab
, vol.20
, pp. 665-679
-
-
Sesti, G.1
-
6
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
-
Hotamisligil S, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271: 665-668.
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
7
-
-
77952708205
-
Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression
-
doi:10.1128/JVI.02344-09
-
Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R (2010) Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. J Virol 84: 5936-5946. doi: 10. 1128/JVI. 02344-09.
-
(2010)
J Virol
, vol.84
, pp. 5936-5946
-
-
Banerjee, A.1
Meyer, K.2
Mazumdar, B.3
Ray, R.B.4
Ray, R.5
-
8
-
-
78651272137
-
Hormonal regulation of gluconeogenic gene transcription in the liver
-
Yabaluri N, Bashyam MD (2010) Hormonal regulation of gluconeogenic gene transcription in the liver. J Biosci 35: 473-484.
-
(2010)
J Biosci
, vol.35
, pp. 473-484
-
-
Yabaluri, N.1
Bashyam, M.D.2
-
9
-
-
0033766219
-
Clastogenic factors as biomarkers of oxidative stress in chronic hepatitis C
-
doi:10.1159/000007814
-
Emerit I, Serejo F, Filipe P et al (2007) Clastogenic factors as biomarkers of oxidative stress in chronic hepatitis C. Digestion 62: 200-207. doi: 10. 1159/000007814.
-
(2007)
Digestion
, vol.62
, pp. 200-207
-
-
Emerit, I.1
Serejo, F.2
Filipe, P.3
-
10
-
-
29244484291
-
Steatosis in chronic hepatitis C: why does it really matter?
-
doi:10.1136/gut.2005.069757
-
Asselah T, Rubbia-Brandt L, Marcellin P, Negro F (2006) Steatosis in chronic hepatitis C: why does it really matter? Gut 55: 123-130. doi: 10. 1136/gut. 2005. 069757.
-
(2006)
Gut
, vol.55
, pp. 123-130
-
-
Asselah, T.1
Rubbia-Brandt, L.2
Marcellin, P.3
Negro, F.4
-
11
-
-
11144330097
-
Modelling how ribavirin improves interferon response rates in hepatitis C virus infection
-
doi:10.1038/nature03153
-
Dixit NM, Layden-Almer JE, Layden TJ, Perelson AS (2004) Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 432: 922-924. doi: 10. 1038/nature03153.
-
(2004)
Nature
, vol.432
, pp. 922-924
-
-
Dixit, N.M.1
Layden-Almer, J.E.2
Layden, T.J.3
Perelson, A.S.4
-
12
-
-
0037852990
-
Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus
-
Arao M, Murase K, Kusakabe A et al (2003) Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus. J Gastroenterol 38: 355-360.
-
(2003)
J Gastroenterol
, vol.38
, pp. 355-360
-
-
Arao, M.1
Murase, K.2
Kusakabe, A.3
-
13
-
-
33845388354
-
Insulin resistance and hepatitis C
-
Romero-Gomez M (2006) Insulin resistance and hepatitis C. World J Gastroenterol 12: 7075-7080.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 7075-7080
-
-
Romero-Gomez, M.1
-
14
-
-
40149089262
-
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream Akt/protein kinase B signaling pathway for insulin resistance
-
doi:10.1128/JVI.01672-07
-
Banerjee S, Saito K, Ait-Goughoulte M, Meyer K, Ratna RB, Ray R (2008) Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream Akt/protein kinase B signaling pathway for insulin resistance. J Virol 82: 2606-2612. doi: 10. 1128/JVI. 01672-07.
-
(2008)
J Virol
, vol.82
, pp. 2606-2612
-
-
Banerjee, S.1
Saito, K.2
Ait-Goughoulte, M.3
Meyer, K.4
Ratna, R.B.5
Ray, R.6
-
15
-
-
46249111657
-
Hepatitis C virus infection: molecular pathways to metabolic syndrome
-
doi:10.1002/hep.22269
-
Sheikh MY, Choi J, Qadri I, Friedman JE, Sanyal AJ (2008) Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology 47: 2127-2133. doi: 10. 1002/hep. 22269.
