-
2
-
-
33750931271
-
The Parkinson disease gene LRRK2: Evolutionary and structural insights
-
Marin, I. (2006) The Parkinson disease gene LRRK2: evolutionary and structural insights. Mol. Biol. Evol. 23, 2423-2433
-
(2006)
Mol. Biol. Evol.
, vol.23
, pp. 2423-2433
-
-
Marin, I.1
-
3
-
-
51349153846
-
The Roco protein family: A functional perspective
-
Marin, I., van Egmond, W.N. and van Haastert, P.J. (2008) The Roco protein family: a functional perspective. FASEB J. 22, 3103-3110
-
(2008)
FASEB J.
, vol.22
, pp. 3103-3110
-
-
Marin, I.1
Van Egmond, W.N.2
Van Haastert, P.J.3
-
4
-
-
41049086705
-
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients
-
Nuytemans, K., Rademakers, R., Theuns, J., Pals, P., Engelborghs, S., Pickut, B., de Pooter, T., Peeters, K., Mattheijssens, M., Van den Broeck, M. et al. (2008) Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients. Eur. J. Hum. Genet. 16, 471-479
-
(2008)
Eur. J. Hum. Genet.
, vol.16
, pp. 471-479
-
-
Nuytemans, K.1
Rademakers, R.2
Theuns, J.3
Pals, P.4
Engelborghs, S.5
Pickut, B.6
De Pooter, T.7
Peeters, K.8
Mattheijssens, M.9
Van Den Broeck, M.10
-
5
-
-
24644486896
-
A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
-
Zabetian, C.P., Samii, A., Mosley, A.D., Roberts, J.W., Leis, B.C., Yearout, D., Raskind, W.H. and Griffith, A. (2005) A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations. Neurology 65, 741-744
-
(2005)
Neurology
, vol.65
, pp. 741-744
-
-
Zabetian, C.P.1
Samii, A.2
Mosley, A.D.3
Roberts, J.W.4
Leis, B.C.5
Yearout, D.6
Raskind, W.H.7
Griffith, A.8
-
6
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisán-Ruíz, C., Jain, S., Evans, E.W., Gilks, W.P., Simón, J., van der Brug, M., López de Munain, A., Aparicio, S., Gil, A.M., Khan, N. et al. (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisán-Ruíz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simón, J.5
Van Der Brug, M.6
López De Munain, A.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
-
7
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R.J., Calne, D.B. et al. (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
-
8
-
-
77954623892
-
Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease
-
Aasly, J.O., Vilarino-Guell, C., Dachsel, J.C., Webber, P.J., West, A.B., Haugarvoll, K., Johansen, K.K., Toft, M., Nutt, J.G., Payami, H. et al. (2010) Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. Mov. Disord. 25, 2156-2163
-
(2010)
Mov. Disord.
, vol.25
, pp. 2156-2163
-
-
Aasly, J.O.1
Vilarino-Guell, C.2
Dachsel, J.C.3
Webber, P.J.4
West, A.B.5
Haugarvoll, K.6
Johansen, K.K.7
Toft, M.8
Nutt, J.G.9
Payami, H.10
-
9
-
-
84861915918
-
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe
-
Rubio, J.P., Topp, S., Warren, L., St Jean, P.L., Wegmann, D., Kessner, D., Novembre, J., Shen, J., Fraser, D., Aponte, J. et al. (2012) Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe. Hum. Mutat. 33, 1087-1098
-
(2012)
Hum. Mutat.
, vol.33
, pp. 1087-1098
-
-
Rubio, J.P.1
Topp, S.2
Warren, L.3
St Jean, P.L.4
Wegmann, D.5
Kessner, D.6
Novembre, J.7
Shen, J.8
Fraser, D.9
Aponte, J.10
-
10
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: Insights from genetic studies
-
Gasser, T. (2009) Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev. Mol. Med. 11, e22
-
(2009)
Expert Rev. Mol. Med.
