The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

Cellular and Molecular Life Sciences

Volumn 70, Issue 1, 2013, Pages 121-136

  Bravo San Pedro, José M ^a   Niso Santano, Mireia ^a   Gómez Sánchez, Rubén ^a   Pizarro Estrella, Elisa ^a   Aiastui Pujana, Ana ^a   Gorostidi, Ana ^a   Climent, Vicente ^b   López De Maturana, Rakel ^c   Sanchez Pernaute, Rosario ^c   López De Munain, Adolfo ^d   Fuentes, José M ^a   González Polo, Rosa A ^a  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^b UNIVERSITY OF EXTREMADURA   (Spain)

^c Fundacion INBIOMED   (Spain)

^d BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

Author keywords

Autophagy; ERK; G2019S; LRRK2; Parkinson's disease

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; LEUCINE RICH REPEAT KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CASE REPORT; CELL MUTANT; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LRRK2 GENE; NERVE CELL NECROSIS; NEUROPATHOLOGY; PARKINSON DISEASE; PHYSICAL SENSITIVITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AGED; AMINO ACID SUBSTITUTION; AUTOPHAGY; CELLS, CULTURED; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBROBLASTS; HUMANS; MACROLIDES; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTON-TRANSLOCATING ATPASES;

EID: 84872362045     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1061-y     Document Type: Article

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