-
(2008)
Hepatology
, vol.47
, pp. 2127-2133
-
-
Sheikh, M.Y.1
Choi, J.2
Qadri, I.3
Friedman, J.E.4
Sanyal, A.J.5
-
16
-
-
12444303314
-
TNF-a, chronic hepatitis C and diabetes: a novel triad
-
doi:10.1093/qjmed/hci001
-
Knobler H, Schattne A (2005) TNF-a, chronic hepatitis C and diabetes: a novel triad. Q J Med 98: 1-6. doi: 10. 1093/qjmed/hci001.
-
(2005)
Q J Med
, vol.98
, pp. 1-6
-
-
Knobler, H.1
Schattne, A.2
-
17
-
-
33846849610
-
Involvement of the PA28γ-dependent pathway in insulin resistance induced by hepatitis C virus core protein
-
doi:10.1128/JVI.01683-06
-
Miyamoto H, Moriishi K, Moriya K et al (2007) Involvement of the PA28γ-dependent pathway in insulin resistance induced by hepatitis C virus core protein. J Virol 81: 1727-1735. doi: 10. 1128/JVI. 01683-06.
-
(2007)
J Virol
, vol.81
, pp. 1727-1735
-
-
Miyamoto, H.1
Moriishi, K.2
Moriya, K.3
-
18
-
-
8544233570
-
Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
-
Li Y, Soos TJ, Li X et al (2004) Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem 279: 45304-45307.
-
(2004)
J Biol Chem
, vol.279
, pp. 45304-45307
-
-
Li, Y.1
Soos, T.J.2
Li, X.3
-
19
-
-
4344614649
-
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford S, Hoehn KL, Liu F, Summers SA (2004) Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 279: 36608-36615.
-
(2004)
J Biol Chem
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
Hoehn, K.L.2
Liu, F.3
Summers, S.A.4
-
20
-
-
84857861919
-
Mechanisms for insulin resistance: common threads and missing links
-
doi:10.1016/j.cell.2012.02.017
-
Samuel VT, Shulman GI (2012) Mechanisms for insulin resistance: common threads and missing links. Cell 148: 852-871. doi: 10. 1016/j. cell. 2012. 02. 017.
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
21
-
-
78149359508
-
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
-
doi:10.1038/nm.2238
-
Herker E, Harris C, Hernandez C et al (2010) Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nature Med 16: 1295-1298. doi: 10. 1038/nm. 2238.
-
(2010)
Nature Med
, vol.16
, pp. 1295-1298
-
-
Herker, E.1
Harris, C.2
Hernandez, C.3
-
22
-
-
84867141784
-
Molecular mechanism of hepatitis C virus-induced glucose metabolic disorders
-
doi:10.3389/fmicb.2011.00278
-
Shoji I, Deng L, Hotta H (2011) Molecular mechanism of hepatitis C virus-induced glucose metabolic disorders. Front Microbiol 2: 278. doi: 10. 3389/fmicb. 2011. 00278.
-
(2011)
Front Microbiol
, vol.2
, pp. 278
-
-
Shoji, I.1
Deng, L.2
Hotta, H.3
-
23
-
-
78149411370
-
C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells
-
doi:10.1016/j.mce.2010.08.014
-
Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE (2011) C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells. Mol Cell Endocrinol 331: 102-108. doi: 10. 1016/j. mce. 2010. 08. 014.
-
(2011)
Mol Cell Endocrinol
, vol.331
, pp. 102-108
-
-
Choudhury, M.1
Qadri, I.2
Rahman, S.M.3
Schroeder-Gloeckler, J.4
Janssen, R.C.5
Friedman, J.E.6
-
24
-
-
77956134573
-
Expression profile of lipid metabolism-associated genes in hepatitis C virus-infected human liver
-
doi:10.1111/j.1872-034X.2010.00700.x
-
Fujino T, Nakamuta M, Yada R et al (2010) Expression profile of lipid metabolism-associated genes in hepatitis C virus-infected human liver. Hepat Res 40: 923-929. doi: 10. 1111/j. 1872-034X. 2010. 00700. x.
-
(2010)
Hepat Res
, vol.40
, pp. 923-929
-
-
Fujino, T.1
Nakamuta, M.2
Yada, R.3
-
25
-
-
34548316984
-
The lipid droplet is an important organelle for hepatitis C virus production
-
doi:10.1038/ncb1631
-
Miyanari Y, Atsuzawa K et al (2007) The lipid droplet is an important organelle for hepatitis C virus production. Nature cell bio 9: 1089-1097. doi: 10. 1038/ncb1631.