, vol.11
-
-
Gasser, T.1
-
11
-
-
67749118059
-
LRRK2 gene variation and its contribution to Parkinson disease
-
Paisán-Ruíz, C. (2009) LRRK2 gene variation and its contribution to Parkinson disease. Hum. Mutat. 30, 1153-1160
-
(2009)
Hum. Mutat.
, vol.30
, pp. 1153-1160
-
-
Paisán-Ruíz, C.1
-
12
-
-
0026026818
-
The GTPase superfamily: Conserved structure and molecular mechanism
-
Bourne, H.R., Sanders, D.A. and McCormick, F. (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
13
-
-
47749114984
-
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
-
Greggio, E., Zambrano, I., Kaganovich, A., Beilina, A., Taymans, J.-M., Daniels, V., Lewis, P., Jain, S., Ding, J., Syed, A. et al. (2008) The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J. Biol. Chem. 283, 16906-16914
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16906-16914
-
-
Greggio, E.1
Zambrano, I.2
Kaganovich, A.3
Beilina, A.4
Taymans, J.-M.5
Daniels, V.6
Lewis, P.7
Jain, S.8
Ding, J.9
Syed, A.10
-
14
-
-
33846818834
-
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
-
Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T. and Iwatsubo, T. (2007) GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry 46, 1380-1388
-
(2007)
Biochemistry
, vol.46
, pp. 1380-1388
-
-
Ito, G.1
Okai, T.2
Fujino, G.3
Takeda, K.4
Ichijo, H.5
Katada, T.6
Iwatsubo, T.7
-
15
-
-
80051611506
-
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding
-
Taymans, J.-M., Vancraenenbroeck, R., Ollikainen, P., Beilina, A., Lobbestael, E., De Maeyer, M., Baekelandt, V. and Cookson, M.R. (2011) LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. PLoS ONE 6, e23207
-
(2011)
PLoS ONE
, vol.6
-
-
Taymans, J.-M.1
Vancraenenbroeck, R.2
Ollikainen, P.3
Beilina, A.4
Lobbestael, E.5
De Maeyer, M.6
Baekelandt, V.7
Cookson, M.R.8
-
16
-
-
77952391573
-
GTPase activity plays a key role in the pathobiology of LRRK2
-
Xiong, Y., Coombes, C.E., Kilaru, A., Li, X., Gitler, A.D., Bowers, W.J., Dawson, V.L., Dawson, T.M. and Moore, D.J. (2010) GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet. 6, e1000902
-
(2010)
PLoS Genet.
, vol.6
-
-
Xiong, Y.1
Coombes, C.E.2
Kilaru, A.3
Li, X.4
Gitler, A.D.5
Bowers, W.J.6
Dawson, V.L.7
Dawson, T.M.8
Moore, D.J.9
-
17
-
-
71849112162
-
The R1441C mutation alters the folding properties of the ROC domain of LRRK2
-
Li, Y., Dunn, L., Greggio, E., Krumm, B., Jackson, G.S., Cookson, M.R., Lewis, P.A. and Deng, J. (2009) The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochim. Biophys. Acta 1792, 1194-1197
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 1194-1197
-
-
Li, Y.1
Dunn, L.2
Greggio, E.3
Krumm, B.4
Jackson, G.S.5
Cookson, M.R.6
Lewis, P.A.7
Deng, J.8
-
18
-
-
33846562487
-
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
West, A.B., Moore, D.J., Choi, C., Andrabi, S.A., Li, X., Dikeman, D., Biskup, S., Zhang, Z., Lim, K.L., Dawson, V.L. and Dawson, T.M. (2007) Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16, 223-232
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
Andrabi, S.A.4
Li, X.5
Dikeman, D.6
Biskup, S.7
Zhang, Z.8
Lim, K.L.9
Dawson, V.L.10
Dawson, T.M.11
-
19
-
-
78650685500
-
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
-
Daniëls, V., Vancraenenbroeck, R., Law, B.M., Greggio, E., Lobbestael, E., Gao, F., De Maeyer, M., Cookson, M.R., Harvey, K., Baekelandt, V. and Taymans, J.-M. (2011) Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. J. Neurochem. 116, 304-315
-
(2011)
