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Volumn 7, Issue 1, 2012, Pages

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

Author keywords

LRRK2; Parkinsons disease; Transgenic mouse

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; OXYGENASE;

EID: 84862230156     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-7-15     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 0036196860 scopus 로고    scopus 로고
    • A new locus for Parkinsons disease (PARK8) maps to chromosome 12p11.2- 290 q13.1
    • 10.1002/ana.10113 11891824
    • A new locus for Parkinsons disease (PARK8) maps to chromosome 12p11.2- 290 q13.1. Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F, Ann Neurol 2002 51 296 301 10.1002/ana.10113 11891824
    • (2002) Ann Neurol , vol.51 , pp. 296-301
    • Funayama, M.1    Hasegawa, K.2    Kowa, H.3    Saito, M.4    Tsuji, S.5    Obata, F.6
  • 2
    • 20444420103 scopus 로고    scopus 로고
    • An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
    • 10.1002/ana.20484 15880653
    • An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, Tsuji S, Obata F, Ann Neurol 2005 57 918 921 10.1002/ana.20484 15880653
    • (2005) Ann Neurol , vol.57 , pp. 918-921
    • Funayama, M.1    Hasegawa, K.2    Ohta, E.3    Kawashima, N.4    Komiyama, M.5    Kowa, H.6    Tsuji, S.7    Obata, F.8
  • 5
    • 14744299357 scopus 로고    scopus 로고
    • The RIP kinases: Crucial integrators of cellular stress
    • 10.1016/j.tibs.2005.01.003 15752987
    • The RIP kinases: crucial integrators of cellular stress. Meylan E, Tschopp J, Trends Biochem Sci 2005 30 151 159 10.1016/j.tibs.2005.01.003 15752987
    • (2005) Trends Biochem Sci , vol.30 , pp. 151-159
    • Meylan, E.1    Tschopp, J.2
  • 6
    • 68249104469 scopus 로고    scopus 로고
    • Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
    • 10.1186/1750-1326-4-25 19523245
    • Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation. Milosevic J, Schwarz SC, Ogunlade V, Meyer AK, Storch A, Schwarz J, Mol Neurodegener 2009 4 25 10.1186/1750-1326-4-25 19523245
    • (2009) Mol Neurodegener , vol.4 , pp. 25
    • Milosevic, J.1    Schwarz, S.C.2    Ogunlade, V.3    Meyer, A.K.4    Storch, A.5    Schwarz, J.6
  • 7
    • 70350450693 scopus 로고    scopus 로고
    • LRRK2 in Parkinsons disease: Function in cells and neurodegeneration
    • 10.1111/j.1742-4658.2009.07342.x 19804415
    • LRRK2 in Parkinsons disease: function in cells and neurodegeneration. Webber PJ, West AB, FEBS J 2009 276 6436 6444 10.1111/j.1742-4658.2009.07342.x 19804415
    • (2009) FEBS J , vol.276 , pp. 6436-6444
    • Webber, P.J.1    West, A.B.2
  • 8
    • 77958093993 scopus 로고    scopus 로고
    • LRRK2 function on actin and microtubule dynamics in Parkinson disease
    • 10.4161/cib.3.5.12286 21057624
    • LRRK2 function on actin and microtubule dynamics in Parkinson disease. Parisiadou L, Cai H, Commun Integr Biol 2010 3 396 400 10.4161/cib.3.5.12286 21057624
    • (2010) Commun Integr Biol , vol.3 , pp. 396-400
    • Parisiadou, L.1    Cai, H.2
  • 9
    • 79955052386 scopus 로고    scopus 로고
    • Diversity in the regulation of autophagy and mitophagy: Lessons from Parkinsons disease
    • Diversity in the regulation of autophagy and mitophagy: lessons from Parkinsons disease. Chu CT, Parkinsons Dis 2011 789431
    • (2011) Parkinsons Dis , pp. 789431
    • Chu, C.T.1
  • 11
  • 12
    • 76149134717 scopus 로고    scopus 로고
    • Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    • Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z, J Neurosci 2009 30 1788 1797
    • (2009) J Neurosci , vol.30 , pp. 1788-1797
    • Li, X.1    Patel, J.C.2    Wang, J.3    Avshalumov, M.V.4    Nicholson, C.5    Buxbaum, J.D.6    Elder, G.A.7    Rice, M.E.8    Yue, Z.9
  • 16
    • 79960972765 scopus 로고    scopus 로고
    • Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine Reuptake
    • 21698001
    • Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine Reuptake. Zhou H, Huang C, Tong J, Hong WC, Liu YJ, Xia XG, Int J Biol Sci 2011 7 753 761 21698001
    • (2011) Int J Biol Sci , vol.7 , pp. 753-761
