Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication

Journal of Hepatology

Volumn 53, Issue 5, 2010, Pages 797-804

  Von Dem Bussche, Annette ^a   MacHida, Raiki ^a   Li, Ke ^a   Loevinsohn, Gideon ^b   Khander, Amrin ^b   Wang, Jianguo ^b   Wakita, Takaji ^b   Wands, Jack R ^a   Li, Jisu ^a  

^a Liver Research Center Brown University Medical School   (United States)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

ER stress; HCV infection; NS2 protein; Viral pathogenesis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; NONSTRUCTURAL PROTEIN 2;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE ACTIVATION; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REPLICON; REPORTER GENE; RNA TRANSCRIPTION; RNA TRANSLATION; UPREGULATION; VIRUS GENOME; VIRUS INFECTION; VIRUS REPLICATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 6; BASE SEQUENCE; CELLS, CULTURED; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; HEPACIVIRUS; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN TRANSPORT; TRANSCRIPTION FACTOR CHOP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 77957375659     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.022     Document Type: Article

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