J. Neurochem.
, vol.116
, pp. 304-315
-
-
Daniëls, V.1
Vancraenenbroeck, R.2
Law, B.M.3
Greggio, E.4
Lobbestael, E.5
Gao, F.6
De Maeyer, M.7
Cookson, M.R.8
Harvey, K.9
Baekelandt, V.10
Taymans, J.-M.11
-
20
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
Lewis, P.A., Greggio, E., Beilina, A., Jain, S., Baker, A. and Cookson, M.R. (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem. Biophys. Res. Commun. 357, 668-671
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.357
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
Cookson, M.R.6
-
21
-
-
34548604567
-
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
-
Guo, L., Gandhi, P.N., Wang, W., Petersen, R.B., Wilson-Delfosse, A.L. and Chen, S.G. (2007) The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp. Cell Res. 313, 3658-3670
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 3658-3670
-
-
Guo, L.1
Gandhi, P.N.2
Wang, W.3
Petersen, R.B.4
Wilson-Delfosse, A.L.5
Chen, S.G.6
-
22
-
-
34548621385
-
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
-
Li, X., Tan, Y.C., Poulose, S., Olanow, C.W., Huang, X.Y. and Yue, Z. (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J. Neurochem. 103, 238-247
-
(2007)
J. Neurochem.
, vol.103
, pp. 238-247
-
-
Li, X.1
Tan, Y.C.2
Poulose, S.3
Olanow, C.W.4
Huang, X.Y.5
Yue, Z.6
-
23
-
-
78149435654
-
Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif
-
Pungaliya, P.P., Bai, Y., Lipinski, K., Anand, V.S., Sen, S., Brown, E.L., Bates, B., Reinhart, P.H., West, A.B., Hirst, W.D. and Braithwaite, S.P. (2010) Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. PLoS ONE 5, e13672
-
(2010)
PLoS ONE
, vol.5
-
-
Pungaliya, P.P.1
Bai, Y.2
Lipinski, K.3
Anand, V.S.4
Sen, S.5
Brown, E.L.6
Bates, B.7
Reinhart, P.H.8
West, A.B.9
Hirst, W.D.10
Braithwaite, S.P.11
-
24
-
-
77749255337
-
Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: Characterization of the kinase and GTPase activities
-
Liu, M., Dobson, B., Glicksman, M.A., Yue, Z. and Stein, R.L. (2010) Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities. Biochemistry 49, 2008-2017
-
(2010)
Biochemistry
, vol.49
, pp. 2008-2017
-
-
Liu, M.1
Dobson, B.2
Glicksman, M.A.3
Yue, Z.4
Stein, R.L.5
-
25
-
-
80054979896
-
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant
-
Liu, M., Kang, S., Ray, S., Jackson, J., Zaitsev, A.D., Gerber, S.A., Cuny, G.D. and Glicksman, M.A. (2011) Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry 50, 9399-9408
-
(2011)
Biochemistry
, vol.50
, pp. 9399-9408
-
-
Liu, M.1
Kang, S.2
Ray, S.3
Jackson, J.4
Zaitsev, A.D.5
Gerber, S.A.6
Cuny, G.D.7
Glicksman, M.A.8
-
26
-
-
77649105209
-
Mechanisms of dominant parkinsonism; the toxic triangle of LRRK2, α-synuclein and tau
-
Taymans, J.-M. and Cookson, M. (2010) Mechanisms of dominant parkinsonism; the toxic triangle of LRRK2, α-synuclein and tau. BioEssays 32, 227-235
-
(2010)
BioEssays
, vol.32
, pp. 227-235
-
-
Taymans, J.-M.1
Cookson, M.2
-
27
-
-
51049117271
-
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
-
Gotthardt, K., Weyand, M., Kortholt, A., Van Haastert, P.J. and Wittinghofer, A. (2008) Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J. 27, 2352
-
(2008)
EMBO J.