    • Zhou, H.1    Huang, C.2    Tong, J.3    Hong, W.C.4    Liu, Y.J.5    Xia, X.G.6
  • 17
    • 77953395313 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions
    • 19570025
    • Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. Greggio E, Cookson MR, ASN Neuro 2009 1 00002 19570025
    • (2009) ASN Neuro , vol.1 , pp. 500002
    • Greggio, E.1    Cookson, M.R.2
  • 18
    • 70449732111 scopus 로고    scopus 로고
    • I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule
    • 10.1016/j.bbrc.2009.10.034 19833102
    • I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule. Ohta E, Katayama Y, Kawakami F, Yamamoto M, Tajima K, Maekawa T, Iida N, Hattori S, Obata F, Biochem Biophys Res Commun 2009 390 710 715 10.1016/j.bbrc.2009.10.034 19833102
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 710-715
    • Ohta, E.1    Katayama, Y.2    Kawakami, F.3    Yamamoto, M.4    Tajima, K.5    Maekawa, T.6    Iida, N.7    Hattori, S.8    Obata, F.9
  • 19
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • 10.1038/emboj.2008.163 18701920
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B, EMBO J 2008 27 2432 2443 10.1038/emboj.2008.163 18701920
    • (2008) EMBO J , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6    Lu, B.7
  • 21
    • 78650389179 scopus 로고    scopus 로고
    • LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    • 10.1523/JNEUROSCI.1807-10.2010 21159966
    • LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. Lee S, Liu HP, Lin WY, Guo H, Lu B, J Neurosci 2010 30 16959 16969 10.1523/JNEUROSCI.1807-10.2010 21159966
    • (2010) J Neurosci , vol.30 , pp. 16959-16969
    • Lee, S.1    Liu, H.P.2    Lin, W.Y.3    Guo, H.4    Lu, B.5
  • 22
    • 0033080404 scopus 로고    scopus 로고
    • Role of microtubules in the organization of the Golgi complex
    • 10.1006/excr.1998.4326 9925741
    • Role of microtubules in the organization of the Golgi complex. Thyberg J, Moskalewski S, Exp Cell Res 1999 246 263 279 10.1006/excr.1998.4326 9925741
    • (1999) Exp Cell Res , vol.246 , pp. 263-279
    • Thyberg, J.1    Moskalewski, S.2
  • 23
    • 0025168495 scopus 로고
    • Effects of MPTP on locomotor activity in mice
    • 10.1016/0892-0362(90)90061-G 2392101
    • Effects of MPTP on locomotor activity in mice. Colotla VA, Flores E, Oscos A, Meneses A, Tapia R, Neurotoxicol. Teratol 1990 12 405 407 10.1016/0892-0362(90)90061-G 2392101
    • (1990) Neurotoxicol. Teratol , vol.12 , pp. 405-407
    • Colotla, V.A.1    Flores, E.2    Oscos, A.3    Meneses, A.4    Tapia, R.5
  • 24
    • 0026552602 scopus 로고
    • The MPTP-treated mouse as a model of parkinsonism: How good is it?
    • 1304327
    • The MPTP-treated mouse as a model of parkinsonism: How good is it? Heikkila RE, Sonsalla PK, Neurochem Int 1992 20 299 303 1304327
    • (1992) Neurochem Int , vol.20 , pp. 299-303
    • Heikkila, R.E.1    Sonsalla, P.K.2
  • 25
    • 35348824170 scopus 로고    scopus 로고
    • Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice
    • 10.1073/pnas.0702753104 17702867
    • Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice. Rommelfanger KS, Edwards GL, Freeman KG, Liles LC, Miller GW, Weinshenker D, Proc Natl Acad Sci U S A 2007 104 34 13804 13809 10.1073/pnas.0702753104 17702867
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.34 , pp. 13804-13809
    • Rommelfanger, K.S.1    Edwards, G.L.2    Freeman, K.G.3    Liles, L.C.4    Miller, G.W.5    Weinshenker, D.6
  • 26
    • 0038392592 scopus 로고    scopus 로고
    • Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum
    • 10.1046/j.1460-9568.2003.02629.x 12752788
    • Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. Allen JP, Hathway GJ, Clarke NJ, Jowett MI, Topps S, Kendrick KM, Humphrey PP, Wilkinson LS, Emson PC, Eur J Neurosci 2003 17 1881 1895 10.1046/j.1460-9568. 2003.02629.x 12752788
    • (2003) Eur J Neurosci , vol.17 , pp. 1881-1895
    • Allen, J.P.1    Hathway, G.J.2    Clarke, N.J.3    Jowett, M.I.4    Topps, S.5    Kendrick, K.M.6    Humphrey, P.P.7    Wilkinson, L.S.8    Emson, P.C.9
  • 27