-
(2007)
Nature Cell Bio
, vol.9
, pp. 1089-1097
-
-
Miyanari, Y.1
Atsuzawa, K.2
-
26
-
-
22544470874
-
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
-
doi:10.1038/nm1268
-
Wakita T, Pietschmann T, Kato T et al (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11: 791-796. doi: 10. 1038/nm1268.
-
(2005)
Nat Med
, vol.11
, pp. 791-796
-
-
Wakita, T.1
Pietschmann, T.2
Kato, T.3
-
27
-
-
21544440397
-
Robust hepatitis C virus infection in vitro
-
doi:10.1073/pnas.0503596102
-
Zhong J, Gastaminza P, Cheng G et al (2005) Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA 102: 9294-9299. doi: 10. 1073/pnas. 0503596102.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9294-9299
-
-
Zhong, J.1
Gastaminza, P.2
Cheng, G.3
-
28
-
-
70449769682
-
Lipid droplets finally get a little R-E-S-P-E-C-T
-
doi:10.1016/j.cell.2009.11.005
-
Farese RV Jr, Walther TC (2009) Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 139: 855-860. doi: 10. 1016/j. cell. 2009. 11. 005.
-
(2009)
Cell
, vol.139
, pp. 855-860
-
-
Farese Jr., R.V.1
Walther, T.C.2
-
29
-
-
33847633412
-
HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPAR gamma
-
Kim KH, Hong SP, Kim K, Park MJ, Kim KJ, Cheong J (2007) HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPAR gamma. Biochem Biophys Res Commun 55: 883-888.
-
(2007)
Biochem Biophys Res Commun
, vol.55
, pp. 883-888
-
-
Kim, K.H.1
Hong, S.P.2
Kim, K.3
Park, M.J.4
Kim, K.J.5
Cheong, J.6
-
30
-
-
76849085285
-
Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway
-
doi:10.1099/vir.0.014340-0
-
Burdette D, Olivarez M, Waris G (2010) Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway. J Gen Virol 91: 681-690. doi: 10. 1099/vir. 0. 014340-0.
-
(2010)
J Gen Virol
, vol.91
, pp. 681-690
-
-
Burdette, D.1
Olivarez, M.2
Waris, G.3
-
31
-
-
70349570571
-
Resistin induces insulin resistance by both AMPK-dependant and AMPK- independent mechanisms in HepG2 cells
-
doi:10.1007/s12020-009-9198-7
-
Luo Z, Zhang Y, Li F, He J, Ding H, Yan L, Cheng H (2009) Resistin induces insulin resistance by both AMPK-dependant and AMPK- independent mechanisms in HepG2 cells. Endocrinol 36: 60-69. doi: 10. 1007/s12020-009-9198-7.
-
(2009)
Endocrinol
, vol.36
, pp. 60-69
-
-
Luo, Z.1
Zhang, Y.2
Li, F.3
He, J.4
Ding, H.5
Yan, L.6
Cheng, H.7
-
32
-
-
79959561822
-
An active part of Artemisia sacrorum Ledeb. Suppresses gluconeogenesis through AMPK mediated GSK3β and CREB phosphorylation in human HepG2 cells
-
doi:/10.1271/bbb.100881
-
Yuan H, Piao GC (2011) An active part of Artemisia sacrorum Ledeb. Suppresses gluconeogenesis through AMPK mediated GSK3β and CREB phosphorylation in human HepG2 cells. Biosci Biotechnol Biochem 75: 1079-1084. doi: 10. 1271/bbb. 100881.
-
(2011)
Biosci Biotechnol Biochem
, vol.75
, pp. 1079-1084
-
-
Yuan, H.1
Piao, G.C.2
-
33
-
-
0030859121
-
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
-
Moriya K, Yotsuyanagi H, Shintani Y, Fujie H et al (1997) Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 78: 1527-1531.
-
(1997)
J Gen Virol
, vol.78
, pp. 1527-1531
-
-
Moriya, K.1
Yotsuyanagi, H.2
Shintani, Y.3
Fujie, H.4
-
34
-
-
0346118919
-
Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication
-
Miyanari Y, Hijikata M, Yamaji M, Hosaka M, Takahashi H, Shimotohno K (2003) Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication. J Biol Chem 278: 50301-50308.