, vol.27
, pp. 2352
-
-
Gotthardt, K.1
Weyand, M.2
Kortholt, A.3
Van Haastert, P.J.4
Wittinghofer, A.5
-
28
-
-
34248575149
-
Integrating signals from RTKs to ERK/MAPK
-
McKay, M.M. and Morrison, D.K. (2007) Integrating signals from RTKs to ERK/MAPK. Oncogene 26, 3113-3121
-
(2007)
Oncogene
, vol.26
, pp. 3113-3121
-
-
McKay, M.M.1
Morrison, D.K.2
-
29
-
-
0028795913
-
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase
-
Herrmann, C., Martin, G.A. and Wittinghofer, A. (1995) Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase. J. Biol. Chem. 270, 2901-2905
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2901-2905
-
-
Herrmann, C.1
Martin, G.A.2
Wittinghofer, A.3
-
30
-
-
40349101849
-
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
-
Deng, J., Lewis, P.A., Greggio, E., Sluch, E., Beilina, A. and Cookson, M.R. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc. Natl. Acad. Sci. U.S.A. 105, 1499-1504
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 1499-1504
-
-
Deng, J.1
Lewis, P.A.2
Greggio, E.3
Sluch, E.4
Beilina, A.5
Cookson, M.R.6
-
31
-
-
70349929185
-
Homo- And heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
-
Klein, C.L., Rovelli, G., Springer, W., Schall, C., Gasser, T. and Kahle, P.J. (2009) Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. J. Neurochem. 111, 703-715
-
(2009)
J. Neurochem.
, vol.111
, pp. 703-715
-
-
Klein, C.L.1
Rovelli, G.2
Springer, W.3
Schall, C.4
Gasser, T.5
Kahle, P.J.6
-
32
-
-
34447118788
-
LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
-
Jaleel, M., Nichols, R.J., Deak, M., Campbell, D.G., Gillardon, F., Knebel, A. and Alessi, D.R. (2007) LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem. J. 405, 307-317
-
(2007)
Biochem. J.
, vol.405
, pp. 307-317
-
-
Jaleel, M.1
Nichols, R.J.2
Deak, M.3
Campbell, D.G.4
Gillardon, F.5
Knebel, A.6
Alessi, D.R.7
-
33
-
-
70449732284
-
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
-
Greggio, E., Taymans, J.-M., Zhen, E.Y., Ryder, J., Vancraenenbroeck, R., Beilina, A., Sun, P., Deng, J., Jaffe, H., Baekelandt, V. et al. (2009) The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochem. Biophys. Res. Commun. 389, 449-454
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.389
, pp. 449-454
-
-
Greggio, E.1
Taymans, J.-M.2
Zhen, E.Y.3
Ryder, J.4
Vancraenenbroeck, R.5
Beilina, A.6
Sun, P.7
Deng, J.8
Jaffe, H.9
Baekelandt, V.10
-
34
-
-
77950631558
-
Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2
-
Gloeckner, C.J., Boldt, K., von Zweydorf, F., Helm, S., Wiesent, L., Sarioglu, H. and Ueffing, M. (2010) Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2. J. Proteome Res. 9, 1738-1745
-
(2010)
J. Proteome Res.
, vol.9
, pp. 1738-1745
-
-
Gloeckner, C.J.1
Boldt, K.2
Von Zweydorf, F.3
Helm, S.4
Wiesent, L.5
Sarioglu, H.6
Ueffing, M.7
-
35
-
-
84860389765
-
Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities
-
Webber, P.J., Smith, A.D., Sen, S., Renfrow, M.B., Mobley, J.A. and West, A.B. (2011) Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. J. Mol. Biol. 412, 94-110
-
(2011)