    • 7044270767 scopus 로고    scopus 로고
    • Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein
    • 10.1523/JNEUROSCI.3080-04.2004 15496679
    • Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. Fleming SM, Salcedo J, Fernagut PO, Rockenstein E, Masliah E, Levine MS, Chesselet MF, J Neurosci 2004 24 9434 9440 10.1523/JNEUROSCI.3080-04.2004 15496679
    • (2004) J Neurosci , vol.24 , pp. 9434-9440
    • Fleming, S.M.1    Salcedo, J.2    Fernagut, P.O.3    Rockenstein, E.4    Masliah, E.5    Levine, M.S.6    Chesselet, M.F.7
  • 28
    • 33845430429 scopus 로고    scopus 로고
    • Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease
    • 10.1016/j.jneumeth.2006.07.006 16942799
    • Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease. Allbutt HN, Henderson JM, J Neurosci Methods 2007 159 195 202 10.1016/j.jneumeth.2006.07.006 16942799
    • (2007) J Neurosci Methods , vol.159 , pp. 195-202
    • Allbutt, H.N.1    Henderson, J.M.2
  • 30
    • 13844253256 scopus 로고    scopus 로고
    • Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal dopamine in a pre-symptomatic stage model of Parkinson's disease
    • 10.1016/j.neures.2004.12.006 15710494
    • Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal dopamine in a pre-symptomatic stage model of Parkinson's disease. Ogura T, Ogata M, Akita H, Jitsuki S, Akiba L, Noda K, Hoka S, Saji M, Neurosci Res 2005 51 299 308 10.1016/j.neures.2004.12.006 15710494
    • (2005) Neurosci Res , vol.51 , pp. 299-308
    • Ogura, T.1    Ogata, M.2    Akita, H.3    Jitsuki, S.4    Akiba, L.5    Noda, K.6    Hoka, S.7    Saji, M.8
  • 31
    • 0030875612 scopus 로고    scopus 로고
    • Autosomal dominant familial Parkinson disease: Older onset of age, and good response to levodopa therapy
    • 9276200
    • Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy. Hasegawa K, Kowa H, Eur Neurol 1997 38 39 43 9276200
    • (1997) Eur Neurol , vol.38 , pp. 39-43
    • Hasegawa, K.1    Kowa, H.2
  • 32
    • 64249149785 scopus 로고    scopus 로고
    • Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes
    • 10.1016/j.parkreldis.2008.07.010 18804399
    • Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes. Hasegawa K, Stoessl AJ, Yokoyama T, Kowa H, Wszolek ZK, Yagishita S, Parkinsonism Relat Disord 2009 15 300 306 10.1016/j.parkreldis.2008.07.010 18804399
    • (2009) Parkinsonism Relat Disord , vol.15 , pp. 300-306
    • Hasegawa, K.1    Stoessl, A.J.2    Yokoyama, T.3    Kowa, H.4    Wszolek, Z.K.5    Yagishita, S.6
  • 33
    • 0006327768 scopus 로고
    • Role of microtubules in the distribution of the Golgi apparatus: Effect of taxol and microinjected anti-alpha-tubulin antibodies
    • 10.1073/pnas.80.14.4286 6136036
    • Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies. Wehland J, Henkart M, Klausner R, Sandoval IV, Proc Natl Acad Sci U S A 1983 80 4286 4290 10.1073/pnas.80.14.4286 6136036
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 4286-4290
    • Wehland, J.1    Henkart, M.2    Klausner, R.3    Sandoval, I.V.4
  • 34
    • 34447118788 scopus 로고    scopus 로고
    • LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
    • 10.1042/BJ20070209 17447891
    • LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR, Biochem J 2007 405 307 317 10.1042/BJ20070209 17447891
    • (2007) Biochem J , vol.405 , pp. 307-317
    • Jaleel, M.1    Nichols, R.J.2    Deak, M.3    Campbell, D.G.4    Gillardon, F.5    Knebel, A.6    Alessi, D.R.7
  • 36
    • 33947663512 scopus 로고    scopus 로고
    • LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins
    • 10.1016/j.cub.2007.01.074 17346966
    • LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Sakaguchi-Nakashima A, Meir JY, Jin Y, Matsumoto K, Hisamoto N, Curr Biol 2007 17 592 598 10.1016/j.cub.2007.01.074 17346966
    • (2007) Curr Biol , vol.17 , pp. 592-598
    • Sakaguchi-Nakashima, A.1    Meir, J.Y.2    Jin, Y.3    Matsumoto, K.4    Hisamoto, N.5
  • 37
    • 33747811791 scopus 로고    scopus 로고
    • Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease
    • 10.1007/s00401-006-0114-4 16855830
    • Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Fujita Y, Ohama E, Takatama M, AI-Sarraj S, Okamoto K, Acta Neuropathol 2006 112 261 265 10.1007/s00401-006-0114-4 16855830
    • (2006) Acta Neuropathol , vol.112 , pp. 261-265
    • Fujita, Y.1    Ohama, E.2    Takatama, M.3    Ai-Sarraj, S.4    Okamoto, K.5
  • 38
    • 33744531110 scopus 로고    scopus 로고
    • Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death
    • 10.1016/j.jns.2006.01.019 16545397
    • Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death. Gonatas NK, Stieber A, Gonatas JO, J Neurol Sci 2006 246 21 30 10.1016/j.jns.2006.01.019 16545397
    • (2006) J Neurol Sci , vol.246 , pp. 21-30
    • Gonatas, N.K.1    Stieber, A.2    Gonatas, J.O.3
  • 39
    • 33845656077 scopus 로고    scopus 로고
    • Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein
    • 10.1111/j.1460-9568.2006.05210.x 17156376
    • Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein. Lee HJ, Khoshaghideh F, Lee S, Lee SJ, Eur J Neurosci 2006 24 3153 3162 10.1111/j.1460-9568.2006.05210.x 17156376
    • (2006) Eur J Neurosci , vol.24 , pp. 3153-3162
    • Lee, H.J.1    Khoshaghideh, F.2    Lee, S.3    Lee, S.J.4
  • 40
    • 33947198314 scopus 로고    scopus 로고
    • Fragmentation of the Golgi apparatus: An early apoptotic event independent of the cytoskeleton
    • 10.1111/j.1600-0854.2007.00542.x 17394485
    • Fragmentation of the Golgi apparatus: an early apoptotic event independent of the cytoskeleton. Mukherjee S, Chiu R, Leung SM, Shields D, Traffic 2007 8 369 378 10.1111/j.1600-0854.2007.00542.x 17394485
    • (2007) Traffic , vol.8 , pp. 369-378
    • Mukherjee, S.1    Chiu, R.2    Leung, S.M.3    Shields, D.4
  • 42
    • 79960033063 scopus 로고    scopus 로고
    • LRRK2: A Problem Lurking in Vesicle Trafficking?
    • 10.1523/JNEUROSCI.1976-11.2011 21734269
    • LRRK2: A Problem Lurking in Vesicle Trafficking? Dihanich S, Manzoni C, J Neurosci 2011 31 9787 9788 10.1523/JNEUROSCI.1976-11.2011 21734269
    • (2011) J Neurosci , vol.31 , pp. 9787-9788
    • Dihanich, S.1    Manzoni, C.2
  • 44
    • 0037073748 scopus 로고    scopus 로고
    • LEE SJ: Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion
    • 10.1074/jbc.M208194200 12351643
    • LEE SJ: Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. Gosavi N, Lee HJ, Lee JS, Patel S, J Biol Chem 2002 277 48984 48992 10.1074/jbc.M208194200 12351643
    • (2002) J Biol Chem , vol.277 , pp. 48984-48992
    • Gosavi, N.1    Lee, H.J.2    Lee, J.S.3    Patel, S.4
  • 45
    • 79951558394 scopus 로고    scopus 로고
    • Structural organization of the Golgi apparatus
    • 10.1016/j.ceb.2010.10.004 21071196
    • Structural organization of the Golgi apparatus. Lowe M, Curr Opin Cell Biol 2011 23 85 93 10.1016/j.ceb.2010.10.004 21071196
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 85-93
    • Lowe, M.1
  • 47
    • 72949106466 scopus 로고    scopus 로고
    • Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis
    • 10.1016/j.bbrc.2009.11.043 19912990
    • Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis. Ohta E, Kubo M, Obata F, Biochem Biophys Res Commun 2010 391 242 7 10.1016/j.bbrc.2009.11.043 19912990
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 242-247
    • Ohta, E.1    Kubo, M.2    Obata, F.3
  • 48
  • 49
    • 0015595694 scopus 로고
    • Microtubule assembly in the absence of added nucleotides
    • 10.1073/pnas.70.3.765 4514990
    • Microtubule assembly in the absence of added nucleotides. Shelanski ML, Gaskinn F, Cantor CR, Proc Natl Acad Sci U S A 1973 70 765 768 10.1073/pnas.70.3.765 4514990
    • (1973) Proc Natl Acad Sci U S A , vol.70 , pp. 765-768
    • Shelanski, M.L.1    Gaskinn, F.2    Cantor, C.R.3
  • 50
    • 0023924214 scopus 로고
    • Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation
    • 2900841
    • Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation. Naoi M, Takahashi T, Nagatsu T, J Chromatogr 1988 427 229 238 2900841
    • (1988) J Chromatogr , vol.427 , pp. 229-238
    • Naoi, M.1    Takahashi, T.2    Nagatsu, T.3


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