Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Science translational medicine

Volumn 4, Issue 164, 2012, Pages

  Sheng, Zejuan ^a   Zhang, Shuo ^b   Bustos, Daisy ^b   Kleinheinz, Tracy ^b   Le Pichon, Claire E ^b   Dominguez, Sara L ^b   Solanoy, Hilda O ^b   Drummond, Jason ^b   Zhang, Xiaolin ^b   Ding, Xiao ^b   Cai, Fang ^b   Song, Qinghua ^b   Li, Xianting ^b   Yue, Zhenyu ^b   van der Brug, Marcel P ^b   Burdick, Daniel J ^b   Gunzner Toste, Janet ^b   Chen, Huifen ^b   Liu, Xingrong ^b   Estrada, Anthony A ^b   Sweeney, Zachary K ^b   Scearce Levie, Kimberly ^b   Moffat, John G ^b   Kirkpatrick, Donald S ^b   Zhu, Haitao ^b   more..

^a GENENTECH INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; LRRK2 PROTEIN, HUMAN; LRRK2 PROTEIN, MOUSE; MUTANT PROTEIN; PHOSPHOSERINE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; BINDING SITE; BRAIN; CELL STRAIN HEK293; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MICROTUBULE; MOUSE; MUTATION; NEURITE; PARKINSON DISEASE; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; RAT;

ANIMALS; BINDING SITES; BRAIN; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HUMANS; MICE; MICROTUBULES; MUTANT PROTEINS; MUTATION; NEURITES; PARKINSON DISEASE; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 84874720265     PISSN: None     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3004485     Document Type: Article

References (0)