-
(2003)
J Biol Chem
, vol.278
, pp. 50301-50308
-
-
Miyanari, Y.1
Hijikata, M.2
Yamaji, M.3
Hosaka, M.4
Takahashi, H.5
Shimotohno, K.6
-
35
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
doi:10.1038/35093050
-
Yoon JC, Puigserver P, Chen G et al (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-138. doi: 10. 1038/35093050.
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
-
36
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
doi:10.1038/35093131
-
Herzig S, Long F, Jhala US et al (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183. doi: 10. 1038/35093131.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
-
37
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
doi:10.1038/nm1044
-
Koo SH, Satoh H, Herzig S et al (2004) PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 10: 530-534. doi: 10. 1038/nm1044.
-
(2004)
Nat Med
, vol.10
, pp. 530-534
-
-
Koo, S.H.1
Satoh, H.2
Herzig, S.3
-
39
-
-
32444451567
-
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
-
doi:10.1016/j.cmet.2006.01.001
-
Wolfrum C, Stoffel M (2006) Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 3: 99-110. doi: 10. 1016/j. cmet. 2006. 01. 001.
-
(2006)
Cell Metab
, vol.3
, pp. 99-110
-
-
Wolfrum, C.1
Stoffel, M.2
-
40
-
-
33646382082
-
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis
-
doi:10.1053/j.gastro.2006.02.035
-
Mirandola S, Realdon S, Iqbal J et al (2006) Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology 130: 1661-1669. doi: 10. 1053/j. gastro. 2006. 02. 035.
-
(2006)
Gastroenterology
, vol.130
, pp. 1661-1669
-
-
Mirandola, S.1
Realdon, S.2
Iqbal, J.3
-
41
-
-
0037732910
-
Hepatitis C virus associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis
-
doi:10.1111/j.1572-0241.2003.07402.x
-
Petit JM, Benichou M, Duvillard L et al (2003) Hepatitis C virus associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis. Am J Gastroenterol 98: 1150-1154. doi: 10. 1111/j. 1572-0241. 2003. 07402. x.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 1150-1154
-
-
Petit, J.M.1
Benichou, M.2
Duvillard, L.3
-
42
-
-
84855209400
-
The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases
-
doi:10.4103/2231-4040.90879
-
Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S (2011) The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases. J Adv Pharm Technol Res 2: 236-240. doi: 10. 4103/2231-4040. 90879.
-
(2011)
J Adv Pharm Technol Res
, vol.2
, pp. 236-240
-
-
Tyagi, S.1
Gupta, P.2
Saini, A.S.3
Kaushal, C.4
Sharma, S.5
-
43
-
-
33646852805
-
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways
-
Kubota N, Terauchi Y, Kubota T et al (2006) Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. Biol Chem 281: 8748-8755.
-
(2006)
Biol Chem
, vol.281
, pp. 8748-8755
-
-
Kubota, N.1
Terauchi, Y.2
Kubota, T.3
-
44
-
-
0842263981
-
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity
-
Ferre P (2004) The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53: S43-S50.
-
(2004)
Diabetes
, vol.53
-
-
Ferre, P.1
-
45
-
-
0034713444
-
Roles of PPARs in health and disease
-
doi:10.1038/35013000
-
Kersten S, Desvergne BA, Wahli W (2000) Roles of PPARs in health and disease. Nature 405: 421-424. doi: 10. 1038/35013000.
-
(2000)
Nature
, vol.405
, pp. 421-424
-
-
Kersten, S.1
Desvergne, B.A.2
Wahli, W.3
-
46
-
-
0033595120
-
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
-
doi:10.1056/nejm199907223410404
-
Cline GW, Petersen KF, Krssak M et al (1999) Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med 341: 240-246. doi: 10. 1056/nejm199907223410404.
-
(1999)
N Engl J Med
, vol.341
, pp. 240-246
-
-
Cline, G.W.1
Petersen, K.F.2
Krssak, M.3
-
47
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
doi:10.1172/jci5001
-
Dresner A, Laurent D, Marcucci M et al (1999) Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103: 253-259. doi: 10. 1172/jci5001.
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
-
48
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
doi:10.1172/jci118742
-
Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97: 2859-2865. doi: 10. 1172/jci118742.
