A direct interaction between leucine-rich repeat kinase 2 and specific β-Tubulin isoforms regulates tubulin acetylation

Journal of Biological Chemistry

Volumn 289, Issue 2, 2014, Pages 895-908

  Law, Bernard M H ^a,f   Spain, Victoria A ^a   Leinster, Veronica H L ^a   Chia, Ruth ^b   Beilina, Alexandra ^b   Cho, Hyun J ^c   Taymans, Jean Marc ^d   Urban, Mary K ^b   Sancho, Rosa M ^a,g   Ramírez, Marian Blanca ^a,h   Biskup, Saskia ^e   Baekelandt, Veerle ^d   Cai, Huaibin ^c   Cookson, Mark R ^b   Berwick, Daniel C ^a   Harvey, Kirsten ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Cell Biology and Gene Expression Unit   (United Kingdom)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d KU LEUVEN UNIVERSITY OF LEUVEN   (Belgium)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f University of Bath   (United Kingdom)

^g Alzheimer's Research UK   (United Kingdom)

^h INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DIRECT INTERACTIONS; ISOFORMS; LEUCINE-RICH REPEATS; MICROTUBULE STABILITY; MICROTUBULES; NEURODEGENERATION; PARKINSON DISEASE;

ACETYLATION; AMINO ACIDS; DISEASES; GENE ENCODING;

ENZYMES;

ALANINE; ALPHA TUBULIN; BETA TUBULIN; LEUCINE RICH REPEAT KINASE 2; LYSINE;

ACETYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DYSTONIA; DYSTONIA TYPE 4; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LRRK2 GENE; MICROTUBULE; MOLECULAR MODEL; MOUSE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

CYTOSKELETAL DYNAMICS; GROWTH CONE; GTPASE MUTATION; LRRK2; MICROTUBULES; MOLECULAR GENETICS; PARKINSON DISEASE; ROCCOR; TUBULIN; TUBULIN ACETYLATION;

ACETYLATION; ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; HEK293 CELLS; HUMANS; LYSINE; MICE; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; TUBULIN;

EID: 84891923527     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.507913     Document Type: Article

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