J. Mol. Biol.
, vol.412
, pp. 94-110
-
-
Webber, P.J.1
Smith, A.D.2
Sen, S.3
Renfrow, M.B.4
Mobley, J.A.5
West, A.B.6
-
36
-
-
72749105819
-
Identification of the autophosphorylation sites of LRRK2
-
Kamikawaji, S., Ito, G. and Iwatsubo, T. (2009) Identification of the autophosphorylation sites of LRRK2. Biochemistry 48, 10963-10975
-
(2009)
Biochemistry
, vol.48
, pp. 10963-10975
-
-
Kamikawaji, S.1
Ito, G.2
Iwatsubo, T.3
-
37
-
-
83855160771
-
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition
-
Doggett, E.A., Zhao, J., Mork, C.N., Hu, D. and Nichols, R.J. (2012) Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition. J. Neurochem. 120, 37-45
-
(2012)
J. Neurochem.
, vol.120
, pp. 37-45
-
-
Doggett, E.A.1
Zhao, J.2
Mork, C.N.3
Hu, D.4
Nichols, R.J.5
-
38
-
-
77956674229
-
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
-
Nichols, R.J., Dzamko, N., Morrice, N.A., Campbell, D.G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A.R. and Alessi, D.R. (2010) 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem. J. 430, 393-404
-
(2010)
Biochem. J.
, vol.430
, pp. 393-404
-
-
Nichols, R.J.1
Dzamko, N.2
Morrice, N.A.3
Campbell, D.G.4
Deak, M.5
Ordureau, A.6
Macartney, T.7
Tong, Y.8
Shen, J.9
Prescott, A.R.10
Alessi, D.R.11
-
39
-
-
79959393264
-
Structure-function relationships of the G domain, a canonical switch motif
-
Wittinghofer, A. and Vetter, I.R. (2011) Structure-function relationships of the G domain, a canonical switch motif. Annu. Rev. Biochem. 80, 943-971
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 943-971
-
-
Wittinghofer, A.1
Vetter, I.R.2
-
40
-
-
13444252631
-
GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
-
Rossman, K.L., Der, C.J. and Sondek, J. (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 167-180
-
-
Rossman, K.L.1
Der, C.J.2
Sondek, J.3
-
41
-
-
0033179296
-
GEFs: Structural basis for their activation of small GTP-binding proteins
-
Cherfils, J. and Chardin, P. (1999) GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24, 306-311
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 306-311
-
-
Cherfils, J.1
Chardin, P.2
-
42
-
-
0034427027
-
Purification and identification of novel Rab effectors using affinity chromatography
-
Christoforidis, S. and Zerial, M. (2000) Purification and identification of novel Rab effectors using affinity chromatography. Methods 20, 403-410
-
(2000)
Methods
, vol.20
, pp. 403-410
-
-
Christoforidis, S.1
Zerial, M.2
-
43
-
-
0029794721
-
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
-
Hart, M.J., Sharma, S., elMasry, N., Qiu, R.G., McCabe, P., Polakis, P. and Bollag, G. (1996) Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J. Biol. Chem. 271, 25452-25458
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25452-25458
-
-
Hart, M.J.1
Sharma, S.2
ElMasry, N.3
Qiu, R.G.4
McCabe, P.5
Polakis, P.6
Bollag, G.7
-
44
-
-
42149172511
-
RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player
-
Häbig, K., Walter, M., Poths, S., Riess, O. and Bonin, M. (2007) RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player. Neurogenetics 9, 83-94
-
(2007)
Neurogenetics
, vol.9
, pp. 83-94
-
-
Häbig, K.1
Walter, M.2
Poths, S.3
Riess, O.4
Bonin, M.5
-
45
-
-
0034711449
-
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho
-
Fukuhara, S., Chikumi, H. and Gutkind, J.S. (2000) Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho. FEBS Lett. 485, 183-188
-
(2000)
FEBS Lett.
