Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications

Neurotherapeutics

Volumn 11, Issue 4, 2014, Pages

  Rudenko, Iakov N ^a   Cookson, Mark R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

cytoskeleton; GTPase; kinase inhibitors; Parkinson s disease; treatment; vesicular trafficking

Indexed keywords

GUANOSINE TRIPHOSPHATASE; LEUCINE RICH REPEAT KINASE 2; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; RAS PROTEIN; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

BLOOD BRAIN BARRIER; CELL INCLUSION; DOPAMINERGIC NERVE CELL; DRUG BIOAVAILABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC VARIABILITY; HUMAN; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PREVALENCE; PROTEIN FUNCTION; REVIEW; RISK FACTOR; ANIMAL; ENZYMOLOGY; GENETIC VARIATION; GENETICS; METABOLISM; MUTATION; NERVE CELL;

ANIMALS; GENETIC VARIATION; HUMANS; MUTATION; NEURONS; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS;

EID: 84944865481     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-014-0284-z     Document Type: Review

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