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
Petersen, K.F.4
Rothman, D.L.5
Cline, G.W.6
Shulman, G.I.7
-
49
-
-
0032934826
-
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
-
Krssak M, Falk Petersen K, Dresner A et al (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42: 113-116.
-
(1999)
Diabetologia
, vol.42
, pp. 113-116
-
-
Krssak, M.1
Falk Petersen, K.2
Dresner, A.3
-
50
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW et al (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277: 50230-50236.
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
51
-
-
0036300538
-
Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
Itani SI, Ruderman NB, Schmieder F, Boden G (2002) Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51: 2005-2011.
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
52
-
-
84899959180
-
MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST
-
Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain MM (2013) MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST. J Biol Chem.
-
(2013)
J Biol Chem.
-
-
Josekutty, J.1
Iqbal, J.2
Iwawaki, T.3
Kohno, K.4
Hussain, M.M.5
-
53
-
-
56949089426
-
Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance
-
doi:10.1016/j.cellsig.2008.10.004
-
Lim JH, Lee HJ, Ho Jung M, Song J (2009) Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cell Signal 21(1): 169-177. doi: 10. 1016/j. cellsig. 2008. 10. 004.
-
(2009)
Cell Signal
, vol.21
, Issue.1
, pp. 169-177
-
-
Lim, J.H.1
Lee, H.J.2
Ho Jung, M.3
Song, J.4
-
54
-
-
13744260319
-
Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication
-
1580.2005, doi:10.1128/jvi.79.3.1569-
-
Waris G, Turkson J, Hassanein T, Siddiqui A (2005) Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol 79(3): 1569-1580. doi: 10. 1128/jvi. 79. 3. 1569-1580. 2005.
-
(2005)
J Virol
, vol.79
, Issue.3
, pp. 1569-1580
-
-
Waris, G.1
Turkson, J.2
Hassanein, T.3
Siddiqui, A.4
-
55
-
-
79954996869
-
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
-
doi:10.1073/pnas.1103451108
-
Jornayvaz FR, Birkenfeld AL, Jurczak MJ, Kanda S, Guigni BA, Jiang DC, Zhang D, Lee HY, Samuel VT, Shulman GI (2011) Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc Natl Acad Sci USA 108(14): 5748-5752. doi: 10. 1073/pnas. 1103451108.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.14
, pp. 5748-5752
-
-
Jornayvaz, F.R.1
Birkenfeld, A.L.2
Jurczak, M.J.3
Kanda, S.4
Guigni, B.A.5
Jiang, D.C.6
Zhang, D.7
Lee, H.Y.8
Samuel, V.T.9
Shulman, G.I.10
-
56
-
-
78149359508
-
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
-
doi:10.1038/nm.2238
-
Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M (2010) Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med 16(11): 1295-1298. doi: 10. 1038/nm. 2238.
-
(2010)
Nat Med
, vol.16
, Issue.11
, pp. 1295-1298
-
-
Herker, E.1
Harris, C.2
Hernandez, C.3
Carpentier, A.4
Kaehlcke, K.5
Rosenberg, A.R.6
Farese Jr., R.V.7
Ott, M.8
-
57
-
-
82755163055
-
Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis
-
doi:10.1074/jbc.M111.285148
-
Harris C, Herker E, Farese RV Jr, Ott M (2011) Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem 286(49): 42615-42625. doi: 10. 1074/jbc. M111. 285148.
-
(2011)
J Biol Chem
, vol.286
, Issue.49
, pp. 42615-42625
-
-
Harris, C.1
Herker, E.2
Farese Jr., R.V.3
Ott, M.4
-
58
-
-
79953186142
-
PGC-1 coactivators in the control of energy metabolism
-
doi:10.1093/abbs/gmr007
-
Liu C, Lin JD (2011) PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin 43(4): 248-257. doi: 10. 1093/abbs/gmr007.
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, Issue.4
, pp. 248-257
-
-
Liu, C.1
Lin, J.D.2
-
59
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-α and SIRt1
-
doi:10.1038/nature03354
-
Rodgers JT, Lerin C, Haas W, Gygi, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-α and SIRt1. Nature 43: 113-118. doi: 10. 1038/nature03354.
-
(2005)
Nature
, vol.43
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi4
Spiegelman, B.M.5
Puigserver, P.6
-
60
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
-
Puigserver P et al (2003) Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature 423: 550-555.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
|