, vol.485
, pp. 183-188
-
-
Fukuhara, S.1
Chikumi, H.2
Gutkind, J.S.3
-
46
-
-
0037085375
-
Regulation of the Cool/Pix proteins: Key binding partners of the Cdc42/Rac targets, the p21-activated kinases
-
Feng, Q., Albeck, J.G., Cerione, R.A. and Yang, W. (2002) Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J. Biol. Chem. 277, 5644-5650
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5644-5650
-
-
Feng, Q.1
Albeck, J.G.2
Cerione, R.A.3
Yang, W.4
-
47
-
-
0031610579
-
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
-
Manser, E., Loo, T.H., Koh, C.G., Zhao, Z.S., Chen, X.Q., Tan, L., Tan, I., Leung, T. and Lim, L. (1998) PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192
-
(1998)
Mol. Cell
, vol.1
, pp. 183-192
-
-
Manser, E.1
Loo, T.H.2
Koh, C.G.3
Zhao, Z.S.4
Chen, X.Q.5
Tan, L.6
Tan, I.7
Leung, T.8
Lim, L.9
-
48
-
-
0033584865
-
Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42
-
Reid, T., Bathoorn, A., Ahmadian, M.R. and Collard, J.G. (1999) Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. J. Biol. Chem. 274, 33587-33593
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33587-33593
-
-
Reid, T.1
Bathoorn, A.2
Ahmadian, M.R.3
Collard, J.G.4
-
49
-
-
78149446290
-
ARHGEF7 (β-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
-
Haebig, K., Gloeckner, C.J., Miralles, M.G., Gillardon, F., Schulte, C., Riess, O., Ueffing, M., Biskup, S. and Bonin, M. (2010) ARHGEF7 (β-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5, e13762
-
(2010)
PLoS ONE
, vol.5
-
-
Haebig, K.1
Gloeckner, C.J.2
Miralles, M.G.3
Gillardon, F.4
Schulte, C.5
Riess, O.6
Ueffing, M.7
Biskup, S.8
Bonin, M.9
-
50
-
-
0037040864
-
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism
-
Furman, C., Short, S.M., Subramanian, R.R., Zetter, B.R. and Roberts, T.M. (2002) DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J. Biol. Chem. 277, 7962-7969
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7962-7969
-
-
Furman, C.1
Short, S.M.2
Subramanian, R.R.3
Zetter, B.R.4
Roberts, T.M.5
-
51
-
-
0029416828
-
The ARF1 GTPase-activating protein: Zinc finger motif and Golgi complex localization
-
Cukierman, E., Huber, I., Rotman, M. and Cassel, D. (1995) The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science 270, 1999-2002
-
(1995)
Science
, vol.270
, pp. 1999-2002
-
-
Cukierman, E.1
Huber, I.2
Rotman, M.3
Cassel, D.4
-
52
-
-
84859187983
-
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
-
Stafa, K., Trancikova, A., Webber, P.J., Glauser, L., West, A.B. and Moore, D.J. (2012) GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet. 8, e1002526
-
(2012)
PLoS Genet.
, vol.8
-
-
Stafa, K.1
Trancikova, A.2
Webber, P.J.3
Glauser, L.4
West, A.B.5
Moore, D.J.6
-
53
-
-
84858050446
-
ArfGAP1 is a GTPase activating protein for LRRK2: Reciprocal regulation of ArfGAP1 by LRRK2
-
Xiong, Y., Yuan, C., Chen, R., Dawson, T.M. and Dawson, V.L. (2012) ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32, 3877-3886
-
(2012)
J. Neurosci.
, vol.32
, pp. 3877-3886
-
-
Xiong, Y.1
Yuan, C.2
Chen, R.3
Dawson, T.M.4
Dawson, V.L.5
-
54
-
-
67349250817
-
It takes two to tango: Regulation of G proteins by dimerization
-
Gasper, R., Meyer, S., Gotthardt, K., Sirajuddin, M. and Wittinghofer, A. (2009) It takes two to tango: regulation of G proteins by dimerization. Nat. Rev. Mol. Cell Biol. 10, 423-429
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 423-429
-
-
Gasper, R.1
Meyer, S.2
Gotthardt, K.3
Sirajuddin, M.4
Wittinghofer, A.5
-
55
-
-
79957636562
-
On the road to leucine-rich repeat kinase 2 signalling: Evidence from cellular and in vivo studies
-
Daniëls, V., Baekelandt, V. and Taymans, J.-M. (2011) On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies. Neurosignals 19, 1-15
-
(2011)
Neurosignals
, vol.19
, pp. 1-15
-
-
Daniëls, V.1
Baekelandt, V.2
Taymans, J.-M.3
-
56
-
-
67650164931
-
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP
-
Ding, X. and Goldberg, M.S. (2009) Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLoS ONE 4, e5949
-
(2009)
PLoS ONE
, vol.4
-
-
Ding, X.1
Goldberg, M.S.2
-
57
-
-
62449124769
-
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
-
Ko, H.S., Bailey, R., Smith, W.W., Liu, Z., Shin, J.H., Lee, Y.I., Zhang, Y.J., Jiang, H., Ross, C.A., Moore, D.J. et al. (2009) CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc. Natl. Acad. Sci. U.S.A. 106, 2897-2902
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 2897-2902
-
-
Ko, H.S.1
Bailey, R.2
Smith, W.W.3
Liu, Z.4
Shin, J.H.5
Lee, Y.I.6
Zhang, Y.J.7
Jiang, H.8
Ross, C.A.9
Moore, D.J.10
-
58
-
-
70349576902
-
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
-
Sancho, R.M., Law, B.M. and Harvey, K. (2009) Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum. Mol. Genet. 18, 3955-3968
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3955-3968
-
-
Sancho, R.M.1
Law, B.M.2
Harvey, K.3
-
59
-
-
45549085874
-
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
-
Gandhi, P.N., Wang, X., Zhu, X., Chen, S.G. and Wilson-Delfosse, A.L. (2008) The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J. Neurosci. Res. 86, 1711-1720
-
(2008)
J. Neurosci. Res.
, vol.86
, pp. 1711-1720
-
-
Gandhi, P.N.1
Wang, X.2
Zhu, X.3
Chen, S.G.4
Wilson-Delfosse, A.L.5
-
60
-
-
80052828693
-
Kinases as targets for Parkinson's disease; from genetics to therapy
-
Vancraenenbroeck, R., Lobbestael, E., De Maeyer, M., Baekelandt, V. and Taymans, J.-M. (2011) Kinases as targets for Parkinson's disease; from genetics to therapy. CNS Neurol. Disord.: Drug Targets 10, 724-740
-
(2011)
CNS Neurol. Disord.: Drug Targets
, vol.10
, pp. 724-740
-
-
Vancraenenbroeck, R.1
Lobbestael, E.2
De Maeyer, M.3
Baekelandt, V.4
Taymans, J.-M.5
-
61
-
-
37149043878
-
Kinase signaling pathways as potential targets in the treatment of Parkinson's disease
-
Greggio, E. and Singleton, A. (2007) Kinase signaling pathways as potential targets in the treatment of Parkinson's disease. Expert Rev. Proteomics 4, 783-792
-
(2007)
Expert Rev. Proteomics
, vol.4
, pp. 783-792
-
-
Greggio, E.1
Singleton, A.2
-
62
-
-
84857285604
-
Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
-
Rudenko, I.N., Chia, R. and Cookson, M.R. (2012) Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? BMC Med. 10, 20
-
(2012)
BMC Med.
, vol.10
, pp. 20
-
-
Rudenko, I.N.1
Chia, R.2
Cookson, M.R.3
|